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Article ; Online: Editorial: non-invasive diagnosis of alcohol-related steatohepatitis in patients ongoing alcohol withdrawal based on cytokeratin 18 and transient elastography.

Thomsen, Karen L / Gronbaek, Henning

2023 Volume 58, Issue 1, Page(s) 118–119

MeSH term(s)	Humans ; Alcoholism ; Substance Withdrawal Syndrome ; Keratin-18 ; Elasticity Imaging Techniques ; Fatty Liver
Chemical Substances	Keratin-18
Language	English
Publishing date	2023-06-12
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17530
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Zs.A 2206: Show issues

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Article ; Online: Hepatocellular carcinoma in autoimmune hepatitis remains rare.

Grønbæk, Lisbet / Grønbæk, Henning

Journal of hepatology

2023 Volume 80, Issue 1, Page(s) 8–9

MeSH term(s)	Humans ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/pathology ; Hepatitis, Autoimmune/complications ; Hepatitis, Autoimmune/diagnosis ; Liver Neoplasms/diagnosis ; Liver Neoplasms/etiology ; Liver Neoplasms/pathology
Language	English
Publishing date	2023-10-10
Publishing country	Netherlands
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2023.09.032
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Zs.A 2027: Show issues

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Article ; Online: High-dose oral thiamine versus placebo for chronic fatigue in patients with primary biliary cholangitis: A crossover randomized clinical trial.

Bager, Palle / Bossen, Lars / Gantzel, Rasmus / Grønbæk, Henning

PloS one

2024 Volume 19, Issue 3, Page(s) e0301354

Abstract: Background & aims: Fatigue has high negative impact on many patients with primary biliary cholangitis (PBC) and treatment options are limited. Recently we showed favorable effects of four weeks of high-dose thiamine treatment on fatigue in patients with ...

Abstract	Background & aims: Fatigue has high negative impact on many patients with primary biliary cholangitis (PBC) and treatment options are limited. Recently we showed favorable effects of four weeks of high-dose thiamine treatment on fatigue in patients with inflammatory bowel disease. We aimed to investigate the effect and safety of high-dose (600-1800 mg daily) oral thiamine treatment on chronic fatigue in patients with PBC. Methods: Randomized, double-blinded, placebo-controlled crossover trial including patients with severe PBC-related fatigue. Participants were allocated 1:1 to either group 1) 4 weeks of high-dose thiamine, 4 weeks of washout, and 4 weeks of placebo; or group 2) 4 weeks of placebo, washout, and high-dose thiamine, respectively. Fatigue severity was quantified using the fatigue subscale of the PBC-40 questionnaire. The primary outcome was a fatigue reduction of ≥ 5 points after 4 weeks of high-dose thiamine treatment. Results: We enrolled 36 patients; 34 completed the study. The overall mean reduction in fatigue was 5.0 points (95% CI: 2.5 to 7.5; p < 0.001) for the combined group 1 and group 2. Crossover analysis showed a mean increase in fatigue of 0.3 points (95% CI: -4.2 to 3.8) after high-dose thiamine treatment compared to a 1.4 points (95% CI: 6.2 to -3.4) mean reduction after placebo (p = 0.55). Only mild and transient adverse events were recorded. Conclusion: Four weeks of high-dose oral thiamine treatment in patients with PBC was well tolerated and safe. However, high-dose thiamine was not superior to placebo in reducing PBC-related fatigue. Trial registration: The trial was registered in the ClinicalTrials.gov (NCT04893993) and EudraCT (2020-004935-26).
MeSH term(s)	Humans ; Liver Cirrhosis, Biliary ; Thiamine/therapeutic use ; Fatigue Syndrome, Chronic ; Double-Blind Method ; Treatment Outcome
Chemical Substances	Thiamine (X66NSO3N35)
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0301354
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Article: The vascular endothelial growth factor system-a new player in the pathogenesis and development of metabolic dysfunction-associated steatotic liver disease.

