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Article ; Online: Metal Ion Release in Cancer Patients Following Megaprosthesis Salvage Surgery.

Fa-Binefa, M / Rojas-Sayol, R / Peiró, A / Trullols, L / Machado, P / Gracia, I

2024

Abstract: Background: Megaprostheses contain many more modular components than conventional total hip and knee arthroplasty, which may lead to higher serum levels of metal ions. The aim of this study was to determine serum concentrations of titanium, chromium, ... ...

Abstract	Background: Megaprostheses contain many more modular components than conventional total hip and knee arthroplasty, which may lead to higher serum levels of metal ions. The aim of this study was to determine serum concentrations of titanium, chromium, and cobalt ions in cancer patients after limb salvage surgery with a megaprosthesis. Methods: A retrospective, descriptive cohort analysis consisting of patients who underwent cancer-related limb salvage surgery with a megaprosthesis at our hospital between 2010 and 2020 was conducted. Baseline and follow-up data were extracted from clinical and surgical records. Blood samples were prospectively obtained. Descriptive statistics were used for the analysis. Results: A total of 71 patients underwent limb salvage surgery during the study period. Of these, 22 (10 women, 12 men) were included in the study. The mean age was 52 years (range, 21 to 80). Most cases (n = 16; 72.7%) involved the femur. Most patients (n = 14, 63.6%) underwent total knee megaprosthesis surgery. Implant revision surgery was required in 45% of cases (n = 10), with a mean interval of 4.32 years between the initial and revision surgeries. The mean follow-up time after revision surgery was 4.05 years. High levels of chromium were observed in 22.7% of patients (n = 5). High cobalt levels were found in 68.2% (n = 15) of patients, with toxic levels in 9.1% (n =2). Titanium levels were high in 77.3% (n = 17) of cases and toxic in 22.7% (n = 5). Postoperative chemotherapy was significantly associated with titanium levels (P = 0.017). No correlation was observed between metal ion levels and time from primary or revision surgery or time from the first to revision surgery. Conclusion: This study shows that cancer-related limb salvage surgery with megaprosthesis is associated with metal ion levels that exceed established safe thresholds. Compared to conventional hip arthroplasty, a higher proportion of the patients in this cohort presented elevated levels of metal ions.
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2024.04.034
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Article ; Online: Skin, gut, and lung barrier: Physiological interface and target of intervention for preventing and treating allergic diseases.

Berni Canani, Roberto / Caminati, Marco / Carucci, Laura / Eguiluz-Gracia, Ibon

Allergy

2024

Abstract: The epithelial barriers of the skin, gut, and respiratory tract are critical interfaces between the environment and the host, and they orchestrate both homeostatic and pathogenic immune responses. The mechanisms underlying epithelial barrier dysfunction ... ...

Abstract	The epithelial barriers of the skin, gut, and respiratory tract are critical interfaces between the environment and the host, and they orchestrate both homeostatic and pathogenic immune responses. The mechanisms underlying epithelial barrier dysfunction in allergic and inflammatory conditions, such as atopic dermatitis, food allergy, eosinophilic oesophagitis, allergic rhinitis, chronic rhinosinusitis, and asthma, are complex and influenced by the exposome, microbiome, individual genetics, and epigenetics. Here, we review the role of the epithelial barriers of the skin, digestive tract, and airways in maintaining homeostasis, how they influence the occurrence and progression of allergic and inflammatory conditions, how current treatments target the epithelium to improve symptoms of these disorders, and what the unmet needs are in the identification and treatment of epithelial disorders.
Language	English
Publishing date	2024-03-04
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.16092
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Article ; Online: Biomarkers predicting the controller dose of omalizumab in patients with chronic spontaneous urticaria.

Zubiaga-Fernandez, L / Testera-Montes, A / Rondon, C / Perez-Sanchez, N / Gomez-Perez, F / Vega-Chicote, J M / Bartra, J / Ferrer, M / Eguiluz-Gracia, I / Torres, M J

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

2024

Abstract: Background: Clinical trials showed the efficacy of 300 mg/4 weeks of omalizumab (OMA) during 6 months in patients with severe chronic spontaneous urticaria (CSU). Nevertheless, in real life, many patients require higher doses and/or longer treatment. ... ...

