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Article ; Online: MRI features of hypernatremic cerebral myelinolysis.

Gratieux, J D / Belkacem, S / Law-Ye, B

2020 Volume 101, Issue 10, Page(s) 689–690

MeSH term(s)	Humans ; Hypernatremia ; Magnetic Resonance Imaging
Language	English
Publishing date	2020-05-11
Publishing country	France
Document type	Journal Article
ZDB-ID	2648283-6
ISSN	2211-5684 ; 2211-5684
ISSN (online)	2211-5684
ISSN	2211-5684
DOI	10.1016/j.diii.2020.04.007
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Article: Spinal cord arterio-venous shunts: From classification to therapeutic management.

Consoli, A / Coskun, O / Di Maria, F / Gratieux, J / Condette-Auliac, S / Smadja, S / Boulin, A / Rodesch, G

Revue neurologique

2021 Volume 177, Issue 5, Page(s) 469–476

Abstract: Spinal Cord Arterio-Venous shunts (SCAVSs) are a rare disease. The aim of this paper is to describe how we classify and consider management of SCAVSs in relation to the location of the shunt focusing mainly on intradural SCAVSs. The anatomical features ... ...

Abstract	Spinal Cord Arterio-Venous shunts (SCAVSs) are a rare disease. The aim of this paper is to describe how we classify and consider management of SCAVSs in relation to the location of the shunt focusing mainly on intradural SCAVSs. The anatomical features of the SCAVSs together with data provided by MRI and CT scans allow identification of four types of SCAVSs: paraspinal, epidural, dural and intradural ones. Clinical and neuroradiologic characteristics are described for each entity as well as the therapeutic endovascular management at our institution between 2002 and 2020. The therapeutic management of SCAVSs, and in particular of intradural shunts, remains mainly based on endovascular treatment as a first-choice approach. Understanding properly the lesional and regional vascular anatomy is mandatory to plan an appropriate therapeutic strategy and obtain good clinical results stable at long term follow up.
MeSH term(s)	Embolization, Therapeutic ; Humans ; Magnetic Resonance Imaging ; Spinal Cord/diagnostic imaging ; Tomography, X-Ray Computed
Language	English
Publishing date	2021-03-26
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	4593-7
ISSN	2213-0004 ; 0035-3787
ISSN (online)	2213-0004
ISSN	0035-3787
DOI	10.1016/j.neurol.2021.01.010
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Article: Imaging of vascular diseases of the spinal cord.

Condette-Auliac, S / Gratieux, J / Boulin, A / Di Maria, F / Consoli, A / Coskun, O / Smajda, S / Rodesch, G

Revue neurologique

2021 Volume 177, Issue 5, Page(s) 477–489

MeSH term(s)	Diagnostic Imaging ; Humans ; Spinal Cord/diagnostic imaging ; Vascular Diseases/diagnostic imaging
Language	English
Publishing date	2021-04-24
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	4593-7
ISSN	2213-0004 ; 0035-3787
ISSN (online)	2213-0004
ISSN	0035-3787
DOI	10.1016/j.neurol.2021.04.001
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Article ; Online: Life-threatening chlorpromazine-induced acquired haemophilia A in a patient with a cavernous malformation involving the medulla oblongata.

Stammler, R / Ackermann, F / Vasse, M / Verrat, A / David, A / Horodyckid, C / Gratieux, J / Marroun, I / Groh, M / Roumier, M / Paule, R

La Revue de medecine interne

2022 Volume 43, Issue 12, Page(s) 739–742

Abstract: Introduction: Chlorpromazine is a commonly used drug in several medical conditions associated with a wide range of side effects. Few cases of hemostatic disorder have been reported in the literature.: Case report: A 39-year-old man had previously ... ...

