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Article ; Online: Primary hyperparathyroidism and acute pancreatitis.

Vera, Cristina / Díez, Manuel / San Román, Rosario / Ratia, Tomás / Granell, Javier

Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion

2013 Volume 60, Issue 5, Page(s) 275–276

MeSH term(s)	Acute Disease ; Adult ; Humans ; Hyperparathyroidism, Primary/complications ; Male ; Pancreatitis/etiology
Language	Spanish
Publishing date	2013-05
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	1469349-5
ISSN	1579-2021 ; 0211-2299 ; 1575-0922
ISSN (online)	1579-2021
ISSN	0211-2299 ; 1575-0922
DOI	10.1016/j.endonu.2012.05.013
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Article ; Online: El estudio de instrumentos de viento se asocia con un patrón obstructivo en la espirometría de adolescentes con buena capacidad de resistencia aeróbica.

Granell, Javier / Granell, Jose / Ruiz, Diana / Tapias, Jose A

Atencion primaria

2010 Volume 43, Issue 3, Page(s) 134–139

Abstract: Objective: There is controversy in the medical literature regarding the beneficial or detrimental effects of playing wind musical instruments on the respiratory system. The aim of this study is to analyse this relationship, taking the physical condition ...

Title translation	Playing of wind instruments is associated with an obstructive pattern in the spirometry of adolescents with a good aerobic resistance capacity.
Abstract	Objective: There is controversy in the medical literature regarding the beneficial or detrimental effects of playing wind musical instruments on the respiratory system. The aim of this study is to analyse this relationship, taking the physical condition of the subjects into consideration. Design: Cross-sectional observational study. Setting: Public institution with coordinated medium grade musical instruction and primary and secondary education. Participants: Young performers (between 13 and 17 years). Data: We collected basic epidemiological parameters (gender, age, weight, size, heath status), and each subject underwent a fitness test ("course navette" cardiorespiratory fitness test) and a forced spirometry. Results: We included 90 students, 53 females and 37 males. Thirty two were wind instrument players and 58 studied other instruments. The two groups were homogeneous with respect to gender, age and body mass index. The maximum oxygen uptake showed no significant difference (P=0.255), further demonstrating an adequate level of fitness compared to the general population. FVC was normal and similar in both groups (P=0.197). The FEV(1) percentage and the FEV(1)/FVC ratio were significantly lower (P<0.0005) in the "wind" group. Practice with wind instruments behaved as a predictor of pathological FEV1/FVC (<70%) in the multivariate analysis (P<0.0005). Conclusion: The study of wind instruments was associated with an obstructive spirometric pattern in young musicians with a normal level of physical fitness.
MeSH term(s)	Adolescent ; Cross-Sectional Studies ; Female ; Humans ; Male ; Music ; Physical Fitness ; Respiratory System/physiopathology ; Spirometry
Language	Spanish
Publishing date	2010-06-02
Publishing country	Spain
Document type	English Abstract ; Journal Article
ZDB-ID	1200787-0
ISSN	1578-1275 ; 0212-6567
ISSN (online)	1578-1275
ISSN	0212-6567
DOI	10.1016/j.aprim.2010.03.013
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Article: Large cell neuroendocrine - Adenocarcinona mixed tumour of colon: Collision tumour with peculiar behaviour. What do we know about these tumours?

Minaya-Bravo, Ana María / Garcia Mahillo, Julio Cesar / Mendoza Moreno, Fernando / Noguelares Fraguas, Fernando / Granell, Javier

Annals of medicine and surgery (2012)

2015 Volume 4, Issue 4, Page(s) 399–403

Abstract: Introduction: Mixed glandular-endocrine carcinomas are rare tumours of gastrointestinal tract (MANEC). They are more frequent in stomach and hardly one hundred cases have been described in colon. According to Lewis, they are classified into collision ( ... ...

