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Article: The Effectiveness of Paracetamol to Reduce the Post-Vaccination SARS-CoV-2 Adverse Effects in an Italian Vaccination Center.

Ricci, Eleonora / Glavasc, Anamaria / Morandini, Barbara / Grassi, Maria Caterina / La Torre, Giuseppe

2023 Volume 11, Issue 9

Abstract: The arrival of specific vaccines was crucial for the eradication of COVID-19. Despite the security of the vaccination, the administration of COVID-19 mRNA vaccines often causes systemic side effects for a short time after the injection, such as headache, ...

Abstract	The arrival of specific vaccines was crucial for the eradication of COVID-19. Despite the security of the vaccination, the administration of COVID-19 mRNA vaccines often causes systemic side effects for a short time after the injection, such as headache, fatigue, fever, muscle pain and nausea. These side effects can limit the adherence to COVID-19 vaccines administration, especially in healthcare workers. This study aims to analyze the impact of the prophylactic use of paracetamol to reduce the post-vaccination Comirnaty/Pfizer adverse effects. The study took place at the San Giovanni Battista Hospital in Rome and included all hospital employees who received two doses of Pfizer-BioNTech. The vaccination health personnel recommended the preventive intake of 1 g of paracetamol before the inoculation of the vaccine and then every 6 h in the first 24 h. Information was collected through forms and subsequent telephone recall. A total of 403 volunteers were involved in the study, with 391 of them receiving two doses and twelve individuals only one dose of the vaccine. The main results demonstrated that the prophylactic therapy influenced the lower onset of asthenia in the first and second doses. However, there were no significant differences between the two groups in terms of fever, headache and localized pain. Paracetamol had a good impact on the side effect of COVID-19 vaccination, reducing asthenia in both doses and mitigating the total of symptoms during the second vaccination.
Language	English
Publishing date	2023-09-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11091493
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Article ; Online: How COVID-19 Lockdown in Italy Has Affected Type of Calls and Management of Toxic Exposures: a Retrospective Analysis of a Poison Control Center Database From March 2020 to May 2020.

Milella, Michele Stanislaw / Boldrini, Paolo / Vivino, Gabriella / Grassi, Maria Caterina

Journal of medical toxicology : official journal of the American College of Medical Toxicology

2021 Volume 17, Issue 3, Page(s) 250–256

Abstract: Introduction: Between early March 2020 and the end of May 2020, Italy issued strict measures to limit further spread of coronavirus disease 2019 (COVID-19) and became the first European country that imposed a lockdown on the population. The aim of this ... ...

Abstract	Introduction: Between early March 2020 and the end of May 2020, Italy issued strict measures to limit further spread of coronavirus disease 2019 (COVID-19) and became the first European country that imposed a lockdown on the population. The aim of this study was to assess the impact of these restricted conditions on the activity of the Poison Control Center (PCC) of Policlinico Umberto I Hospital-Sapienza University of Rome. Methods: This was a retrospective analysis of calls received by the PCC during the lockdown period March 9, 2020 through May 31, 2020 compared to the same time period in year 2019 (reference). Results: We observed a reduction in calls from hospitals and emergency departments and an increase in calls from private citizens about exposures to products or intoxications during the lockdown. There were increases in unintentional exposures and exposures to hand and surface sanitizers among household and cleaning products. There was a decrease in calls concerning medications, which were mostly from hospitals and emergency departments. We observed increases in exposures requiring clinical observations among adults and referral to the emergency department among pre-school children. Conclusions: Public health protection measures against COVID-19 to improve hygiene and maintain clean environments can increase exposures to hazardous products in the domestic environment. We observed an increase in unintentional exposures to household and cleaning products during the lockdown and an increase in ED referrals for pre-school children compared to the previous year. Our data suggest the need for improvements in public campaigns that promote safer handling of household products and prevent unnecessary exposures during a lockdown. The public health promotion activity can benefit the community after the pandemic and prepare the community for lockdowns in the future.
MeSH term(s)	Adolescent ; Adult ; Aged ; COVID-19/epidemiology ; COVID-19/prevention & control ; Child ; Child, Preschool ; Emergency Service, Hospital ; Household Products ; Humans ; Italy/epidemiology ; Middle Aged ; Poison Control Centers ; Poisoning/prevention & control ; Poisoning/therapy ; Public Health ; Retrospective Studies ; SARS-CoV-2 ; Young Adult
Language	English
Publishing date	2021-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2435016-3
ISSN	1937-6995 ; 1556-9039
ISSN (online)	1937-6995
ISSN	1556-9039
DOI	10.1007/s13181-021-00839-2
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Article ; Online: Transfer of chemicals to a secondary container, from the introduction of new labelling regulation to COVID-19 lockdown: A retrospective analysis of exposure calls to the Poison Control Centre of Rome, Italy, 2017-2020.