Grønbæk, Henning / Mellemkjær, Anders / Nielsen, Søren / Magkos, Faidon

Hepatobiliary surgery and nutrition

2023 Volume 12, Issue 6, Page(s) 963–965

Language	English
Publishing date	2023-11-15
Publishing country	China (Republic : 1949- )
Document type	Editorial ; Comment
ZDB-ID	2812398-0
ISSN	2304-389X ; 2304-3881
ISSN (online)	2304-389X
ISSN	2304-3881
DOI	10.21037/hbsn-23-552
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Article ; Online: A nationwide study of autoimmune liver diseases in the Faroe Islands: Incidence, prevalence, and causes of death 2004 - 2021.

Nielsen, Kári Rubek / Midjord, Jóngerð / Johannesen, Herborg Líggjasardóttir / Grønbæk, Henning

International journal of circumpolar health

2023 Volume 82, Issue 1, Page(s) 2221368

Abstract: Background and aims: ...

Abstract	Background and aims:
MeSH term(s)	Humans ; Incidence ; Prevalence ; Cause of Death ; Liver Cirrhosis, Biliary/epidemiology ; Liver Cirrhosis, Biliary/diagnosis ; Carcinoma, Hepatocellular ; Cohort Studies ; Liver Neoplasms ; Liver Diseases/diagnosis ; Hepatitis, Autoimmune/epidemiology ; Hepatitis, Autoimmune/diagnosis ; Liver Failure
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1386707-6
ISSN	2242-3982 ; 1239-9736
ISSN (online)	2242-3982
ISSN	1239-9736
DOI	10.1080/22423982.2023.2221368
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Zs.A 2467: Show issues

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Article ; Online: The prevalence and disease course of autoimmune liver diseases in Greenland.

Gantzel, Rasmus Hvidbjerg / Bagge, Carina Nørskov / Villadsen, Gerda Elisabeth / Rex, Karsten Fleischer / Grønbæk, Henning / Pedersen, Michael Lynge

International journal of circumpolar health

2024 Volume 83, Issue 1, Page(s) 2327693

Abstract: Autoimmune liver diseases are rare serious diseases causing chronic inflammation and fibrosis in the liver parenchyma and bile ducts. Yet, the prevalence and burden of autoimmune liver diseases are largely unexplored in Arctic native populations. We ... ...

Abstract	Autoimmune liver diseases are rare serious diseases causing chronic inflammation and fibrosis in the liver parenchyma and bile ducts. Yet, the prevalence and burden of autoimmune liver diseases are largely unexplored in Arctic native populations. We investigated the prevalence and management of autoimmune liver diseases in Greenland using nationwide cross-sectional register data and subsequent medical chart reviews validating diagnoses and extracting liver histology examinations and medical treatments. The overall prevalence of autoimmune liver diseases in Greenland was 24.6 per 100,000 (95% CI: 14.7-41.3). This was based on 7 patients with autoimmune hepatitis (AIH) (12.3 per 100,000), 3 patients with primary biliary cholangitis (PBC) (5.3 per 100,000), 4 patients with AIH/PBC overlap disease (7.0 per 100,000), and no patients with primary sclerosing cholangitis. All diagnoses were confirmed by liver histology examinations. Medical treatments adhered to internal recommendations and induced complete remission in most patients with AIH, and complete or partial remission in 1 patient with PBC and 3 patients with AIH/PBC overlap disease. One patient had established cirrhosis at the time of diagnosis, while 2 patients progressed to cirrhosis. In conclusion, the prevalence of autoimmune liver diseases was lower in Greenland than in Scandinavia and among Alaska Inuit.
MeSH term(s)	Humans ; Liver Cirrhosis, Biliary/diagnosis ; Liver Cirrhosis, Biliary/epidemiology ; Prevalence ; Greenland/epidemiology ; Cross-Sectional Studies ; Cholangitis, Sclerosing/diagnosis ; Cholangitis, Sclerosing/epidemiology ; Liver Diseases ; Hepatitis, Autoimmune/diagnosis ; Hepatitis, Autoimmune/epidemiology ; Liver Cirrhosis
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1386707-6
ISSN	2242-3982 ; 1239-9736
ISSN (online)	2242-3982
ISSN	1239-9736
DOI	10.1080/22423982.2024.2327693
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Zs.A 2467: Show issues

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Article: Effects of Peptide Receptor Radiotherapy in Patients with Advanced Paraganglioma and Pheochromocytoma: A Nation-Wide Cohort Study.