Abstract	Introduction: Mixed glandular-endocrine carcinomas are rare tumours of gastrointestinal tract (MANEC). They are more frequent in stomach and hardly one hundred cases have been described in colon. According to Lewis, they are classified into collision (side by side pattern), composite (intermingled) or amphicrine (neuroendocrine and glandular features inside a same cell). Collision tumours are related to biclonal theory: two simultaneous cancerogenic events. Conversely, multidirectional differentiation from a stem cell is accepted as origin of composite tumours. The aim of this paper is to analyse the behaviour of these tumours, with an especial concern about how these tumours metastasise, and the different theories about carcinogenesis. Presentation of case: We report a rare case of collision adenocarcinoma-large cell neuroendocrine tumour of colon that after a three-year period of follow-up has presented a retroperitoneal recurrence that features adenocarcinoma and large cell neuroendocrine components. Discussion: After an exhaustive review of the English literature, we found that only two cases of collision tumour of colon with metastases showing glandular and endocrine components have been described up to date, so we report the third case, and the first happening in transverse colon. Conclusion: We conclude that not all collision tumours follow the biclonal theory and more studies are needed to clarify the origin of these neoplasms, and consequently, to reach an adequate treatment.
Language	English
Publishing date	2015-10-08
Publishing country	England
Document type	Case Reports
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2015.10.004
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Article ; Online: Influence of atmospheric pressure on the incidence of spontaneous pneumothorax.

Díaz, Raúl / Díez, Manuel Mariano / Medrano, María José / Vera, Cristina / Guillamot, Paloma / Sánchez, Ana / Ratia, Tomás / Granell, Javier

Cirugia espanola

2014 Volume 92, Issue 6, Page(s) 415–420

Abstract: Background: This study analyses the relationship between the incidence of idiopathic spontaneous pneumothorax (ISP) and atmospheric pressure (AP).: Methods: A total of 288 cases of ISP were included, 229 men and 59 women. The AP of the day of ... ...

Abstract	Background: This study analyses the relationship between the incidence of idiopathic spontaneous pneumothorax (ISP) and atmospheric pressure (AP). Methods: A total of 288 cases of ISP were included, 229 men and 59 women. The AP of the day of diagnosis, of the 3 prior days and the monthly average was registered. The association between the incidence of ISP and AP was analyzed by calculating standardized incidence ratio (SIR) and Poisson regression. Results: The AP on the day of admission (mean±standard deviation) (1,017.9±7 hectopascals [hPa]) was higher than the monthly average AP (1,016.9±4.1 hPa) (P=.005). There was a monthly distribution pattern of ISP with the highest incidence in the months of January, February and September and the lowest in April. When AP was less than 1,014 hPa, there were fewer cases registered than what would statistically have been expected (58/72 cases). In contrast, when the pressure was higher than 1,019 hPa, the registered cases were more than expected (109/82 cases) (SIR=1.25; 95% CI: 1.04 to 1.51). The risk of ISP increased 1.15 times (95% CI: 1.05 to 1.25, P=.001) for each hPa of AP, regardless of sex, age and monthly average AP. A dose-response relationship was observed, with progressive increases in risk (IRR=1.06 when the AP was 1,014-1016 hPa; 1.17 hPa when the AP was 1,016-1,019 hPa and 1.69 when AP was superior to 1,019 hPa) (P for trend=.089). Conclusion: The AP is a risk factor for the onset of idiopathic spontaneous pneumothorax.
MeSH term(s)	Adult ; Atmospheric Pressure ; Female ; Humans ; Incidence ; Male ; Pneumothorax/epidemiology ; Pneumothorax/etiology ; Retrospective Studies ; Seasons
Language	Spanish
Publishing date	2014-06
Publishing country	Spain
Document type	Journal Article
ZDB-ID	730701-9
ISSN	1578-147X ; 0009-739X
ISSN (online)	1578-147X
ISSN	0009-739X
DOI	10.1016/j.ciresp.2013.02.028
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Article ; Online: Efecto de la deficiencia de vitamina D sobre la hipocalcemia tras tiroidectomía total por bocio benigno.

