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  1. Article ; Online: More than a "monstrous obesity"! Time to overcome the "anti-fat" bias.

    Palmese, Francesco / Reggidori, Nicola / Pappas, Georgios / Gramenzi, Annagiulia

    Clinical obesity

    2020  Volume 11, Issue 1, Page(s) e12413

    Abstract: A 54-years-old woman complained of unintentional important body weight gain associated with abdominal bloating. For this reason, she had consulted many different diet and nutritional professionals, general practitioners and a gastroenterology specialist, ...

    Abstract A 54-years-old woman complained of unintentional important body weight gain associated with abdominal bloating. For this reason, she had consulted many different diet and nutritional professionals, general practitioners and a gastroenterology specialist, but no one went beyond a simple diagnosis of "monstrous obesity". At our hospital division, based on physical examination, a computed tomography (CT) of the abdomen and pelvis was performed. It showed a voluminous intraperitoneal mass occupying the most part of the abdomen. The patient underwent laparotomy with resection of the abdomino-pelvic mass, originating from the left ovary, measuring 60 x 45 cm and weighing 46 kg. Histopathology examination revealed a tumor composed of three different areas, including a well-differentiated adenocarcinoma of intestinal-type. It is emblematic of a grotesque misdiagnosis generated by a non-comprehensive patient assessment and consequently by a too quick judgement related to the "anti-fat bias".
    MeSH term(s) Abdomen ; Female ; Humans ; Middle Aged ; Obesity/diagnosis ; Pelvis ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-09-28
    Publishing country England
    Document type Case Reports
    ZDB-ID 2625816-X
    ISSN 1758-8111 ; 1758-8103
    ISSN (online) 1758-8111
    ISSN 1758-8103
    DOI 10.1111/cob.12413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reply to "Re: Survival and Tolerability of Transarterial Chemoembolization in Greater Versus less than 70 Years of Age Patients with Unresectable Hepatocellular Carcinoma-A Propensity Analysis".

    Mosconi, Cristina / Gramenzi, Annagiulia / Cappelli, Alberta / Biselli, Maurizio / Golfieri, Rita

    Cardiovascular and interventional radiology

    2021  Volume 44, Issue 7, Page(s) 1135–1136

    MeSH term(s) Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/therapy ; Chemoembolization, Therapeutic ; Humans ; Liver Neoplasms/mortality ; Liver Neoplasms/therapy ; Propensity Score
    Language English
    Publishing date 2021-03-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-021-02799-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Impact of Sarcopenia on the Survival of Patients with Hepatocellular Carcinoma Treated with Sorafenib.

    Biselli, Maurizio / Reggidori, Nicola / Iavarone, Massimo / Renzulli, Matteo / Lani, Lorenzo / Granito, Alessandro / Piscaglia, Fabio / Lorenzini, Stefania / Alimenti, Eleonora / Vara, Giulio / Caraceni, Paolo / Sangiovanni, Angelo / Marignani, Massimo / Gigante, Elia / Brandi, Nicolò / Gramenzi, Annagiulia / Trevisani, Franco

    Cancers

    2024  Volume 16, Issue 6

    Abstract: Background and aims: Sarcopenia has been associated with poor outcomes in patients with cirrhosis and hepatocellular carcinoma. We investigated the impact of sarcopenia on survival in patients with advanced hepatocellular carcinoma treated with ... ...

    Abstract Background and aims: Sarcopenia has been associated with poor outcomes in patients with cirrhosis and hepatocellular carcinoma. We investigated the impact of sarcopenia on survival in patients with advanced hepatocellular carcinoma treated with Sorafenib.
    Methods: A total of 328 patients were retrospectively analyzed. All patients had an abdominal CT scan within 8 weeks prior to the start of treatment. Two cohorts of patients were analyzed: the "Training Group" (215 patients) and the "Validation Group" (113 patients). Sarcopenia was defined by reduced skeletal muscle index, calculated from an L3 section CT image.
    Results: Sarcopenia was present in 48% of the training group and 50% of the validation group. At multivariate analysis, sarcopenia (HR: 1.47,
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16061080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Probiotics History.

    Gasbarrini, Giovanni / Bonvicini, Fiorenza / Gramenzi, Annagiulia

    Journal of clinical gastroenterology

    2016  Volume 50 Suppl 2, Proceedings from the 8th Probiotics, Prebiotics & New Foods for Microbiota and Human Health meeting held in Rome, Italy on September 13-15, 2015, Page(s) S116–S119

    Abstract: Gut microbiota promotes healthy effects on the host and prevents diseases. Probiotic (probios, for life) are defined as "live microorganisms which when administered in adequate amounts confer a health benefit on the host." At the beginning of 1900s Louis ...

