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  1. Article: Review of the role of statins in cirrhosis and portal hypertension.

    Gratacós-Ginès, Jordi / Pose, Elisa

    Clinical liver disease

    2023  Volume 22, Issue 2, Page(s) 50–57

    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1097/CLD.0000000000000015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Defining recompensation of alcohol-related liver disease: A step beyond decompensated cirrhosis.

    Gratacós-Ginès, Jordi / Pose, Elisa

    Liver international : official journal of the International Association for the Study of the Liver

    2023  Volume 43, Issue 10, Page(s) 2060–2061

    MeSH term(s) Humans ; Liver Diseases, Alcoholic/diagnosis ; Liver Cirrhosis
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reply: Medications promoting abstinence in alcohol-associated cirrhosis.

    Gratacós-Ginès, Jordi / López-Pelayo, Hugo / Pose, Elisa

    Hepatology (Baltimore, Md.)

    2023  Volume 79, Issue 3, Page(s) E100–E101

    MeSH term(s) Humans ; Liver Cirrhosis, Alcoholic ; Alcohol Drinking ; Alcoholism/complications ; Alcohol Abstinence
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Another case of autoimmune hepatitis after SARS-CoV-2 vaccination - still casualty?

    Londoño, Maria-Carlota / Gratacós-Ginès, Jordi / Sáez-Peñataro, Joaquín

    Journal of hepatology

    2021  Volume 75, Issue 5, Page(s) 1248–1249

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Hepatitis, Autoimmune/etiology ; Humans ; SARS-CoV-2 ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-06-12
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2021.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Medications for alcohol use disorder promote abstinence in alcohol-associated cirrhosis: Results from a systematic review and meta-analysis.

    Gratacós-Ginès, Jordi / Bruguera, Pol / Pérez-Guasch, Martina / López-Lazcano, Ana / Borràs, Roger / Hernández-Évole, Helena / Pons-Cabrera, Maria T / Lligoña, Anna / Bataller, Ramón / Ginès, Pere / López-Pelayo, Hugo / Pose, Elisa

    Hepatology (Baltimore, Md.)

    2023  Volume 79, Issue 2, Page(s) 368–379

    Abstract: Background and aims: The role of medications for alcohol use disorder (MAUD) in patients with cirrhosis is not well established. Evidence on the efficacy and safety of these drugs in these patients is scarce.: Approach and results: We performed a ... ...

    Abstract Background and aims: The role of medications for alcohol use disorder (MAUD) in patients with cirrhosis is not well established. Evidence on the efficacy and safety of these drugs in these patients is scarce.
    Approach and results: We performed a systematic review and meta-analysis according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocol guidelines on the efficacy of MAUD in patients with cirrhosis. A search was conducted in PubMed, Embase, and Scopus, including all studies until May 2022. The population was defined as patients with AUD and cirrhosis. The primary outcome was alcohol abstinence. Safety was a secondary outcome. We performed a random-effect analysis and expressed the results as relative risk of alcohol consumption. Heterogeneity was measured by I2 . Out of 4095 unique references, 8 studies on 4 different AUD treatments [baclofen (n = 6), metadoxine (n = 1), acamprosate (n = 1), and fecal microbiota transplant (n = 1)] in a total of 794 patients were included. Four were cohort studies, and 4 were RCTs. Only RCTs were included in the meta-analysis. MAUD was associated with a reduced rate of alcohol consumption [relative risk = 0.68 (CI: 0.48-0.97), P = 0.03], increasing alcohol abstinence by 32% compared to placebo or standard treatment, despite high heterogeneity ( I2 = 67%). Regarding safety, out of 165 serious adverse events in patients treated with MAUD, only 5 (3%) were possibly or probably related to study medications.
    Conclusion: MAUD in patients with cirrhosis is effective in promoting alcohol abstinence and has a good safety profile. Larger studies on the effects of MAUD are needed, especially in patients with advanced liver disease.
    MeSH term(s) Humans ; Alcoholism/complications ; Alcohol Drinking/adverse effects ; Acamprosate/therapeutic use ; Liver Cirrhosis, Alcoholic/drug therapy ; Liver Cirrhosis/drug therapy
    Chemical Substances Acamprosate (N4K14YGM3J)
    Language English
    Publishing date 2023-08-25
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: An uncommon presentation of alcoholic liver disease.

    Gratacós-Ginès, Jordi / Jung, Gerhard / Díaz, Alba / Forns, Xavier

    Liver international : official journal of the International Association for the Study of the Liver

    2018  Volume 38, Issue 8, Page(s) 1514

    MeSH term(s) Adult ; Alcoholism/complications ; Bilirubin/blood ; Cholesterol/blood ; Diagnosis, Differential ; Foam Cells/pathology ; Humans ; Liver/pathology ; Liver Diseases, Alcoholic/diagnosis ; Liver Diseases, Alcoholic/pathology ; Male
    Chemical Substances Cholesterol (97C5T2UQ7J) ; Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2018-05-21
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.13868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Prospective validation of the EASL management algorithm for acute kidney injury in cirrhosis.

