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  1. Article ; Online: Acute 'locked' dorsal dislocation of the scaphoid in four patients.

    Brown, Matthew T / Graham, Alastair J

    The Journal of hand surgery, European volume

    2020  Volume 46, Issue 1, Page(s) 91–92

    MeSH term(s) Humans ; Joint Dislocations/diagnostic imaging ; Joint Dislocations/surgery ; Scaphoid Bone/diagnostic imaging ; Scaphoid Bone/surgery
    Language English
    Publishing date 2020-07-22
    Publishing country England
    Document type Letter
    ZDB-ID 2272801-6
    ISSN 2043-6289 ; 1753-1934
    ISSN (online) 2043-6289
    ISSN 1753-1934
    DOI 10.1177/1753193420942697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Currency Futures

    Graham, Alastair

    (Glenlake Series in Risk Management)

    2014  

    Abstract: First Published in 2001. Routledge is an imprint of Taylor & Francis, an informa ... ...

    Series title Glenlake Series in Risk Management
    Abstract First Published in 2001. Routledge is an imprint of Taylor & Francis, an informa company
    Language English
    Size Online-Ressource (120 p)
    Publisher Taylor and Francis
    Publishing place Hoboken
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9781579582968 ; 1579582966
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Book ; Online: Currency Options

    Graham, Alastair

    (Glenlake Series in Risk Management)

    2014  

    Abstract: First Published in 2001. Routledge is an imprint of Taylor & Francis, an informa ... ...

    Series title Glenlake Series in Risk Management
    Abstract First Published in 2001. Routledge is an imprint of Taylor & Francis, an informa company
    Language English
    Size Online-Ressource (154 p)
    Publisher Taylor and Francis
    Publishing place Hoboken
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9781579582951 ; 1579582958
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Book ; Online: Hedging Currency Exposure

    Graham, Alastair

    (Glenlake Series in Risk Management)

    2014  

    Abstract: First Published in 2001. Routledge is an imprint of Taylor & Francis, an informa ... ...

    Series title Glenlake Series in Risk Management
    Abstract First Published in 2001. Routledge is an imprint of Taylor & Francis, an informa company
    Language English
    Size Online-Ressource (182 p)
    Publisher Taylor and Francis
    Publishing place Hoboken
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9781135968380 ; 1135968381
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Book ; Online: Introduction to Currency Risk

    Graham, Alastair

    (Glenlake Series in Risk Management)

    2013  

    Abstract: First Published in 2001. Routledge is an imprint of Taylor & Francis, an informa ... ...

    Series title Glenlake Series in Risk Management
    Abstract First Published in 2001. Routledge is an imprint of Taylor & Francis, an informa company
    Language English
    Size Online-Ressource (131 p)
    Publisher Taylor and Francis
    Publishing place Hoboken
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9781579582173 ; 1579582176
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Article ; Online: Hazards of interpreting the late results on durability of bioprosthetic valves. Cautions & suggestions.

    Parissis, Haralabos / Graham, Alastair

    International journal of cardiology

    2016  Volume 221, Page(s) 511–514

    MeSH term(s) Aged ; Animals ; Bioprosthesis/trends ; Female ; Follow-Up Studies ; Heart Valve Diseases/mortality ; Heart Valve Diseases/surgery ; Heart Valve Prosthesis/trends ; Humans ; Male ; Middle Aged ; Prosthesis Failure/trends ; Survival Rate/trends ; Swine
    Language English
    Publishing date 2016-10-15
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2016.07.112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Examining the forgotten valve: outcomes of tricuspid valve surgery, a 15-year experience.

    O'Sullivan, Katie E / Cull, Susan / Armstrong, Lara / McKendry, Aine / Graham, Alastair N J

    Irish journal of medical science

    2021  Volume 191, Issue 2, Page(s) 699–704

    Abstract: Background: We have entered an era of renewed interest in novel approaches to surgical intervention and minimally invasive and transcatheter technique. With an aging population, isolated tricuspid valve regurgitation incidence is rising; however, ... ...