    Abstract Gut microbiota promotes healthy effects on the host and prevents diseases. Probiotic (probios, for life) are defined as "live microorganisms which when administered in adequate amounts confer a health benefit on the host." At the beginning of 1900s Louis Pasteur identified the microorganisms responsible for the process of fermentation, whereas E. Metchnikoff associated the enhanced longevity of Bulgarian rural people to the regular consumption of fermented dairy products such as yogurt. He suggested that lactobacilli might counteract the putrefactive effects of gastrointestinal metabolism that contributed to illness and aging. Hippocrates declared, 2000 years earlier, that "death sits in the bowels." Metchnikoff considered the lactobacilli as probiotics ("probios," conducive to life of the host as opposed to antibiotics); probiotics could have a positive influence on health and prevent aging. During the neolitic period of the age of the stone, the domestication of animals occurred and man began to get fermented food. Probably serendipitous contaminations in favorable environments played a major role. Fecal microbiota transplantation dates to a fourth-century Chinese handbook for food poisoning or severe diarrhea. To date fecal transplant cures Clostridium difficile infections with more efficacy than vancomycin, and prevents recurrence.
    MeSH term(s) Fecal Microbiota Transplantation/history ; Gastrointestinal Microbiome ; Gastrointestinal Tract/microbiology ; History, 20th Century ; History, Ancient ; Humans ; Probiotics/history
    Language English
    Publishing date 2016-10-12
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 448460-5
    ISSN 1539-2031 ; 0192-0790
    ISSN (online) 1539-2031
    ISSN 0192-0790
    DOI 10.1097/MCG.0000000000000697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Biomarkers for the early diagnosis of bacterial infection and the surveillance of hepatocellular carcinoma in cirrhosis.

    Conti, Fabio / Dall'Agata, Marco / Gramenzi, Annagiulia / Biselli, Maurizio

    Biomarkers in medicine

    2015  Volume 9, Issue 12, Page(s) 1343–1351

    Abstract: The early detection of bacterial infections and hepatocellular carcinoma (HCC) could ameliorate the prognosis of cirrhosis. C-reactive protein and procalcitonin are under investigation in the setting of cirrhosis as markers of sepsis. In the attempt to ... ...

    Abstract The early detection of bacterial infections and hepatocellular carcinoma (HCC) could ameliorate the prognosis of cirrhosis. C-reactive protein and procalcitonin are under investigation in the setting of cirrhosis as markers of sepsis. In the attempt to discriminate bacterial infection from systemic inflammation, the role of novel biomarkers such as lypopolysaccharide binding-protein, mid-regional fragment of pro-adrenomedullin and delta neutrophil index are currently in development. Concerning HCC, many studies attempted to evaluate biomarkers in the hope of ameliorating the accuracy of the surveillance based on ultrasound. The use of α-fetoprotein (AFP) has been extensively investigated, as well as other biomarkers expressed in the serum of HCC patients like lens culinaris agglutinin-reactive fraction of AFP, des-γ-carboxy prothrombin, glypican-3, α-l-fucosidase and their combined use.
    MeSH term(s) Bacterial Infections/complications ; Bacterial Infections/diagnosis ; Biomarkers/metabolism ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/diagnosis ; Early Diagnosis ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Liver Neoplasms/complications ; Liver Neoplasms/diagnosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm.15.100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Computed Tomography-Colonography With Intravenous Contrast Medium and Urographic Phase for the Evaluation of Pelvic Deep Infiltrating Endometriosis of Intestinal and Urinary Tract.

    Coppola, Francesca / Paradisi, Roberto / Zanardi, Sara / Papadopoulos, Dimitris / Gramenzi, Annagiulia / Valerio, Domenico / Pierotti, Luisa / Zannoni, Letizia / Seracchioli, Renato / Golfieri, Rita

    Journal of computer assisted tomography

    2019  Volume 43, Issue 3, Page(s) 513–518

    Abstract: Objectives: The aim of this study was to evaluate the diagnostic accuracy of a specific protocol of computed tomography-colonography with intravenous contrast medium and urographic phase, which combined simultaneously the study of the intestinal and ... ...