Milella, Michele Stanislaw / Grassi, Maria Caterina / Gasbarri, Alessia / Mezzanotte, Valeria / Pugliese, Francesco / Vivino, Gabriella

Basic & clinical pharmacology & toxicology

2021 Volume 130, Issue 1, Page(s) 200–207

Abstract: The transfer of a chemical product from its original container to an unlabelled secondary container by consumers is a potential health hazard that may result in unintentional exposures and intoxications. The aim of this study was to describe the pattern ... ...

Abstract	The transfer of a chemical product from its original container to an unlabelled secondary container by consumers is a potential health hazard that may result in unintentional exposures and intoxications. The aim of this study was to describe the pattern of prevalence of exposures to transferred products in Italy from year 2017, when the new European labelling regulation for chemicals became fully operative, to 2020, year of the coronavirus 19 disease first outbreak. Calls to the Poison Control Centre (PCC) of Policlinico Umberto I Hospital - Sapienza University of Rome were analysed retrospectively for characteristics, clinical presentation and circumstances related to the event. We registered 198 cases of interest. There was a reduction in cases from 2017 (4.9%) to 2019 (2.2%), followed by an increased prevalence in 2020 (4.2%) mainly due to the months "post-lockdown." The transferred product was very frequently diluted, and an empty drinking bottle was usually used as secondary container. Exposures were mostly of minor severity, and no deaths occurred. The study highlights the importance of PCCs data in the evaluation of the hazard communication to users through labels and advises for public campaigns to promote safe behaviours during future lockdowns to prevent exposures at a later period.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/epidemiology ; Child ; Child, Preschool ; Environmental Exposure/statistics & numerical data ; Female ; Hazardous Substances/toxicity ; Humans ; Infant ; Infant, Newborn ; Italy/epidemiology ; Male ; Middle Aged ; Poison Control Centers ; Poisoning/epidemiology ; Product Labeling/legislation & jurisprudence ; Product Packaging ; Retrospective Studies ; Rome
Chemical Substances	Hazardous Substances
Language	English
Publishing date	2021-11-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2134679-3
ISSN	1742-7843 ; 1742-7835
ISSN (online)	1742-7843
ISSN	1742-7835
DOI	10.1111/bcpt.13678
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Article ; Online: Tobacco smoking: the evidence from prevention and cessation.

La Torre, Giuseppe / Ferketich, Amy / Grassi, Maria Caterina

BioMed research international

2014 Volume 2014, Page(s) 894208

MeSH term(s)	China ; Humans ; Smoking/epidemiology ; Smoking/physiopathology ; Smoking Cessation ; Tobacco Use Disorder/epidemiology ; Tobacco Use Disorder/physiopathology
Language	English
Publishing date	2014
Publishing country	United States
Document type	Editorial ; Introductory Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2014/894208
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Article ; Online: Cardiovascular and Hepatic Toxicity of Cocaine: Potential Beneficial Effects of Modulators of Oxidative Stress.

Graziani, Manuela / Antonilli, Letizia / Togna, Anna Rita / Grassi, Maria Caterina / Badiani, Aldo / Saso, Luciano

Oxidative medicine and cellular longevity

2016 Volume 2016, Page(s) 8408479

Abstract: Oxidative stress (OS) is thought to play an important role in the pharmacological and toxic effects of various drugs of abuse. Herein we review the literature on the mechanisms responsible for the cardiovascular and hepatic toxicity of cocaine with ... ...

