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  1. Article: ECG findings in professional rugby players using international screening recommendations.

    McHugh, Clíodhna / Petek, Bradley / Grant, Aubrey J / Gustus, Sarah / van Dyk, Nicol / Hind, Karen / Wilson, Fiona / Wasfy, Meagan

    BMJ open sport & exercise medicine

    2024  Volume 10, Issue 1, Page(s) e001813

    Abstract: Background: While World Rugby guidelines do not mandate the inclusion of an electrocardiogram (ECG) for all players, this is required for entry into international rugby competitions. We, therefore, sought to describe sport-specific normative ECG values ... ...

    Abstract Background: While World Rugby guidelines do not mandate the inclusion of an electrocardiogram (ECG) for all players, this is required for entry into international rugby competitions. We, therefore, sought to describe sport-specific normative ECG values and evaluate the performance of contemporary athlete ECG guidelines in male and female professional rugby players.
    Methods: We retrospectively analysed professional rugby players' ECGs (n=356, male 79%) obtained during preparticipation screening (2010-2022), comparing by sex and playing position (forwards vs backs). ECGs were categorised as normal 'training-related', borderline and abnormal findings, as defined by the 2017 International Recommendations.
    Results: 84% of players had one or more normal, 'training-related' findings, with males having a higher prevalence than females (91% vs 60%, p<0.001). Most ECG findings did not vary by position. No female player had borderline or abnormal ECG findings. Borderline findings were present in 3% (n=12/356) of players. Abnormal findings were present in 2% (n=7/356) of players. Overall, 2.2% of ECGs were 'positive' (n=8/356, including n=1 ECG with two borderline findings).
    Conclusions: The application of contemporary ECG interpretation criteria resulted in a low positivity rate isolated to male players. These results help inform the logistic feasibility of ECG-inclusive screening, which is already required to enter major tournaments.
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2817580-3
    ISSN 2055-7647
    ISSN 2055-7647
    DOI 10.1136/bmjsem-2023-001813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Consumer Wearable Health and Fitness Technology in Cardiovascular Medicine: JACC State-of-the-Art Review.

    Petek, Bradley J / Al-Alusi, Mostafa A / Moulson, Nathaniel / Grant, Aubrey J / Besson, Cyril / Guseh, J Sawalla / Wasfy, Meagan M / Gremeaux, Vincent / Churchill, Timothy W / Baggish, Aaron L

    Journal of the American College of Cardiology

    2023  Volume 82, Issue 3, Page(s) 245–264

    Abstract: The use of consumer wearable devices (CWDs) to track health and fitness has rapidly expanded over recent years because of advances in technology. The general population now has the capability to continuously track vital signs, exercise output, and ... ...

    Abstract The use of consumer wearable devices (CWDs) to track health and fitness has rapidly expanded over recent years because of advances in technology. The general population now has the capability to continuously track vital signs, exercise output, and advanced health metrics. Although understanding of basic health metrics may be intuitive (eg, peak heart rate), more complex metrics are derived from proprietary algorithms, differ among device manufacturers, and may not historically be common in clinical practice (eg, peak V˙O
    MeSH term(s) Humans ; Exercise ; Cardiovascular Agents ; Exercise Therapy ; Technology ; Wearable Electronic Devices
    Chemical Substances Cardiovascular Agents
    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2023.04.054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Progenitor Cells and Clinical Outcomes in Patients With Acute Coronary Syndromes.

    Samman Tahhan, Ayman / Hammadah, Muhammad / Raad, Mohamad / Almuwaqqat, Zakaria / Alkhoder, Ayman / Sandesara, Pratik B / Mohamed-Kelli, Heval / Hayek, Salim S / Kim, Jeong Hwan / O'Neal, Wesley T / Topel, Matthew L / Grant, Aubrey J / Sabbak, Nabil / Heinl, Robert E / Gafeer, Mohamad Mazen / Obideen, Malik / Kaseer, Belal / Abdelhadi, Nasser / Ko, Yi-An /
    Liu, Chang / Hesaroieh, Iraj / Mahar, Ernestine A / Vaccarino, Viola / Waller, Edmund K / Quyyumi, Arshed A

    Circulation research

    2018  Volume 122, Issue 11, Page(s) 1565–1575

    Abstract: Rationale: Circulating progenitor cells (CPCs) mobilize in response to ischemic injury, but their predictive value remains unknown in acute coronary syndrome (ACS).: Objective: We aimed to investigate the number of CPCs in ACS compared with those ... ...

    Abstract Rationale: Circulating progenitor cells (CPCs) mobilize in response to ischemic injury, but their predictive value remains unknown in acute coronary syndrome (ACS).
    Objective: We aimed to investigate the number of CPCs in ACS compared with those with stable coronary artery disease (CAD), relationship between bone marrow PCs and CPCs, and whether CPC counts predict mortality in patients with ACS.
    Methods and results: In 2028 patients, 346 had unstable angina, 183 had an acute myocardial infarction (AMI), and the remaining 1499 patients had stable CAD. Patients with ACS were followed for the primary end point of all-cause death. CPCs were enumerated by flow cytometry as mononuclear cells expressing a combination of CD34+, CD133+, vascular endothelial growth factor receptor 2+, or chemokine (C-X-C motif) receptor 4+. CPC counts were higher in subjects with AMI compared those with stable CAD even after adjustment for age, sex, race, body mass index, renal function, hypertension, diabetes mellitus, hyperlipidemia, and smoking; CD34+, CD34+/CD133+, CD34+/CXCR4+, and CD34+/VEGFR2+ CPC counts were 19%, 25%, 28%, and 142% higher in those with AMI, respectively, compared with stable CAD. There were strong correlations between the concentrations of CPCs and the PC counts in bone marrow aspirates in 20 patients with AMI. During a 2 (interquartile range, 1.31-2.86)-year follow-up period of 529 patients with ACS, 12.4% died. In Cox regression models adjusted for age, sex, body mass index, heart failure history, estimated glomerular filtration rate, and AMI, subjects with low CD34+ cell counts had a 2.46-fold (95% confidence interval, 1.18-5.13) increase in all-cause mortality,
    Conclusions: CPC levels are significantly higher in patients after an AMI compared with those with stable CAD and reflect bone marrow PC content. Among patients with ACS, a lower number of hematopoietic-enriched CPCs are associated with a higher mortality.
    MeSH term(s) Acute Coronary Syndrome/blood ; Acute Coronary Syndrome/mortality ; Aged ; Angina Pectoris/blood ; Antigens, CD34/metabolism ; Bone Marrow Cells/cytology ; Bone Marrow Cells/metabolism ; Cell Count/methods ; Cell Movement ; Confidence Intervals ; Female ; Flow Cytometry ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Myocardial Infarction/blood ; Myocardial Infarction/mortality ; Non-ST Elevated Myocardial Infarction/blood ; Non-ST Elevated Myocardial Infarction/mortality ; Receptors, CXCR4/metabolism ; ST Elevation Myocardial Infarction/blood ; ST Elevation Myocardial Infarction/mortality ; Stem Cells/cytology ; Stem Cells/metabolism ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; fms-Like Tyrosine Kinase 3/metabolism
    Chemical Substances Antigens, CD34 ; CXCR4 protein, human ; Receptors, CXCR4 ; FLT3 protein, human (EC 2.7.10.1) ; KDR protein, human (EC 2.7.10.1) ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1)
    Language English
    Publishing date 2018-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.118.312821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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