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  1. Article ; Online: Effect of modafinil on subjective fatigue in multiple sclerosis and stroke patients.

    Brioschi, Andrea / Gramigna, Sandrine / Werth, Esther / Staub, Fabienne / Ruffieux, Christiane / Bassetti, Claudio / Schluep, Myriam / Annoni, Jean-Marie

    European neurology

    2009  Volume 62, Issue 4, Page(s) 243–249

    Abstract: Background: Modafinil has anecdotal response to neurological fatigue, but such an effect may depend on the type and location of cerebral impairment.: Objectives: It was the aim of this study to compare fatigue observed in different neurological ... ...

    Abstract Background: Modafinil has anecdotal response to neurological fatigue, but such an effect may depend on the type and location of cerebral impairment.
    Objectives: It was the aim of this study to compare fatigue observed in different neurological pathologies, to evaluate the tolerability to modafinil, and to describe changes in subjective fatigue.
    Methods: We enrolled 14 brainstem or diencephalic stroke (BDS) patients, 9 cortical stroke (CS) patients and 17 multiple sclerosis (MS) patients. The Fatigue Assessment Instrument severity scale was performed at baseline, after 3 months of modafinil and after 1 month of washout. Cognition, mood and somnolence were assessed. A subgroup of 14 patients underwent activity measures before and during treatment.
    Results: Thirty-one patients completed the study (10 BDS, 9 CS, 12 MS). The responder profile is more frequent in MS than in CS (p = 0.04), and in BDS than in CS patients (p = 0.04). Actiwatch measures showed no changes in activity during, before and after therapy.
    Conclusion: Modafinil was tolerated in 75% of patients at small doses and seemed to improve the severity of fatigue in the MS and BDS groups but not in the CS group. There was no modification in measured physical activity.
    MeSH term(s) Adult ; Benzhydryl Compounds/adverse effects ; Benzhydryl Compounds/therapeutic use ; Central Nervous System Stimulants/therapeutic use ; Dose-Response Relationship, Drug ; Fatigue/complications ; Fatigue/drug therapy ; Female ; Humans ; Male ; Middle Aged ; Multiple Sclerosis/complications ; Neuropsychological Tests ; Patient Selection ; Psychiatric Status Rating Scales ; Severity of Illness Index ; Sleep/drug effects ; Stroke/complications ; Surveys and Questionnaires ; Treatment Outcome ; Wakefulness/drug effects
    Chemical Substances Benzhydryl Compounds ; Central Nervous System Stimulants ; modafinil (R3UK8X3U3D)
    Language English
    Publishing date 2009
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209426-5
    ISSN 1421-9913 ; 0014-3022
    ISSN (online) 1421-9913
    ISSN 0014-3022
    DOI 10.1159/000232927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 575: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Emotional disturbances after stroke.

    Annoni, Jean-Marie / Staub, Fabienne / Bruggimann, Laure / Gramigna, Sandrine / Bogousslavsky, Julien

    Clinical and experimental hypertension (New York, N.Y. : 1993)

    2001  Volume 28, Issue 3-4, Page(s) 243–249

    Abstract: Impairment after stroke may have acute and long-lasting psychological implications. Additionally, organic brain dysfunction also appears to play an important role in poststroke affective modifications. Emotional state is multidetermined and can be ... ...

    Abstract Impairment after stroke may have acute and long-lasting psychological implications. Additionally, organic brain dysfunction also appears to play an important role in poststroke affective modifications. Emotional state is multidetermined and can be specifically modified by alteration of some brain networks. This article illustrates a certain number of acute and more chronic emotional disturbances after stroke, such as mood disorders, emotional dyscontrol, and modification of emotional experiences. Some neural mechanisms implicated in these modifications are discussed. The main modifications described are depression anxiety, psychosis, modification of emotional experience, and fatigue.
    MeSH term(s) Affective Symptoms/etiology ; Affective Symptoms/psychology ; Humans ; Risk Factors ; Severity of Illness Index ; Stroke/complications ; Stroke/psychology
    Language English
    Publishing date 2001-01-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604757-9
    ISSN 1064-1963 ; 0730-0077
    ISSN 1064-1963 ; 0730-0077
    DOI 10.1080/10641960600549173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1429: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Effect of Modafinil on Subjective Fatigue in Multiple Sclerosis and Stroke Patients

    Brioschi, Andrea / Gramigna, Sandrine / Werth, Esther / Staub, Fabienne / Ruffieux, Christiane / Bassetti, Claudio / Schluep, Myriam / Annoni, Jean-Marie

    European Neurology

    2009  Volume 62, Issue 4, Page(s) 243–249

    Abstract: Background: Modafinil has anecdotal response to neurological fatigue, but such an effect may depend on the type and location of cerebral impairment. Objectives: It was the aim of this study to compare fatigue observed in different neurological ... ...

