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Article: STIM1 interacts with HCN4 channels to coordinate diastolic depolarization in the mouse Sinoatrial node.

Zhang, Hengtao / Graham, Victoria / Nepliouev, Igor / Stiber, Jonathan A / Rosenberg, Paul

bioRxiv : the preprint server for biology

2023

Abstract: Cardiomyocytes in the sinoatrial node (SAN) are specialized to undergo spontaneous diastolic depolarization (DD) to create action potentials (AP) that serve as the origin of the heartbeat. Two cellular clocks govern DD: the membrane clock where ion ... ...

Abstract	Cardiomyocytes in the sinoatrial node (SAN) are specialized to undergo spontaneous diastolic depolarization (DD) to create action potentials (AP) that serve as the origin of the heartbeat. Two cellular clocks govern DD: the membrane clock where ion channels contribute ionic conductance to create DD and the Ca
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.05.03.539287
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Establishment of a Nipah Virus Disease Model in Hamsters, including a Comparison of Intranasal and Intraperitoneal Routes of Challenge.

Findlay-Wilson, Stephen / Flett, Lucy / Salguero, Francisco J / Ruedas-Torres, Ines / Fotheringham, Susan / Easterbrook, Linda / Graham, Victoria / Dowall, Stuart

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 8

Abstract: Nipah virus (NiV) is an emerging pathogen that can cause severe respiratory illness and encephalitis in humans. The main reservoir is fruit bats, distributed across a large geographical area that includes Australia, Southeast Asia, and Africa. Incursion ... ...

Abstract	Nipah virus (NiV) is an emerging pathogen that can cause severe respiratory illness and encephalitis in humans. The main reservoir is fruit bats, distributed across a large geographical area that includes Australia, Southeast Asia, and Africa. Incursion into humans is widely reported through exposure of infected pigs, ingestion of contaminated food, or through contact with an infected person. With no approved treatments or vaccines, NiV poses a threat to human public health and has epidemic potential. To aid with the assessment of emerging interventions being developed, an expansion of preclinical testing capability is required. Given variations in the model parameters observed in different sites during establishment, optimisation of challenge routes and doses is required. Upon evaluating the hamster model, an intranasal route of challenge was compared with intraperitoneal delivery, demonstrating a more rapid dissemination to wider tissues in the latter. A dose effect was observed between those causing respiratory illness and those resulting in neurological disease. The data demonstrate the successful establishment of the hamster model of NiV disease for subsequent use in the evaluation of vaccines and antivirals.
Language	English
Publishing date	2023-07-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12080976
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Use of a Preclinical Natural Transmission Model to Study Antiviral Effects of a Carbohydrate-Binding Module Therapy against SARS-CoV-2 in Hamsters.

Knott, Daniel / Fell, Rachel / Potter, Jane A / Yuille, Samantha / Salguero, Franscisco J / Graham, Victoria A / Hewson, Roger / Howat, David / Dowall, Stuart D

Viruses

2023 Volume 15, Issue 3

Abstract: The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV-2) and its expansion to a worldwide pandemic resulted in efforts to assess and develop interventions to reduce the disease burden. Despite the introduction of vaccine programmes ... ...

Abstract	The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV-2) and its expansion to a worldwide pandemic resulted in efforts to assess and develop interventions to reduce the disease burden. Despite the introduction of vaccine programmes against SARS-CoV-2, global incidence levels in early 2022 remained high, demonstrating a need for the development of physiologically relevant models, which are essential for the identification of alternative antiviral strategies. The hamster model of SARS-CoV-2 infection has been widely adopted due to similarities with humans in terms of host cell entry mechanism (via ACE2), and aspects of symptomology and virus shedding. We have previously described a natural transmission hamster model that better represents the natural course of infection. In the present study, we have conducted further testing of the model using the first-in-class antiviral Neumifil, which has previously shown promise against SARS-CoV-2 after a direct intranasal challenge. Neumifil is an intranasally delivered carbohydrate-binding module (CBM) which reduces the binding of viruses to their cellular receptor. By targeting the host cell, Neumifil has the potential to provide broad protection against multiple pathogens and variants. This study demonstrates that using a combination of a prophylactic and therapeutic delivery of Neumifil significantly reduces the severity of clinical signs in animals infected via a natural route of transmission and indicates a reduction of viral loads in the upper respiratory tract. Further refinements of the model are required in order to ensure the adequate transmission of the virus. However, our results provide additional data to the evidence base of Neumifil efficacy against respiratory virus infection and demonstrate that the transmission model is a potentially valuable tool for testing antiviral compounds against SARS-CoV-2.
MeSH term(s)	Animals ; Cricetinae ; Humans ; SARS-CoV-2/metabolism ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Antiviral Agents/chemistry ; COVID-19 ; Carbohydrates
Chemical Substances	Antiviral Agents ; Carbohydrates
Language	English
Publishing date	2023-03-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15030725
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Article ; Online: Lineage-dependent differences of Zika virus infection in a susceptible mouse model are associated with different profiles of cytokines, chemokines, growth factors and acute phase proteins.