Abstract	Introduction: Chlorpromazine is a commonly used drug in several medical conditions associated with a wide range of side effects. Few cases of hemostatic disorder have been reported in the literature. Case report: A 39-year-old man had previously been diagnosed with a cavernous malformation of the medulla oblongata. Chlorpromazine was started to treat persistent hiccups. Twenty days later, the patient presented hepatitis and a pruritic rash. Haemostasis tests revealed a prolonged partial thromboplastin time associated with isolated decrease of factor VIII level and anti-factor VIII antibodies. Magnetic resonance imaging revealed recent asymptomatic bleeding. Introduction of eptacog alfa and prednisone allowed clinical and biological improvement as well as a prolonged remission after 12 months of follow-up.
MeSH term(s)	Male ; Humans ; Adult ; Hemophilia A/chemically induced ; Hemophilia A/diagnosis ; Hemophilia A/drug therapy ; Chlorpromazine/adverse effects ; Hemorrhage ; Medulla Oblongata
Chemical Substances	Chlorpromazine (U42B7VYA4P)
Language	English
Publishing date	2022-09-06
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2022.08.009
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Article ; Online: A case of spontaneous brain arteriovenous malformation occlusion: Imaging analysis and clinical debate.

Milazzo, Nicola / Pizzuto, Silvia / Gratieux, Julie / Sgreccia, Alessandro / Di Maria, Federico / Coskun, Oghuzan / Condette-Auliac, Stephanie / Boulin, Anne / Rodesch, Georges / Consoli, Arturo

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

2024 , Page(s) 15910199231226142

Abstract: The spontaneous occlusion of brain arteriovenous malformations (bAVMs) is a rare event, particularly for unruptured ones. Associated factors include single-venous drainage and small nidus size. Most of the previously reported cases were ruptured bAVMs. ... ...

Abstract	The spontaneous occlusion of brain arteriovenous malformations (bAVMs) is a rare event, particularly for unruptured ones. Associated factors include single-venous drainage and small nidus size. Most of the previously reported cases were ruptured bAVMs. We report the case of a middle-aged male patient with an unruptured, rolandic, left-sided bAVM associated with a 30-year history of refractory epilepsy. We documented the spontaneous thrombosis of the venous drainage of the AVM without any sign of bleeding. Finally, we underline the difference between ruptured-induced occlusion and truly spontaneous thrombosis of the bAVMs.
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1354913-3
ISSN	2385-2011 ; 1591-0199 ; 1123-9344
ISSN (online)	2385-2011
ISSN	1591-0199 ; 1123-9344
DOI	10.1177/15910199231226142
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Article ; Online: Traitement interventionnel des anévrismes mycotiques cérébraux.

Consoli, A / Coskun, O / Perier, M / Di Maria, F / Gratieux, J / Dean, P / Pizzuto, S / Badat, N / Condette-Auliac, S / Boulin, A / Rodesch, G

Annales de cardiologie et d'angeiologie

2020 Volume 69, Issue 6, Page(s) 411–414

Abstract: Infective endocardites are associated with both ischemic and hemorrhagic neurological complications and also with cerebral abscesses and the development of "mycotic" aneurysms, which are detected in about 5 % of patients in the acute and sub-acute phase ... ...

Title translation	Therapeutic and endovascular management of cerebral mycotic aneurysms.
Abstract	Infective endocardites are associated with both ischemic and hemorrhagic neurological complications and also with cerebral abscesses and the development of "mycotic" aneurysms, which are detected in about 5 % of patients in the acute and sub-acute phase of the infection. Data about their natural history and their hemorrhagic risk are scarce and fragmented. The therapeutic management is represented by the medical treatment of the infection with interventional abstention, the surgical treatment and the endovascular approach by selective embolization of the aneurysm. No evidence is provided concerning the superiority of a specific approach. Mycotic aneurysms remain a diagnostic and therapeutic challenge and their management is necessarily based on a multidiscplinary approach.
MeSH term(s)	Aneurysm, Infected/diagnosis ; Aneurysm, Infected/microbiology ; Aneurysm, Infected/therapy ; Cerebral Hemorrhage/surgery ; Endovascular Procedures/methods ; Humans ; Incidental Findings ; Intracranial Aneurysm/diagnosis ; Intracranial Aneurysm/microbiology ; Intracranial Aneurysm/therapy
Language	French
Publishing date	2020-10-31
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	418425-7
ISSN	1768-3181 ; 0003-3928
ISSN (online)	1768-3181
ISSN	0003-3928
DOI	10.1016/j.ancard.2020.10.002
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Article ; Online: Intradural spinal cord arteriovenous shunts in a personal series of 210 patients: novel classification with emphasis on anatomical disposition and angioarchitectonic distribution, related to spinal cord histogenetic units.

