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Article ; Online: Rapid exchange cooling with trapped ions.

Fallek, Spencer D / Sandhu, Vikram S / McGill, Ryan A / Gray, John M / Tinkey, Holly N / Clark, Craig R / Brown, Kenton R

Nature communications

2024 Volume 15, Issue 1, Page(s) 1089

Abstract: The trapped-ion quantum charge-coupled device (QCCD) architecture is a leading candidate for advanced quantum information processing. In current QCCD implementations, imperfect ion transport and anomalous heating can excite ion motion during a ... ...

Abstract	The trapped-ion quantum charge-coupled device (QCCD) architecture is a leading candidate for advanced quantum information processing. In current QCCD implementations, imperfect ion transport and anomalous heating can excite ion motion during a calculation. To counteract this, intermediate cooling is necessary to maintain high-fidelity gate performance. Cooling the computational ions sympathetically with ions of another species, a commonly employed strategy, creates a significant runtime bottleneck. Here, we demonstrate a different approach we call exchange cooling. Unlike sympathetic cooling, exchange cooling does not require trapping two different atomic species. The protocol introduces a bank of "coolant" ions which are repeatedly laser cooled. A computational ion can then be cooled by transporting a coolant ion into its proximity. We test this concept experimentally with two
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45232-z
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Article ; Online: Characterization of a vacuum ultraviolet light source at 118 nm.

Gray, John M / Bossert, Jason / Shyur, Yomay / Saarel, Ben / Briles, Travis C / Lewandowski, H J

The Journal of chemical physics

2021 Volume 154, Issue 2, Page(s) 24201

Abstract: Vacuum ultraviolet (VUV) light at 118 nm has been shown to be a powerful tool to ionize molecules for various gas-phase chemical studies. A convenient table top source of 118 nm light can be produced by frequency tripling 355 nm light from a Nd:YAG laser ...

Abstract	Vacuum ultraviolet (VUV) light at 118 nm has been shown to be a powerful tool to ionize molecules for various gas-phase chemical studies. A convenient table top source of 118 nm light can be produced by frequency tripling 355 nm light from a Nd:YAG laser in xenon gas. This process has a low efficiency, typically producing only nJ/pulse of VUV light. Simple models of the tripling process predict that the power of 118 nm light produced should increase quadratically with increasing xenon pressure. However, experimental 118 nm production has been observed to reach a maximum and then decrease to zero with increasing xenon pressure. Here, we describe the basic theory and experimental setup for producing 118 nm light and a new proposed model for the mechanism limiting the production based on pressure broadened absorption.
Language	English
Publishing date	2021-01-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0033135
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Article ; Online: The effect of self-monitoring on Wisconsin Card Sorting Test performance in euthymic patients with bipolar disorder: a pilot study.

Robinson, Lucy J / Gray, John M / Ferrier, I Nicol / Gallagher, Peter

Cognitive neuropsychiatry

2016 Volume 21, Issue 3, Page(s) 256–270

Abstract: Objectives: Euthymic patients with bipolar disorder (BD) show executive impairment. Assisting cognitive function with non-pharmacological strategies has not been widely explored in BD. In schizophrenia, concomitant verbalisation (self-monitoring) during ...

Abstract	Objectives: Euthymic patients with bipolar disorder (BD) show executive impairment. Assisting cognitive function with non-pharmacological strategies has not been widely explored in BD. In schizophrenia, concomitant verbalisation (self-monitoring) during executive tests improved performance. The present pilot study assesses the effects of self-monitoring whilst completing the Wisconsin Card Sorting Test (WCST) in BD patients. Methods: Thirty-six euthymic BD patients and 42 healthy controls participated. Twenty patients with BD and 20 controls received standard administration and 16 patients and 22 controls used self-monitoring during the test. Results: ANCOVA revealed a significant "group by administration" interaction. Patients who received the standard administration were significantly worse than healthy controls (trials administered: p = .012, η p (2) = 0.17; trials to first category: p = .046, η p (2) = 0.11; failure to maintain set: p = .003, η p (2) = 0.23). BD patients who self-monitored performed significantly better than patients receiving the standard administration (trials to first category: p = .020, η p (2) = 0.17) and showed no significant differences in performance compared to controls. Conclusion: Self-monitoring deserves further investigation as a tool that may be helpful for patients with BD. Further exploration of the utility, generalisability, and stability of the effects of self-monitoring is needed.
MeSH term(s)	Adolescent ; Adult ; Bipolar Disorder/psychology ; Case-Control Studies ; Cognition Disorders/psychology ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Pilot Projects ; Self Concept ; Young Adult
Language	English
Publishing date	2016-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2028330-1
ISSN	1464-0619 ; 1354-6805
ISSN (online)	1464-0619
ISSN	1354-6805
DOI	10.1080/13546805.2016.1184134
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Article ; Online: Processing of Facial Emotion in Bipolar Depression and Euthymia.

Robinson, Lucy J / Gray, John M / Burt, Mike / Ferrier, I Nicol / Gallagher, Peter

Journal of the International Neuropsychological Society : JINS

2015 Volume 21, Issue 9, Page(s) 709–721

Abstract: Previous studies of facial emotion processing in bipolar disorder (BD) have reported conflicting findings. In independently conducted studies, we investigate facial emotion labeling in euthymic and depressed BD patients using tasks with static and ... ...