Dowall, Stuart D / Graham, Victoria A / Hewson, Roger

Cytokine

2019 Volume 125, Page(s) 154864

Abstract: Zika virus (ZIKV) is phylogenetically divided into two lineages comprising African ( ... ...

Abstract	Zika virus (ZIKV) is phylogenetically divided into two lineages comprising African (ZIKV
MeSH term(s)	Acute-Phase Proteins/metabolism ; Animals ; Chemokines/blood ; Chemokines/metabolism ; Cytokines/blood ; Cytokines/metabolism ; Disease Models, Animal ; Disease Progression ; Inflammation/metabolism ; Inflammation/virology ; Intercellular Signaling Peptides and Proteins/blood ; Intercellular Signaling Peptides and Proteins/metabolism ; Male ; Mice ; Receptor, Interferon alpha-beta/deficiency ; Receptor, Interferon alpha-beta/genetics ; Receptor, Interferon alpha-beta/metabolism ; Zika Virus/pathogenicity ; Zika Virus Infection/metabolism ; Zika Virus Infection/physiopathology ; Zika Virus Infection/virology
Chemical Substances	Acute-Phase Proteins ; Chemokines ; Cytokines ; Intercellular Signaling Peptides and Proteins ; Receptor, Interferon alpha-beta (156986-95-7)
Language	English
Publishing date	2019-09-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2019.154864
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Zs.A 2840: Show issues

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Book: Neuroscience and neuroanatomy for physical therapy

Mosconi, Tony / Graham, Victoria

2017

Author's details	Tony Mosconi, Victoria Graham
MeSH term(s)	Physical Therapy Modalities ; Nervous System/anatomy & histology
Language	English
Size	p. ;, cm.
Document type	Book
ISBN	9780071828888 ; 0071828885
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Multifactoral measures of fall risk in the visually impaired population: A pilot study.

Graham, Victoria / Napier-Dovorany, Kierstyn

Journal of bodywork and movement therapies

2016 Volume 20, Issue 1, Page(s) 104–109

Abstract: Objective: To determine the feasibility of taking multiple measures of visual and physical function in adults with visual impairment. A second objective was to obtain preliminary data on risk for falls in this population.: Design: Cohort feasibility ... ...

Abstract	Objective: To determine the feasibility of taking multiple measures of visual and physical function in adults with visual impairment. A second objective was to obtain preliminary data on risk for falls in this population. Design: Cohort feasibility study. Setting: University ambulatory patient care center and research center. Participants: Convenience sample of community-dwelling men and women over age 18 with visual impairment (n = 12). Thirteen subjects were enrolled in the study; one was subsequently excluded due to self-reported cognitive decline at time of testing. Subjects were grouped by prospective fall incidence. Interventions: Verbal education. Main outcome measures: Subjective measures of function; objective measures of visual and physical function. Results: Visually impaired adults can safely complete a battery of physical functions to predict fall risk. Recent onset of visual impairment was correlated with higher fall risk [-0.53 ± 0.22, p = 0.04]. Conclusions: It is feasible for an interdisciplinary team to measure risk for falls in adults with a visual impairment. Further investigation is needed to identify predictors of falls in adults of all ages with visual impairment.
MeSH term(s)	Accidental Falls/prevention & control ; Adult ; Aged ; Aged, 80 and over ; Disability Evaluation ; Female ; Health Status ; Hospitals, University ; Humans ; Male ; Middle Aged ; Pilot Projects ; Postural Balance ; Prospective Studies ; Risk Assessment/methods ; Risk Factors ; Vision Disorders/epidemiology
Language	English
Publishing date	2016-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2029441-4
ISSN	1532-9283 ; 1360-8592
ISSN (online)	1532-9283
ISSN	1360-8592
DOI	10.1016/j.jbmt.2015.06.012
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Zs.A 5620: Show issues

Location:
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Southeast Asian protected areas are effective in conserving forest cover and forest carbon stocks compared to unprotected areas.

