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  1. Article ; Online: Detection of Myocardial Injury After Noncardiac Surgery: Levelling the Troponin Playing Field.

    Gouda, Pishoy / Graham, Michelle M

    The Canadian journal of cardiology

    2023  Volume 39, Issue 3, Page(s) 319–320

    MeSH term(s) Humans ; Troponin ; Myocardial Ischemia/diagnosis ; Myocardial Infarction ; Heart Injuries ; Postoperative Complications/diagnosis ; Surgical Procedures, Operative ; Biomarkers ; Troponin T
    Chemical Substances Troponin ; Biomarkers ; Troponin T
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2023.01.007
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  2. Article ; Online: Malnutrition - a predominant issue in hospitalized older adults, yet an undeveloped research space with huge potential.

    O'Neill, Deirdre E / Heckman, George A / Graham, Michelle M

    The Canadian journal of cardiology

    2024  

    Language English
    Publishing date 2024-05-02
    Publishing country England
    Document type Letter
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2024.04.020
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  3. Article ; Online: The epidemic of immobility in hospitalized patients: How to get your patient up and moving.

    O'Neill, Deirdre E / Heckman, George A / Graham, Michelle M

    The Canadian journal of cardiology

    2024  

    Abstract: The global population is ageing and with cardiovascular disease (CVD) prevalence also increasing, the face of the prototypical cardiology inpatient is changing, from a middle-aged man with cardiovascular risk factors, to an older adult with ... ...

    Abstract The global population is ageing and with cardiovascular disease (CVD) prevalence also increasing, the face of the prototypical cardiology inpatient is changing, from a middle-aged man with cardiovascular risk factors, to an older adult with multimorbidity and frailty. Hospital care is inherently harmful, with immobilization and reliance on others causing functional decline to be the leading complication of hospitalization in older adults. It is imperative to reinvent hospital care, employing age-friendly health systems to maintain health and function in older adults, improving not only CVD outcomes, but patient-centered outcomes such as function and independence and preventing avoidable harms.
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2024.03.010
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  4. Article ; Online: Primum Non Nocere: TAVR, Frailty, and Moral Decision Making.

    Gamble, Nathan K J / Graham, Michelle M

    The Canadian journal of cardiology

    2023  Volume 40, Issue 3, Page(s) 468–469

    MeSH term(s) Humans ; Frailty ; Transcatheter Aortic Valve Replacement ; Morals ; Decision Making
    Language English
    Publishing date 2023-12-01
    Publishing country England
    Document type Editorial
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2023.11.035
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  5. Article ; Online: The Indirect Impact of COVID-19 on Cardiac Care and Outcomes: Lessons From a Stretched System.

    Graham, Michelle M / Simpson, Christopher S

    The Canadian journal of cardiology

    2021  Volume 37, Issue 10, Page(s) 1502–1503

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-09-30
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2021.06.002
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  6. Article ; Online: Geriatric Cardiology: Moving Beyond Learning by Osmosis.

    Heckman, George A / Bhangu, Jaspreet / Graham, Michelle M / Keen, Sabina / O'Neill, Deirdre E

    The Canadian journal of cardiology

    2024  

    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2024.02.018
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  7. Article ; Online: Anemia, Cardiovascular Disease, and Frailty in the Older Adult.

    O'Neill, Deirdre E / Graham, Michelle M

    The Canadian journal of cardiology

    2022  Volume 38, Issue 6, Page(s) 715–717

    MeSH term(s) Aged ; Anemia/epidemiology ; Anemia/etiology ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/epidemiology ; Frail Elderly ; Frailty/complications ; Geriatric Assessment ; Humans
    Language English
    Publishing date 2022-03-05
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2022.03.001
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  8. Article ; Online: Association of Frailty, Age, Socioeconomic Status, and Type of Surgery With Perioperative Outcomes in Patients Undergoing Noncardiac Surgery.

