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Thesis ; Online: Local manufacturing of drinking water filters in low and middle-income countries

Gröninger, Olivier G.

2022

Keywords	info:eu-repo/classification/ddc/540 ; Chemistry
Language	English
Publishing date	2022-02-28
Publisher	ETH Zurich
Publishing country	ch
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Knowledge Transfer in Support of the Development of Oxygen Concentrators in Emergency Settings During the COVID-19 Pandemic.

Lustenberger, Urs B / Krestnikova, Alexandra / Gröninger, Olivier G / Grass, Robert N / Stark, Wendelin J

Journal of chemical education

2023 Volume 100, Issue 5, Page(s) 1858–1865

Abstract: The COVID-19 pandemic simultaneously disrupted supply chains and generated an urgent demand in medical infrastructure. Among personal protective equipment and ventilators, there was also an urgent demand for chemical oxygen. As devices to purify oxygen ... ...

Abstract	The COVID-19 pandemic simultaneously disrupted supply chains and generated an urgent demand in medical infrastructure. Among personal protective equipment and ventilators, there was also an urgent demand for chemical oxygen. As devices to purify oxygen could not be manufactured and shipped rapidly enough, a simple and accessible oxygen concentrator based on pressure swing adsorption was developed at ETH Zurich in spring 2020. Instead of building devices locally and shipping them, it was decided to educate others in need of oxygen. The implementation encompassed education on process chemistry, material choice, and assembly and optimization of the concentrator and was realized using synchronous teaching tools, such as video call, and asynchronous ones, such as a website and video streaming. The project gained traction and interaction with engineering teams from universities and non-Governmental Organizations (Red Cross and the UN Development Program) in developing countries and emerging market economies, including Ecuador, Mexico, Somalia, and Peru. At the end of the project, the teams were surveyed regarding their experience in the educative knowledge transfer. It was reported that the learning experience prepared these groups well to build the device and to teach others as well. Major challenges were accessing some parts of the device and optimizing its performance. While synchronous communication is expected to be a very effective teaching method, the survey results showed that explanations via a website and video streaming have contributed the most to the implementation of the oxygen concentrator and thereby provide autonomous and sustainable education tools.
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	218164-2
ISSN	1938-1328 ; 0021-9584
ISSN (online)	1938-1328
ISSN	0021-9584
DOI	10.1021/acs.jchemed.2c00925
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Article: Pro-angiogenic and antibacterial copper containing nanoparticles in PLGA/amorphous calcium phosphate bone nanocomposites.

Näf, Lukas / Miescher, Iris / Pfuderer, Lara / Schweizer, Tiziano A / Brunner, David / Dürig, Johannes / Gröninger, Olivier / Rieber, Julia / Meier-Buergisser, Gabriella / Spanaus, Katharina / Calcagni, Maurizio / Bosshard, Philipp P / Achermann, Yvonne / Stark, Wendelin J / Buschmann, Johanna

Heliyon

2024 Volume 10, Issue 5, Page(s) e27267

Abstract: Large bone defects after trauma demand for adequate bone substitutes. Bone void fillers should be antibacterial and pro-angiogenic. One viable option is the use of composite materials like the combination of PLGA and amorphous calcium phosphate (aCaP). ... ...

Abstract	Large bone defects after trauma demand for adequate bone substitutes. Bone void fillers should be antibacterial and pro-angiogenic. One viable option is the use of composite materials like the combination of PLGA and amorphous calcium phosphate (aCaP). Copper stimulates angiogenesis and has antibacterial qualities. Either copper oxide (CuO) nanoparticles (NPs) were therefore added to PLGA/aCaP/CuO in different concentrations (1, 5 and 10 w/w %) or copper-doped tricalcium phosphate NPs (TCP with 2% of copper) were electrospun into PLGA/CuTCP nanocomposites. Bi-layered nanocomposites of PLGA/aCaP with different copper NPs (CuO or TCP) and a second layer of pristine PLGA were fabricated. Two clinical bacterial isolates (
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e27267
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Article ; Online: Hybrid nanocomposite as a chest wall graft with improved vascularization by copper oxide nanoparticles.