Abstract	Background: Clinical trials showed the efficacy of 300 mg/4 weeks of omalizumab (OMA) during 6 months in patients with severe chronic spontaneous urticaria (CSU). Nevertheless, in real life, many patients require higher doses and/or longer treatment. This study assesses the real-life performance of OMA in severe CSU and identifies factors associated with the response. Methods: CSU patients eligible for OMA were recruited prospectively. Clinical data and a blood test were collected before OMA initiation. Urticaria Activity Score 7 (UAS7) was calculated at baseline and every 3 months during OMA treatment. CSU control was defined as UAS7 <7 points. This work was partially sponsored by OMA manufacturer. Results: Eighty-nine adults (19.1% males) with severe CSU were recruited. Median duration of CSU prior to OMA initiation was 2 years, and median severity by UAS7 at baseline was 24 points (range 10-42 points). OMA controlled 94.4% of patients, but 17.9% of responders required doses >300 mg/4 weeks. A blood basophil count >20 cells/μL (OR 13.33; 95% CI 3.32-52.63; p < .001) and the absence of hypothyroidism (OR 3.65; 95% CI 0.78-16.95; p = .099) were identified as predictive factors to achieve control with 300 mg/4 weeks. Twelve patients were able to stop OMA during the study (responders in remission, RR). RR had received OMA for a median of 29 months (12-53 months). Conversely, 32 patients had been on OMA for >29 months at the end of the study (active responders, AR). AR had received OMA for a median of 45 months (30-100 months). There were no significant differences in clinical or analytical factors between RR and AR patients. Conclusions: Low blood basophil count and the presence of hypothyroidism might serve as biomarkers for the controller dose of OMA in severe CSU patients.
Language	English
Publishing date	2024-02-11
Publishing country	England
Document type	Journal Article
ZDB-ID	645204-8
ISSN	1365-2222 ; 0954-7894 ; 0960-2178
ISSN (online)	1365-2222
ISSN	0954-7894 ; 0960-2178
DOI	10.1111/cea.14462
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Article ; Online: Omega-3 fatty acids and the regulation of adipogenesis.

Eguiluz-Gracia, Ibon / Bogas, Gador

Allergy

2020 Volume 75, Issue 5, Page(s) 1281–1282

MeSH term(s)	Adipogenesis ; Dietary Fats ; Fatty Acids, Omega-3 ; Humans
Chemical Substances	Dietary Fats ; Fatty Acids, Omega-3
Language	English
Publishing date	2020-02-16
Publishing country	Denmark
Document type	News ; Research Support, Non-U.S. Gov't
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.14208
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Article: Antibacterial Activity Assessment of Chitosan/Alginate Lavender Essential Oil Membranes for Biomedical Applications.

Cruz Sánchez, Encarnación / García, María Teresa / Gracia, Ignacio / Fernández-Bermejo, Soledad Illescas / Rodríguez, Juan Francisco / García-Vargas, Jesús Manuel / Vidal Roig, Dolors

Membranes

2024 Volume 14, Issue 1

Abstract: The demand for natural products in the treatment of dermatological pathologies has boosted the use of bioactive substances such as lavender essential oil (LEO), which stands out for its anti-inflammatory and antioxidant properties and its antimicrobial ... ...

Abstract	The demand for natural products in the treatment of dermatological pathologies has boosted the use of bioactive substances such as lavender essential oil (LEO), which stands out for its anti-inflammatory and antioxidant properties and its antimicrobial potential. Biopolymers such as chitosan (CHT) and alginate (ALG) are biodegradable and biocompatible and have proven their viability in biomedical applications such as skin regeneration. The inhibitory effect of LEO on the growth of skin-related bacterial species
Language	English
Publishing date	2024-01-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2614641-1
ISSN	2077-0375
ISSN	2077-0375
DOI	10.3390/membranes14010012
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Article ; Online: Medical algorithm: Diagnosis and treatment of local allergic rhinitis.

Eguiluz-Gracia, Ibon / Testera-Montes, Almudena / Rondon, Carmen

Allergy

2021 Volume 76, Issue 9, Page(s) 2927–2930

MeSH term(s)	Algorithms ; Allergens ; Humans ; Nasal Provocation Tests ; Rhinitis, Allergic/diagnosis ; Rhinitis, Allergic/therapy
Chemical Substances	Allergens
Language	English
Publishing date	2021-04-22
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.14848
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Article: Garlic Extracts: Effect of pH on Inhibition of

García, Maria Teresa / Garcia-Vargas, Jesus Manuel / Fernández, Luis Antonio Gómez / Cuevas, Pedro / Gracia, Ignacio

Life (Basel, Switzerland)

2023 Volume 13, Issue 7

Abstract: The present work studies the influence of pH on the stability of thiosulfinates, compounds responsible for the bacteriostatic properties shown by ethanolic and acetonic garlic extracts (EGE and AGE) against the in vitro growth ... ...

Abstract	The present work studies the influence of pH on the stability of thiosulfinates, compounds responsible for the bacteriostatic properties shown by ethanolic and acetonic garlic extracts (EGE and AGE) against the in vitro growth of
Language	English
Publishing date	2023-06-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13071434
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Article ; Online: Chondroblastomas in Children and Young Adults: Revision of 55 Cases.

Brunet, Laia / Torner, Ferran / Suñol, Mariona / Martínez, Judit / Gracia, Isidre / Peiró, Ana / Machado, Pau

Journal of pediatric orthopedics

2023 Volume 44, Issue 2, Page(s) e184–e191

Abstract: Background: Chondroblastomas are uncommon primary bone tumors localized in long bone epiphyses in children and young adults. The risk of metastasis is rare, but they have a high capacity for local recurrence. Surgical curettage with bone grafting or ... ...

