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Article ; Online: Das Angioödem in der Notaufnahme.

Bühler, Laura / Schmid, Bonaventura / Fabritius, Elisabeth / Grauvogel, Tanja Daniela

Medizinische Klinik, Intensivmedizin und Notfallmedizin

2022 Volume 118, Issue 1, Page(s) 4–13

Abstract: Acute angioedema is mostly found in the head and neck region. Therefore, it can be life threatening by potentially endangering air way patency. Pathophysiologically angioedemas can be divided into mast cell-mediated or bradykinin-mediated forms. ... ...

Title translation	Angioedema in the emergency department.
Abstract	Acute angioedema is mostly found in the head and neck region. Therefore, it can be life threatening by potentially endangering air way patency. Pathophysiologically angioedemas can be divided into mast cell-mediated or bradykinin-mediated forms. Differentiation is essential due to the different therapeutic strategies. In cases of doubt, initial therapy with adrenalin, antihistamines, and glucocorticoids should be initiated. This initial emergency treatment is comparable to the treatment of allergic reactions. For diagnosed or suspected hereditary angioedema, specific treatments are available. For drug-associated forms, immediate and life-long cessation of the medication is crucial. In the emergency situation, diagnosis can only be based on medical history and clinical symptoms. Recognition of impending airway obstruction and securing the airway is of highest priority; final diagnosis must be confirmed later.
MeSH term(s)	Humans ; Angioedema/therapy ; Angioedema/drug therapy ; Bradykinin/therapeutic use ; Emergency Service, Hospital ; Epinephrine/therapeutic use
Chemical Substances	Bradykinin (S8TIM42R2W) ; Epinephrine (YKH834O4BH)
Language	German
Publishing date	2022-12-29
Publishing country	Germany
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	2636018-4
ISSN	2193-6226 ; 1435-1420 ; 0723-5003 ; 2193-6218 ; 0175-3851
ISSN (online)	2193-6226 ; 1435-1420
ISSN	0723-5003 ; 2193-6218 ; 0175-3851
DOI	10.1007/s00063-022-00983-9
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Article: Digital Patient-Reported Outcome Measures Assessing Health-Related Quality of Life in Skull Base Diseases-Analysis of Feasibility and Pitfalls Two Years after Implementation.

Steiert, Christine / Lambeck, Johann / Grauvogel, Tanja Daniela / Beck, Juergen / Grauvogel, Juergen

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 4

Abstract: Health-related quality of life (HRQoL) assessment is becoming increasingly important in neurosurgery following the trend toward patient-centered care, especially in the context of skull base diseases. The current study evaluates the systematic assessment ...

Abstract	Health-related quality of life (HRQoL) assessment is becoming increasingly important in neurosurgery following the trend toward patient-centered care, especially in the context of skull base diseases. The current study evaluates the systematic assessment of HRQoL using digital patient-reported outcome measures (PROMs) in a tertiary care center specialized in skull base diseases. The methodology and feasibility to conduct digital PROMs using both generic and disease-specific questionnaires were investigated. Infrastructural and patient-specific factors affecting participation and response rates were analyzed. Since August 2020, 158 digital PROMs were implemented in skull base patients presenting for specialized outpatient consultations. Reduced personnel capacity led to significantly fewer PROMs being conducted during the second versus (vs.) the first year after introduction (mean: 0.77 vs. 2.47 per consultation day,
Language	English
Publishing date	2023-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11040472
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Article ; Online: Prospects and limitations of different registration modalities in electromagnetic ENT navigation.

Soteriou, Eric / Grauvogel, Juergen / Laszig, Roland / Grauvogel, Tanja Daniela

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2016 Volume 273, Issue 11, Page(s) 3979–3986

Abstract: The present study examined electromagnetic tracking technology for ENT navigation. Five different registration modalities were compared and navigation accuracy was assessed. Four skull models were individually fabricated with a three-dimensional printer, ...