Buschmann, Johanna / Andreoli, Stefano / Jang, Jae-Hwi / Gröninger, Olivier / Stark, Wendelin / Spanaus, Katharina / Opelz, Christine / Meier Bürgisser, Gabriella / Calcagni, Maurizio / Jungraithmayr, Wolfgang

Journal of biomaterials applications

2022 Volume 36, Issue 10, Page(s) 1826–1837

Abstract: Chest wall repair can be necessary after tumor resection or chest injury. In order to cover or replace chest wall defects, autologous tissue or different synthetic materials are commonly used, among them the semi-rigid gold standard Gore-Tex® and prolene ...

Abstract	Chest wall repair can be necessary after tumor resection or chest injury. In order to cover or replace chest wall defects, autologous tissue or different synthetic materials are commonly used, among them the semi-rigid gold standard Gore-Tex® and prolene meshes. Synthetic tissues include composite materials with an organic and an inorganic component. On the basis of previously reported hybrid nanocomposite poly-lactic-co-glycolic acid amorphous calcium phosphate nanocomposite (PLGA/aCaP), a CuO component was incorporated to yield (60%/35%/5%). This graft was tested
MeSH term(s)	Animals ; Copper ; Mice ; Nanocomposites ; Nanoparticles ; Oxides ; Thoracic Wall/surgery ; Tissue Engineering ; Tissue Scaffolds
Chemical Substances	Oxides ; Copper (789U1901C5)
Language	English
Publishing date	2022-03-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639283-0
ISSN	1530-8022 ; 0885-3282
ISSN (online)	1530-8022
ISSN	0885-3282
DOI	10.1177/08853282211065624
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Article ; Online: Directing Stem Cell Commitment by Amorphous Calcium Phosphate Nanoparticles Incorporated in PLGA: Relevance of the Free Calcium Ion Concentration.

Gröninger, Olivier / Hess, Samuel / Mohn, Dirk / Schneider, Elia / Stark, Wendelin / Märsmann, Sonja / Wolint, Petra / Calcagni, Maurizio / Cinelli, Paolo / Buschmann, Johanna

International journal of molecular sciences

2020 Volume 21, Issue 7

Abstract: The microenvironment of mesenchymal stem cells (MSCs) is responsible for the modulation in MSC commitment. Nanocomposites with an inorganic and an organic component have been investigated, and osteogenesis of MSCs has been attributed to inorganic phases ... ...

Abstract	The microenvironment of mesenchymal stem cells (MSCs) is responsible for the modulation in MSC commitment. Nanocomposites with an inorganic and an organic component have been investigated, and osteogenesis of MSCs has been attributed to inorganic phases such as calcium phosphate under several conditions. Here, electrospun meshes and two-dimensional films of poly(lactic-co-glycolic acid) (PLGA) or nanocomposites of PLGA and amorphous calcium phosphate nanoparticles (PLGA/aCaP) seeded with human adipose-derived stem cells (ASCs) were analyzed for the expression of selected marker genes. In a two-week in vitro experiment, osteogenic commitment was not found to be favored on PLGA/aCaP compared to pure PLGA. Analysis of the medium revealed a significant reduction of the Ca
MeSH term(s)	Adipose Tissue/cytology ; Adipose Tissue/metabolism ; Calcification, Physiologic ; Calcium/metabolism ; Calcium/pharmacology ; Calcium Phosphates/chemistry ; Cell Culture Techniques ; Cell Differentiation ; Cells, Cultured ; Gene Expression Profiling ; Humans ; Nanoparticles/chemistry ; Nanoparticles/ultrastructure ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Stem Cells/cytology ; Stem Cells/drug effects ; Stem Cells/metabolism ; Stem Cells/ultrastructure ; Tissue Scaffolds/chemistry ; Transcriptome
Chemical Substances	Calcium Phosphates ; amorphous calcium phosphate ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-04-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21072627
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Methanol-essential growth of Escherichia coli.

