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Article ; Online: A comparative retrospective analysis on robot-assisted laparoscopic surgery compared to conventional laparoscopy in case of myomectomy: experience in a third-level hospital of Southern Italy.

Della Corte, Luigi / D'Angelo, Giuseppe / Ascione, Mario / Granata, Marcello / Giampaolino, Pierluigi / Di Spiezio Sardo, Attilio / Bifulco, Giuseppe

Updates in surgery

2024

Abstract: Uterine myomas are the most common gynecological disease in reproductive-aged women, present several symptoms, and require effective medical and/or surgical strategies. This study aimed to compare robotic-assisted laparoscopic myomectomy (RALM) with ... ...

Abstract	Uterine myomas are the most common gynecological disease in reproductive-aged women, present several symptoms, and require effective medical and/or surgical strategies. This study aimed to compare robotic-assisted laparoscopic myomectomy (RALM) with laparoscopic myomectomy (LM) in terms of operative times, intraoperative estimated blood loss, pre- and post-hemoglobin levels drop, and length of hospital stay. Data from 50 clinical records (25 RALM in Group A and 25 LM in Group B) of patients with uterine fibroids were collected from December 2022 to December 2023 at Gynecological Unit of DAI Materno-Infantile Federico II in Naples, Italy. Patients aged 30-49 years with symptomatic fibroids were included. Data on peri-operative outcomes, including operative time for myomectomy (OTM), overall operative time (OOT), intraoperative estimated blood loss (EBL), pre- and post-operative hemoglobin levels, and length of hospital stay were analyzed. The OTM in the presence of > 5 myomas was 59 [52-65] vs 69 min [61-96] (p < 0.001) for RALM and LM groups, respectively. Moreover, also in presence of ≤ 5 myomas, a difference was observed in the RALM group 48[43-55] compared to the LM group 53[50-61] min (p = 0.07). The OOT was also statistically significant for Group A compared to Group B (83[65-93] vs 72[56-110] min, p < 0.001). There were no significant differences between the two groups in terms of pre- and post-operative hemoglobin levels and EBL (p = 0.178). Group A demonstrated a notably shorter hospital stay 1.2 [1-2] days compared to Group B 2.9[3-3.75] days (p = 0.007). Our study suggests potential advantages of RALM over LM in terms of reduced operative times and shorter hospital stays. The standardized approach and extensive surgical experience likely contributed to the favorable outcomes of RALM.
Language	English
Publishing date	2024-04-30
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2572692-4
ISSN	2038-3312 ; 2038-131X
ISSN (online)	2038-3312
ISSN	2038-131X
DOI	10.1007/s13304-024-01863-x
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Article: Nutritional ecology of martens (Martes foina and Martes martes) in the western Italian Alps

Granata, Marco / Mosini, Andrea / Piana, Manuel / Zambuto, Francesco / Capelli, Enrica / Balestrieri, Alessandro

Ecological research. 2022 Jan., v. 37, no. 1

2022

Abstract: The macronutrient requirements of the strictly related pine marten (Martes martes) and stone marten (Martes foina) are almost identical, but, at range scale, in areas of putative sympatry (overlapping European ranges) the stone marten tends to be more ... ...