Abstract	The present study examined electromagnetic tracking technology for ENT navigation. Five different registration modalities were compared and navigation accuracy was assessed. Four skull models were individually fabricated with a three-dimensional printer, based on patients' computer tomography datasets. Individual silicone masks were fitted for skin and soft tissue simulation. Five registration modalities were examined: (1) invasive marker, (2) automatic, (3) surface matching (AccuMatch), (4) anatomic landmarks, and (5) oral splint registration. Overall navigation accuracy and accuracy on selected anatomic locations were assessed by targeting 26 titanium screws previously placed over the skull. Overall navigation accuracy differed significantly between all registration modalities. The target registration error was 0.94 ± 0.06 mm (quadratic mean ± standard deviation) for the invasive marker registration, 1.41 ± 0.04 mm for the automatic registration, 1.59 ± 0.14 mm for the surface matching registration, and 5.15 ± 0.66 mm (four landmarks) and 4.37 ± 0.73 mm (five landmarks) for the anatomic landmark registration. Oral splint registration proved itself to be inapplicable to this navigation system. Invasive marker registration was superior on most selected anatomic locations. However, on the ethmoid and sphenoid sinus the automatic registration process revealed significantly lower target registration error values. Only automatic and surface registration met the accuracy requirements for noninvasive registration. Particularly, the automatic image-to-world registration reaches target registration error values on the anterior skull base which are comparable with the gold standard of invasive screw registration.
MeSH term(s)	Anatomic Landmarks/diagnostic imaging ; Bone Screws ; Diagnosis, Computer-Assisted/methods ; Electromagnetic Fields ; Fiducial Markers ; Humans ; Imaging, Three-Dimensional/methods ; Otolaryngology/instrumentation ; Otolaryngology/methods ; Skull/diagnostic imaging ; Titanium ; Tomography, X-Ray Computed
Chemical Substances	Titanium (D1JT611TNE)
Language	English
Publishing date	2016-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-016-4063-9
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Article ; Online: Navigation accuracy after automatic- and hybrid-surface registration in sinus and skull base surgery.

Grauvogel, Tanja Daniela / Engelskirchen, Paul / Semper-Hogg, Wiebke / Grauvogel, Juergen / Laszig, Roland

PloS one

2017 Volume 12, Issue 7, Page(s) e0180975

Abstract: Objective: Computer-aided-surgery in ENT surgery is mainly used for sinus surgery but navigation accuracy still reaches its limits for skull base procedures. Knowledge of navigation accuracy in distinct anatomical regions is therefore mandatory. This ... ...

Abstract	Objective: Computer-aided-surgery in ENT surgery is mainly used for sinus surgery but navigation accuracy still reaches its limits for skull base procedures. Knowledge of navigation accuracy in distinct anatomical regions is therefore mandatory. This study examined whether navigation accuracy can be improved in specific anatomical localizations by using hybrid registration technique. Study design: Experimental phantom study. Setting: Operating room. Subjects and methods: The gold standard of screw registration was compared with automatic LED-mask-registration alone, and in combination with additional surface matching. 3D-printer-based skull models with individual fabricated silicone skin were used for the experiments. Overall navigation accuracy considering 26 target fiducials distributed over each skull was measured as well as the accuracy on selected anatomic localizations. Results: Overall navigation accuracy was <1.0 mm in all cases, showing the significantly lowest values after screw registration (0.66 ± 0.08 mm), followed by hybrid registration (0.83± 0.08 mm), and sole mask registration (0.92 ± 0.13 mm).On selected anatomic localizations screw registration was significantly superior on the sphenoid sinus and on the internal auditory canal. However, mask registration showed significantly better accuracy results on the midface. Navigation accuracy on skull base localizations could be significantly improved by the combination of mask registration and additional surface matching. Conclusion: Overall navigation accuracy gives no sufficient information regarding navigation accuracy in a distinct anatomic area. The non-invasive LED-mask-registration proved to be an alternative in clinical routine showing best accuracy results on the midface. For challenging skull base procedures a hybrid registration technique is recommendable which improves navigation accuracy significantly in this operating field. Invasive registration procedures are reserved for selected challenging skull base operations where the required high precision warrants the invasiveness.
MeSH term(s)	Humans ; Paranasal Sinuses/surgery ; Skull Base/surgery ; Surgery, Computer-Assisted/methods
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0180975
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Article ; Online: Piezosurgery-A Safe Technique to Perform Lateral Suboccipital Craniotomy?

Grauvogel, Juergen / Masalha, Waseem / Heiland, Dieter Henrik / Jarc, Nadja / Grauvogel, Tanja Daniela / Scheiwe, Christian

Operative neurosurgery (Hagerstown, Md.)

2017 Volume 15, Issue 6, Page(s) 664–671

Abstract: Background: Piezosurgery (PS) is a relatively new technique based on microvibrations generated by the piezoelectric effect. It selectively cuts bone tissue and preserves the surrounding soft tissue.: Objective: To evaluate the use of PS for ... ...