Abstract	Background: Chondroblastomas are uncommon primary bone tumors localized in long bone epiphyses in children and young adults. The risk of metastasis is rare, but they have a high capacity for local recurrence. Surgical curettage with bone grafting or bone substitute is the preferred treatment. Methods: We performed an observational retrospective study of chondroblastomas treated in 2 hospitals in Barcelona from 1988 to 2018. We reviewed the location of the tumor, clinical presentation, imaging, histopathology, initial treatment, and cases of recurrence with a review of their treatment. We assessed the correlation between recurrence and index surgery, anatomic location, and certain histopathologic findings (presence of mitotic figures, necrosis, and positivity for protein S-100). Results: The series included 55 patients treated from 1988 to 2018, with ages ranging from 6 to 26, and a mean follow-up of 6.1 years (±3.7). The most common location was the distal femur metaphyseal/epiphyseal region. The most frequent clinical presentation was pain in the affected. Forty-five cases (81.8%) were treated with curettage of the tumor, and 4 cases (7.3%) with a wide resection. Forty-two cases (85.7%) received bone substitutes after curettage or resection. We found 5 cases of recurrence (9.1% recurrence rate); however, we could not find a statistically significant correlation between index surgery and recurrence ( P =0.24), anatomic location and recurrence ( P =0.49), or recurrence and histopathologic findings (mitotic figures, P =0.49; necrosis, P =0.60; positivity for protein S-100, P =0.52). In all the cases the treatment for the local recurrence was surgical, with a final healing rate of 100%. Conclusions: Chondroblastomas should be considered in children and adolescents when presenting with pain and an image suggestive of a tumoral lesion on plain x-ray, most frequently in epiphyses of long bones.Surgical treatment is preferred, obtaining good results after curettage and bone substitute. Chondroblastomas are tumors with a high capacity for recurrence, therefore an adequate surgical technique and surgeon experience are paramount to achieve good outcomes. Level of evidence: Level IV (case series). Therapeutic studies-investigating results or treatment.
MeSH term(s)	Adolescent ; Child ; Humans ; Young Adult ; Bone Neoplasms/pathology ; Bone Substitutes ; Chondroblastoma/surgery ; Curettage ; Necrosis/etiology ; Necrosis/surgery ; Neoplasm Recurrence, Local/surgery ; Pain/etiology ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Bone Substitutes
Language	English
Publishing date	2023-12-12
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	604642-3
ISSN	1539-2570 ; 0271-6798
ISSN (online)	1539-2570
ISSN	0271-6798
DOI	10.1097/BPO.0000000000002589
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Article ; Online: Medical algorithm: Diagnosis and treatment of house dust mite-driven allergic asthma.

Schulze, Johannes / Agache, Ioana / Eguiluz-Gracia, Ibon / Trischler, Jordis / Zielen, Stefan

Allergy

2023 Volume 78, Issue 5, Page(s) 1397–1399

MeSH term(s)	Animals ; Humans ; Pyroglyphidae ; Asthma/diagnosis ; Asthma/etiology ; Asthma/therapy ; Dermatophagoides pteronyssinus ; Dust ; Allergens
Chemical Substances	Dust ; Allergens
Language	English
Publishing date	2023-02-02
Publishing country	Denmark
Document type	News
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15654
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Article ; Online: Allergen Immunotherapy for Local Respiratory Allergy.

Eguiluz-Gracia, I / Ariza, A / Testera-Montes, A / Rondón, C / Campo, P

Current allergy and asthma reports

2020 Volume 20, Issue 7, Page(s) 23

Abstract: Purpose of reviesw: Local respiratory allergy (LRA) is an eosinophilic phenotype of chronic airway disease. Three entities have been described within the LRA spectrum: local allergic rhinitis (LAR) and local allergic asthma (LAA) in non-atopic patients, ...

Abstract	Purpose of reviesw: Local respiratory allergy (LRA) is an eosinophilic phenotype of chronic airway disease. Three entities have been described within the LRA spectrum: local allergic rhinitis (LAR) and local allergic asthma (LAA) in non-atopic patients, and dual allergic rhinitis (DAR) in atopic patients (coexistence of LAR and allergic rhinitis). In this article, we aim to review the current evidence on the therapeutic options for LRA. Recent findings: No controlled study has assessed the effect of standard therapy (oral antihistamines, intranasal or inhaled corticosteroids, bronchodilators) in LRA subjects. Three randomized clinical trials and one observational study demonstrated that allergen immunotherapy (AIT) is able to control nasal and ocular symptoms, decrease the need for rescue medication, and improve quality of life in LAR individuals. Nasal or inhaled steroids can be expected to improve eosinophilic inflammation in LRA patients but cannot change the natural course of the disease. Moreover, the long-term and disease-modifying effects of AIT in LRA subjects need to be investigated.
MeSH term(s)	Desensitization, Immunologic/methods ; Humans ; Quality of Life/psychology ; Rhinitis, Allergic/immunology ; Rhinitis, Allergic/therapy
Language	English
Publishing date	2020-05-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2057370-4
ISSN	1534-6315 ; 1529-7322
ISSN (online)	1534-6315
ISSN	1529-7322
DOI	10.1007/s11882-020-00920-w
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