    Abstract Objectives: The aim of this study was to evaluate the diagnostic accuracy of a specific protocol of computed tomography-colonography with intravenous contrast medium and urographic phase, which combined simultaneously the study of the intestinal and urinary tract, in the preoperative evaluation of women with deep infiltrating endometriosis (DIE) of anterior and posterior pelvic compartments.
    Methods: We retrospectively analyzed 73 women who underwent 74 computed tomography-colonography with intravenous contrast medium and urographic phase examinations for strong clinical suspicion of DIE. All the women had surgical confirmation.
    Results: Computed tomography-colonography with intravenous contrast medium and urographic phase in detecting DIE rectosigmoid involvement had a sensitivity of 82.3% and a specificity of 66.7%, while in detecting DIE urinary tract involvement had a sensitivity of 45.9% and a specificity of 78.4%.
    Conclusions: Computed tomography-colonography with intravenous contrast medium and urographic phase is a useful technique for the preoperative planning of selected women with DIE, in particular, for the detection of sigmoid colon and bladder lesions especially when performed with a dose reduction protocol.
    MeSH term(s) Administration, Intravenous ; Adult ; Colonography, Computed Tomographic ; Contrast Media/administration & dosage ; Endometriosis/diagnostic imaging ; Female ; Humans ; Intestines/diagnostic imaging ; Middle Aged ; Multimodal Imaging ; Pelvis/diagnostic imaging ; Retrospective Studies ; Sensitivity and Specificity ; Urinary Tract/diagnostic imaging ; Urography
    Chemical Substances Contrast Media
    Language English
    Publishing date 2019-05-13
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 80392-3
    ISSN 1532-3145 ; 0363-8715
    ISSN (online) 1532-3145
    ISSN 0363-8715
    DOI 10.1097/RCT.0000000000000867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Authors' reply: comment to "liver transplantation for patients with alcoholic liver disease: an open question".

    Gramenzi, Annagiulia / Biselli, Maurizio / Andreone, Pietro

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2013  Volume 45, Issue 1, Page(s) 81

    MeSH term(s) Alcoholism/diagnosis ; Humans ; Liver Diseases, Alcoholic/diagnosis ; Liver Diseases, Alcoholic/surgery ; Liver Transplantation
    Language English
    Publishing date 2013-01
    Publishing country Netherlands
    Document type Comment ; Letter
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2012.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The HEART score with high-sensitive troponin T at presentation: ruling out patients with chest pain in the emergency room.

    Santi, Luca / Farina, Gabriele / Gramenzi, Annagiulia / Trevisani, Franco / Baccini, Margherita / Bernardi, Mauro / Cavazza, Mario

    Internal and emergency medicine

    2017  Volume 12, Issue 3, Page(s) 357–364

    Abstract: The HEART score is a simple scoring system, ranging from 0 to 10, specifically developed for risk stratification of patients with undifferentiated chest pain. It has been validated for the conventional troponin, but not for high-sensitive troponin. We ... ...

    Abstract The HEART score is a simple scoring system, ranging from 0 to 10, specifically developed for risk stratification of patients with undifferentiated chest pain. It has been validated for the conventional troponin, but not for high-sensitive troponin. We assess a modified version of the HEART score using a single high-sensitivity troponin T dosage at presentation, regardless of symptom duration, and with different ECG criteria to evaluate if the patients with a low HEART score could be safely discharged early. The secondary aim was to confirm a statistically significant difference in each HEART score group (low 0-3, intermediate 4-6, high 7-10) in the occurrence of major adverse cardiac events at 30 and 180 days. We retrospectively analyzed the HEART score of 1597 consecutive patients admitted to the Emergency Department of our Hospital for chest pain between January 1 and June 30, 2014. Of these, 190 did not meet the inclusion criteria and 29 were lost to follow-up. None of the 512 (37.2 %) patients with a low HEART score had an event within 180 days. The difference between the cumulative incidences of events in the three HEART score groups was statistically significant (P < 0.0001). We demonstrate that it might be possible to safely discharge Emergency Department chest pain patients with a low modified HEART score after an initial determination of high-sensitive troponin T, without a prolonged observation period or an additional cardiac testing.
    MeSH term(s) Adult ; Aged ; Electrocardiography/classification ; Emergency Service, Hospital/organization & administration ; Female ; Humans ; Italy ; Male ; Middle Aged ; Myocardial Infarction/diagnosis ; Prospective Studies ; Retrospective Studies ; Risk Assessment/methods ; Risk Assessment/standards ; Risk Factors ; Severity of Illness Index ; Troponin T/analysis
    Chemical Substances Troponin T
    Language English
    Publishing date 2017-04
    Publishing country Italy
    Document type Journal Article ; Observational Study
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-016-1461-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Hepatitis C virus reinfection after liver transplantation: is there a role for direct antiviral agents?

    Dall'Agata, Marco / Gramenzi, Annagiulia / Biselli, Maurizio / Bernardi, Mauro

    World journal of gastroenterology

    2014  Volume 20, Issue 28, Page(s) 9253–9260

    Abstract: Recurrence of hepatitis C virus (HCV) infection following liver transplantation (LT) is almost universal and can accelerate graft cirrhosis in up to 30% of patients. The development of effective strategies to treat or prevent HCV recurrence after LT ... ...