Meyer, Fabian / Keller, Philipp / Hartl, Johannes / Gröninger, Olivier G / Kiefer, Patrick / Vorholt, Julia A

Nature communications

2018 Volume 9, Issue 1, Page(s) 1508

Abstract: Methanol represents an attractive substrate for biotechnological applications. Utilization of reduced one-carbon compounds for growth is currently limited to methylotrophic organisms, and engineering synthetic methylotrophy remains a major challenge. ... ...

Abstract	Methanol represents an attractive substrate for biotechnological applications. Utilization of reduced one-carbon compounds for growth is currently limited to methylotrophic organisms, and engineering synthetic methylotrophy remains a major challenge. Here we apply an in silico-guided multiple knockout approach to engineer a methanol-essential Escherichia coli strain, which contains the ribulose monophosphate cycle for methanol assimilation. Methanol conversion to biomass was stoichiometrically coupled to the metabolization of gluconate and the designed strain was subjected to laboratory evolution experiments. Evolved strains incorporate up to 24% methanol into core metabolites under a co-consumption regime and utilize methanol at rates comparable to natural methylotrophs. Genome sequencing reveals mutations in genes coding for glutathione-dependent formaldehyde oxidation (frmA), NAD(H) homeostasis/biosynthesis (nadR), phosphopentomutase (deoB), and gluconate metabolism (gntR). This study demonstrates a successful metabolic re-routing linked to a heterologous pathway to achieve methanol-dependent growth and represents a crucial step in generating a fully synthetic methylotrophic organism.
MeSH term(s)	Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Computer Simulation ; Escherichia coli/physiology ; Gene Knockout Techniques ; Genome, Bacterial/genetics ; Gluconates/metabolism ; Metabolic Engineering ; Metabolic Networks and Pathways/genetics ; Methanol/metabolism
Chemical Substances	Bacterial Proteins ; Gluconates ; gluconic acid (R4R8J0Q44B) ; Methanol (Y4S76JWI15)
Language	English
Publishing date	2018-04-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2041-1723
ISSN (online)	2041-1723
DOI	10.1038/s41467-018-03937-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SAXS imaging reveals optimized osseointegration properties of bioengineered oriented 3D-PLGA/aCaP scaffolds in a critical size bone defect model

Casanova, Elisa A. / Rodriguez-Palomo, Adrian / Stähli, Lisa / Arnke, Kevin / Gröninger, Olivier / Generali, Melanie / Neldner, Yvonne / Tiziani, Simon / Dominguez, Ana Perez / Guizar-Sicairos, Manuel / Gao, Zirui / Appel, Christian / Nielsen, Leonard C. / Georgiadis, Marios / Weber, Franz E. / Stark, Wendelin / Pape, Hans-Christoph / Cinelli, Paolo / Liebi, Marianne

Biomaterials. 2023 Mar., v. 294 p.121989-

2023

Abstract: Healing large bone defects remains challenging in orthopedic surgery and is often associated with poor outcomes and complications. A major issue with bioengineered constructs is achieving a continuous interface between host bone and graft to enhance ... ...

Abstract	Healing large bone defects remains challenging in orthopedic surgery and is often associated with poor outcomes and complications. A major issue with bioengineered constructs is achieving a continuous interface between host bone and graft to enhance biological processes and mechanical stability. In this study, we have developed a new bioengineering strategy to produce oriented biocompatible 3D PLGA/aCaP nanocomposites with enhanced osseointegration. Decellularized scaffolds -containing only extracellular matrix- or scaffolds seeded with adipose-derived mesenchymal stromal cells were tested in a mouse model for critical size bone defects. In parallel to micro-CT analysis, SAXS tensor tomography and 2D scanning SAXS were employed to determine the 3D arrangement and nanostructure within the critical-sized bone. Both newly developed scaffold types, seeded with cells or decellularized, showed high osseointegration, higher bone quality, increased alignment of collagen fibers and optimal alignment and size of hydroxyapatite minerals.
Keywords	biocompatible materials ; collagen ; hydroxyapatite ; mice ; micro-computed tomography ; models ; nanocomposites ; nanomaterials ; surgery ; Mesenchymal stromal cells ; Critical size bone defect ; Scaffold ; PLGA/aCaP ; Extracellular matrix ; SAXS tomography
Language	English
Dates of publication	2023-03
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	603079-8
ISSN	0142-9612
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2022.121989
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: 3D microtissue-derived human stem cells seeded on electrospun nanocomposites under shear stress: Modulation of gene expression.

