LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: Gamma Knife Stereotactic Radiosurgery for the treatment of chordomas and chondrosarcomas.

    Cahill, Julian / Ibrahim, Ramez / Mezey, Geza / Yianni, John / Bhattacharyya, Debapriya / Walton, Lee / Grainger, Alison / Radatz, Matthias W R

    Acta neurochirurgica

    2021  Volume 163, Issue 4, Page(s) 1003–1011

    Abstract: Introduction: Primary chordomas and chondrosarcomas of the skull base are difficult tumours to treat successfully. Despite advances in surgical techniques, a gross total resection is often impossible to achieve. In addition, some patients may be deemed ... ...

    Abstract Introduction: Primary chordomas and chondrosarcomas of the skull base are difficult tumours to treat successfully. Despite advances in surgical techniques, a gross total resection is often impossible to achieve. In addition, some patients may be deemed unsuitable or not wish to undergo extensive surgery for these conditions. This study examines the role of Gamma Knife Stereotactic Radiosurgery (GKRS) in the treatment of these difficult cases.
    Methods: All patients harbouring either a chordoma or chondrosarcoma treated at the National Centre for Stereotactic Radiosurgery, Royal Hallamshire Hospital, Sheffield, UK, between 1985 and 2018, were reviewed with regard to their clinical presentations, pre- and post-treatment imaging, GKRS prescriptions and outcomes.
    Results: In total, 24 patients with a mean tumour volume of 13 cm
    Conclusions: GKRS offers a comparable option to proton beam therapy for the treatment of these tumours. Early intervention for tumour volumes of less than 7 cm
    MeSH term(s) Adult ; Aged ; Chondrosarcoma/pathology ; Chondrosarcoma/radiotherapy ; Chordoma/pathology ; Chordoma/radiotherapy ; Female ; Humans ; Male ; Middle Aged ; Radiosurgery/methods ; Skull Base Neoplasms/pathology ; Skull Base Neoplasms/radiotherapy ; Survival Rate ; Tumor Burden
    Language English
    Publishing date 2021-02-19
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-021-04768-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.180: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Gamma Knife radiosurgery for glomus jugulare tumors: a single-center series of 75 cases.

    Ibrahim, Ramez / Ammori, Mohannad B / Yianni, John / Grainger, Alison / Rowe, Jeremy / Radatz, Matthias

    Journal of neurosurgery

    2016  Volume 126, Issue 5, Page(s) 1488–1497

    Abstract: OBJECTIVE Glomus jugulare tumors are rare indolent tumors that frequently involve the lower cranial nerves (CNs). Complete resection can be difficult and associated with lower CN injury. Gamma Knife radiosurgery (GKRS) has established its role as a ... ...

    Abstract OBJECTIVE Glomus jugulare tumors are rare indolent tumors that frequently involve the lower cranial nerves (CNs). Complete resection can be difficult and associated with lower CN injury. Gamma Knife radiosurgery (GKRS) has established its role as a noninvasive alternative treatment option for these often formidable lesions. The authors aimed to review their experience at the National Centre for Stereotactic Radiosurgery, Sheffield, United Kingdom, specifically the long-term tumor control rate and complications of GKRS for these lesions. METHODS Clinical and radiological data were retrospectively reviewed for patients treated between March 1994 and December 2010. Data were available for 75 patients harboring 76 tumors. The tumors in 3 patients were treated in 2 stages. Familial and/or hereditary history was noted in 12 patients, 2 of whom had catecholamine-secreting and/or active tumors. Gamma Knife radiosurgery was the primary treatment modality in 47 patients (63%). The median age at the time of treatment was 55 years. The median tumor volume was 7 cm
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Disease-Free Survival ; Female ; Glomus Jugulare Tumor/mortality ; Glomus Jugulare Tumor/pathology ; Glomus Jugulare Tumor/radiotherapy ; Humans ; Male ; Middle Aged ; Radiosurgery ; Retrospective Studies ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2016-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2016.4.JNS152667
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.135: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Staged-Volume Radiosurgery of Large Arteriovenous Malformations Improves Outcome by Reducing the Rate of Adverse Radiation Effects.

    Nagy, Gábor / Grainger, Alison / Hodgson, Timothy J / Rowe, Jeremy G / Coley, Stuart C / Kemeny, Andras A / Radatz, Matthias W R

    Neurosurgery

    2017  Volume 80, Issue 2, Page(s) 180–192

    Abstract: Background: The treatment of large arteriovenous malformations (AVMs) remains challenging. Recently, staged-volume radiosurgery (SVRS) has become an option.: Objective: To compare the outcome of SVRS on large AVMs with our historical, single-stage ... ...