Graham, Victoria / Geldmann, Jonas / Adams, Vanessa M / Negret, Pablo Jose / Sinovas, Pablo / Chang, Hsing-Chung

Scientific reports

2021 Volume 11, Issue 1, Page(s) 23760

Abstract: Protected areas aim to conserve nature, ecosystem services, and cultural values; however, they have variable success in doing so under high development pressure. Southeast Asian protected areas faced the highest level of human pressure at the turn of the ...

Abstract	Protected areas aim to conserve nature, ecosystem services, and cultural values; however, they have variable success in doing so under high development pressure. Southeast Asian protected areas faced the highest level of human pressure at the turn of the twenty-first century. To estimate their effectiveness in conserving forest cover and forest carbon stocks for 2000-2018, we used statistical matching methods to control for the non-random location of protected areas, to compare protection against a matched counterfactual. We found Southeast Asian protected areas had three times less forest cover loss than similar landscapes without protection. Protected areas that had completed management reporting using the Management Effectiveness Tracking Tool (METT) conserved significantly more forest cover and forest carbon stocks than those that had not. Management scores were positively associated with the level of carbon emissions avoided, but not the level of forest cover loss avoided. Our study is the first to find that METT scores could predict the level of carbon emissions avoided in protected areas. Given that only 11% of protected areas in Southeast Asia had completed METT surveys, our results illustrate the need to scale-up protected area management effectiveness reporting programs to improve their effectiveness for conserving forests, and for storing and sequestering carbon.
Language	English
Publishing date	2021-12-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-03188-w
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Article ; Online: Use and reliability of multiplex bead-based assays (Luminex) at Containment Level 4.

Dowall, Stuart D / Graham, Victoria A / Fletcher, Tom / Hewson, Roger

Methods (San Diego, Calif.)

2019 Volume 158, Page(s) 17–21

Abstract: In the UK, research on hazard group 4 (HG4) pathogens requires specialised Containment Level 4 (CL4) facilities. These differ from Biosafety Level 4 (BSL4) conditions in that work is conducted in class III microbiological safety cabinets for primary ... ...

Abstract	In the UK, research on hazard group 4 (HG4) pathogens requires specialised Containment Level 4 (CL4) facilities. These differ from Biosafety Level 4 (BSL4) conditions in that work is conducted in class III microbiological safety cabinets for primary containment instead of using positive pressure suits. This presents unique challenges associated with the physical restrictions of working in a limited space, and prohibits the use of many techniques and specialist equipment. In consequence, detailed studies on the biology of HG4 pathogens and in particular their immunological relationships with the host are understudied in the UK; for example, the majority of immunological assays with which the immune system is interrogated require specialist equipment that is unsuitable for CL4. Multiplexing to simultaneously measure multiple analytes is increasingly being used in immunological studies. This assay is attractive for CL4 work because it reduces the time spent in the laboratory whilst maximising the use of valuable sample volume. The Luminex microsphere approach allows for the determination of many cytokines and chemokines, however, the detection system uses fixed aligned lasers and integrated computer systems which are unsuitable for use at CL4. Therefore, we have developed an approach in which the Luminex assay is conducted within the CL4 laboratory and a formalin-fixation stage is introduced to allow for analysis to be undertaken outside of containment. Quality control preparations allow the assay characteristics to be monitored and analysis of assay performance to be evaluated. Our data demonstrate that Luminex is an applicable tool for use at CL4 and that assays can be run reliably to generate reproducible standardised data across different plates and individual experiments.
MeSH term(s)	Clinical Laboratory Services ; Communicable Diseases/diagnosis ; Communicable Diseases/microbiology ; Containment of Biohazards/standards ; Fixatives/chemistry ; Formaldehyde/chemistry ; High-Throughput Screening Assays/instrumentation ; High-Throughput Screening Assays/methods ; High-Throughput Screening Assays/standards ; Humans ; Laboratories/standards ; Microbiology/standards ; Microspheres ; Quality Control ; Reproducibility of Results ; Tissue Fixation/methods ; Tissue Fixation/standards
Chemical Substances	Fixatives ; Formaldehyde (1HG84L3525)
Language	English
Publishing date	2019-02-13
Publishing country	United States
Document type	Journal Article ; Validation Study
ZDB-ID	1066584-5
ISSN	1095-9130 ; 1046-2023
ISSN (online)	1095-9130
ISSN	1046-2023
DOI	10.1016/j.ymeth.2019.02.008
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Zs.A 3239: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Glycosylation and In Vitro Antiviral Assays.