Díez, Manuel / Vera, Cristina / Ratia, Tomás / Diego, Lucía / Mendoza, Fernando / Guillamot, Paloma / San Román, Rosario / Mugüerza, José M / Rodríguez, Angel / Medina, Carlos / Gómez, Beatriz / Granell, Javier

Cirugia espanola

2013 Volume 91, Issue 4, Page(s) 250–256

Abstract: Introduction: The purpose of this study was to analyse the relationship between preoperative serum levels of vitamin D and postoperative hypocalcaemia after total thyroidectomy.: Material and methods: A prospective observational study was conducted ... ...

Title translation	Effect of vitamin D deficiency on hypocalcaemia after total thyroidectomy due to benign goitre.
Abstract	Introduction: The purpose of this study was to analyse the relationship between preoperative serum levels of vitamin D and postoperative hypocalcaemia after total thyroidectomy. Material and methods: A prospective observational study was conducted on 113 patients treated by total thyroidectomy due to benign disease. Preoperative vitamin D serum levels and postoperative albumin-corrected calcium and parathormone (PTH) levels were determined. Sensitivity, specificity, positive predictive value and negative predictive value of vitamin D and PTH levels, respectively, in the diagnosis of postoperative hypocalcaemia were calculated. Results: Hypocalcaemia was diagnosed in 44 (38.9%) patients. Vitamin D levels were significantly higher in the group of patients with normal postoperative calcium (median: 25.4pg/mL; range: 4-60), compared to those who developed hypocalcaemia (median: 16.4pg/mL; range: 6.3-46.9) (P=.001). Postoperative hypocalcaemia was more frequent in patients with vitamin D < 30ng/mL (39/78) (50%), than among those with normal levels (5/35) (14.2%) (P=.001). Sensitivity, specificity, positive predictive value and negative predictive value were 88% and 68%, 43% and 82%, 50% and 71%, and 85% and 80% for vitamin D and PTH, respectively. Vitamin D and PTH showed independent prognostic values on the risk of hypocalcaemia. The OR associated with vitamin D < 30ng/mL was 4.25 (95% CI: 1.31-13.78) (P=.016), and the OR of PTH<13pg/mL was 15.4 (95% CI: 4.83-49.1) (P<.001). Conclusion: Vitamin D deficiency is a risk factor of hypocalcaemia after total thyroidectomy for benign goitre. The vitamin D level provides independent prognostic information, which is complementary to that given by PTH.
MeSH term(s)	Adolescent ; Adult ; Aged ; Female ; Goiter/complications ; Humans ; Hypocalcemia/etiology ; Male ; Middle Aged ; Postoperative Complications/etiology ; Prospective Studies ; Risk Factors ; Thyroidectomy/methods ; Vitamin D Deficiency/complications ; Young Adult
Language	Spanish
Publishing date	2013-04
Publishing country	Spain
Document type	English Abstract ; Journal Article ; Observational Study
ZDB-ID	730701-9
ISSN	1578-147X ; 0009-739X
ISSN (online)	1578-147X
ISSN	0009-739X
DOI	10.1016/j.ciresp.2012.09.006
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Article ; Online: Relación entre concentración intraoperatoria de parathormona y evolución postoperatoria del hiperparatiroidismo primario.

Díez, Manuel / Ratia, Tomás / Medrano, María José / Mugüerza, José María / San Román, M Rosario / Medina, Carlos / Rodríguez, Angel / Sánchez-Seco, María Isabel / Vera, Cristina / Díaz, Raúl / Franco, Pilar / Granell, Javier

Cirugia espanola

2011 Volume 89, Issue 6, Page(s) 386–391

Abstract: Introduction: The relationship between the intra-operative concentration of parathyroid hormone (IOPTH) and the long-term outcome of patients intervened due to primary hyperparathyroidism (PHPT).: Patients and methods: A prospective observational ... ...

