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  1. Article: Primary lower urinary tract reconstruction for nonfunctioning renal moieties associated with obstructing ureteroceles.

    Gran, Christopher D / Kropp, Bradley P / Cheng, Earl Y / Kropp, Kenneth A

    The Journal of urology

    2005  Volume 173, Issue 1, Page(s) 198–201

    Abstract: Purpose: Upper pole heminephrectomy is the conventional treatment for severely compromised nonfunctioning renal units associated with ureteroceles due to the potential morbidity of leaving a nonfunctioning renal moiety in place. This approach often ... ...

    Abstract Purpose: Upper pole heminephrectomy is the conventional treatment for severely compromised nonfunctioning renal units associated with ureteroceles due to the potential morbidity of leaving a nonfunctioning renal moiety in place. This approach often fails to address the pathological anatomical defect present at the bladder level, and during long-term followup the majority of patients require subsequent lower tract surgery due to persistent ureterocele, new or persistent vesicoureteral reflux, or recurrent infections. We determined the success of primary lower urinary tract reconstruction for nonfunctioning renal moieties and the morbidity associated with leaving nonfunctioning renal units in situ.
    Materials and methods: We present the collective experience of 2 institutions using definitive lower urinary tract reconstruction without upper tract ablative surgery in 16 patients with duplex collecting systems and an associated nonfunctioning renal moiety due to obstructing ureteroceles.
    Results: At a mean followup of 62 months upper tract dilatation was decreased or completely resolved in all patients, no loss of renal function was present and 15 of 16 patients (94%) had no evidence of persistent reflux. Postoperative complications in the form of a urinary tract infection occurred in 2 of 16 patients (13%). No patient was febrile. No patient had development of hypertension, proteinuria or tumor during followup.
    Conclusions: We believe that primary, single stage, lower urinary tract reconstruction in children with severely compromised or nonfunctioning renal moieties damaged by ureteroceles is superior to upper urinary tract ablative surgery, successfully correcting the obstructive or refluxing pathology with minimal morbidity and risk during long-term followup.
    MeSH term(s) Child ; Child, Preschool ; Duty to Recontact ; Female ; Humans ; Hydronephrosis/complications ; Hydronephrosis/diagnostic imaging ; Hydronephrosis/surgery ; Infant ; Male ; Retrospective Studies ; Ultrasonography ; Ureterocele/complications ; Vesico-Ureteral Reflux/complications
    Language English
    Publishing date 2005-01
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/01.ju.0000148374.64478.b5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.91: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 331: Show issues

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  2. Article: Abnormal expression of molecular markers for bladder impermeability and differentiation in the urothelium of patients with interstitial cystitis.

    Slobodov, Gennady / Feloney, Michael / Gran, Christopher / Kyker, Kimberly D / Hurst, Robert E / Culkin, Daniel J

    The Journal of urology

    2004  Volume 171, Issue 4, Page(s) 1554–1558

    Abstract: Purpose: Despite a lack of consensus concerning the etiology of interstitial cystitis (IC) the loss of impermeability and other abnormalities of the urothelium are features of the disease. In this study the distribution of proteins involved with ... ...

    Abstract Purpose: Despite a lack of consensus concerning the etiology of interstitial cystitis (IC) the loss of impermeability and other abnormalities of the urothelium are features of the disease. In this study the distribution of proteins involved with epithelial adhesion, cellular differentiation and bladder impermeability in urothelial biopsies were explored by the immunohistochemical assessment of E-cadherin, ZO-1, uroplakin and chondroitin sulfate.
    Materials and methods: Biopsies obtained from 27 patients with IC and 7 controls were immediately fixed in formalin, immunohistochemically labeled for the described proteins and scored for protein expression, morphology and differentiation.
    Results: Only 3 IC samples appeared completely normal, while 24 of the 27 showed an abnormality in at least 1 marker and in 6 all 4 markers were abnormal. In patients vs controls findings were abnormal for uroplakin in 13 of 27 vs 1 of 7 (p = 0.085), for E-cadherin (over expressed) in 18 of 27 vs 0 of 7 (p = 0.0021), for ZO-1 in 11 of 27 vs 0 of 7 (p = 0.046) and for chondroitin sulfate in 15 of 27 vs 0 of 7 (p = 0.0054). The morphology/polarity score significantly correlated with ZO-1 (Pearson r = 0.3935, p = 0.0423) and chondroitin sulfate (Pearson r = 0.7079, p <0.0001) expression. Chondroitin sulfate and ZO-1 showed a high correlation with each other (Pearson r = 0.5587, p = 0.0025). Uroplakin and E-cadherin expression were independent of all other markers.
    Conclusions: The findings reported strongly suggest abnormal differentiation in the IC bladder. The disruption of ZO-1 is similar to that reported in feline IC. Elevated E-cadherin may represent an adaptation to increased bladder permeability.
    MeSH term(s) Adult ; Aged ; Antibodies, Monoclonal ; Biomarkers/analysis ; Cadherins/analysis ; Cadherins/biosynthesis ; Chondroitin Sulfates/analysis ; Chondroitin Sulfates/biosynthesis ; Cystitis, Interstitial/metabolism ; Cystitis, Interstitial/pathology ; Cystitis, Interstitial/physiopathology ; Female ; Humans ; Male ; Membrane Proteins/analysis ; Membrane Proteins/biosynthesis ; Middle Aged ; Urinary Bladder/metabolism ; Urinary Bladder/pathology ; Urinary Bladder/physiopathology ; Uroplakin II ; Urothelium/metabolism ; Urothelium/pathology
    Chemical Substances Antibodies, Monoclonal ; Biomarkers ; Cadherins ; Membrane Proteins ; UPK2 protein, human ; Uroplakin II ; Chondroitin Sulfates (9007-28-7)
    Language English
    Publishing date 2004-04
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/01.ju.0000118938.09119.a5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.91: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 331: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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