Kornerup, Linda Skibsted / Andreassen, Mikkel / Knigge, Ulrich / Arveschoug, Anne Kirstine / Poulsen, Per Løgstup / Kjær, Andreas / Oturai, Peter Sandor / Grønbæk, Henning / Dam, Gitte

Cancers

2024 Volume 16, Issue 7

Abstract: Introduction: Pheochromocytomas and paragangliomas are rare neuroendocrine tumours that originate from chromaffin cells within the adrenal medulla or extra-adrenal sympathetic ganglia. Management of disseminated or metastatic pheochromocytomas and ... ...

Abstract	Introduction: Pheochromocytomas and paragangliomas are rare neuroendocrine tumours that originate from chromaffin cells within the adrenal medulla or extra-adrenal sympathetic ganglia. Management of disseminated or metastatic pheochromocytomas and paragangliomas continues to pose challenges and relies on limited evidence. Method: In this study, we report retrospective data on median overall survival (OS) and median progression-free survival (PFS) for all Danish patients treated with peptide receptor radionuclide therapy (PRRT) with Results: We included 28 patients; 10 were diagnosed with pheochromocytoma and 18 with paraganglioma. Median age at first PRRT was 47 (IQR 15-76) years. The median follow-up time was 31 (IQR 17-37) months. Eight patients died during follow-up. Median OS was 72 months, and 5-year survival was 65% with no difference between pheochromocytoma and paraganglioma. Patients with germline mutations had better survival than patients without mutations ( Conclusions: The median OS of around 6 years and median PFS of around 2.5 years found in this study are comparable to those reported in previous studies employing PRRT. Based on historical data, the efficacy of PRRT may be superior to
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16071349
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Article: Clinical Progression of Metabolic-Associated Fatty Liver Disease Is Rare in a Danish Tertiary Liver Center.

Laursen, Tea Lund / Kjær, Mikkel Breinholt / Kristensen, Louise / Grønbæk, Henning

Journal of clinical medicine

2022 Volume 11, Issue 9

Abstract: Data concerning non-invasive discrimination of simple steatosis from steatohepatitis in metabolic-associated fatty liver disease (MAFLD) and risk of disease progression in patients with MAFLD are conflicting. We aimed to investigate these factors in an ... ...

Abstract	Data concerning non-invasive discrimination of simple steatosis from steatohepatitis in metabolic-associated fatty liver disease (MAFLD) and risk of disease progression in patients with MAFLD are conflicting. We aimed to investigate these factors in an MAFLD cohort at a Danish tertiary liver centre. We retrospectively assessed 129 patients with biopsy-proven MAFLD. Patients were divided according to the presence of simple steatosis or steatohepatitis in liver biopsies. Histological and clinical progression were assessed during follow-up. Patients with steatohepatitis had higher BMIs, liver stiffness, HbA1c and soluble (sCD163) and were more prone to have metabolic syndrome at baseline compared with simple steatosis patients. Of the 129 patients, 31 had a follow-up biopsy after a median of 287 days; simple steatosis progressed to steatohepatitis in 7 cases, while 2 regressed. Twenty patients had the same fibrosis stage according to the follow-up biopsy, seven progressed and four regressed. Only 14 patients progressed clinically (median follow-up time was 3.8 years). Clinical progression was associated with female sex, high creatinine, high sCD163 and disease severity in the diagnostic liver biopsy. Steatohepatitis was associated with metabolic and inflammatory parameters including fibroscan. Disease progression was seen in only 11% of cases and was mainly related to more severe histological disease at baseline.
Language	English
Publishing date	2022-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11092271
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Article ; Online: Management of cardiovascular risk in patients with metabolic dysfunction-associated steatotic liver disease.