Schneider, Isabelle / Baumgartner, Walter / Gröninger, Olivier / Stark, Wendelin J / Märsmann, Sonja / Calcagni, Maurizio / Cinelli, Paolo / Wolint, Petra / Buschmann, Johanna

Journal of the mechanical behavior of biomedical materials

2019 Volume 102, Page(s) 103481

Abstract: Objective: Different microenvironments trigger distinct differentiation of stem cells. Even without chemical supplementation, mechanical stimulation by shear stress may help to induce the desired differentiation. The cell format, such as three- ... ...

Abstract	Objective: Different microenvironments trigger distinct differentiation of stem cells. Even without chemical supplementation, mechanical stimulation by shear stress may help to induce the desired differentiation. The cell format, such as three-dimensional (3D) microtissues (MTs), MT-derived cells or single cells (SCs), may have a pivotal impact as well. Here, we studied modulation of gene expression in human adipose-derived stem cells (ASCs) exposed to shear stress and/or after MT formation. Materials and methods: Electrospun meshes of poly-lactic-co-glycolic acid and amorphous calcium phosphate nanoparticles (PLGA/aCaP) at a weight ratio of 60:40 were seeded with human ASCs as MTs or as SCs and cultured in Dulbecco's modified Eagle's medium without chemical supplementation. After 2 weeks of static culture, the scaffolds were cultured statically for another 2 weeks or placed in a Bose® bioreactor with a flow rate per area of 0.16 mL cm Results: MTs decayed completely within 2 weeks after seeding on PLGA/aCaP. The osteogenic marker gene alkaline phosphatase and the endothelial cell marker gene CD31 were upregulated in MT-derived ASCs compared with SCs. Shear stress realised by fluid flow perfusion upregulated peroxisome proliferator-activated receptor gamma 2 expression in MT-derived ASCs and in SCs. The nuclear-to-cytoplasmic ratio of YAP expression was doubled under perfusion compared with that under static culture for MT-derived ASCs and SCs. Conclusions: Osteogenic and angiogenic commitments were more pronounced in MT-derived ASCs seeded on bone biomimetic electrospun nanocomposite PLGA/aCaP than in SCs seeded without induction medium. Furthermore, the static culture was superior to the perfusion regimen used here, as shear stress resulted in adipogenic commitment for MT-derived ASCs and SCs, although the YAP nuclear-to-cytoplasmic ratio indicated higher cell tensions under perfusion, usually associated with preferred osteogenic differentiation.
MeSH term(s)	Adipose Tissue ; Cell Differentiation ; Cells, Cultured ; Gene Expression ; Humans ; Nanocomposites ; Osteogenesis/genetics ; Stem Cells ; Tissue Scaffolds
Language	English
Publishing date	2019-10-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2378381-3
ISSN	1878-0180 ; 1751-6161
ISSN (online)	1878-0180
ISSN	1751-6161
DOI	10.1016/j.jmbbm.2019.103481
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Article ; Online: SAXS imaging reveals optimized osseointegration properties of bioengineered oriented 3D-PLGA/aCaP scaffolds in a critical size bone defect model.

