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  1. Article: More Than a Rash: Recurrent Hepatocellular Carcinoma After Liver Transplantation.

    Moraveji, Sharareh / Pedersen, Mark R / Chandramouli, Shruti / Kerr, Thomas A / Grant, Lafaine M

    ACG case reports journal

    2019  Volume 6, Issue 7, Page(s) e00107

    Abstract: Recurrent hepatocellular carcinoma (HCC) after liver transplant is uncommon in patients who have favorable pretransplant characteristics. We present a 56-year-old man with a history of liver transplant 8 weeks prior for hepatitis C cirrhosis and HCC who ... ...

    Abstract Recurrent hepatocellular carcinoma (HCC) after liver transplant is uncommon in patients who have favorable pretransplant characteristics. We present a 56-year-old man with a history of liver transplant 8 weeks prior for hepatitis C cirrhosis and HCC who presented for shortness of breath. He was found to have a microangiopathic hemolytic anemia and an erythematous, nodular skin rash on his left lower abdomen. Biopsy of the skin rash would demonstrate metastatic HCC, determined to be the cause of hemolysis as well. Recurrent malignancy should be considered in patients with a history of HCC who present with new, unexplained skin nodules.
    Language English
    Publishing date 2019-07-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2814825-3
    ISSN 2326-3253
    ISSN 2326-3253
    DOI 10.14309/crj.0000000000000107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Drug-induced liver injury.

    Grant, Lafaine M / Rockey, Don C

    Current opinion in gastroenterology

    2012  Volume 28, Issue 3, Page(s) 198–202

    Abstract: Purpose of review: Drug-induced liver injury (DILI) remains an important disease in clinical practice. It is difficult to predict, diagnose and manage. Studies in the peer-reviewed literature in the last 2 years, focusing on the diagnosis, prediction ... ...

    Abstract Purpose of review: Drug-induced liver injury (DILI) remains an important disease in clinical practice. It is difficult to predict, diagnose and manage. Studies in the peer-reviewed literature in the last 2 years, focusing on the diagnosis, prediction and management of DILI will be reviewed.
    Recent findings: Antibiotics remain the most common drug causing DILI in the United States and Europe. Expert opinion may still be the better method of diagnosing DILI compared with an objective tool such as the Roussel-Uclaf Causality Assessment Method. Hepatitis E represents an alternative diagnosis to some cases of presumed drug hepatotoxicity. There is ongoing research into the genetics of the pathophysiology and susceptibility of DILI. A genome-wide association study confirmed the association between human leukocyte antigen (HLA) class II and susceptibility to coamoxiclav (amoxicillin-clavulanic acid) induced DILI. There is new information on the protective effect of HLA-DRB1*07 family of alleles. MicroRNAs are a potential marker of DILI. Keratin variants may predict outcome of acute liver failure. N-acetylcysteine may be protective against DILI while taking antituberculosis medication.
    Summary: Recent findings in the genetics of pathophysiology and susceptibility of DILI can help with predicting and avoiding DILI in clinical practice and provide the foundation for ongoing research.
    MeSH term(s) Acetylcysteine/therapeutic use ; Amoxicillin-Potassium Clavulanate Combination/adverse effects ; Anti-Bacterial Agents/adverse effects ; Antitubercular Agents/adverse effects ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/epidemiology ; Chemical and Drug Induced Liver Injury/physiopathology ; Disease Susceptibility ; Europe/epidemiology ; Female ; Genome-Wide Association Study ; Genotype ; HLA-DRB1 Chains ; Humans ; Male ; Protective Agents/therapeutic use ; Risk Factors ; United States/epidemiology
    Chemical Substances Anti-Bacterial Agents ; Antitubercular Agents ; HLA-DRB1 Chains ; Protective Agents ; Amoxicillin-Potassium Clavulanate Combination (74469-00-4) ; Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2012-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632571-3
    ISSN 1531-7056 ; 0267-1379
    ISSN (online) 1531-7056
    ISSN 0267-1379
    DOI 10.1097/MOG.0b013e3283528b5d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2072: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Clinical and histological features of idiosyncratic acute liver injury caused by temozolomide.

    Grant, Lafaine M / Kleiner, David E / Conjeevaram, Hari S / Vuppalanchi, Raj / Lee, William M

    Digestive diseases and sciences

    2012  Volume 58, Issue 5, Page(s) 1415–1421

    MeSH term(s) Aged ; Antineoplastic Agents, Alkylating/adverse effects ; Chemical and Drug Induced Liver Injury/pathology ; Dacarbazine/adverse effects ; Dacarbazine/analogs & derivatives ; Female ; Humans ; Liver/drug effects ; Liver/pathology ; Male ; Middle Aged ; Temozolomide
    Chemical Substances Antineoplastic Agents, Alkylating ; Dacarbazine (7GR28W0FJI) ; Temozolomide (YF1K15M17Y)
    Language English
    Publishing date 2012-12-05
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-012-2493-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.35: Show issues Location:
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  4. Article: Nonalcoholic fatty liver disease.

    Grant, Lafaine M / Lisker-Melman, Mauricio

    Annals of hepatology

    2004  Volume 3, Issue 3, Page(s) 93–99

    Abstract: Nonalcoholic fatty liver disease is a clinicopathologic syndrome that encompasses several clinical entities. The spectrum of conditions ranges from simple steatosis to steatohepatitis, fibrosis and end stage liver disease. The condition was originally ... ...

    Abstract Nonalcoholic fatty liver disease is a clinicopathologic syndrome that encompasses several clinical entities. The spectrum of conditions ranges from simple steatosis to steatohepatitis, fibrosis and end stage liver disease. The condition was originally described in obese, diabetic, middle-aged females without a history of significant alcohol use with liver histology consistent with alcoholic hepatitis. It is known that this entity occurs without any particular sex predilection, in lean individuals, as well as an increasing number of obese children. Other terms have been used to describe this clinical entity such as alcohol-like hepatitis, pseudo-alcoholic hepatitis, diabetic hepatitis and steatonecrosis. Ludwig and colleagues introduced the term nonalcoholic steatohepatitis (NASH) to describe patients fitting the picture of alcoholic hepatitis but without a history of significant alcohol abuse. The term nonalcoholic fatty liver disease (NAFLD) is used more frequently to include the spectrum of conditions that range from steatosis through steatohepatitis, fibrosis and cirrhosis. NASH is reserved for patients with steatohepatitis and fibrosis. NAFLD is now being recognized as the most common cause of elevated liver enzymes in the United States. Although the exact etiology of NAFLD is not known, it may be caused by insulin resistance coupled with increased oxidative stress to the hepatocytes. No specific therapy has been approved for this condition and the mainstay of management is weight loss.
    MeSH term(s) Fatty Liver/diagnostic imaging ; Fatty Liver/physiopathology ; Fatty Liver/therapy ; Humans ; Obesity/physiopathology ; Obesity/therapy ; Radiography
    Language English
    Publishing date 2004-07
    Publishing country Mexico
    Document type Journal Article ; Review
    ZDB-ID 2188733-0
    ISSN 1665-2681
    ISSN 1665-2681
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6221: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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