Abstract	Oxidative stress (OS) is thought to play an important role in the pharmacological and toxic effects of various drugs of abuse. Herein we review the literature on the mechanisms responsible for the cardiovascular and hepatic toxicity of cocaine with special focus on OS-related mechanisms. We also review the preclinical and clinical literature concerning the putative therapeutic effects of OS modulators (such as N-acetylcysteine, superoxide dismutase mimetics, nitroxides and nitrones, NADPH oxidase inhibitors, xanthine oxidase inhibitors, and mitochondriotropic antioxidants) for the treatment of cocaine toxicity. We conclude that available OS modulators do not appear to have clinical efficacy.
MeSH term(s)	Acetylcysteine/chemistry ; Animals ; Antioxidants/pharmacology ; Cardiovascular Diseases/chemically induced ; Catecholamines/metabolism ; Cattle ; Cocaine/chemistry ; Cocaine/toxicity ; Humans ; Liver/drug effects ; Male ; Mice ; Mitochondria/drug effects ; Myocytes, Smooth Muscle/metabolism ; NADPH Oxidases/antagonists & inhibitors ; Nitrogen Oxides/chemistry ; Oxidative Stress ; Rats ; Reactive Oxygen Species/metabolism ; Receptors, Adrenergic, alpha-1/metabolism ; Receptors, Adrenergic, beta/metabolism ; Xanthine Oxidase/antagonists & inhibitors
Chemical Substances	Antioxidants ; Catecholamines ; Nitrogen Oxides ; Reactive Oxygen Species ; Receptors, Adrenergic, alpha-1 ; Receptors, Adrenergic, beta ; nitrones ; Xanthine Oxidase (EC 1.17.3.2) ; NADPH Oxidases (EC 1.6.3.-) ; Cocaine (I5Y540LHVR) ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1942-0994
ISSN (online)	1942-0994
DOI	10.1155/2016/8408479
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Article: Bidirectional tachycardia after an acute intravenous administration of digitalis for a suicidal gesture.

Sabatini, Diletta / Truscelli, Giovanni / Ciccaglioni, Antonio / Gaudio, Carlo / Grassi, Maria Caterina

Case reports in psychiatry

2014 Volume 2014, Page(s) 109167

Abstract: Acute digoxin intoxication is a life-threating condition associated with severe cardiotoxicity. Female gender, age, low lean body mass, hypertension, and renal insufficiency may worsen the prognosis. Arrhythmias caused by digitalis glycosides are ... ...

Abstract	Acute digoxin intoxication is a life-threating condition associated with severe cardiotoxicity. Female gender, age, low lean body mass, hypertension, and renal insufficiency may worsen the prognosis. Arrhythmias caused by digitalis glycosides are characterized by an increased automaticity coupled with concomitant conduction delay. Bidirectional tachycardia is pathognomonic of digoxin intoxication, but it is rarely observed. An 83-year-old woman was admitted to the Emergency Department after self-administration of 5 mg of digoxin i.v. for suicidal purpose. Her digoxin serum concentration was 17.4 ng/mL. The patient developed a bidirectional tachycardia and the Poison Control Center of the hospital provided digoxin immune fab. Bidirectional tachycardia quickly reversed and the patient remained stable throughout the hospital stay. This case shows that a multiple disciplinary approach, involving cardiologists and toxicologists, is essential for the management of digoxin intoxication. The optimal treatment of this rare event depends on the clinical conditions and on the serum drug concentration of the patient. Digoxin immune fab represents a safe, effective, and specific method for rapidly reversing digitalis cardiotoxicity and should be started as soon as the diagnosis is defined.
Language	English
Publishing date	2014-08-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2629914-8
ISSN	2090-6838 ; 2090-682X
ISSN (online)	2090-6838
ISSN	2090-682X
DOI	10.1155/2014/109167
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Article: Validity of the Italian version of the Severity of Dependence Scale (SDS) for nicotine dependence in smokers intending to quit.