Mellemkjær, Anders / Kjær, Mikkel Breinholt / Haldrup, David / Grønbæk, Henning / Thomsen, Karen Louise

European journal of internal medicine

2023 Volume 122, Page(s) 28–34

Abstract: The novel term Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is proposed to replace non-alcoholic fatty liver disease (NAFLD) to highlight the close association with the metabolic syndrome. MASLD encompasses patients with liver ... ...

Abstract	The novel term Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is proposed to replace non-alcoholic fatty liver disease (NAFLD) to highlight the close association with the metabolic syndrome. MASLD encompasses patients with liver steatosis and at least one of five cardiometabolic risk factors which implies that these patients are at increased risk of cardiovascular disease (CVD). Indeed, the prevalence of CVD in MASLD patients is increased and CVD is recognized as the most common cause of death in MASLD patients. We here present an update on the pathophysiology of CVD in MASLD, discuss the risk factors, and suggest screening for CVD in patients with MASLD. Currently, there is no FDA-approved pharmacological treatment for MASLD, and no specific treatment recommended for CVD in patients with MASLD. Thus, the treatment strategy is based on weight loss and a reduction and treatment of CVD risk factors. We recommend screening of MASLD patients for CVD using the SCORE2 system with guidance to specific treatment algorithms. In all patients with CVD risk factors, lifestyle intervention to induce weight loss through diet and exercise is recommended. Especially a Mediterranean diet may improve hyperlipidemia and if further treatment is needed, statins should be used as first-line treatment. Further, anti-hypertensive drugs should be used to treat hypertension. With the epidemic of obesity and type 2 diabetes mellitus (T2DM) the risk of MASLD and CVD is expected to increase, and preventive measures, screening, and effective treatments are highly needed to reduce morbidity and mortality in MASLD patients.
MeSH term(s)	Humans ; Cardiovascular Diseases/epidemiology ; Diabetes Mellitus, Type 2 ; Risk Factors ; Metabolic Diseases ; Heart Disease Risk Factors ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/therapy ; Weight Loss
Language	English
Publishing date	2023-11-25
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2023.11.012
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Zs.A 2608: Show issues

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Article ; Online: Measurement of particle removal performance for a novel design of range hood

Shu Lei / Fang Lei / Grønbæk Henning / Bendtsen Jacob / Olesen Bjarne W.

E3S Web of Conferences, Vol 356, p

2022 Volume 05070

Abstract: A novel range hood (NRH) consisting of a high-efficiency particulate air (HEPA) filter circulation component and exhaust component was designed to improve indoor air quality. The HEPA filter circulation component with an airflow rate of 72 l/s was used ... ...

Abstract	A novel range hood (NRH) consisting of a high-efficiency particulate air (HEPA) filter circulation component and exhaust component was designed to improve indoor air quality. The HEPA filter circulation component with an airflow rate of 72 l/s was used to remove the particulate matter generated by cooking activities and return filtered clean air to the room. The exhaust component was used to reject both particulate matter and other indoor air pollutants to the outdoors. Field measurements were carried out in an open kitchen of a two-floor residential house. The total occupied zone was about 160 m³ with a living area of 64 m2 (including an open kitchen) and a height of 2.5 m. Frying bacon that can generate a large number of particles of different sizes was used to simulate the daily cooking activities. Four operating conditions of the NRH were studied, i.e. 38 l/s exhaust airflow rate with the HEPA circulation on and off, and 78 l/s exhaust airflow rate with the HEPA circulation on and off. The concentration of PM0.1 count, PM2.5 mass, and PM10 mass were measured during measurements. The HEPA filter circulation part of the NRH can dramatically reduce the concentration of all sizes of particles generated by cooking activities. By combining the HEPA filter circulation component, the NRH can separately reduce the concentration of PM0.1, PM2.5, PM10 by up to 91.9%, 95.7%, 94.6% compared to that when only running the exhaust part.
Keywords	Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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