Tyrrell, Beatrice E / Kumar, Abhinav / Gangadharan, Bevin / Alonzi, Dominic / Brun, Juliane / Hill, Michelle / Bharucha, Tehmina / Bosworth, Andrew / Graham, Victoria / Dowall, Stuart / Miller, Joanna L / Zitzmann, Nicole

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 3

Abstract: Crimean-Congo haemorrhagic fever virus (CCHFV) is a pathogen of increasing public health concern, being a widely distributed arbovirus and the causative agent of the potentially fatal Crimean-Congo haemorrhagic fever. Hazara virus (HAZV) is a genetically ...

Abstract	Crimean-Congo haemorrhagic fever virus (CCHFV) is a pathogen of increasing public health concern, being a widely distributed arbovirus and the causative agent of the potentially fatal Crimean-Congo haemorrhagic fever. Hazara virus (HAZV) is a genetically and serologically related virus that has been proposed as a surrogate for antiviral and vaccine testing for CCHFV. Glycosylation analysis of HAZV has been limited; first, we confirmed for the first time the occupation of two N-glycosylation sites in the HAZV glycoprotein. Despite this, there was no apparent antiviral efficacy of a panel of iminosugars against HAZV, as determined by quantification of the total secretion and infectious virus titres produced following infection of SW13 and Vero cells. This lack of efficacy was not due to an inability of deoxynojirimycin (DNJ)-derivative iminosugars to access and inhibit endoplasmic reticulum α-glucosidases, as demonstrated by free oligosaccharide analysis in uninfected and infected SW13 and uninfected Vero cells. Even so, iminosugars may yet have potential as antivirals for CCHFV since the positions and importance of N-linked glycans may differ between the viruses, a hypothesis requiring further evaluation.
Language	English
Publishing date	2023-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12030399
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Article ; Online: Pathogenesis of Rift Valley Fever Virus in a BALB/c Mouse Model Is Affected by Virus Culture Conditions and Sex of the Animals.

Graham, Victoria A / Easterbrook, Linda / Kennedy, Emma / Rayner, Emma / Findlay-Wilson, Stephen / Flett, Lucy / Wise, Emma Louise / Treagus, Samantha / Fotheringham, Susan / Kempster, Sarah / Almond, Neil / Dowall, Stuart

Viruses

2023 Volume 15, Issue 12

Abstract: Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen causing disease in livestock and humans. Whilst initially restricted to the African continent, recent spread to the Arabian Peninsula has highlighted the likelihood of entry into new ... ...

Abstract	Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen causing disease in livestock and humans. Whilst initially restricted to the African continent, recent spread to the Arabian Peninsula has highlighted the likelihood of entry into new regions. Due to the absence of a regulatory-approved human vaccine, work is ongoing to develop and assess countermeasures. As such, small animal models play a pivotal role in providing information on disease pathogenesis and elucidating which intervention strategies confer protection. To develop and establish the BALB/c mouse model, we challenged mice with RVFV grown from two separate cell lines: one derived from mosquitoes (C6/36) and the other mammalian derived (Vero E6). Following infection, we assessed the clinical course of disease progression at days 1 and 3 post-challenge and evaluated viral tropism and immune analytes. The results demonstrated that RVFV infection was affected by the cell line used to propagate the challenge virus, with those grown in insect cells resulting in a more rapid disease progression. The lowest dose that caused uniform severe disease remained the same across both virus preparations. In addition, to demonstrate reproducibility, the lowest dose was used for a subsequent infection study using male and female animals. The results further demonstrated that male mice succumbed to infection more rapidly than their female counterparts. Our results establish an RVFV mouse model and key parameters that affect the course of disease progression in BALB/c mice.
MeSH term(s)	Male ; Female ; Humans ; Animals ; Mice ; Rift Valley fever virus ; Rift Valley Fever ; Mice, Inbred BALB C ; Reproducibility of Results ; Disease Progression ; Mammals
Language	English
Publishing date	2023-11-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15122369
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