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  1. Article: Associations between the Mediterranean Diet Pattern and Weight Status and Cognitive Development in Preschool Children

    Granziera, Federico / Guzzardi, Maria Angela / Iozzo, Patricia

    Nutrients. 2021 Oct. 22, v. 13, no. 11

    2021  

    Abstract: Cognitive dysfunctions are a global health concern. Early-life diet and weight status may contribute to children’s cognitive development. For this reason, we explored the associations between habitual food consumption, body mass index (BMI) and cognitive ...

    Abstract Cognitive dysfunctions are a global health concern. Early-life diet and weight status may contribute to children’s cognitive development. For this reason, we explored the associations between habitual food consumption, body mass index (BMI) and cognitive outcomes in 54 preschool children belonging to the Pisa birth Cohort (PISAC). We estimated groups of foods, nutrients and calorie intakes through a food frequency questionnaire (FFQ) and Italian national databases. Then, we adopted the Mediterranean diet (MD) score to assess relative MD adherence. Cognition was examined using the Griffiths Mental Development Scales-Extended Revised (GMDS-ER). We found that higher, compared to low and moderate, adherence to MD was associated with higher performance scores. Furthermore, white meat consumption was positively related to BMI, and BMI (age–gender specific, z-scores) categories were negatively related to practical reasoning scores. All associations were independent of maternal IQ estimates, parents’ socioeconomic status, exclusive/non-exclusive breastfeeding, actual age at cognitive assessment and gender. In conclusion, in preschool children, very high adherence to MD seemed protective, whereas BMI (reinforced by the intake of white meat) was negatively associated with cognition.
    Keywords Mediterranean diet ; body mass index ; breast feeding ; cognition ; cognitive development ; eating habits ; food consumption ; food frequency questionnaires ; gender ; meat ; meat consumption ; socioeconomic status
    Language English
    Dates of publication 2021-1022
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13113723
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Associations between the Mediterranean Diet Pattern and Weight Status and Cognitive Development in Preschool Children.

    Granziera, Federico / Guzzardi, Maria Angela / Iozzo, Patricia

    Nutrients

    2021  Volume 13, Issue 11

    Abstract: Cognitive dysfunctions are a global health concern. Early-life diet and weight status may contribute to children's cognitive development. For this reason, we explored the associations between habitual food consumption, body mass index (BMI) and cognitive ...

    Abstract Cognitive dysfunctions are a global health concern. Early-life diet and weight status may contribute to children's cognitive development. For this reason, we explored the associations between habitual food consumption, body mass index (BMI) and cognitive outcomes in 54 preschool children belonging to the Pisa birth Cohort (PISAC). We estimated groups of foods, nutrients and calorie intakes through a food frequency questionnaire (FFQ) and Italian national databases. Then, we adopted the Mediterranean diet (MD) score to assess relative MD adherence. Cognition was examined using the Griffiths Mental Development Scales-Extended Revised (GMDS-ER). We found that higher, compared to low and moderate, adherence to MD was associated with higher performance scores. Furthermore, white meat consumption was positively related to BMI, and BMI (age-gender specific, z-scores) categories were negatively related to practical reasoning scores. All associations were independent of maternal IQ estimates, parents' socioeconomic status, exclusive/non-exclusive breastfeeding, actual age at cognitive assessment and gender. In conclusion, in preschool children, very high adherence to MD seemed protective, whereas BMI (reinforced by the intake of white meat) was negatively associated with cognition.
    MeSH term(s) Adult ; Body Mass Index ; Body Weight/physiology ; Child, Preschool ; Cognition/physiology ; Diet, Mediterranean ; Energy Intake ; Feeding Behavior ; Female ; Guideline Adherence ; Humans ; Male
    Language English
    Publishing date 2021-10-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13113723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Exclusive Breastfeeding Predicts Higher Hearing-Language Development in Girls of Preschool Age

    Guzzardi, Maria Angela / Granziera, Federico / Sanguinetti, Elena / Ditaranto, Francesca / Muratori, Filippo / Iozzo, Patricia

    Nutrients. 2020 Aug. 02, v. 12, no. 8

    2020  

    Abstract: Cognitive disorders are increasing in prevalence. Nutritional or metabolic stressors during early life, and female sex, are predisposing conditions towards the development of cognitive diseases, including Alzheimer’s disease. Though there is evidence ... ...

    Abstract Cognitive disorders are increasing in prevalence. Nutritional or metabolic stressors during early life, and female sex, are predisposing conditions towards the development of cognitive diseases, including Alzheimer’s disease. Though there is evidence that breastfeeding may play a beneficial role in children’s neurocognitive development, the literature remains controversial. In this study we aimed at assessing the association between exclusive breastfeeding and children’s cognitive development from six months to five years of age, addressing sex differences. In 80 mother-child pairs from the Pisa birth cohort (PISAC), we measured cognitive development in groups of children of 6, 12, 18, 24, 36, and 60 months by Griffiths Mental Development Scales, parents’ intelligence quotient (IQ) by Raven’s progressive matrices, and maternal and infants’ anthropometric parameters. We found that exclusive breastfeeding was associated with higher hearing-language development in five years old girls, independent of maternal IQ, age and BMI (body mass index). Exclusive breastfeeding in the first three months of life seemed sufficient to establish this positive relationship. In conclusion, our data indicate that exclusive breastfeeding is a positive predictor of cognitive development in preschool-age girls, paving the way for the implementation of sex-specific cognitive disease risk detection and prevention strategies from early life. Further studies are warranted to explore causality and longer term effects.
    Keywords age ; body mass index ; breast feeding ; cognition ; cognitive development ; detection ; females ; literature ; prevalence ; risk
    Language English
    Dates of publication 2020-0802
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12082320
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Exclusive Breastfeeding Predicts Higher Hearing-Language Development in Girls of Preschool Age.