    Abstract Recurrence of hepatitis C virus (HCV) infection following liver transplantation (LT) is almost universal and can accelerate graft cirrhosis in up to 30% of patients. The development of effective strategies to treat or prevent HCV recurrence after LT remains a major challenge, considering the shortage of donor organs and the accelerated progression of HCV in LT recipients. Standard antiviral therapy with pegylated-interferon plus ribavirin is the current treatment of choice for HCV LT recipients, even though the combination is not as effective as it is in immunocompetent patients. A sustained virological response in the setting of LT improves patient and graft survival, but this is only achieved in 30%-45% of patients and the treatment is poorly tolerated. To improve the efficacy of pre- and post-transplant antiviral therapy, a new class of potent direct-acting antiviral agents (DAAs) has been developed. The aim of this review is to summarize the use of DAAs in LT HCV patients. PubMed, Cochrane Library, MEDLINE, EMBASE, Web of Science and clinical trial databases were searched for this purpose. To date, only three clinical studies on the topic have been published and most of the available data are in abstract form. Although a moderately successful early virological response has been reported, DAA treatment regimens were associated with severe toxicity mitigating their potential usefulness. Moreover, the ongoing nature of data, the lack of randomized studies, the small number of enrolled patients and the heterogeneity of these studies make the results largely anecdotal and questionable. In conclusion, large well-designed clinical studies on DAAs in HCV LT patients are required before these drugs can be recommended after transplantation.
    MeSH term(s) Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; Hepacivirus/drug effects ; Hepacivirus/pathogenicity ; Hepatitis C/complications ; Hepatitis C/diagnosis ; Hepatitis C/drug therapy ; Humans ; Immunosuppressive Agents/adverse effects ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/surgery ; Liver Cirrhosis/virology ; Liver Transplantation/adverse effects ; Recurrence ; Risk Factors ; Treatment Outcome ; Virus Activation/drug effects
    Chemical Substances Antiviral Agents ; Immunosuppressive Agents
    Language English
    Publishing date 2014-05-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v20.i28.9253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Survival and Tolerability of Transarterial Chemoembolization in Greater Versus less than 70 Years of Age Patients with Unresectable Hepatocellular Carcinoma: A Propensity Score Analysis.

    Mosconi, Cristina / Gramenzi, Annagiulia / Biselli, Maurizio / Cappelli, Alberta / Bruno, Antonio / De Benedittis, Caterina / Cucchetti, Alessandro / Modestino, Francesco / Peta, Giuliano / Bianchi, Giampaolo / Trevisani, Franco / Golfieri, Rita

    Cardiovascular and interventional radiology

    2020  Volume 43, Issue 7, Page(s) 1015–1024

    Abstract: Background: The number of elderly patients diagnosed with hepatocellular carcinoma (HCC) is progressively increasing. The aim of this study was to determine the safety and efficacy of conventional transarterial chemoembolization (TACE) in elderly HCC ... ...

    Abstract Background: The number of elderly patients diagnosed with hepatocellular carcinoma (HCC) is progressively increasing. The aim of this study was to determine the safety and efficacy of conventional transarterial chemoembolization (TACE) in elderly HCC patients compared with younger adults.
    Methods: A consecutive cohort of unresectable HCC patients treated with TACE as a first-line treatment was retrospectively analyzed. Patients were categorized into "elderly" (≥ 70 years, 80 patients) and "younger" (< 70 years, 145 patients). Liver-related death and progression-free survival after TACE were compared before and after propensity score matching. A competing risk regression analysis was used for univariate/multivariate survival data analysis.
    Results: cTACE was well tolerated in both groups. The cumulative risk of both liver-related death and progression-free survival after cTACE was comparable between "elderly" and "younger" (death: 73.8% vs 69.4%, P = 0.505; progression-free survival: 48.2% vs 44.8%, P = 0.0668). Propensity model matched 61 patients in each group for gender and Barcelona Clinic Liver Cancer staging. Even after matching, the cumulative risk of liver-related death and of progression-free survival did not differ between the two groups. At multivariate analysis, Child-Pugh class, tumor gross pathology and alpha-fetoprotein were independently associated with the liver-related mortality risk.
    Conclusions: This study confirms that TACE is well tolerated and effective in patients aged 70 years or more with unresectable HCC as it is for their younger counterparts (< 70 years). Liver-related mortality was not associated with age ≥ 70 years and primarily predicted by tumor multifocality, Child-Pugh class B and an increased alpha-fetoprotein value (> 31 ng/ml).
    MeSH term(s) Adult ; Age Factors ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/therapy ; Chemoembolization, Therapeutic/adverse effects ; Cohort Studies ; Female ; Humans ; Liver Neoplasms/mortality ; Liver Neoplasms/therapy ; Male ; Middle Aged ; Propensity Score ; Retrospective Studies ; alpha-Fetoproteins
    Chemical Substances AFP protein, human ; alpha-Fetoproteins
    Language English
    Publishing date 2020-03-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-020-02451-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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