Mizutani, Katsuhiro / Consoli, Arturo / Maria, Federico Di / Condette Auliac, Stéphanie / Boulin, Anne / Coskun, Oguzhan / Gratieux, Julie / Rodesch, Georges

Journal of neurosurgery. Spine

2021 Volume 34, Issue 6, Page(s) 920–930

Abstract: Objective: Few classifications of intradural spinal arteriovenous shunts (ID-SAVSs) have considered their anatomical localization in relation to their phenotype and angioarchitectonics. The authors propose another vision of ID-SAVSs allowing a ... ...

Abstract	Objective: Few classifications of intradural spinal arteriovenous shunts (ID-SAVSs) have considered their anatomical localization in relation to their phenotype and angioarchitectonics. The authors propose another vision of ID-SAVSs allowing a reappraised classification based on analysis of the anatomical disposition, angioarchitecture, and histogenetic location of these vascular malformations. Methods: The radiological and clinical records of 210 patients with ID-SAVSs were retrospectively reviewed, considering their localization, vascular architectonics, and correlation with the 5 histogenetic units of the spinal cord. Among these, 183 files with complete data allowed precise analysis of the ID-SAVSs. Results: Among these 183 files (162 and 21 cases with single and multiple lesions, respectively), different entities were identified: 13 pial macro arteriovenous fistulas (MAVFs), 92 pial micro arteriovenous fistulas (mAVFs), 33 superficial pial niduses, and 69 intramedullary niduses. Thirteen sulcal shunts (either fistulas or niduses) were considered subtypes of pial lesions. Among the 21 multiple cases, 11 were monomyelomeric while 10 were multimyelomeric. Pial lesions, either fistulas or niduses, were dominantly vascularized by pial arteries (anterior or posterior depending on the localization of the shunt) and occasionally (except for MAVFs) by transmedullary arteries. Pial niduses occasionally extended into the funiculus by recruiting intrinsic veins or by extension of the nidus itself inside the white matter. Intramedullary niduses were always vascularized by both centrifugal and centripetal feeders, respectively, from sulcal arteries (SAs) and pial arteries. Sulcal lesions are pial lesions located within the ventral median sulcus and vascularized by SAs and veins. Single or multiple ID-SAVSs can be part of various syndromes such as hereditary hemorrhagic telangiectasia, Parkes-Weber, RASA1, CLOVES, and spinal arteriovenous metameric syndromes. Histogenetic analyses revealed a specific distribution of each ID-SAVS in the 5 histogenetic units of the spinal cord: intramedullary niduses were found almost equally from cervical to thoracic units, while MAVFs and mAVFs were mostly found from thoracic to postcrural ones. Pial niduses showed intermediate features between intramedullary and fistulous lesions and were mostly distributed from brachial to crural segments. Conclusions: Precise analysis of the anatomical disposition of ID-SAVSs in relation to functional histogenetic units allows a better understanding of these lesions and improved therapeutic management.
Language	English
Publishing date	2021-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2158643-3
ISSN	1547-5646 ; 1547-5654
ISSN (online)	1547-5646
ISSN	1547-5654
DOI	10.3171/2020.9.SPINE201258
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Article ; Online: Vemurafenib and cobimetinib overcome resistance to vemurafenib in

Touat, Mehdi / Gratieux, Julie / Condette Auliac, Stephanie / Sejean, Karine / Aldea, Sorin / Savatovsky, Julien / Perkins, Géraldine / Blons, Hélène / Ligon, Keith L / Idbaih, Ahmed / Hollebecque, Antoine / Gimenez-Roqueplo, Anne-Paule / Laurent-Puig, Pierre / Sanson, Marc / Villa, Chiara / Di Stefano, Anna Luisa

Neurology

2018 Volume 91, Issue 11, Page(s) 523–525

MeSH term(s)	Adult ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Azetidines/therapeutic use ; Brain Neoplasms/drug therapy ; Brain Neoplasms/genetics ; Drug Resistance, Neoplasm/drug effects ; Ganglioglioma/drug therapy ; Ganglioglioma/genetics ; Humans ; Male ; Mutation ; Piperidines/therapeutic use ; Proto-Oncogene Proteins B-raf/genetics ; Vemurafenib/therapeutic use
Chemical Substances	Antineoplastic Agents ; Azetidines ; Piperidines ; Vemurafenib (207SMY3FQT) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; cobimetinib (ER29L26N1X)
Language	English
Publishing date	2018-08-17
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000006171
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Article ; Online: Sustained Tumor Control With MAPK Inhibition in