    Abstract Background: The treatment of large arteriovenous malformations (AVMs) remains challenging. Recently, staged-volume radiosurgery (SVRS) has become an option.
    Objective: To compare the outcome of SVRS on large AVMs with our historical, single-stage radiosurgery (SSRS) series.
    Methods: We have been prospectively collecting data of patients treated by SVRS since 2007. There were 84 patients who had a median age of 37 years (range, 9-62 years) who were treated until July 2013. The outcomes of 76 of those who had follow-ups available were analyzed and compared with the outcomes of 122 patients treated with the best SSRS technique.
    Results: There were 21.5% of AVMs that were deep seated, and 44% presented with hemorrhage resulting in 45% fixed neurological deficit. There were 14% of patients who had undergone embolization before radiosurgery. The median nidus treatment volume was 19.7 cm3 (6.65-68.7) and 17.5 Gy (13-22.5) prescription isodose was given. Of the 44 lesions having radiological follow-up at 4 years, 61.4% were completely obliterated. Previous embolization (50% with and 63% without) and higher Spetzler-Martin grades appeared to be the negative factors in successful obliteration, but treatment volume was not. Within 3 years after radiosurgery, the annual bleed rates of unruptured and previously ruptured AVMs were 3.2% and 5.6%, respectively. Three bleeds were fatal and 2 resulted in significant modified Rankin scale 3 morbidity. These rates differ little from SSRS. Temporary adverse radiation effects (AREs) did not change significantly, but permanent AREs dropped from 15% to 6.5% (P = .03) compared with SSRS.
    Conclusion: Obliteration and hemorrhage rates of large AVMs treated by SVRS are similar to historical SSRS. However, SVRS offers a lower rate of AREs.
    MeSH term(s) Adolescent ; Adult ; Child ; Humans ; Intracranial Arteriovenous Malformations/radiotherapy ; Middle Aged ; Postoperative Complications/prevention & control ; Prospective Studies ; Radiosurgery/adverse effects ; Radiosurgery/methods ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2017-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/NEU.0000000000001212
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1424: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 539: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Safety of radiosurgery applied to conditions with abnormal tumor suppressor genes.

    Rowe, Jeremy / Grainger, Alison / Walton, Lee / Radatz, Matthias / Kemeny, Andras

    Neurosurgery

    2007  Volume 60, Issue 5, Page(s) 860–4; discussion 860–4

    Abstract: Objective: To assess the risk of radiosurgery inducing malignancy in neurofibromatosis-2 (NF2) and von Hippel-Lindau disease.: Methods: A retrospective cohort study of 118 NF2 and 19 von Hippel-Lindau disease patients, totalling 906 and 62 patient- ... ...

    Abstract Objective: To assess the risk of radiosurgery inducing malignancy in neurofibromatosis-2 (NF2) and von Hippel-Lindau disease.
    Methods: A retrospective cohort study of 118 NF2 and 19 von Hippel-Lindau disease patients, totalling 906 and 62 patient-years of follow-up data, respectively.
    Results: Two cases of intracranial malignancy were identified, both of which occurred in NF2 patients. One of these was thought to have arisen before the radiosurgery; the other was a glioblastoma diagnosed 3 years after radiosurgery.
    Conclusion: Because gliomas may occur in as many as 4% of NF2 patients, this may not represent an increased risk. We continue to offer radiosurgery treatment to selected NF2 and von Hippel-Lindau disease patients and consider that the late risk of malignancy arising after irradiation must be put in the context of the condition being treated, the treatment options available to these individuals, and their life expectancy.
    MeSH term(s) Adult ; Cohort Studies ; Female ; Follow-Up Studies ; Genes, Tumor Suppressor ; Humans ; Male ; Middle Aged ; Neurofibromatosis 2/epidemiology ; Neurofibromatosis 2/genetics ; Neurofibromatosis 2/surgery ; Radiosurgery/adverse effects ; Radiosurgery/trends ; Retrospective Studies ; von Hippel-Lindau Disease/epidemiology ; von Hippel-Lindau Disease/genetics ; von Hippel-Lindau Disease/surgery
    Language English
    Publishing date 2007-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/01.NEU.0000255426.08926.95
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1424: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 539: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Risk of malignancy after gamma knife stereotactic radiosurgery.

    Rowe, Jeremy / Grainger, Alison / Walton, Lee / Silcocks, Paul / Radatz, Matthias / Kemeny, Andras

    Neurosurgery

    2007  Volume 60, Issue 1, Page(s) 60–5; discussion 65–6

    Abstract: Objective: To assess the risk of radiosurgery to cause malignant transformation in benign tumors or to induce new malignancies.: Methods: A retrospective cohort study comparing the Sheffield, England, radiosurgery patient database with national ... ...

    Abstract Objective: To assess the risk of radiosurgery to cause malignant transformation in benign tumors or to induce new malignancies.
    Methods: A retrospective cohort study comparing the Sheffield, England, radiosurgery patient database with national mortality and cancer registries. This data set comprises approximately 5000 patients and 30,000 patient-years of follow-up, with more than 1200 patients having a follow-up period longer than 10 years.
    Results: In this material, a single new astrocytoma was diagnosed, whereas, based on national incidence figures, 2.47 cases would have been predicted.
    Conclusion: No increased risk of malignancy was detected in this series, supporting the safety of radiosurgery. Pragmatically, in advising patients, the risks of malignancy would seem small, particularly if such risks are considered in the context of the other risks faced by patients with intracranial pathologies requiring radiosurgical treatments.
    MeSH term(s) Adult ; Brain Neoplasms/diagnosis ; Brain Neoplasms/etiology ; Brain Neoplasms/mortality ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoplasm Seeding ; Radiosurgery/adverse effects ; Retrospective Studies ; Risk Factors ; Survival Rate
    Language English
    Publishing date 2007-01
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/01.NEU.0000255492.34063.32
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1424: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 539: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top