Casanova, Elisa A / Rodriguez-Palomo, Adrian / Stähli, Lisa / Arnke, Kevin / Gröninger, Olivier / Generali, Melanie / Neldner, Yvonne / Tiziani, Simon / Dominguez, Ana Perez / Guizar-Sicairos, Manuel / Gao, Zirui / Appel, Christian / Nielsen, Leonard C / Georgiadis, Marios / Weber, Franz E / Stark, Wendelin / Pape, Hans-Christoph / Cinelli, Paolo / Liebi, Marianne

Biomaterials

2023 Volume 294, Page(s) 121989

Abstract	Healing large bone defects remains challenging in orthopedic surgery and is often associated with poor outcomes and complications. A major issue with bioengineered constructs is achieving a continuous interface between host bone and graft to enhance biological processes and mechanical stability. In this study, we have developed a new bioengineering strategy to produce oriented biocompatible 3D PLGA/aCaP nanocomposites with enhanced osseointegration. Decellularized scaffolds -containing only extracellular matrix- or scaffolds seeded with adipose-derived mesenchymal stromal cells were tested in a mouse model for critical size bone defects. In parallel to micro-CT analysis, SAXS tensor tomography and 2D scanning SAXS were employed to determine the 3D arrangement and nanostructure within the critical-sized bone. Both newly developed scaffold types, seeded with cells or decellularized, showed high osseointegration, higher bone quality, increased alignment of collagen fibers and optimal alignment and size of hydroxyapatite minerals.
MeSH term(s)	Animals ; Mice ; Osseointegration ; Polylactic Acid-Polyglycolic Acid Copolymer ; Tissue Scaffolds/chemistry ; Polyglycolic Acid/chemistry ; Bone Regeneration ; Lactic Acid/chemistry ; Scattering, Small Angle ; X-Ray Diffraction ; Osteogenesis
Chemical Substances	Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Polyglycolic Acid (26009-03-0) ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2023-01-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2022.121989
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Article ; Online: Catalyst and Process Design for the Continuous Manufacture of Rare Sugar Alcohols by Epimerization-Hydrogenation of Aldoses.

Lari, Giacomo M / Gröninger, Olivier G / Li, Qiang / Mondelli, Cecilia / López, Núria / Pérez-Ramírez, Javier

ChemSusChem

2016 Volume 9, Issue 24, Page(s) 3407–3418

Abstract: Sugar alcohols are applied in the food, pharmaceutical, polymer, and fuel industries and are commonly obtained by reduction of the corresponding saccharides. In view of the rarity of some sugar substrates, epimerization of a readily available ... ...

Abstract	Sugar alcohols are applied in the food, pharmaceutical, polymer, and fuel industries and are commonly obtained by reduction of the corresponding saccharides. In view of the rarity of some sugar substrates, epimerization of a readily available monosaccharide has been proposed as a solution, but an efficient catalytic system has not yet been identified. Herein, a molybdenum heteropolyacid-based catalyst is developed to transform glucose, arabinose, and xylose into less-abundant mannose, ribose, and lyxose, respectively. Adsorption of molybdic acid onto activated carbon followed by ion exchange to the cesium form limits leaching of the active phase, which greatly improves the catalyst stability over 24 h on stream. The hydrogenation of mixtures of epimers is studied over ruthenium catalysts, and it is found that the precursor to the desired polyol is advantageously converted with faster kinetics. This is explained by density functional theory on the basis of its more favorable adsorption on the metal surface and the lower energy barrier for the addition of a hydrogen atom to the primary carbon atom. Finally, different designs for a continuous process for the conversion of glucose into mannitol are studied, and it is uncovered that two reactors in series with one containing the epimerization catalyst and the other containing a mixture of the epimerization and hydrogenation catalysts increases the mannitol/sorbitol ratio to 1.5 from 1 for a single mixed-bed reactor. This opens a prospective route to the efficient valorization of renewables to added-value chemicals.
MeSH term(s)	Carbohydrate Conformation ; Catalysis ; Hydrogenation ; Models, Molecular ; Monosaccharides/chemistry ; Quantum Theory ; Stereoisomerism ; Sugar Alcohols/chemistry
Chemical Substances	Monosaccharides ; Sugar Alcohols
Language	English
Publishing date	2016-12-20
Publishing country	Germany
Document type	Journal Article
ISSN	1864-564X
ISSN (online)	1864-564X
DOI	10.1002/cssc.201600755
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