    Institution Department of Neurology, and Social and Preventive Medicine, Lausanne University Hospital, Lausanne Department of Neurology, University Hospital Zurich, Zurich, and Department of Neurology, Geneva University Hospital, Geneva, Switzerland
    Abstract Background: Modafinil has anecdotal response to neurological fatigue, but such an effect may depend on the type and location of cerebral impairment. Objectives: It was the aim of this study to compare fatigue observed in different neurological pathologies, to evaluate the tolerability to modafinil, and to describe changes in subjective fatigue. Methods: We enrolled 14 brainstem or diencephalic stroke (BDS) patients, 9 cortical stroke (CS) patients and 17 multiple sclerosis (MS) patients. The Fatigue Assessment Instrument severity scale was performed at baseline, after 3 months of modafinil and after 1 month of washout. Cognition, mood and somnolence were assessed. A subgroup of 14 patients underwent activity measures before and during treatment. Results: Thirty-one patients completed the study (10 BDS, 9 CS, 12 MS). The responder profile is more frequent in MS than in CS (p = 0.04), and in BDS than in CS patients (p = 0.04). Actiwatch measures showed no changes in activity during, before and after therapy. Conclusion: Modafinil was tolerated in 75% of patients at small doses and seemed to improve the severity of fatigue in the MS and BDS groups but not in the CS group. There was no modification in measured physical activity.
    Keywords Stroke ; Multiple sclerosis ; Modafinil ; Fatigue
    Language English
    Publishing date 2009-08-07
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Original Paper
    ZDB-ID 209426-5
    ISSN 1421-9913 ; 0014-3022
    ISSN (online) 1421-9913
    ISSN 0014-3022
    DOI 10.1159/000232927
    Database Karger publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 575: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Chronic cognitive impairment following laterothalamic infarcts: a study of 9 cases.

    Annoni, Jean-Marie / Khateb, Asaid / Gramigna, Sandrine / Staub, Fabienne / Carota, Antonio / Maeder, Philippe / Bogousslavsky, Julien

    Archives of neurology

    2003  Volume 60, Issue 10, Page(s) 1439–1443

    Abstract: Background: The occlusion of the lateral thalamic arteries leads to infarcts of ventrolateral thalamic nuclei, the ventroposterior nucleus, and the rostrolateral part of pulvinar, and produces hemisensory loss with or without hemiataxia. Cognitive ... ...

    Abstract Background: The occlusion of the lateral thalamic arteries leads to infarcts of ventrolateral thalamic nuclei, the ventroposterior nucleus, and the rostrolateral part of pulvinar, and produces hemisensory loss with or without hemiataxia. Cognitive impairment after such strokes has not been systematically studied.
    Objective: To determine the nature and the extent of long-lasting cognitive deficits following lateral thalamic strokes.
    Design: Case series.
    Setting: Neurology department, Lausanne University Hospital, Lausanne, Switzerland.
    Patients: Nine patients with hemisensory loss due to an isolated laterothalamic infarct.
    Main outcome measures: Three to 6 months after stroke onset, standard neuropsychologic evaluation, including testing of language, ideomotor and constructive praxis, visual gnosis, spatial attention, learning abilities, and executive functions.
    Results: Six of 9 patients showed some degree of cognitive impairment. Executive functions tasks, particularly verbal fluency, were impaired in 5 patients (4 with right and 1 with left lesion). Learning and delayed recall in visuospatial and verbal tasks, but not in recognition, were impaired in 3 patients (2 with right and 1 with left lesion). Difficulties in visual gnosia were observed in 1 patient with right lesion while word-finding difficulties were observed in 1 patient with left lesion.
    Conclusions: Our observations show that while learning, naming, and gnosic difficulties fit with the classical verbal/nonverbal dichotomy (left and right hemisphere, respectively), executive dysfunctions, including verbal fluency tasks, were more dominant after right thalamic infarcts. Although the observed deficits appeared to be less severe than those generally found with dorsomedial and polar thalamic strokes, the dominance of executive dysfunction suggests that ventrolateral thalamic lesions may disrupt frontothalamic subcortical loops.
    MeSH term(s) Aged ; Aging/psychology ; Cerebral Infarction/complications ; Cerebral Infarction/psychology ; Cognition Disorders/etiology ; Cognition Disorders/psychology ; Echoencephalography ; Female ; Functional Laterality/physiology ; Humans ; Lateral Thalamic Nuclei/pathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuropsychological Tests ; Stroke/complications ; Stroke/psychology ; Ventral Thalamic Nuclei/pathology ; Verbal Behavior
    Language English
    Publishing date 2003-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80049-1
    ISSN 1538-3687 ; 0003-9942
    ISSN (online) 1538-3687
    ISSN 0003-9942
    DOI 10.1001/archneur.60.10.1439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.191: Show issues Location:
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