Article ; Online: Simultaneous Water Sorption and Crystallization in ASDs 1: Stability Studies Lasting for Two Years.
2024 Volume 21, Issue 2, Page(s) 957–969
Abstract: One way to increase the slow dissolution rate and the associated low bioavailability of newly developed active pharmaceutical ingredients (APIs) is to dissolve the API in a polymer, leading to a so-called amorphous solid dispersion (ASD). However, APIs ... ...
Abstract | One way to increase the slow dissolution rate and the associated low bioavailability of newly developed active pharmaceutical ingredients (APIs) is to dissolve the API in a polymer, leading to a so-called amorphous solid dispersion (ASD). However, APIs are often supersaturated in ASDs and thus tend to crystallize during storage. The kinetics of the crystallization process is determined by the amount of water the ASD absorbs during storage at relative humidity (RH), storage temperature, polymer type, and the drug load of the ASD. Here, the crystallization kinetics and shelf life of spray-dried ASDs were investigated for ASDs consisting of nifedipine (NIF) or celecoxib (CCX) as the APIs and of poly(vinylpyrrolidone- |
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MeSH term(s) | Crystallization ; Water/chemistry ; Drug Stability ; Solubility ; Polymers/chemistry |
Chemical Substances | Water (059QF0KO0R) ; Polymers |
Language | English |
Publishing date | 2024-01-03 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 2138405-8 |
ISSN | 1543-8392 ; 1543-8384 |
ISSN (online) | 1543-8392 |
ISSN | 1543-8384 |
DOI | 10.1021/acs.molpharmaceut.3c01056 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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