Title translation	Relationship between parathormone concentration during surgery and the post-operative outcome of primary hyperparathyroidism.
Abstract	Introduction: The relationship between the intra-operative concentration of parathyroid hormone (IOPTH) and the long-term outcome of patients intervened due to primary hyperparathyroidism (PHPT). Patients and methods: A prospective observational study was performed with 120 patients. Three determinations were made of PTH in blood: baseline, when the diseases gland was located, and 10 minutes after its extirpation. The calcium, PTH and vitamin D (25-OH-D3) levels were measured during follow up. Results: A decrease in IOPTH > 50% was observed in 96 (80%) patients, and the post-extirpation value returned to the normal range (Group I), in 18 (15%) a decrease of > 50% but the final value remained higher than normal (Group II) and in 6 (5%) the decrease was<50% (Group III). Persistent PHPT was detected during follow up in 6 patients (5%): one in Group I (1%), 3 (16.7%) in II and 2 (33.3%) in group III (P<.001). The risk of persistent PHPT was higher in Group II (odds ratio: 19; 95% CI: 1.85-194) and in Group III (odds ratio: 47; 95% CI: 3.53-639). There were no cases of recurrent PHPT. A normal calcium with an increased PTH was detected in 20 patients of Group I (20.8%), 11 (61.1%) in II and 3 (50%) in III (P<.001). These patients had a lower concentration of post-operative vitamin D (17 ng/ml, range: 24; compared to 28 ng/ml, range: 21) (P=.008) and higher frequency of hypovitaminosis D (70.6% compared to 26.2%) (P>.001). Conclusion: The risk of persistent PHPT is higher when the IOPTH decreases more than 50% but still remains high.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Hyperparathyroidism, Primary/blood ; Hyperparathyroidism, Primary/surgery ; Intraoperative Period ; Male ; Middle Aged ; Parathyroid Hormone/blood ; Postoperative Period ; Prospective Studies ; Time Factors ; Treatment Outcome
Chemical Substances	Parathyroid Hormone
Language	Spanish
Publishing date	2011-06
Publishing country	Spain
Document type	English Abstract ; Journal Article
ZDB-ID	730701-9
ISSN	1578-147X ; 0009-739X
ISSN (online)	1578-147X
ISSN	0009-739X
DOI	10.1016/j.ciresp.2011.02.007
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Article: Rhodococcus equi pneumonia: highly active antiretroviral therapy helps but does not cure lung infection.

Sanz-Moreno, José / Flores-Segovia, Julio / Olmedilla-Arregui, Gabriel / Gómez-Herruz, Peña / Granell, Javier

AIDS (London, England)

2002 Volume 16, Issue 3, Page(s) 509–511

MeSH term(s)	AIDS-Related Opportunistic Infections/drug therapy ; AIDS-Related Opportunistic Infections/pathology ; Actinomycetales Infections/complications ; Actinomycetales Infections/drug therapy ; Actinomycetales Infections/pathology ; Adult ; Antiretroviral Therapy, Highly Active ; Humans ; Male ; Pneumonia, Bacterial/complications ; Pneumonia, Bacterial/drug therapy ; Pneumonia, Bacterial/pathology ; Rhodococcus equi
Language	English
Publishing date	2002-02-15
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/00002030-200202150-00035
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Article: Variación del valor pronóstico de la proteína p53 en relación con el estadio tumoral en pacientes con adenocarcinoma colorrectal.

Díez, Manuel / Pollán, Marina / Ramos, Paloma / Villeta, Rafael / Ratia, Tomás / Hernández, Pilar / Lozano, Oscar / Noguerales, Fernando / Granell, Javier

Cirugia espanola

2006 Volume 77, Issue 4, Page(s) 213–220

Abstract: Objective: To analyze the prognostic value of p53 protein as a marker of recurrence risk in each tumoral stage.: Patients and method: A prospective study of a cohort of 288 patients who underwent surgery for colorectal adenocarcinoma was performed. ... ...