Grassi, Maria Caterina / Ferketich, Amy K / Enea, Domenico / Culasso, Franco / Nencini, Paolo

Psychological reports

2014 Volume 114, Issue 1, Page(s) 1–13

Abstract: The objective was to test the psychometric properties of an Italian version of the Severity of Dependence Scale, a five-item measure designed to assess the compulsive dimension of drug dependence. 635 smokers enrolled in a tobacco dependence treatment ... ...

Abstract	The objective was to test the psychometric properties of an Italian version of the Severity of Dependence Scale, a five-item measure designed to assess the compulsive dimension of drug dependence. 635 smokers enrolled in a tobacco dependence treatment program served as the participants. The Fagerström Test for Nicotine Dependence was used as a comparative measure. Dimensionality of the Severity of Dependence Scale and the Fagerström Test for Nicotine Dependence was assessed by factor analysis. Prediction of smoking at one year was evaluated by logistic regression. Factor analysis yielded a two-factor solution; however, the second factor explained very little variance. Factor 1 had a Cronbach's alpha of .66 (overall Scale coefficient = .44). The total Severity of Dependence Score predicted smoking at one year (OR = 1.10).
MeSH term(s)	Adolescent ; Adult ; Aged ; Female ; Humans ; Intention ; Male ; Middle Aged ; Psychometrics/instrumentation ; Reproducibility of Results ; Severity of Illness Index ; Smoking/psychology ; Smoking Cessation/psychology ; Tobacco Use Disorder/diagnosis ; Young Adult
Language	English
Publishing date	2014-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205658-6
ISSN	1558-691X ; 0033-2941
ISSN (online)	1558-691X
ISSN	0033-2941
DOI	10.2466/18.15.PR0.114k16w7
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Article ; Online: Association between positivity and smoking cessation.

Grassi, Maria Caterina / Alessandri, Guido / Pasquariello, Stefania / Milioni, Michela / Enea, Domenico / Ceccanti, Mauro / Nencini, Paolo / Caprara, Gian Vittorio

BioMed research international

2014 Volume 2014, Page(s) 780146

Abstract: The literature documents that personality characteristics are associated with healthy lifestyles, including smoking. Among positive traits, Positivity (POS), defined as a general disposition conducive to facing experience under a positive outlook has ... ...

Abstract	The literature documents that personality characteristics are associated with healthy lifestyles, including smoking. Among positive traits, Positivity (POS), defined as a general disposition conducive to facing experience under a positive outlook has shown robust associations with psychological health. Thus, the present study investigated the extent to which POS is able to predict (i) relapse after quitting smoking and (ii) the desire to smoke again. All participants (481) had previously attended a Group Counselling Program (GCP) for Smoking Cessation (from 2005 through 2010). They were contacted through telephone interview. Among participants, 244 were ex-smokers (age: years 56.3 ± 10.08, 52% female) and 237 were still-smokers (age: years 55.0 ± 9.63; 63.5% female). The association of POS with "craving to smoke" levels was assessed with multivariate linear regression analysis while controlling also for important differences in personality such as conscientiousness and general self-efficacy, as well as for gender and age. Results showed that POS was significantly and negatively associated with smoking status and with craving to smoke. Among covariates (i.e., conscientiousness, generalized self-efficacy), gender was associated with smoking status and with craving to smoke. Altogether these findings corroborate the idea that POS plays a significant role in sustaining individuals' efforts to quit smoking.
MeSH term(s)	Adult ; Age Factors ; Attitude to Health ; Craving ; Female ; Humans ; Interviews as Topic ; Male ; Middle Aged ; Sex Factors ; Smoking Cessation
Language	English
Publishing date	2014-05-22
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2014/780146
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Article ; Online: Effectiveness of varenicline for smoking cessation: a 1-year follow-up study.