    Ma, Ann Thu / Solé, Cristina / Juanola, Adrià / Escudé, Laia / Napoleone, Laura / Avitabile, Emma / Pérez-Guasch, Martina / Carol, Marta / Pompili, Enrico / Gratacós-Ginés, Jordi / Soria, Anna / Rubio, Ana Belén / Cervera, Marta / Moreta, Maria José / Morales, Manuel / Solà, Elsa / Poch, Esteban / Fabrellas, Núria / Graupera, Isabel /
    Pose, Elisa / Ginès, Pere

    Journal of hepatology

    2024  

    Abstract: Background and aims: The management of acute kidney injury (AKI) in cirrhosis is challenging. The EASL guidelines proposed an algorithm, but this has never been validated. We aimed to prospectively evaluate this algorithm in clinical practice.: ... ...

    Abstract Background and aims: The management of acute kidney injury (AKI) in cirrhosis is challenging. The EASL guidelines proposed an algorithm, but this has never been validated. We aimed to prospectively evaluate this algorithm in clinical practice.
    Methods: Prospective cohort study of consecutive hospitalized patients with cirrhosis and AKI. EASL management algorithm includes identification/treatment of precipitating factors, 2-day albumin infusion in patients with AKI ≥ stage 1B, and treatment with terlipressin in patients with hepatorenal syndrome (HRS-AKI). Primary outcome was treatment response, which included both full and partial response. Secondary outcomes were survival and adverse events associated with terlipressin therapy.
    Results: A total of 202 AKI episodes in 139 patients were included. Overall treatment response was 80%, while renal replacement therapy was required in only 8%. Response to albumin infusion was achieved in 1/3 of episodes. Of patients not responding to albumin, most (74%) did not meet the diagnostic criteria of HRS-AKI, with ATN being the most common phenotype. Response rate in patients not meeting criteria of HRS-AKI was 70%. Only 30 patients met the diagnostic criteria HRS-AKI, and response rate to terlipressin was 61%. Median time from AKI diagnosis to terlipressin initiation was only 2.5 days. While urinary neutrophil gelatinase-associated lipocalin (uNGAL) could differentiate acute tubular necrosis (ATN) vs other phenotypes (AUROC 0.78), it did not predict response to therapy in HRS-AKI. Ninety-day transplant-free survival was negatively associated with MELD-Na, ATN and HRS-AKI as well as uNGAL. Three patients treated with terlipressin developed pulmonary edema.
    Conclusions: The application of the EASL AKI algorithm is associated with very good response rates and does not significantly delay initiation of terlipressin therapy.
    Language English
    Publishing date 2024-03-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2024.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Adding Inflammatory Markers and Refining National Institute on Alcohol Abuse and Alcoholism Criteria Improve Diagnostic Accuracy for Alcohol-associated Hepatitis.

    Avitabile, Emma / Díaz, Alba / Montironi, Carla / Pérez-Guasch, Martina / Gratacós-Ginès, Jordi / Hernández-Évole, Helena / Moreira, Roger K / Sehrawat, Tejasav S / Malhi, Harmeet / Olivas, Pol / Hernández-Gea, Virginia / Bataller, Ramón / Shah, Vijay H / Kamath, Patrick S / Ginès, Pere / Pose, Elisa

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2023  Volume 21, Issue 12, Page(s) 3080–3088.e9

    Abstract: Background & aims: Although histology is considered the gold standard for diagnosis of alcohol-associated hepatitis (AH), it is not required for entry into therapeutic studies if patients meet National Institute on Alcohol Abuse and Alcoholism (NIAAA) ... ...

    Abstract Background & aims: Although histology is considered the gold standard for diagnosis of alcohol-associated hepatitis (AH), it is not required for entry into therapeutic studies if patients meet National Institute on Alcohol Abuse and Alcoholism (NIAAA) consensus criteria for probable AH. Our aim was to assess the diagnostic accuracy of NIAAA criteria against liver biopsy and to explore new criteria to enhance diagnostic accuracy for AH.
    Methods: A total of 268 consecutive patients with alcohol-related liver disease with liver biopsy were prospectively included: 210 and 58 in the derivation and validation cohorts, respectively. NIAAA criteria and histological diagnosis of alcoholic steatohepatitis (ASH) were independently reviewed by clinical investigators and pathologists from Hospital Clínic and Mayo Clinic. Using biopsy-proven ASH as gold standard we determined diagnostic capability of NIAAA criteria and proposed the new improved criteria.
    Results: In the derivation cohort, diagnostic accuracy of NIAAA for AH was modest (72%) due to low sensitivity (63%). Subjects who did not meet NIAAA with ASH at liver biopsy had lower 1-year survival compared with subjects without ASH (70% vs 90%; P < .001). NIAAAm-CRP criteria, created by adding C-reactive protein and modifying the variables of the original NIAAA, had higher sensitivity (70%), accuracy (78%), and specificity (83%). Accuracy was also higher in a sensitivity analysis in severe AH (74% vs 65%). In the validation cohort, NIAAAm-CRP and NIAAA criteria had a sensitivity of 56% vs 52% and an accuracy of 76% vs 69%, respectively.
    Conclusion: NIAAA criteria are suboptimal for the diagnosis of AH. The proposed NIAAAm-CRP criteria may improve accuracy for noninvasive diagnosis of AH in patients with alcohol-related liver disease.
    MeSH term(s) United States ; Humans ; National Institute on Alcohol Abuse and Alcoholism (U.S.) ; Hepatitis, Alcoholic/diagnosis ; Fatty Liver, Alcoholic/diagnosis ; Alcoholism/complications ; Alcoholism/diagnosis
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2023.03.023
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  9. Article: Performance of a new flexible 19 G EUS needle in pancreatic solid lesions located in the head and uncinate process: A prospective multicenter study.