Berzero, Giulia / Bellu, Luisa / Baldini, Capucine / Ducray, François / Guyon, David / Eoli, Marica / Silvani, Antonio / Dehais, Caroline / Idbaih, Ahmed / Younan, Nadia / Nguyen-Them, Ludovic / Gaillard, Stephan / Pasqualetti, Francesco / Lepage-Seydoux, Coralie / Sekkate, Sakina / Tresca, Patricia / Kas, Aurélie / Gratieux, Julie / Ammari, Samy /

Saragoussi, Edouard / Savatovsky, Julien / Delattre, Jean-Yves / Hoang-Xuan, Khê / Meyronet, David / Villa, Chiara / Bielle, Franck / Sanson, Marc / Touat, Mehdi / Di Stefano, Anna Luisa

Neurology

2021 Volume 97, Issue 7, Page(s) e673–e683

Abstract: Objective: To assess whether RAF and MEK inhibitors (RAFi/MEKi) can provide long-term clinical benefit in adult patients with : Methods: We performed a retrospective search in the institutional databases of 6 neuro-oncology departments for adult ... ...

Abstract	Objective: To assess whether RAF and MEK inhibitors (RAFi/MEKi) can provide long-term clinical benefit in adult patients with Methods: We performed a retrospective search in the institutional databases of 6 neuro-oncology departments for adult patients with recurrent or disseminated Results: Twenty-eight adults with recurrent or disseminated Conclusions: Our study highlights the long-term clinical benefits of RAFi/MEKi in adult patients with Classification of evidence: This study provides Class III evidence that, for adult patients with
MeSH term(s)	Adult ; Astrocytoma/drug therapy ; Astrocytoma/genetics ; Azetidines/pharmacology ; Brain Neoplasms/drug therapy ; Brain Neoplasms/genetics ; Databases, Factual ; Female ; Ganglioglioma/drug therapy ; Ganglioglioma/genetics ; Glioma/drug therapy ; Glioma/genetics ; Humans ; Imidazoles/pharmacology ; Karnofsky Performance Status ; MAP Kinase Kinase Kinases/antagonists & inhibitors ; Male ; Middle Aged ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors ; Outcome Assessment, Health Care ; Oximes/pharmacology ; Piperidines/pharmacology ; Progression-Free Survival ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins B-raf/genetics ; Pyridones/pharmacology ; Pyrimidinones/pharmacology ; Retrospective Studies ; Vemurafenib/pharmacology ; raf Kinases/antagonists & inhibitors
Chemical Substances	Azetidines ; Imidazoles ; Oximes ; Piperidines ; Protein Kinase Inhibitors ; Pyridones ; Pyrimidinones ; Vemurafenib (207SMY3FQT) ; trametinib (33E86K87QN) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; raf Kinases (EC 2.7.11.1) ; MAP Kinase Kinase Kinases (EC 2.7.11.25) ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2) ; cobimetinib (ER29L26N1X) ; dabrafenib (QGP4HA4G1B)
Language	English
Publishing date	2021-06-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000012330
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Article ; Online: Mechanical Thrombectomy for Acute Ischemic Stroke Amid the COVID-19 Outbreak ; Decreased Activity, and Increased Care Delays

Kerleroux, Basile / Fabacher, Thibaut / Bricout, Nicolas / Moïse, Martin / Testud, Benoit / Vingadassalom, Sivadji / Ifergan, Héloïse / Janot, Kévin / Consoli, Arturo / Ben Hassen, Wagih / Shotar, Eimad / Ognard, Julien / Charbonnier, Guillaume / L’Allinec, Vincent / Guédon, Alexis / Bolognini, Federico / Marnat, Gaultier / Forestier, Géraud / Rouchaud, Aymeric /

