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  1. Book ; Online ; E-Book: Health Impacts of Developmental Exposure to Environmental Chemicals

    Kishi, Reiko / Grandjean, Philippe

    (Current Topics in Environmental Health and Preventive Medicine,)

    2020  

    Abstract: This book provides concise and cutting-edge studies on threats resulting from exposure to environmental chemicals that can affect human health and development, with a particular emphasis on the DOHaD concept. The book is divided into five main parts, the ...

    Author's details edited by Reiko Kishi, Philippe Grandjean
    Series title Current Topics in Environmental Health and Preventive Medicine,
    Abstract This book provides concise and cutting-edge studies on threats resulting from exposure to environmental chemicals that can affect human health and development, with a particular emphasis on the DOHaD concept. The book is divided into five main parts, the first of which includes an introduction to theimpacts of developmental exposure to environmental chemicals and historical perspectives, while the second focuses on how environmental chemicals can affect human organs, including neurodevelopment, immune functions, etc. In turn, the third part addresses the characteristics of specific chemicals and their effects on human health and development, while the fourth part provides a basis for future studies by highlighting the latest innovations in toxicology, remaining challenges, and promising strategies in children’s environmental health research, as well as ideas on how to bridge the gap between research evidence and practical policymaking. The fifth and last part outlines further research directions and related policymaking aspects. Health Impacts of Developmental Exposure to Environmental Chemicals will appeal to young and veteran researchers, students, and physicians (especially gynecologists and pediatricians) who are seeking comprehensive information on how children’s health can be affected by harmful chemicals and other environmental toxicants.
    Keywords Health promotion ; Maternal and child health services ; Health Promotion and Disease Prevention ; Maternal and Child Health
    Subject code 615.902
    Language English
    Size 1 online resource (554 pages).
    Edition 1st ed. 2020.
    Publisher Springer Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-15-0520-9 ; 981-15-0519-5 ; 978-981-15-0520-1 ; 978-981-15-0519-5
    DOI 10.1007/978-981-15-0520-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Conference proceedings: The precautionary principle

    Grandjean, Philippe

    implications for research and prevention in environmental and occupational health ; an international conference [convened in Bologna]

    (Ramazzini Foundation library ; 2 ; European journal of oncology)

    2003  

    Author's details ed. by Philippe Grandjean
    Series title Ramazzini Foundation library ; 2
    European journal of oncology
    Collection
    Subject code 362
    Language English
    Size 247 S. : Ill., graph. Darst.
    Publisher European Foundation of Oncology and Environmental Sciences "B. Ramazzini"
    Publishing place Bologna
    Publishing country Italy
    Document type Book ; Conference proceedings
    HBZ-ID HT014304639
    ISBN 88-86235-80-1 ; 978-88-86235-80-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 1438 order for loan Magazin

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  3. Article ; Online: Benchmark dose calculations for PFAS exposure based on two data sets on immunotoxic effects.

    Budtz-Jørgensen, Esben / Grandjean, Philippe

    Environmental health : a global access science source

    2023  Volume 22, Issue 1, Page(s) 40

    Abstract: Background: Exposure to perfluorinated alkylate substances (PFAS) is associated with harmful effects on human health, including developmental immunotoxicity. This outcome was chosen as the critical effect by the European Food Safety Authority (EFSA), ... ...

    Abstract Background: Exposure to perfluorinated alkylate substances (PFAS) is associated with harmful effects on human health, including developmental immunotoxicity. This outcome was chosen as the critical effect by the European Food Safety Authority (EFSA), which calculated a new joint reference dose for four PFAS using a Benchmark Dose (BMD) analysis of a study of 1-year old children. However, the U.S. Environmental Protection Agency (EPA) recently proposed much lower exposure limits.
    Methods: We explored the BMD methodology for summary and individual data and compared the results with and without grouping for two data sets available. We compared the performance of different dose-response models including a hockey-stick model and a piecewise linear model. We considered different ways of testing the assumption of equal weight-based toxicity of the four PFAS and evaluated more flexible models with exposure indices allowing for differences in toxicity.
    Results: Results relying on full and decile-based data were in good accordance. However, BMD results for the larger study were lower than observed by EFSA for the smaller study. EFSA derived a lower confidence limit for the BMD of 17.5 ng/mL for the sum of serum-PFAS concentration, while similar calculations in the larger cohort yielded values of about 1.5 ng/mL. As the assumption of equal weight-based toxicity of the four PFAS seems questionable, we confirmed dose-dependencies that allowed potency differences between PFAS. We also found that models linear in the parameters for the BMD analysis showed superior coverage probabilities. In particular, we found the piecewise linear model to be useful for Benchmark analysis.
    Conclusions: Both data sets considered could be analyzed on a decile basis without important bias or loss of power. The larger study showed substantially lower BMD results, both for individual PFAS and for joint exposures. Overall, EFSA's proposed tolerable exposure limit appears too high, while the EPA proposal is in better accordance with the results.
    MeSH term(s) Child ; Humans ; Infant ; Benchmarking/methods ; Fluorocarbons/toxicity
    Chemical Substances Fluorocarbons
    Language English
    Publishing date 2023-05-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2092232-2
    ISSN 1476-069X ; 1476-069X
    ISSN (online) 1476-069X
    ISSN 1476-069X
    DOI 10.1186/s12940-023-00985-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Conference proceedings: Biomarkers in environmental toxicology