Abstract	Background: Piezosurgery (PS) is a relatively new technique based on microvibrations generated by the piezoelectric effect. It selectively cuts bone tissue and preserves the surrounding soft tissue. Objective: To evaluate the use of PS for performing lateral suboccipital craniotomy. Methods: PS was used to perform a lateral suboccipital craniotomy in 22 patients who underwent surgery for different cerebellopontine angle (CPA) pathologies in the neurosurgical department. The applicability of PS for lateral suboccipital craniotomy was evaluated with respect to safety, preciseness of bone cutting, and in particular the preservation of the adjacent dura and sigmoid and transverse sinuses. Results: Lateral suboccipital craniotomy in 22 patients who underwent surgery for different CPA pathologies (13 vestibular schwannoma, 5 petrous bone meningioma, 1 petroclival meningioma, 2 epidermoid cysts, and 1 petrous bone cholesterol granuloma) was performed with PS without any complications. A burr hole was set before piezosurgical craniotomy in 6 patients, with no prior burr hole in 16 patients. Incidental durotomy during piezosurgical craniotomy occurred in 6 patients, and small lacerations of the sigmoid sinus caused by the piezosurgical device were observed in 3 patients. Conclusion: Although PS is a safe and selective bone cutting technique that preserves the surrounding soft tissue, it can still lead to unintended dural tears during lateral suboccipital craniotomy. This must be kept in mind when using PS for craniotomies and relying on the selective bone cutting properties of PS.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Craniotomy/methods ; Female ; Humans ; Male ; Meningeal Neoplasms/surgery ; Meningioma/surgery ; Middle Aged ; Neuroma, Acoustic/surgery ; Piezosurgery/methods ; Skull Base Neoplasms/surgery
Language	English
Publishing date	2017-12-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2767575-0
ISSN	2332-4260 ; 2332-4252
ISSN (online)	2332-4260
ISSN	2332-4252
DOI	10.1093/ons/opx272
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Zs.A 1424 -ON-: Show issues

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Article ; Online: Comparison of 3D C-arm-based registration to conventional pair-point registration regarding navigation accuracy in ENT surgery.

Grauvogel, Tanja Daniela / Becker, Christoph / Hassepass, Frederike / Arndt, Susan / Laszig, Roland / Maier, Wolfgang

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

2015 Volume 152, Issue 2, Page(s) 266–271

Abstract: Objective: Navigation surgery on the skull base requires high navigation accuracy. The registration process is related to the main loss in accuracy. This study compared titanium screw registration with an inbuilt registration process of a 3-dimensional ( ...

Abstract	Objective: Navigation surgery on the skull base requires high navigation accuracy. The registration process is related to the main loss in accuracy. This study compared titanium screw registration with an inbuilt registration process of a 3-dimensional (3D) C-arm. Study design: Experimental phantom study. Setting: Operating room. Subjects and methods: Four skull models were fabricated with a 3D printer based on the patient's computed tomography (CT) data sets and fitted with an individually customized silicone skin. A 3D-isocentric C-arm fluoroscopic image intensifier system combined with a flat panel detector performed scans of petrous bones (PB) and paranasal sinuses (PS). The navigation accuracy of pair-point registration (PPR) with titanium screws was compared with C-arm-based registration. Results: Overall navigation accuracy was 1.53 ± 0.51 mm after PPR and 1.26 ± 0.12 mm after C-arm registration (P = .0259). PPR showed the best accuracy results on PS (1.28 ± 0.69 mm), followed by right PB (1.43 ± 0.52 mm) and left PB (1.74 ± 0.69 mm). A significant difference was seen only between PS and left PB (P = .0206). In contrast, C-arm registration revealed significantly lower target registration errors (TREs) on PB (0.99 ± 0.23 mm right PB, P < .0001; 1.2 ± 0.35 mm left PB, P = .0412) compared with PS. When comparing both registration modalities, C-arm registration was significantly superior on PB. With respect to specific anatomic locations, C-arm-based registration showed significantly lower TREs on the frontal and lateral skull base than PPR. Conclusion: C-arm-based navigation shows higher navigation accuracy on the skull base compared with PPR. As the 3D C-arm allows real-time imaging and real-time navigation, it will be a helpful tool for skull base surgeons.
MeSH term(s)	Bone Screws ; Humans ; Imaging, Three-Dimensional/instrumentation ; Paranasal Sinuses/surgery ; Phantoms, Imaging ; Skull Base/surgery ; Surgery, Computer-Assisted/methods ; Titanium ; Tomography, X-Ray Computed/instrumentation ; X-Ray Intensifying Screens
Chemical Substances	Titanium (D1JT611TNE)
Language	English
Publishing date	2015-02
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	392085-9
ISSN	1097-6817 ; 0161-6439 ; 0194-5998
ISSN (online)	1097-6817
ISSN	0161-6439 ; 0194-5998
DOI	10.1177/0194599814561175
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Ul II Zs.83/a: Show issues

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Article ; Online: Combined effects of chronic and acute ethanol on pancreatic injury and microcirculation.