Abstract	The macronutrient requirements of the strictly related pine marten (Martes martes) and stone marten (Martes foina) are almost identical, but, at range scale, in areas of putative sympatry (overlapping European ranges) the stone marten tends to be more frugivorous, which makes the contribution of carbohydrate energy to be higher than the target. In contrast, the macronutrient intake of the pine marten would be unaffected by the occurrence of the stone marten, supporting the putative dominance of the first in interspecific interactions. Most available studies examined marten diets separately, highlighting the need for further studies in areas of actual co‐occurrence. With this aim, we compared the two martens' diets in the Italian Alps both in sympatric and allopatric conditions, as assessed by the genetic identification of scats. Although fruit and rodents formed the bulk of both species' diets, as predicted the stone marten consumed twice as many fruit species as the pine marten and ate fruit more often in areas of sympatry, thus consuming less protein and more carbohydrates respect to its intake target. This competition‐driven, nutritionally imbalanced diet may affect the fitness of stone marten populations and play an important and still underreported role in regulating the relative abundance of marten communities.
Keywords	Martes foina ; Martes martes ; allopatry ; carbohydrates ; diet ; energy ; frugivores ; fruits ; genetic testing ; nutritional ecology ; research ; sympatry
Language	English
Dates of publication	2022-01
Size	p. 127-136.
Publishing place	John Wiley & Sons, Inc.
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	233459-8
ISSN	1440-1703 ; 0912-3814
ISSN (online)	1440-1703
ISSN	0912-3814
DOI	10.1111/1440-1703.12277
Database	NAL-Catalogue (AGRICOLA)

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Article: Observations on the biochemical types of S. typhi and the possible variability in vivo.

SPANEDDA, A / GRANATA, M

Giornale di batteriologia e immunologia

2010 Volume 35, Issue 3, Page(s) 211–216

Title translation	Osservazioni sui tipi biochimici della S. typhi e l'eventuale variabilità in vivo.
MeSH term(s)	Salmonella typhi ; Typhoid Fever
Language	Italian
Publishing date	2010-02-28
Publishing country	Italy
Document type	Journal Article
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Article ; Online: Eosinophilic granulomatosis with polyangiitis (EGPA) and PRES: a case-based review of literature in ANCA-associated vasculitides.

Marra, A M / Barilaro, G / Villella, V / Granata, M

Rheumatology international

2015 Volume 35, Issue 9, Page(s) 1591–1595

Abstract: Eosinophilic granulomatosis with polyangiitis (EGPA) is a small-sized vessel systemic necrotizing vasculitis and belongs to the family of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides. The involvement of central nervous system in ... ...

Abstract	Eosinophilic granulomatosis with polyangiitis (EGPA) is a small-sized vessel systemic necrotizing vasculitis and belongs to the family of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides. The involvement of central nervous system in this condition is pretty rare. Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiological entity described for the first time by Hinchey et al. (N Engl J Med 334(8):494-500, 1996) and characterized by MRI findings of reversible subcortical vasogenic edema predominantly in the white matter of posterior cerebral lobes. There are few case reports describing the concurrence of PRES with ANCA-associated vasculitides. We describe a case of PRES in a patient with a diagnosis of EGPA with a concise review of the literature. The exact cause of this syndrome is unknown. It has been related to eclampsia, drug-induced hypertension, renal insufficiency and also to rheumatologic diseases. Endothelial injury, hypertension and immunosuppressive medications can compromise the regulation of cerebral blood flow. In ANCA-associated vasculitides, patients presenting with symptoms of PRES represent a challenge to treatment with immunosuppressive medications. However, since an inflammatory process might be implicated, judicious use of these agents along with tight control of blood pressure and a supportive therapy may contribute to the resolution of the encephalopathic syndrome treating at the same time other manifestation related to the rheumatologic disease. Larger clinical studies are warranted to optimize the management of vasculitis-associated PRES.
MeSH term(s)	Adult ; Brain/pathology ; Churg-Strauss Syndrome/complications ; Churg-Strauss Syndrome/pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Posterior Leukoencephalopathy Syndrome/complications ; Posterior Leukoencephalopathy Syndrome/pathology
Language	English
Publishing date	2015-09
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-015-3261-x
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Article ; Online: S100A7 in Psoriasis: Immunodetection and Activation by CRISPR technology.

Granata, Mariagrazia / Skarmoutsou, Evangelia / Mazzarino, Maria Clorinda / D'Amico, Fabio

Methods in molecular biology (Clifton, N.J.)