    Grandjean, Philippe

    1 - 3 June, 1995, Cannes, France ; [proceedings]

    (Clinical chemistry ; 41,12B = Suppl.)

    1995  

    Institution International Federation of Clinical Chemistry
    Event/congress Arnold O. Beckman IFCC European Conference on Environmental Toxicology (2, 1995, Cannes)
    Author's details The Arnold O. Beckman/IFCC European Conference on Environmental Toxicology. [Organizing and ed. committee: Philippe Grandjean ...]
    Series title Clinical chemistry ; 41,12B = Suppl.
    Collection
    Keywords Biological Markers / congresses ; Environmental Exposure / analysis / congresses ; Environmental Monitoring / congresses ; Umwelttoxikologie ; Bioindikator ; Marker ; Biomonitoring
    Subject Biological monitoring ; Markierungssubstanz ; Ökotoxikologie ; Bioindikatoren
    Language English
    Size 3B, S. 1799 - 1929 : graph. Darst.
    Publisher American Assoc. for Clin. Chemistry
    Publishing place Washington, DC
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT006857153
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 171 -41- verfügbar in Königswinter Königswinter

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  5. Article ; Online: Developmental fluoride neurotoxicity: an updated review.

    Grandjean, Philippe

    Environmental health : a global access science source

    2019  Volume 18, Issue 1, Page(s) 110

    Abstract: Background: After the discovery of fluoride as a caries-preventing agent in the mid-twentieth century, fluoridation of community water has become a widespread intervention, sometimes hailed as a mainstay of modern public health. However, this practice ... ...

    Abstract Background: After the discovery of fluoride as a caries-preventing agent in the mid-twentieth century, fluoridation of community water has become a widespread intervention, sometimes hailed as a mainstay of modern public health. However, this practice results in elevated fluoride intake and has become controversial for two reasons. First, topical fluoride application in the oral cavity appears to be a more direct and appropriate means of preventing caries. Second, systemic fluoride uptake is suspected of causing adverse effects, in particular neurotoxicity during early development. The latter is supported by experimental neurotoxicity findings and toxicokinetic evidence of fluoride passing into the brain.
    Method: An integrated literature review was conducted on fluoride exposure and intellectual disability, with a main focus on studies on children published subsequent to a meta-analysis from 2012.
    Results: Fourteen recent cross-sectional studies from endemic areas with naturally high fluoride concentrations in groundwater supported the previous findings of cognitive deficits in children with elevated fluoride exposures. Three recent prospective studies from Mexico and Canada with individual exposure data showed that early-life exposures were negatively associated with children's performance on cognitive tests. Neurotoxicity appeared to be dose-dependent, and tentative benchmark dose calculations suggest that safe exposures are likely to be below currently accepted or recommended fluoride concentrations in drinking water.
    Conclusion: The recent epidemiological results support the notion that elevated fluoride intake during early development can result in IQ deficits that may be considerable. Recognition of neurotoxic risks is necessary when determining the safety of fluoride-contaminated drinking water and fluoride uses for preventive dentistry purposes.
    MeSH term(s) Adolescent ; Adolescent Development/drug effects ; Child ; Child Development/drug effects ; Child, Preschool ; Fluorides/toxicity ; Humans ; Infant ; Infant, Newborn
    Chemical Substances Fluorides (Q80VPU408O)
    Language English
    Publishing date 2019-12-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2092232-2
    ISSN 1476-069X ; 1476-069X
    ISSN (online) 1476-069X
    ISSN 1476-069X
    DOI 10.1186/s12940-019-0551-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Conference proceedings: Biomarkers of chemical exposure

    Grandjean, Philippe

    programme & abstracts

    1993  

    Event/congress Arnold O. Beckman European Conference on Environmental Toxicology (1, 1993, München)
    Author's details The Arnold O. Beckman IFCC European Conference on Environmental Toxicology, 16 - 18 June 1993 Hotel Vier Jahreszeiten Munich, Germany. [Organising committee Philippe Grandjean (chairman)]
    Language English
    Size 89 S.
    Publishing place S.l.
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT014323064
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 C 51 order for loan Magazin

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  7. Article ; Online: Delayed discovery, dissemination, and decisions on intervention in environmental health: a case study on immunotoxicity of perfluorinated alkylate substances.