Grauvogel, Juergen / Grauvogel, Tanja Daniela / Gebhard, Martha-Maria / Werner, Jens

Pancreas

2012 Volume 41, Issue 5, Page(s) 717–723

Abstract: Objectives: Aim of the study was to investigate pancreatic microcirculatory and histopathological changes in rats after chronic ethanol liquid diet feeding.: Methods: To investigate the influence of chronic alcohol exposition (CAE) on the pancreas, ... ...

Abstract	Objectives: Aim of the study was to investigate pancreatic microcirculatory and histopathological changes in rats after chronic ethanol liquid diet feeding. Methods: To investigate the influence of chronic alcohol exposition (CAE) on the pancreas, rats were fed with either Lieber-DeCarli (LDC) control diet or LDC alcohol diet for 2, 4, or 6 weeks and received additionally an acute ethanol administration (AEA) for 90 minutes. Intravital microscopy was performed at baseline, 45 minutes, and 90 minutes after starting AEA. Pancreatic perfusion and leukocyte adhesion were assessed, and pancreatic damage was evaluated by histology. Results: Capillary perfusion was reduced in all animals after AEA. After previous CAE, there was a significant increase in leukocyte adhesion compared to control groups (P < 0.05). Most importantly, leukocyte adhesions were already increased at baseline after CAE and before the acute bolus was infused (P < 0.05). Moreover, only animals that received LDC alcohol diet developed mild histological changes consisting of pancreatic edema and vacuoles, whereas those that received AEA alone did not. Histological changes and cytokine levels correlated with the duration of prior CAE. Conclusions: Long-term alcohol intake activates endothelium and sensitizes the pancreas for inflammatory reactions leading to an increased likelihood of a clinically evident episode of acute pancreatitis.
MeSH term(s)	Acute Disease ; Animals ; Cell Adhesion/drug effects ; Central Nervous System Depressants/administration & dosage ; Central Nervous System Depressants/toxicity ; Diet ; Edema/chemically induced ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Ethanol/administration & dosage ; Ethanol/toxicity ; Infusions, Intravenous ; Interleukin-6/metabolism ; Leukocytes/drug effects ; Leukocytes/metabolism ; Male ; Microcirculation/drug effects ; Pancreas/blood supply ; Pancreas/drug effects ; Pancreas/pathology ; Pancreatitis/chemically induced ; Rats ; Rats, Wistar ; Time Factors
Chemical Substances	Central Nervous System Depressants ; Interleukin-6 ; Ethanol (3K9958V90M)
Language	English
Publishing date	2012-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0b013e318243a640
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Zs.A 2160: Show issues

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Conference proceedings: Vergleich nicht-invasiver Referenzierungs- und Registrierungsverfahren an 3 Navigationssystemen mit unterschiedlicher Tracking-Technologie

Grauvogel, Tanja Daniela / Engelskirchen, Paul / Soteriou, Eric / Maier, Wolfgang / Laszig, Roland

2016 , Page(s) 16hnod074

Event/congress	87. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; Düsseldorf; Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 2016
Keywords	Medizin, Gesundheit
Publishing date	2016-03-30
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/16hnod074
Database	German Medical Science

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Conference proceedings: Wie exakt ist eine ausschließlich nichtinvasive Navigation in der Schädelbasischirurgie? Experimentelle Analyse invasiver und nichtinvasiver Registrierungsverfahren am Schädelphantom

Maier, Wolfgang / Engelskirchen, Paul / Schulte-Mönting, Jürgen / Grauvogel, Tanja Daniela

2013 , Page(s) 13hnod101

Event/congress	84. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; Nürnberg; Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 2013
Keywords	Medizin, Gesundheit
Publishing date	2013-04-15
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/13hnod101
Database	German Medical Science

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Conference proceedings: Experimentelle Messungen zur Navigationsgenauigkeit von 3D-Aufnahmen durch ein C-Bogen-System mit Flachdetektor

Becker, Christoph / Grauvogel, Tanja Daniela / Aschendorff, Antje / Maier, Wolfgang

2012 , Page(s) 12hnod073

Event/congress	83. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; Mainz; Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 2012
Keywords	Medizin, Gesundheit
Publishing date	2012-04-04
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/12hnod073
Database	German Medical Science

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