    Abstract Background: We have entered an era of renewed interest in novel approaches to surgical intervention and minimally invasive and transcatheter technique. With an aging population, isolated tricuspid valve regurgitation incidence is rising; however, referral for surgical intervention remains low.
    Aims: We undertook this retrospective review to assess outcomes and challenges associated with tricuspid valve intervention.
    Methods: A comprehensive retrospective review of all patients undergoing tricuspid valve intervention in our institution between 2004 and 2018 was carried out.
    Results: A total of 259 patients who underwent a tricuspid intervention between 2004 and 2018 were identified. Of those, 229 underwent a repair and 30 underwent a replacement. Median survival for repair was 3124 days, and replacement was 2294 days. In-patient mortality was 12% for those undergoing repair and 7% for the replacement patients. Of those undergoing redo tricuspid valve intervention, eight patients (61.5%) were alive at most recent follow-up. Eight patients required intraoperative pacemakers, 2 required postoperative pacemakers. Of those who had intraoperative epicardial pacing systems placed, 5 of the 8 remained pacing dependent on most recent follow up.
    Conclusion: Beyond technical challenges, decision making regarding pacemaker requirement requires further exploration. Redo tricuspid valve surgery carries a significant mortality risk and consideration should be given to earlier intervention in this context.
    MeSH term(s) Aged ; Cardiac Surgical Procedures ; Heart Valve Prosthesis Implantation/methods ; Humans ; Pacemaker, Artificial ; Retrospective Studies ; Treatment Outcome ; Tricuspid Valve/surgery ; Tricuspid Valve Insufficiency/etiology ; Tricuspid Valve Insufficiency/surgery
    Language English
    Publishing date 2021-04-06
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 390895-1
    ISSN 1863-4362 ; 0021-1265
    ISSN (online) 1863-4362
    ISSN 0021-1265
    DOI 10.1007/s11845-021-02608-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An overview of realist evaluation for simulation-based education.

    Graham, Alastair C / McAleer, Sean

    Advances in simulation (London, England)

    2018  Volume 3, Page(s) 13

    Abstract: This article describes the key features of realist (realistic) evaluation and illustrates their application using, as an example, a simulation-based course for final year medical students. The use of simulation-based education (SBE) is increasing and so ... ...

    Abstract This article describes the key features of realist (realistic) evaluation and illustrates their application using, as an example, a simulation-based course for final year medical students. The use of simulation-based education (SBE) is increasing and so too is the evidence supporting its value as a powerful technique which can lead to substantial educational benefits. Accompanying these changes is a call for research into its use to be more theory-driven and to investigate both 'Did it work?' and as importantly 'Why did it work (or not)?' An evaluation methodology that is capable of answering both questions is realist evaluation. Realist evaluation is an emerging methodology that is suited to evaluating complex interventions such as SBE. The realist philosophy positions itself between positivist and constructivist paradigms and seeks to answer the question 'What works for whom, in what circumstances and why?' In seeking to answer this question, realist evaluation sets out to identify three fundamental components of an intervention, namely context, mechanism and outcome. Educational programmes work (successful outcomes) when theory-driven interventions (mechanisms) are applied to groups under appropriate conditions (context). Realist research uses a mixed methods (qualitative and quantitative) approach to gathering data in order to test the proposed context-mechanism-outcome (CMO) configurations of the intervention under investigation. Realist evaluation offers a valuable methodology for researchers investigating interventions utilising simulation-based education. By investigating and understanding the context, mechanisms and outcomes of SBE interventions, realist evaluation can provide the deeper level of understanding being called for.
    Language English
    Publishing date 2018-07-17
    Publishing country England
    Document type Journal Article
    ISSN 2059-0628
    ISSN (online) 2059-0628
    DOI 10.1186/s41077-018-0073-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Role of preoperative blood markers as prognostic factors for lung cancer surgery.

    Hamid, Umar Imran / Al-Saudi, Reza / Paul, Ian / Graham, Alastair

    Asian cardiovascular & thoracic annals

    2019  Volume 27, Issue 4, Page(s) 288–293

    Abstract: Objective: This study was undertaken to assess the potential value of preoperative blood components as prognostic markers of outcome after lung cancer resection, and hence their potential to aid in the selection of patients for curative surgery.: ... ...