2019 Volume 1929, Page(s) 729–738

Abstract: Psoriasis, an inflammatory autoimmune skin disease, is the result of a chronic interaction between hyperproliferative keratinocytes and infiltrating activated immune cells. The mechanisms underlying psoriasis pathogenesis remain largely unknown, although ...

Abstract	Psoriasis, an inflammatory autoimmune skin disease, is the result of a chronic interaction between hyperproliferative keratinocytes and infiltrating activated immune cells. The mechanisms underlying psoriasis pathogenesis remain largely unknown, although a combination of genetic and environmental factors plays an important role in its development. S100A7 is overexpressed in psoriasis, and there is growing evidence that S100A7 may be involved in the pathogenesis of psoriasis. Since the mechanisms underlying S100A7 regulation and function remain elusive, a better understanding of these mechanisms may be useful to uncover additional treatment approaches for psoriasis. Immunohistology provides invaluable tools for a better understanding of the pathogenetic mechanisms of psoriasis. Here, we describe basic methods for immunofluorescence and immunohistochemistry analysis of S100A7 expression in psoriatic patients as well as in S100A7 CRISPR-activated human keratinocyte cell line.
MeSH term(s)	COP9 Signalosome Complex/metabolism ; CRISPR-Cas Systems ; Cell Line ; Fluorescent Antibody Technique ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Keratinocytes/cytology ; Keratinocytes/metabolism ; Peptide Hydrolases/metabolism ; Psoriasis/genetics ; Psoriasis/metabolism ; S100 Calcium Binding Protein A7/genetics ; S100 Calcium Binding Protein A7/metabolism ; Transcriptional Activation ; Up-Regulation
Chemical Substances	Intracellular Signaling Peptides and Proteins ; S100 Calcium Binding Protein A7 ; S100A7 protein, human ; Peptide Hydrolases (EC 3.4.-) ; COPS5 protein, human (EC 3.4.-.-) ; COP9 Signalosome Complex (EC 3.4.19.12)
Language	English
Publishing date	2019-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-9030-6_45
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Factors Associated with SARS-CoV-2 Infection Evaluated by Antibody Response in a Sample of Workers from the Emilia-Romagna Region, Northern Italy.

Paduano, Stefania / Granata, Michele / Turchi, Sara / Modenese, Alberto / Galante, Pasquale / Poggi, Alessandro / Marchesi, Isabella / Frezza, Giuseppina / Dervishaj, Giulia / Vivoli, Roberto / Verri, Sara / Marchetti, Simona / Gobba, Fabriziomaria / Bargellini, Annalisa

Antibodies (Basel, Switzerland)

2023 Volume 12, Issue 4

Abstract: Factors associated with SARS-CoV-2 infection risk are still debated. This case-control study aims to investigate the possible relationship between SARS-CoV-2 infection, evaluated through antibody response, and the main sociodemographic, occupational, ... ...

Abstract	Factors associated with SARS-CoV-2 infection risk are still debated. This case-control study aims to investigate the possible relationship between SARS-CoV-2 infection, evaluated through antibody response, and the main sociodemographic, occupational, clinical-anamnestic, and biochemical factors in a population of Modena province (Northern Italy), mainly workers. Both workers who voluntarily joined the screening campaign proposed by companies and self-referred individuals who underwent serological testing were enrolled. Subjects with antibody positivity were recruited as cases (
Language	English
Publishing date	2023-12-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661514-9
ISSN	2073-4468 ; 2073-4468
ISSN (online)	2073-4468
ISSN	2073-4468
DOI	10.3390/antib12040077
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Article ; Online: Biological therapy downregulates the heterodimer S100A8/A9 (calprotectin) expression in psoriatic patients.

D'Amico, F / Granata, M / Skarmoutsou, E / Trovato, C / Lovero, G / Gangemi, P / Longo, V / Pettinato, M / Mazzarino, M C

Inflammation research : official journal of the European Histamine Research Society ... [et al.