    Ginès, Angels / Fusaroli, Pietro / Sendino, Oriol / Seicean, Andrada / Gimeno-Garcia, Antonio Z / Gratacós-Ginès, Jordi / Araujo, Isis K / Rodríguez-Carunchio, Leonardo / Alós, Silvia / Lisotti, Andrea / Cominardi, Anna / Montenegro, Andrea / Fernández-Esparrach, Glòria

    Endoscopy international open

    2021  Volume 9, Issue 8, Page(s) E1269–E1275

    Abstract: Background and study ... ...

    Abstract Background and study aims
    Language English
    Publishing date 2021-07-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722
    ISSN (online) 2196-9736
    ISSN 2364-3722
    DOI 10.1055/a-1480-0428
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  10. Article: Serological levels of IGF-1 and IGFBP-3 in patients with Barrett's esophagus and esophageal adenocarcinoma: Longitudinal study.

    Uchima, Hugo / Da Fieno, Angella / Bonilla, Araceli / Melo-Borges, Jordana / Sánchez-Montes, Cristina / Cuatrecasas, Míriam / Córdova, Henry / Elizalde, Ignasi / Rakislova, Natalia / Gratacós-Ginès, Jordi / Bayarri, Carolina / Casanova, Gherzon / Ginès, Àngels / Llach, Josep / Balaguer, Francesc / Fernández-Esparrach, Glòria

    Gastroenterologia y hepatologia

    2022  Volume 46, Issue 5, Page(s) 360–368

    Abstract: Background: Barrett's esophagus (BE) is an entity with a known histological progression to malignancy. The insulin-like growth factor (IGF) system is involved in the carcinogenesis through obesity-related mechanisms that include IGF and it has been ... ...

    Title translation Niveles séricos de IGF-1 e IGFBP-3 en pacientes con esófago de Barrett y adenocarcinoma de esófago. Estudio longitudinal.
    Abstract Background: Barrett's esophagus (BE) is an entity with a known histological progression to malignancy. The insulin-like growth factor (IGF) system is involved in the carcinogenesis through obesity-related mechanisms that include IGF and it has been associated with several types of cancer.
    Objectives: To evaluate the serological levels of IGF-1 and IGFBP-3 in patients with BE and esophageal adenocarcinoma.
    Patients and methods: Prospective study of patients with BE and esophageal adenocarcinoma who underwent upper endoscopy between September 2012 and December 2015. A baseline determination of IGF-1 and IGFBP-3 was performed. We included a control group of patients without BE.
    Results: One hundred sixteen patients were included: 36 controls, 62 with BE (42 without dysplasia and 20 with dysplasia) and 18 with adenocarcinoma. IGF-1 and IGF-1/IGFBP-3 molar ratio showed a progression to high levels in BE and adenocarcinoma than in controls (IGF-1: 135.55±66.07ng/ml, 148.33±81.5ng/ml, 108.19±46.69ng/ml, respectively; P=.049) (molar ratio: 0.23±0.91, 0.29±0.11, 0.19±0.06, respectively; P=.001), without differences between the histological types of BE. Fifty-four out of the 65 patients with BE were followed up (median of 58.50 months, range 12-113) and 11 of them (20.4%) presented progression to low-grade dysplasia (n=8) or high-grade dysplasia/adenocarcinoma (n=3), without differences in the IGF system compared with patients without progression.
    Conclusions: Patients with BE and esophageal adenocarcinoma have changes in the IGF system although the serological levels of IGF-1 and IGFBP-3 do not correlate with histological progression of BE.
    MeSH term(s) Humans ; Barrett Esophagus/metabolism ; Barrett Esophagus/pathology ; Longitudinal Studies ; Insulin-Like Growth Factor Binding Protein 3 ; Insulin-Like Growth Factor I/metabolism ; Prospective Studies ; Disease Progression ; Esophageal Neoplasms/pathology ; Adenocarcinoma/pathology
    Chemical Substances Insulin-Like Growth Factor Binding Protein 3 ; Insulin-Like Growth Factor I (67763-96-6)
    Language Spanish
    Publishing date 2022-09-28
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 632502-6
    ISSN 0210-5705
    ISSN 0210-5705
    DOI 10.1016/j.gastrohep.2022.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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