Grassi, Maria Caterina / Enea, Domenico / Ferketich, Amy K / Lu, Bo / Pasquariello, Stefania / Nencini, Paolo

Journal of substance abuse treatment

2011 Volume 41, Issue 1, Page(s) 64–70

Abstract: We examined the rate of smoking cessation associated with 6 weeks of group counseling therapy (GCT) given alone or in combination with 12 weeks of varenicline (VAR) in 112 smokers. Follow-ups were conducted at 12, 26, and 52 weeks post enrollment. Since ... ...

Abstract	We examined the rate of smoking cessation associated with 6 weeks of group counseling therapy (GCT) given alone or in combination with 12 weeks of varenicline (VAR) in 112 smokers. Follow-ups were conducted at 12, 26, and 52 weeks post enrollment. Since participants chose the treatment, differences between the two groups were adjusted using propensity matching. Only 33.3% completed VAR treatment, yet at 1 year, the abstinence rate among participants who were not compliant was not different from subjects who were compliant. VAR resulted in a 23% improvement in the abstinence rates at 26 and 52 weeks (GCT + VAR rates were 62.5% and 56.3%, respectively; GCT-only rates were 39.6% and 33.3%, respectively). Increased carbon monoxide concentration, cigarette consumption, and Beck Depression Inventory score were associated with continued smoking. In conclusion, we found that the combination of counseling and VAR is effective at promoting abstinence at 1 year even when compliance with the medication is not 100%.
MeSH term(s)	Adult ; Benzazepines/therapeutic use ; Counseling ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Nicotinic Agonists/therapeutic use ; Psychotherapy, Group ; Quinoxalines/therapeutic use ; Smoking Cessation/methods ; Varenicline
Chemical Substances	Benzazepines ; Nicotinic Agonists ; Quinoxalines ; Varenicline (W6HS99O8ZO)
Language	English
Publishing date	2011-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605923-5
ISSN	1873-6483 ; 0740-5472
ISSN (online)	1873-6483
ISSN	0740-5472
DOI	10.1016/j.jsat.2011.01.014
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Article ; Online: Knowledge about health effects of cigarette smoking and quitting among Italian university students: the importance of teaching nicotine dependence and treatment in the medical curriculum.

Grassi, Maria Caterina / Baraldo, Massimo / Chiamulera, Christian / Culasso, Franco / Raupach, Tobias / Ferketich, Amy K / Patrono, Carlo / Nencini, Paolo

BioMed research international

2014 Volume 2014, Page(s) 321657

Abstract: Aims of the study were to compare medical students (MS) to non-MS with respect to their knowledge of smoking and to investigate the effect of a short educational intervention on MS knowledge. MS (n = 962) and students of architecture and law (n = 229) ... ...

Abstract	Aims of the study were to compare medical students (MS) to non-MS with respect to their knowledge of smoking and to investigate the effect of a short educational intervention on MS knowledge. MS (n = 962) and students of architecture and law (n = 229) were asked to complete a 60-item questionnaire addressing knowledge of smoking epidemiology and health effects ("Score 1"), and effectiveness of cessation treatments ("Score 2"). Upon completion of questionnaire, fourth year MS received a lecture on tobacco dependence. These students were asked to complete the same questionnaire one and two years later. Mean values for Score 1 were 48.9 ± 11.5% in MS and 40.5 ± 11.4% in non-MS (P < 0.001; d = 0.69). Respective values for Score 2 were 48.1 ± 10.8% and 42.6 ± 10.6% (P < 0.001; d = 0.50). Fifth year students who had attended the lecture in year 4 scored higher than students who had not attended the lecture. Significant differences were noted one but not two years after the educational intervention. In conclusion, MS know slightly more about smoking-related diseases and methods to achieve cessation than nonmedical students; a short educational intervention was associated with better knowledge one year later, but the effect was moderate and short-lived.
MeSH term(s)	Adult ; Female ; Humans ; Italy ; Male ; Patient Education as Topic ; Smoking/adverse effects ; Smoking Cessation ; Surveys and Questionnaires ; Time Factors ; Tobacco Use Disorder ; Universities
Language	English
Publishing date	2014-04-06
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2014/321657
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