2018 Volume 67, Issue 7, Page(s) 609–616

Abstract: The pathophysiology of psoriasis is very complex and involves an interplay between immune cells and keratinocytes. The keratinocyte production of calprotectin (S100A8/A9), induced by the inflammatory psoriatic milieu, may be involved in initiating immune ...

Abstract	The pathophysiology of psoriasis is very complex and involves an interplay between immune cells and keratinocytes. The keratinocyte production of calprotectin (S100A8/A9), induced by the inflammatory psoriatic milieu, may be involved in initiating immune cell invasion, as well as in propagating inflammation. However, the exact role of calprotectin in psoriasis remains unclear. Therapeutic approaches utilizing adalimumab, etanercept and ustekinumab are widely used in psoriatic treatment, but their anti-inflammatory mechanisms are not fully understood. The aim of this study was to investigate, by immunohistochemical analysis, the expression of the heterocomplex S100A8/A9 in lesional skin from psoriatic patients undergoing biological therapy with adalimumab, etanercept or ustekinumab. Our results showed that S100A8/A9, absent or present at very low level in skin biopsies from healthy subjects, is dramatically upregulated in each epidermal layer from psoriatic patients. Interestingly, calprotectin was mainly localized in keratinocyte nuclei from psoriatic patients, suggesting a role of S100A8/A9 in keratinocyte nuclear function. Furthermore, we have shown that the biological treatment induced a drastic reduction of S100A8/A9 expression in skin biopsies from treated patients, correlating with PASI reduction. Our results suggest that calprotectin may play a crucial role as a significant marker of inflammation in psoriasis, and that its reduction of expression may be considered a favourable prognostic marker in psoriasis.
MeSH term(s)	Adalimumab/pharmacology ; Adalimumab/therapeutic use ; Adult ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Biological Therapy ; Calgranulin A/immunology ; Calgranulin B/immunology ; Dermatologic Agents/pharmacology ; Dermatologic Agents/therapeutic use ; Down-Regulation ; Etanercept/pharmacology ; Etanercept/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Psoriasis/drug therapy ; Psoriasis/immunology ; Skin/drug effects ; Skin/immunology ; Ustekinumab/pharmacology ; Ustekinumab/therapeutic use
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Calgranulin A ; Calgranulin B ; Dermatologic Agents ; Ustekinumab (FU77B4U5Z0) ; Adalimumab (FYS6T7F842) ; Etanercept (OP401G7OJC)
Language	English
Publishing date	2018-03-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1221794-3
ISSN	1420-908X ; 1023-3830
ISSN (online)	1420-908X
ISSN	1023-3830
DOI	10.1007/s00011-018-1147-6
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Zs.A 675: Show issues

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Article ; Online: Progress in the measurement and reduction of thermal noise in optical coatings for gravitational-wave detectors.

Granata, M / Amato, A / Cagnoli, G / Coulon, M / Degallaix, J / Forest, D / Mereni, L / Michel, C / Pinard, L / Sassolas, B / Teillon, J

Applied optics

2020 Volume 59, Issue 5, Page(s) A229–A235

Abstract: Coating thermal noise is a fundamental limit for precision experiments based on optical and quantum transducers. In this review, after a brief overview of the techniques for coating thermal noise measurements, we present the latest worldwide research ... ...

Abstract	Coating thermal noise is a fundamental limit for precision experiments based on optical and quantum transducers. In this review, after a brief overview of the techniques for coating thermal noise measurements, we present the latest worldwide research activity on low-noise coatings, with a focus on the results obtained at the Laboratoire des Matériaux Avancés. We report new updated values for the
Language	English
Publishing date	2020-03-26
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.377293
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Article ; Online: Contribution of Immunohistochemistry in Revealing S100A7/JAB1 Colocalization in Psoriatic Epidermal Keratinocyte.