Pop, Raoul / Raynaud, Nicolas / Zhu, François / Cortese, Jonathan / Chalumeau, Vanessa / Berge, Jérome / Escalard, Simon / Boulouis, Grégoire / Chivot, Cyril / Hanafi, Riyad / Pasco, Anne / Girot, Jean-Baptiste / Biondi, Alessandra / Di Caterino, Fortunato / Primikiris, Panagiotis / Vitale, Giovanni / Bonnet, Louise / Gariel, Florent / Barreau, Xavier / Debruxelles, Sabrina / Lucas, Ludovic / Menegon, Patrice / Olindo, Stéphane / Poli, Mathilde / Renou, Pauline / Sagnier, Sharmila / Sibon, Igor / Veunac, Louis / Gentric, Jean-Christophe / Barbier, Charlotte / Boulanger, Marion / Cogez, Julien / Guettier, Sophie / Schneckenburger, Romain / Touze, Emmanuel / Delaitre, Mariette / Lebendinsky, Pablo / Musacchio, Mariano / Ricolfi, Frédéric / Thouant, Pierre / Caparros, François / Casolla, Barbara / Della Schiava, Lucie / Dequatre, Nelly / Henon, Hilde / Pasi, Marco / Kazemi, Apolline / Bala, Fouzi / Estrade, Laurent / Mounayer, Charbel / Saleme, Susanna / Macian-Montoro, Francisco / Eker, Omer / Cotton, François / Blanc-Lasserre, Karine / Cakmak, Serkan / Cho, Tae-Hee / Derex, Laurent / Lukaszewicz, Anne-Claire / Mechtouff, Laura / Nighoghossian, Norbert / Philippeau, Frédéric / Riva, Roberto / Turjman, Francis / Vallet, Anne-Evelyne / Carle, Xavier / Dory-Lautrec, Philippe / Reyre, Anthony / Hak, Jean-François / Brunel, Hervé / Benali, Amel / Collemiche, François-Louis / Dargazanli, Cyril / Cagnazzo, Frederico / Derraz, Imad / Arquizan, Caroline / Corti, Lucas / Costalat, Vincent / Gaillard, Nicolas / Gascou, Grégory / Lefèvre, Pierre-Henri / Mourand, Isabelle / Riquelme, Carlos / Derelle, Anne Laure / Gory, Benjamin / Liao, Liang / Tonnelet, Romain / Anxionnat, René / Bonnerot, Mathieu / Bracard, Serge / Braun, Marc / Humbertjean, Lisa / Lacour, Jean-Christophe / Mione, Gioia / Planel, Sophie / Richard, Sébastien / Riou-Comte, Nolwenn / Schmitt, Emmanuelle / Bourcier, Romain / Detraz, Lili / Desal, Hubert / Alexandre, Pierre-Louis / Daumas-Duport, Benjamin / Lenoble, Cédric / Roy, Monica / Coskun, Oghuzan / Di Maria, Frederico / Lapergue, Bertrand / Rodesch, Georges / Wang, Adrien / Weisenburger-Lile, David / Zimatore, Sergio / Ajili, Nadia / Buard, Géraldine / Evrard, Serge / Gorza, Lucas / Gratieux, Julie / Leguen, Morgan / Marinier, Sylvie / Pico, Fernando / Poll, Roxanna / Rakotoharinandrasana, Haja / Tassan, Philippe / Tchikviladze, Maya / Delvoye, François / Hebert, Solène / Blanc, Raphaël / Ciccio, Gabriele / Desilles, Jean-Philippe / Maier, Benjamin / Mazighi, Mikael / Piotin, Michel / Redjem, Hocine / Smajda, Stanislas / Ben Maacha, Malek / Corabianu, Ovide / De Broucker, Thomas / Ille, Olivier / Manchon, Eric / Obadia, Michael / Obadia, Mickael / Raynouard, Igor / Peres, Roxanne / Sabben, Candice / Smadja, Didier / Taylor, Guillaume / Thion, Laurie-Anne / Lecler, Augustin / Spelle, Laurent / Denier, Christian / Caroff, Jildaz / Chassin, Olivier / Spelle, laurent / Venditti, Laura / Aymard, Armand / Betty, Jean / Civelli, Vittorio / Eliezer, Michael / Fantoni, Matteo / Houdart, Emmanuel / Labeyrie, Marc-Antoine / Saint Maurice, Jean-Pierre / Kalsoum, Erwah / Pacini, Aurelien / Ramadane, Chawkat / Tuilier, Titien / Villain, Adrien / Clarencon, Frédéric / Degos, Vincent / Elhfnawy, Ahmed / Elhorany, Mahmoud / Lenck, Stéphanie / Premat, Kevin / Sourour, Nader-Antoine / Alamowitch, Sonia / Baronnet, Flore / Crozier, Sophie / Deltour, Sandrine / Leger, Anne / Rosso, Charlotte / Pyatigorskaya, Nadya / Rodriguez Regent, Christine / Trystram, Denis / Naggara, Olivier / Seners, Pierre / Turc, Guillaume / Edjlali, Myriam / Agbonon, Rémi / Alotaibi, Mohammed / Sonchet, Antoine / Oppenheim, Catherine / Meder, Jean François / Benzakoun, Joseph / Legrand, Laurence / Fauché, Cédric / Velasco, Stéphane / Manceau, Pierre François / Moulin, Sebastien Solène Soize / Eugene, François / Ferre, Jean-Christophe / Paya, Christophe / Gauvrit, Jean-Yves / Langnier-Lemercier, Sophie / Lassale, Maria / Raoult, helene / Ronziere, thomas / Tracol, Clément / Vannier, Stéphane / Burel, Julien / Le Moal, Julien / Papagiannaki, Chrysanthi / Aggour, Mohamed / Sachet, Marina / Boutet, Claire / Beaujeux, Remy / Hasiu, Anca / Manisor, Monica / Mihoc, Dan / Kremer, Stéphane / Arteaga, Charles / Gazzola, Sébastien / Darcourt, Jean / Cognard, Christophe / Bonneville, Fabrice / Christine Januel, Anne / Olivot, Jean-Marc / Raposo, Nicolas / Viguier, Alain / Bibi, Richard / Boustia, Fakhreddine / Herbreteau, Denis / Maldonado, Igor / Narata, Ana-Paula