    Abstract Objective: This study was undertaken to assess the potential value of preoperative blood components as prognostic markers of outcome after lung cancer resection, and hence their potential to aid in the selection of patients for curative surgery.
    Methods: This was a single-center study on 313 patients who underwent surgery for non-small-cell lung cancer from 2006 to 2008. Data were analyzed retrospectively from a prospectively maintained thoracic database. Preoperative blood results including plasma fibrinogen levels, serum C-reactive protein, hemoglobin concentration, and platelet count were included in the analysis.
    Results: The mean age was 75 years, and 40% of the patients were females. The most common resection was lobectomy in 68% of patients, followed by pneumonectomy, wedge resection, and segmentectomy in 18%, 10%, and 1.6%, respectively. Patients with abnormal C-reactive protein, fibrinogen, and hemoglobin levels had a worse overall survival. Large tumor size and nodal metastasis on clinical staging was also associated with poor survival. However, on Cox regression analysis, plasma fibrinogen and nodal metastasis were the only independent predictors of survival after lung resection.
    Conclusions: Among the different blood markers, elevated preoperative plasma fibrinogen was an independent marker of reduced survival in patients with resected non-small-cell lung cancer, and its value in selecting patients who may benefit from surgery needs further investigation.
    MeSH term(s) Aged ; Aged, 80 and over ; Biomarkers/blood ; Blood Platelets ; C-Reactive Protein/analysis ; Carcinoma, Non-Small-Cell Lung/blood ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/secondary ; Carcinoma, Non-Small-Cell Lung/surgery ; Clinical Decision-Making ; Databases, Factual ; Female ; Fibrinogen/analysis ; Hemoglobins/analysis ; Humans ; Lung Neoplasms/blood ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Lymphatic Metastasis ; Male ; Middle Aged ; Pneumonectomy/adverse effects ; Pneumonectomy/mortality ; Predictive Value of Tests ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome ; Up-Regulation
    Chemical Substances Biomarkers ; Hemoglobins ; Fibrinogen (9001-32-5) ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2019-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1400468-9
    ISSN 1816-5370 ; 0218-4923
    ISSN (online) 1816-5370
    ISSN 0218-4923
    DOI 10.1177/0218492319834812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Synchronous retreat of Thwaites and Pine Island glaciers in response to external forcings in the presatellite era.

    Clark, Rachel W / Wellner, Julia S / Hillenbrand, Claus-Dieter / Totten, Rebecca L / Smith, James A / Miller, Lauren E / Larter, Robert D / Hogan, Kelly A / Graham, Alastair G C / Nitsche, Frank O / Lehrmann, Asmara A / Lepp, Allison P / Kirkham, James D / Fitzgerald, Victoria T / Garcia-Barrera, Georgina / Ehrmann, Werner / Wacker, Lukas

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 11, Page(s) e2211711120

    Abstract: Today, relatively warm Circumpolar Deep Water is melting Thwaites Glacier at the base of its ice shelf and at the grounding zone, contributing to significant ice retreat. Accelerating ice loss has been observed since the 1970s; however, it is unclear ... ...

    Abstract Today, relatively warm Circumpolar Deep Water is melting Thwaites Glacier at the base of its ice shelf and at the grounding zone, contributing to significant ice retreat. Accelerating ice loss has been observed since the 1970s; however, it is unclear when this phase of significant melting initiated. We analyzed the marine sedimentary record to reconstruct Thwaites Glacier's history from the early Holocene to present. Marine geophysical surveys were carried out along the floating ice-shelf margin to identify core locations from various geomorphic settings. We use sedimentological data and physical properties to define sedimentary facies at seven core sites. Glaciomarine sediment deposits reveal that the grounded ice in the Amundsen Sea Embayment had already retreated to within ~45 km of the modern grounding zone prior to ca. 9,400 y ago. Sediments deposited within the past 100+ y record abrupt changes in environmental conditions. On seafloor highs, these shifts document ice-shelf thinning initiating at least as early as the 1940s. Sediments recovered from deep basins reflect a transition from ice proximal to slightly more distal conditions, suggesting ongoing grounding-zone retreat since the 1950s. The timing of ice-shelf unpinning from the seafloor for Thwaites Glacier coincides with similar records from neighboring Pine Island Glacier. Our work provides robust new evidence that glacier retreat in the Amundsen Sea was initiated in the mid-twentieth century, likely associated with climate variability.
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2211711120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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