Granata, Mariagrazia / Skarmoutsou, Evangelia / Mazzarino, Maria Clorinda / Libra, Massimo / D'Amico, Fabio

Methods in molecular biology (Clifton, N.J.)

2019 Volume 2109, Page(s) 67–74

Abstract: The application of immunohistological methods provides an invaluable contribution in revealing the protein colocalization, which may reflect the occurrence of molecular interaction processes.This chapter describes comprehensive protocols for detection of ...

Abstract	The application of immunohistological methods provides an invaluable contribution in revealing the protein colocalization, which may reflect the occurrence of molecular interaction processes.This chapter describes comprehensive protocols for detection of S100A7/JAB1 colocalization by immunohistochemistry in archival formalin-fixed and paraffin-embedded skin biopsies from healthy and psoriatic subjects. In addition, we provide a protocol for immunocytochemical detection of S100A7/JAB1 colocalization in S100A7 CRISPR-activated human keratinocyte cell line.
MeSH term(s)	Biopsy ; COP9 Signalosome Complex/metabolism ; CRISPR-Cas Systems ; Case-Control Studies ; Cell Line ; Humans ; Immunohistochemistry ; Intracellular Signaling Peptides and Proteins/metabolism ; Keratinocytes/metabolism ; Peptide Hydrolases/metabolism ; Psoriasis/metabolism ; Psoriasis/pathology ; S100 Calcium Binding Protein A7/genetics ; S100 Calcium Binding Protein A7/metabolism ; Tissue Embedding ; Tissue Fixation
Chemical Substances	Intracellular Signaling Peptides and Proteins ; S100 Calcium Binding Protein A7 ; S100A7 protein, human ; Peptide Hydrolases (EC 3.4.-) ; COPS5 protein, human (EC 3.4.-.-) ; COP9 Signalosome Complex (EC 3.4.19.12)
Language	English
Publishing date	2019-08-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/7651_2019_251
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Hylan g-f 20: review of its safety and efficacy in the management of joint pain in osteoarthritis.

Migliore, A / Giovannangeli, F / Granata, M / Laganà, B

Clinical medicine insights. Arthritis and musculoskeletal disorders

2010 Volume 3, Page(s) 55–68

Abstract: Background: Osteoarthritis (OA) is a chronic degenerative joint disease that is a clinically and economically important disease. The increased prevalence of OA with aging, coupled to the demographics of aging populations, make OA a high priority health ... ...

Abstract	Background: Osteoarthritis (OA) is a chronic degenerative joint disease that is a clinically and economically important disease. The increased prevalence of OA with aging, coupled to the demographics of aging populations, make OA a high priority health care problem. Viscosupplementation (VS) is a well-established treatment option in knee OA that is included in the professional guidelines for treatment of this joint disease, and could potentially provide a useful alternative in treating such patients with painful OA. Theoretically VS is an approach that should apply to all synovial joints. Objectives: The aim of this review is to assess the efficacy and safety of viscosupplementation with Hylan GF-20 (Synvisc(®)) in the management of joint pain in osteoarthritis. Methods: THE FOLLOWING DATABASES WERE SEARCHED: Medline, Database of Abstract on Reviews and Effectiveness, Cochrane Database of Systematic Reviews. Furthermore, the lists of references of retrieved publications were manually checked for additional references. The search terms Review, Viscosupplementation, Osteoarthritis, Hyaluronic acid, Hyaluronan, Sodium Hyaluronate, Hylan GF-20, Synvisc, intra-articular injection were used to identify all studies relating to the use of Synvisc(®) viscosupplementation therapy in OA. Results: Hylan GF-20 is a safe and effective treatment for decreasing pain and improving function in patients suffering from knee and hip OA but new evidences are emerging for its use in other joints.
Language	English
Publishing date	2010-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2590933-2
ISSN	1179-5441 ; 1179-5441
ISSN (online)	1179-5441
ISSN	1179-5441
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