    Grandjean, Philippe

    Environmental health : a global access science source

    2018  Volume 17, Issue 1, Page(s) 62

    Abstract: Identification and characterization of environmental hazards that impact human health must rely on the best possible science to inform and inspire appropriate public health intervention. The perfluorinated alkylate substances (PFASs) are persistent ... ...

    Abstract Identification and characterization of environmental hazards that impact human health must rely on the best possible science to inform and inspire appropriate public health intervention. The perfluorinated alkylate substances (PFASs) are persistent emerging pollutants that are now being recognized as important human health hazards. Although the PFASs have been produced for over 60 years, academic research on environmental health aspects has appeared only in the most recent 10 years or so. In the meantime, these persistent chemicals accumulated in the global environment. Some early studies e.g., on population exposures and toxicity, were not released to the public until after year 2000. Still, the first PFAS risk assessments ignored these reports and relied on scant journal publications. The first guidelines and legal limits for PFAS exposure, e.g., from drinking water, were proposed 10 years ago. They have decreased substantially since then, but remain higher than suggested by data on human adverse effects, especially on the immune system, that occur at background exposure levels. By now, the best-known PFASs are being phased out, and related PFASs are being introduced as substitutes. Given the substantial delays in discovery of PFAS toxicity, in dissemination of findings, and in regulatory decisions, PFAS substitutes and other persistent industrial chemicals should be subjected to prior scrutiny before widespread usage.
    MeSH term(s) Environmental Exposure/analysis ; Environmental Health ; Environmental Monitoring ; Environmental Pollutants/toxicity ; Fluorocarbons/toxicity ; Humans
    Chemical Substances Environmental Pollutants ; Fluorocarbons
    Language English
    Publishing date 2018-07-31
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 2092232-2
    ISSN 1476-069X ; 1476-069X
    ISSN (online) 1476-069X
    ISSN 1476-069X
    DOI 10.1186/s12940-018-0405-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Health Status of Workers Exposed to Perfluorinated Alkylate Substances.

    Grandjean, Philippe

    Journal of occupational and environmental medicine

    2018  Volume 60, Issue 10, Page(s) e562

    MeSH term(s) Alkanesulfonic Acids ; Caprylates ; Fluorocarbons ; Health Status ; Humans
    Chemical Substances Alkanesulfonic Acids ; Caprylates ; Fluorocarbons ; perfluorooctanoic acid (947VD76D3L) ; perfluorooctane sulfonic acid (9H2MAI21CL)
    Language English
    Publishing date 2018-10-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000001411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 155: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Book ; Conference proceedings: Ecogenetics

    Grandjean, Philippe

    genetic predisposition to the toxic effects of chemicals ; [proceedings of a WHO meeting held in Krefeld, Federal Republic of Germany, 17 - 20 October 1989 ; based on papers presented at the Consultation on Genetic Predisposition to Toxic Effects of Chemicals]

    1991  

    Event/congress Consultation on Genetic Predisposition to Toxic Effects of Chemicals (1989, Krefeld)
    Author's details ed.-in-chief Philippe Grandjean
    Keywords Pharmacogenetics / congresses ; Xenobiotics / toxicity / congresses ; Disease Susceptibility / genetics / congresses ; Umweltchemikalie ; Mutagenität ; Erblichkeit ; DNS-Schädigung ; Disposition
    Subject Umweltchemikalien ; Heredität ; Gentoxizität ; Genotoxizität ; Mutagene Wirkung ; Gentoxische Wirkung ; Anfälligkeit ; DNA-Schädigung ; DNS ; DNA-Schaden ; DNS-Schaden
    Size XIV, 288 S. : graph. Darst.
    Edition 1. ed.
    Publisher Chapman and Hall
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT003909962
    ISBN 0-412-39290-9 ; 978-0-412-39290-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 A 4941 order for loan Magazin

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  10. Book: Assessment of health risks in infants associated with exposure to PCBs, PCDDs and PCDFs in breast milk

    Grandjean, Philippe

    report on a WHO working group ; Abano Terme, Padua, 16 - 19 February 1987

    (Environmental health series ; 29)

    1988  

    Title variant PCBs, PCDDs and PCDFs in breast milk
    Institution Weltgesundheitsorganisation
    Author's details ed. board: P. Grandjean
    Series title Environmental health series ; 29
    Collection
    Keywords Polychlorinated Biphenyls / congresses ; Dioxins / congresses ; Furans / congresses ; Milk, Human / congresses ; Infant Nutrition / congresses
    Size VIII, 116 S.
    Publisher WHO, Regional Office for Europe
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book
    HBZ-ID HT003524521
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 3176 order for loan Magazin

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