Title translation	Variation in the prognostic value of p53 protein in relation to tumoral stage in patients with colorectal adenocarcinoma.
Abstract	Objective: To analyze the prognostic value of p53 protein as a marker of recurrence risk in each tumoral stage. Patients and method: A prospective study of a cohort of 288 patients who underwent surgery for colorectal adenocarcinoma was performed. Stage 1 of the tumor-node-metastasis (TNM) classification was found in 42 patients (14.6%), stage II in 144 (50%) and stage III in 102 (35.4%). Histopathological variables were examined in tumor samples fixed in formol and embedded in paraffin and p53 (DO7 antibody) and proliferative cell nuclear antigen (PC-10 antibody) proteins were determined using immunohistochemistry. The results of p53 were analyzed in each of the categories of clinical and histopathological variables. Recurrence-free survival was calculated using the Kaplan-Meier method. The value of each variable as a predictive marker for tumoral recurrence was analyzed using Cox regression analysis. Hazard ratios and 95% confidence intervals were calculated as indicators of relative risk. The analysis was applied to the whole cohort and was subsequently repeated in each TNM tumoral stage separately. Results: Tumors with p53 protein overexpression more frequently recurred and showed lower recurrence-free survival at 5 years. However, the association between p53 expression and postoperative outcome was statistically significant in stage III tumors only. In this subgroup of patients, recurrence-free survival at 60 months was 60% in p53-negative tumors and was 26% in p53-positive tumors (p=0.010). In the multivariate analysis, p53 was an independent prognostic factor associated with a high risk of recurrence in stage III tumors (hazard ratio=2.76; 95% CI, 1.29-5.9; p=0.009). Overexpression of p53 showed prognostic value as a marker of high risk of recurrence in the form of metastases (hazard ratio=2.23; 95% CI, 1.04-4.75), but not as a prognostic marker of locoregional recurrence. No relationship was found between the state of p53 protein and the effect of postoperative adjuvant therapy. Conclusion: The p53 protein does not have the same prognostic value in all tumoral stages. This protein is only predictive of high recurrence risk in the subgroup of patients with stage III tumors.
MeSH term(s)	Adenocarcinoma/chemistry ; Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Aged ; Colorectal Neoplasms/chemistry ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Staging ; Prognosis ; Prospective Studies ; Tumor Suppressor Protein p53/analysis ; Tumor Suppressor Protein p53/biosynthesis
Chemical Substances	Tumor Suppressor Protein p53
Language	Spanish
Publishing date	2006-01-06
Publishing country	Spain
Document type	English Abstract ; Journal Article
ZDB-ID	730701-9
ISSN	0009-739X
ISSN	0009-739X
DOI	10.1016/s0009-739x(05)70840-x
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Article: Herpesvirus saimiri transformation may help disclose inherent functional defects of mucosal T lymphocytes in patients with gastric adenocarcinoma.

Valeri, Anna P / Aguilera-Montilla, Noemí / López-Santalla, Mercedes / Mencía, Angeles / Rodríguez-Juan, Cristina / Gutiérrez-Calvo, Alberto / Martín, Javer / Lasa, Inmaculada / García-Sancho, Luis / Granell, Javier / Pérez-Blas, Mercedes / Martín-Villa, José M

Immunology and cell biology

2008 Volume 86, Issue 3, Page(s) 289–291

Abstract: To dissect the phenotypic and functional features of mucosal T lymphocytes in patients with gastric adenocarcinoma, we have used the Herpesvirus saimiri transformation procedure to achieve T-cell lines from gastric origin. Once achieved, cell function ... ...