    Wu, Kai Yi / Gouda, Pishoy / Wang, Xiaoming / Graham, Michelle M

    JAMA network open

    2022  Volume 5, Issue 7, Page(s) e2224625

    MeSH term(s) Frailty/epidemiology ; Humans ; Perioperative Care ; Risk Factors ; Social Class
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.24625
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  9. Article ; Online: P2Y12 inhibitor adherence trajectories in patients with acute coronary syndrome undergoing percutaneous coronary intervention: prognostic implications.

    Turgeon, Ricky D / Koshman, Sheri L / Dong, Yuan / Graham, Michelle M

    European heart journal

    2022  Volume 43, Issue 24, Page(s) 2303–2313

    Abstract: Aims: Post-acute coronary syndrome (ACS) P2Y12 inhibitor non-adherence is common and associated with greater risk of major adverse cardiovascular events (MACEs). Non-adherence can follow different trajectories from an inability to initiate, implement, ... ...

    Abstract Aims: Post-acute coronary syndrome (ACS) P2Y12 inhibitor non-adherence is common and associated with greater risk of major adverse cardiovascular events (MACEs). Non-adherence can follow different trajectories from an inability to initiate, implement, or continue therapy for the intended duration. We aimed to evaluate P2Y12 inhibitor adherence trajectories among ACS patients treated with percutaneous coronary intervention (PCI), their frequency, and association with MACE.
    Methods and results: We conducted a cohort study of adults discharged alive after PCI for ACS (2012-16) using the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease registry linked with administrative data. The primary outcome was P2Y12 inhibitor adherence trajectory in the year after PCI assessed using group-based trajectory modelling. We used logistic regression and Cox proportional-hazards regression to assess associations of trajectories with risk factors and MACE, respectively. We included 12 844 patients (mean age 62.4 years, 23.6% female). Five trajectories were identified: early consistent non-adherence (11.0%), rapid decline (7.7%), delayed initiation (6.0%), gradual decline (20.5%), and persistent adherence (54.8%). Compared with persistent adherence, rapid decline [hazard ratio (HR) 1.23, 95% confidence interval (CI) 1.01-1.49] and delayed initiation (HR 1.41, 95% CI 1.12-1.78) were associated with higher MACE in the overall cohort, whereas early consistent non-adherence was associated with higher MACE only in the subgroup receiving a drug-eluting stent (HR 2.44, 95% CI 1.60-3.71).
    Conclusion: After PCI for ACS, patients followed one of five distinct P2Y12 inhibitor adherence trajectories. Rapid decline and delayed initiation were associated with a higher risk of MACE, whereas early consistent non-adherence was only associated with higher MACE risk in patients with a drug-eluting stent.
    MeSH term(s) Acute Coronary Syndrome/etiology ; Clopidogrel/adverse effects ; Cohort Studies ; Drug-Eluting Stents ; Female ; Humans ; Male ; Middle Aged ; Percutaneous Coronary Intervention/adverse effects ; Platelet Aggregation Inhibitors/adverse effects ; Prognosis ; Purinergic P2Y Receptor Antagonists/therapeutic use ; Ticagrelor/adverse effects ; Treatment Outcome
    Chemical Substances Platelet Aggregation Inhibitors ; Purinergic P2Y Receptor Antagonists ; Clopidogrel (A74586SNO7) ; Ticagrelor (GLH0314RVC)
    Language English
    Publishing date 2022-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac116
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  10. Article ; Online: A New Way to Listen to Patients: Heeding Patient Reported Experiences to Improve Quality of Care.

    Graham, Michelle M / Norris, Colleen M

    The Canadian journal of cardiology

    2019  Volume 35, Issue 10, Page(s) 1265–1266

    MeSH term(s) Coronary Artery Bypass ; Humans ; Patient Reported Outcome Measures ; Patient Satisfaction
    Language English
    Publishing date 2019-08-21
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2019.05.026
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