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  1. Article: Bidirectional multiciliated cell extrusion is controlled by Notch driven basal extrusion and Piezo 1 driven apical extrusion.

    Ventrella, Rosa / Kim, Sun K / Sheridan, Jennifer / Grata, Aline / Bresteau, Enzo / Hassan, Osama / Suva, Eve E / Walentek, Peter / Mitchell, Brian

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Xenopus: Summay statement: Cell extrusion typically occurs unidirectionally. We have identified a single population of multiciliated cells that extrudes bidirectionally: Notch-driven basal extrusion and Piezo 1-mediated apical extrusion. ...

    Abstract Xenopus
    Summay statement: Cell extrusion typically occurs unidirectionally. We have identified a single population of multiciliated cells that extrudes bidirectionally: Notch-driven basal extrusion and Piezo 1-mediated apical extrusion.
    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.12.523838
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Novel centriolar defects underlie a primary ciliary dyskinesia phenotype in an adenylate kinase 7 deficient ciliated epithelium.

    Sheridan, Jennifer / Grata, Aline / Suva, Eve E / Bresteau, Enzo / Mitchell, Linus R / Hassan, Osama / Mitchell, Brian

    bioRxiv : the preprint server for biology

    2023  

    Abstract: ... The skin ... ...

    Abstract The skin of
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.25.550535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Bidirectional multiciliated cell extrusion is controlled by Notch-driven basal extrusion and Piezo1-driven apical extrusion.

    Ventrella, Rosa / Kim, Sun K / Sheridan, Jennifer / Grata, Aline / Bresteau, Enzo / Hassan, Osama A / Suva, Eve E / Walentek, Peter / Mitchell, Brian J

    Development (Cambridge, England)

    2023  Volume 150, Issue 17

    Abstract: Xenopus embryos are covered with a complex epithelium containing numerous multiciliated cells (MCCs). During late-stage development, there is a dramatic remodeling of the epithelium that involves the complete loss of MCCs. Cell extrusion is a well- ... ...

    Abstract Xenopus embryos are covered with a complex epithelium containing numerous multiciliated cells (MCCs). During late-stage development, there is a dramatic remodeling of the epithelium that involves the complete loss of MCCs. Cell extrusion is a well-characterized process for driving cell loss while maintaining epithelial barrier function. Normal cell extrusion is typically unidirectional, whereas bidirectional extrusion is often associated with disease (e.g. cancer). We describe two distinct mechanisms for MCC extrusion, a basal extrusion driven by Notch signaling and an apical extrusion driven by Piezo1. Early in the process there is a strong bias towards basal extrusion, but as development continues there is a shift towards apical extrusion. Importantly, response to the Notch signal is age dependent and governed by the maintenance of the MCC transcriptional program such that extension of this program is protective against cell loss. In contrast, later apical extrusion is regulated by Piezo1, such that premature activation of Piezo1 leads to early extrusion while blocking Piezo1 leads to MCC maintenance. Distinct mechanisms for MCC loss underlie the importance of their removal during epithelial remodeling.
    MeSH term(s) Animals ; Epithelium ; Signal Transduction ; Xenopus laevis
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.201612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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