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  1. Article: The Influence of Pretherapeutic and Preoperative Sarcopenia on Short-Term Outcome after Esophagectomy.

    Grün, Johanna / Elfinger, Lea / Le, Han / Weiß, Christel / Otto, Mirko / Reißfelder, Christoph / Blank, Susanne

    Cancers

    2020  Volume 12, Issue 11

    Abstract: By introducing minimally invasive surgery the rate of postoperative morbidity in esophageal cancer patients could be reduced. But esophagectomy is still associated with a relevant risk of postoperative morbidity and mortality. Patients often present with ...

    Abstract By introducing minimally invasive surgery the rate of postoperative morbidity in esophageal cancer patients could be reduced. But esophagectomy is still associated with a relevant risk of postoperative morbidity and mortality. Patients often present with nutritional deficiency and sarcopenia even at time of diagnosis. This study focuses on the influence of skeletal muscle index (SMI) on postoperative morbidity and mortality. Fifty-two patients were included in this study. SMI was measured using computer tomographic images at the time of diagnosis and before surgery. Then, SMI and different clinicopathological and demographic features were correlated with postoperative morbidity. There was no correlation between SMI before neoadjuvant therapy (
    Language English
    Publishing date 2020-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12113409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online ; Thesis: Etablierung und Charakterisierung der neuen cholangiozellulären Zelllinie CCC-5

    Grün, Johanna [Verfasser] / Rückert, Felix [Akademischer Betreuer]

    2018  

    Author's details Johanna Luisa Grün ; Betreuer: Felix Rückert
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Heidelberg
    Publishing place Heidelberg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article: GAS2L1 Is a Potential Biomarker of Circulating Tumor Cells in Pancreatic Cancer.

    Zhu, Lei / Kan, Ke-Jia / Grün, Johanna L / Hissa, Barbara / Yang, Cui / Győrffy, Balázs / Loges, Sonja / Reißfelder, Christoph / Schölch, Sebastian

    Cancers

    2020  Volume 12, Issue 12

    Abstract: Pancreatic cancer is a malignant disease with high mortality and a dismal prognosis. Circulating tumor cell (CTC) detection and characterization have emerged as essential techniques for early detection, prognostication, and liquid biopsy in many solid ... ...

    Abstract Pancreatic cancer is a malignant disease with high mortality and a dismal prognosis. Circulating tumor cell (CTC) detection and characterization have emerged as essential techniques for early detection, prognostication, and liquid biopsy in many solid malignancies. Unfortunately, due to the low EPCAM expression in pancreatic cancer CTCs, no specific marker is available to identify and isolate this rare cell population. This study analyzed single-cell RNA sequencing profiles of pancreatic CTCs from a genetically engineered mouse model (GEMM) and pancreatic cancer patients. Through dimensionality reduction analysis, murine pancreatic CTCs were grouped into three clusters with different biological functions.
    Language English
    Publishing date 2020-12-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12123774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: High-Density Lipoprotein Reduction Differentially Modulates to Classical and Nonclassical Monocyte Subpopulations in Metabolic Syndrome Patients and in LPS-Stimulated Primary Human Monocytes

    Grün, Johanna L / Manjarrez-Reyna, Aaron N / Gómez-Arauz, Angélica Y / Leon-Cabrera, Sonia / Rückert, Felix / Fragoso, José M / Bueno-Hernández, Nallely / Islas-Andrade, Sergio / Meléndez-Mier, Guillermo / Escobedo, Galileo

    Journal of immunology research

    2018  Volume 2018, Page(s) 2737040

    Abstract: The effect of metabolic syndrome on human monocyte subpopulations has not yet been studied. Our main goal was to examine monocyte subpopulations in metabolic syndrome patients, while also identifying the risk factors that could directly influence these ... ...

    Abstract The effect of metabolic syndrome on human monocyte subpopulations has not yet been studied. Our main goal was to examine monocyte subpopulations in metabolic syndrome patients, while also identifying the risk factors that could directly influence these cells. Eighty-six subjects were divided into metabolic syndrome patients and controls. Monocyte subpopulations were quantified by flow cytometry, and interleukin- (IL-) 1
    MeSH term(s) Adult ; Cells, Cultured ; Diet Therapy ; Female ; Flow Cytometry ; Humans ; Interleukin-1beta/metabolism ; Lipopolysaccharides/immunology ; Lipoproteins, HDL/metabolism ; Male ; Metabolic Syndrome/diet therapy ; Metabolic Syndrome/immunology ; Middle Aged ; Monocytes/physiology ; Primary Cell Culture ; Young Adult
    Chemical Substances Interleukin-1beta ; Lipopolysaccharides ; Lipoproteins, HDL
    Language English
    Publishing date 2018-04-03
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-8861
    ISSN (online) 2314-7156
    ISSN 2314-8861
    DOI 10.1155/2018/2737040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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