Stroke

2020 Volume 51, Issue 7, Page(s) 2012–2017

Abstract: Background and Purpose: The efficiency of prehospital care chain response and the adequacy of hospital resources are challenged amid the coronavirus disease 2019 (COVID-19) outbreak, with suspected consequences for patients with ischemic stroke eligible ... ...

Abstract	Background and Purpose: The efficiency of prehospital care chain response and the adequacy of hospital resources are challenged amid the coronavirus disease 2019 (COVID-19) outbreak, with suspected consequences for patients with ischemic stroke eligible for mechanical thrombectomy (MT). Methods: We conducted a prospective national-level data collection of patients treated with MT, ranging 45 days across epidemic containment measures instatement, and of patients treated during the same calendar period in 2019. The primary end point was the variation of patients receiving MT during the epidemic period. Secondary end points included care delays between onset, imaging, and groin puncture. To analyze the primary end point, we used a Poisson regression model. We then analyzed the correlation between the number of MTs and the number of COVID-19 cases hospitalizations, using the Pearson correlation coefficient (compared with the null value). Results: A total of 1513 patients were included at 32 centers, in all French administrative regions. There was a 21% significant decrease (0.79; [95%CI, 0.76–0.82]; P <0.001) in MT case volumes during the epidemic period, and a significant increase in delays between imaging and groin puncture, overall (mean 144.9±SD 86.8 minutes versus 126.2±70.9; P <0.001 in 2019) and in transferred patients (mean 182.6±SD 82.0 minutes versus 153.25±67; P <0.001). After the instatement of strict epidemic mitigation measures, there was a significant negative correlation between the number of hospitalizations for COVID and the number of MT cases ( R 2 −0.51; P =0.04). Patients treated during the COVID outbreak were less likely to receive intravenous thrombolysis and to have unwitnessed strokes (both P <0.05). Conclusions: Our study showed a significant decrease in patients treated with MTs during the first stages of the COVID epidemic in France and alarming indicators of lengthened care delays. These findings prompt immediate consideration of local and regional stroke networks preparedness in the varying contexts of COVID-19 pandemic evolution.
Keywords	Advanced and Specialised Nursing ; Clinical Neurology ; Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publishing country	us
Document type	Article ; Online
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/strokeaha.120.030373
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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