Abstract	To dissect the phenotypic and functional features of mucosal T lymphocytes in patients with gastric adenocarcinoma, we have used the Herpesvirus saimiri transformation procedure to achieve T-cell lines from gastric origin. Once achieved, cell function was assessed by in vitro stimulation with mitogens. CD2-specific monoclonal antibodies (alpha-CD2), alone or in combination with interleukin (IL)-2, rendered fewer counts in patients (34 408+/-3965 and 52 157+/-6473 c.p.m., respectively) than in controls (67 471+/-11 755 c.p.m., P<0.01 and 77 864+/-12 545 c.p.m., P<0.05, respectively). Likewise, CD3-based responses were defective in cancer cell lines: alpha-CD3 (54 794+/-9269 vs 86 104+/-10 341 c.p.m., P<0.01), alpha-CD3+IL-2 (57 789+/-8590 vs 88855+/-8516 c.p.m., P<0.01) and alpha-CD3+alpha-CD2 (52 130+/-7559 vs 120 852+/-16 552 c.p.m., P<0.01). Finally, IL-2 failed to adequately stimulate patient cell lines (39 310+/-4023 vs 60 945+/-9463 c.p.m., P<0.05). These results suggest that mucosal T lymphocytes in cancer patients are inherently impaired in their proliferative ability. This may be crucial in the control of tumour growth.
MeSH term(s)	Adenocarcinoma/immunology ; Adenocarcinoma/pathology ; Aged ; Antigens, CD/immunology ; Cell Line, Transformed ; Cell Proliferation ; Cell Transformation, Viral ; Female ; Gastric Mucosa/immunology ; Gastric Mucosa/pathology ; Herpesvirus 2, Saimiriine ; Humans ; Immunity, Cellular ; Immunophenotyping ; Lymphocyte Activation ; Male ; Middle Aged ; Stomach Neoplasms/immunology ; Stomach Neoplasms/pathology ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; T-Lymphocytes/virology
Chemical Substances	Antigens, CD
Language	English
Publishing date	2008-02-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	284057-1
ISSN	1440-1711 ; 0818-9641
ISSN (online)	1440-1711
ISSN	0818-9641
DOI	10.1038/sj.icb.7100157
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Article: Expression of CD45 and proliferative response to CD3 as suitable classification markers of patients with gastric adenocarcinoma.

López-Santalla, Mercedes / Valeri, Anna P / Pérez-Blas, Mercedes / Aguilera-Montilla, Noemí / Gutiérrez, Alberto / Lasa, Inmaculada / Mugüerza, José M / Martín, José / García-Sancho, Luis / Granell, Javier / Martín-Villa, José M

Cancer immunology, immunotherapy : CII

2005 Volume 55, Issue 6, Page(s) 744–748

Abstract: 25 patients with resectable gastric adenocarcinoma, subdivided according to the absence or presence of residual neoplasic disease (RND- or RND+, respectively), were studied. Cytofluorometric analysis and proliferative responses to mitogens was performed ... ...

Abstract	25 patients with resectable gastric adenocarcinoma, subdivided according to the absence or presence of residual neoplasic disease (RND- or RND+, respectively), were studied. Cytofluorometric analysis and proliferative responses to mitogens was performed in peripheral blood mononuclear cells of patients. When compared to healthy subjects, the percentage of CD3-expressing cells was significantly reduced in both groups of patients studied (p < 0.0001 in all instances). However, when CD45 is considered instead of (CD3, its expression is found to be significantly reduced only in the RND+ patients (72% +/- 11), when compared with the control group (96 +/- 1%, p < 0.0001). Likewise, cells from these patients significantly less proliferated when stimulated with monoclonal antibodies to CD3 than control cells (18,920 +/- 6,019 cpm vs. 42,697 +/- 1,798 cpm, p = 0.0036); a difference not found if RND- patients (33,619 +/- 11,733 cpm) were considered. We propose that the low expression of CD45 and the poor response to CD3 are markers that are able to identify the subgroup of patients in whom the disease will tend to progress more rapidly. We also suggest the use of such markers as additional criteria for the classification of patients with gastric adenocarcinoma or to identify patients who require more aggressive therapeutic strategies.
MeSH term(s)	Adenocarcinoma/immunology ; Adenocarcinoma/metabolism ; Adenocarcinoma/surgery ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/immunology ; CD3 Complex/biosynthesis ; CD3 Complex/immunology ; Female ; Flow Cytometry ; Humans ; Leukocyte Common Antigens/biosynthesis ; Leukocyte Common Antigens/immunology ; Male ; Middle Aged ; Neoplasm, Residual ; Prognosis ; Stomach Neoplasms/immunology ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/surgery
Chemical Substances	Biomarkers, Tumor ; CD3 Complex ; Leukocyte Common Antigens (EC 3.1.3.48)
Language	English
Publishing date	2005-09-21
Publishing country	Germany
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	195342-4
ISSN	1432-0851 ; 0340-7004
ISSN (online)	1432-0851
ISSN	0340-7004
DOI	10.1007/s00262-005-0072-z
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