    Guzzardi, Maria Angela / Granziera, Federico / Sanguinetti, Elena / Ditaranto, Francesca / Muratori, Filippo / Iozzo, Patricia

    Nutrients

    2020  Volume 12, Issue 8

    Abstract: Cognitive disorders are increasing in prevalence. Nutritional or metabolic stressors during early life, and female sex, are predisposing conditions towards the development of cognitive diseases, including Alzheimer's disease. Though there is evidence ... ...

    Abstract Cognitive disorders are increasing in prevalence. Nutritional or metabolic stressors during early life, and female sex, are predisposing conditions towards the development of cognitive diseases, including Alzheimer's disease. Though there is evidence that breastfeeding may play a beneficial role in children's neurocognitive development, the literature remains controversial. In this study we aimed at assessing the association between exclusive breastfeeding and children's cognitive development from six months to five years of age, addressing sex differences. In 80 mother-child pairs from the Pisa birth cohort (PISAC), we measured cognitive development in groups of children of 6, 12, 18, 24, 36, and 60 months by Griffiths Mental Development Scales, parents' intelligence quotient (IQ) by Raven's progressive matrices, and maternal and infants' anthropometric parameters. We found that exclusive breastfeeding was associated with higher hearing-language development in five years old girls, independent of maternal IQ, age and BMI (body mass index). Exclusive breastfeeding in the first three months of life seemed sufficient to establish this positive relationship. In conclusion, our data indicate that exclusive breastfeeding is a positive predictor of cognitive development in preschool-age girls, paving the way for the implementation of sex-specific cognitive disease risk detection and prevention strategies from early life. Further studies are warranted to explore causality and longer term effects.
    MeSH term(s) Adult ; Anthropometry ; Body Mass Index ; Breast Feeding ; Child Development ; Child, Preschool ; Female ; Hearing ; Humans ; Infant ; Intelligence Tests ; Language Development ; Male ; Obesity, Maternal ; Pregnancy ; Schools ; Sex Characteristics
    Language English
    Publishing date 2020-08-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12082320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Gut-derived metabolites mediating cognitive development in 5-year-old children: Early-life transplant in mice has lasting effects throughout adulthood.

    Guzzardi, Maria Angela / La Rosa, Federica / Granziera, Federico / Panetta, Daniele / Pardo-Tendero, Mercedes / Barone, Monica / Turroni, Silvia / Faita, Francesco / Kusmic, Claudia / Brigidi, Patrizia / Monleon, Daniel / Iozzo, Patricia

    Brain, behavior, and immunity

    2023  Volume 114, Page(s) 94–110

    Abstract: The gut microbiota has been causally linked to cognitive development. We aimed to identify metabolites mediating its effect on cognitive development, and foods or nutrients related to most promising metabolites. Faeces from 5-year-old children (DORIAN- ... ...

    Abstract The gut microbiota has been causally linked to cognitive development. We aimed to identify metabolites mediating its effect on cognitive development, and foods or nutrients related to most promising metabolites. Faeces from 5-year-old children (DORIAN-PISAC cohort, including 90 general population families with infants, 42/48 females/males, born in 2011-2014) were transplanted (FMT) into C57BL/6 germ-free mice. Children and recipient mice were stratified by cognitive phenotype, or based on protective metabolites. Food frequency questionnaires were obtained in children. Cognitive measurements in mice included five Y-maze tests until 23 weeks post-FMT, and (at 23 weeks) PET-CT for brain metabolism and radiodensity, and ultrasound-based carotid vascular indices. Children (faeces, urine) and mice (faeces, plasma) metabolome was measured by 1H NMR spectroscopy, and the faecal microbiota was profiled in mice by 16S rRNA amplicon sequencing. Cognitive scores of children and recipient mice were correlated. FMT-dependent modifications of brain metabolism were observed. Mice receiving FMT from high-cognitive or protective metabolite-enriched children developed superior cognitive-behavioural performance. A panel of metabolites, namely xanthine, hypoxanthine, formate, mannose, tyrosine, phenylalanine, glutamine, was found to mediate the gut-cognitive axis in donor children and recipient mice. Vascular indices partially explained the metabolite-to-phenotype relationships. Children's consumption of legumes, whole-milk yogurt and eggs, and intake of iron, zinc and vitamin D appeared to support protective gut metabolites. Overall, metabolites involved in inflammation, purine metabolism and neurotransmitter synthesis mediate the gut-cognitive axis, and holds promise for screening. The related dietary and nutritional findings offer leads to microbiota-targeted interventions for cognitive protection, with long-lasting effects.
    Language English
    Publishing date 2023-08-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2023.08.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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