Abstract	Previous studies of facial emotion processing in bipolar disorder (BD) have reported conflicting findings. In independently conducted studies, we investigate facial emotion labeling in euthymic and depressed BD patients using tasks with static and dynamically morphed images of different emotions displayed at different intensities. Study 1 included 38 euthymic BD patients and 28 controls. Participants completed two tasks: labeling of static images of basic facial emotions (anger, disgust, fear, happy, sad) shown at different expression intensities; the Eyes Test (Baron-Cohen, Wheelwright, Hill, Raste, & Plumb, 2001), which involves recognition of complex emotions using only the eye region of the face. Study 2 included 53 depressed BD patients and 47 controls. Participants completed two tasks: labeling of "dynamic" facial expressions of the same five basic emotions; the Emotional Hexagon test (Young, Perret, Calder, Sprengelmeyer, & Ekman, 2002). There were no significant group differences on any measures of emotion perception/labeling, compared to controls. A significant group by intensity interaction was observed in both emotion labeling tasks (euthymia and depression), although this effect did not survive the addition of measures of executive function/psychomotor speed as covariates. Only 2.6-15.8% of euthymic patients and 7.8-13.7% of depressed patients scored below the 10th percentile of the controls for total emotion recognition accuracy. There was no evidence of specific deficits in facial emotion labeling in euthymic or depressed BD patients. Methodological variations-including mood state, sample size, and the cognitive demands of the tasks-may contribute significantly to the variability in findings between studies.
MeSH term(s)	Adult ; Bipolar Disorder/psychology ; Case-Control Studies ; Depression/psychology ; Emotions ; Executive Function ; Facial Expression ; Female ; Humans ; Male ; Middle Aged ; Psychomotor Performance
Language	English
Publishing date	2015-10-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1230632-0
ISSN	1469-7661 ; 1355-6177
ISSN (online)	1469-7661
ISSN	1355-6177
DOI	10.1017/S1355617715000909
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Article ; Online: Performance monitoring and executive control of attention in euthymic bipolar disorder: employing the CPT-AX paradigm.

Robinson, Lucy J / Thompson, Jill M / Gallagher, Peter / Gray, John M / Young, Allan H / Ferrier, I Nicol

Psychiatry research

2013 Volume 210, Issue 2, Page(s) 457–464

Abstract: Reduced cognitive test performance has been demonstrated in patients with bipolar disorder (BD), even when euthymic. Several studies have explored aspects of attention, including sustained attention, and reported patients show lower accuracy compared to ... ...

Abstract	Reduced cognitive test performance has been demonstrated in patients with bipolar disorder (BD), even when euthymic. Several studies have explored aspects of attention, including sustained attention, and reported patients show lower accuracy compared to controls. It is necessary to modify existing attentional paradigms to fully characterise such deficits. The present study sought to examine if there are changes in the profile of performance and error-types during a sustained attention task in BD. Twenty-two euthymic patients with DSM-IV diagnosed BD and 21 healthy controls were recruited. Participants completed a modified CPT-AX paradigm with a high proportion of target trials (70%) with cues and probes presented at continuous intervals. This modification increases the demands on response inhibition and permits the deconstruction of attentional/executive deficits previously described. Overall, BD patients showed significantly poorer target discriminability compared to controls. In block one (first quarter) of the task, patients showed no significant differences to controls, but by the final fourth block (last quarter) they made significantly fewer hits and more errors (both 'AX' misses and 'BX' false alarms). BD patients completed initial stages of the task similarly to controls, but as demands on the attentional system continued difficulties emerged, consistent with problems in context-maintenance.
MeSH term(s)	Adult ; Attention/physiology ; Bipolar Disorder/complications ; Bipolar Disorder/psychology ; Case-Control Studies ; Diagnostic and Statistical Manual of Mental Disorders ; Executive Function/physiology ; Female ; Humans ; Interviews as Topic ; Male ; Middle Aged ; Psychiatric Status Rating Scales/statistics & numerical data ; Psychomotor Performance/physiology ; Reaction Time/physiology ; Task Performance and Analysis
Language	English
Publishing date	2013-12-15
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2013.06.039
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Article: Neurocognitive function following remission in major depressive disorder: potential objective marker of response?

Gallagher, Peter / Robinson, Lucy J / Gray, John M / Porter, Richard J / Young, Allan H

The Australian and New Zealand journal of psychiatry

2007 Volume 41, Issue 1, Page(s) 54–61

Abstract: Objective: Neurocognitive deficits have been widely reported in patients with mood disorders. However, relatively little is known of the short-term trajectory of neurocognitive improvement once treatment has been initiated.: Method: A neurocognitive ... ...

Abstract	Objective: Neurocognitive deficits have been widely reported in patients with mood disorders. However, relatively little is known of the short-term trajectory of neurocognitive improvement once treatment has been initiated. Method: A neurocognitive test battery was administered to unipolar depressed (major depressive disorder, MDD) patients (aged 18-65 years) who had been medication-free for at least 6 weeks, and to healthy controls. Patients were then treated according to clinical need, predominantly with standard pharmacotherapy, and all participants were followed up within 6 months. Results: Of the 25 MDD patients who returned at follow up, 11 were defined as remitted and 14 as not remitted. Significantly less baseline psychomotor dysfunction was observed in patients who remitted compared to those who did not (effect size, d =0.78, 95% confidence interval (CI) =0.07-1.44). Analysis of the change scores between assessments revealed a significantly greater improvement in verbal memory in patients who remitted compared to those who did not (d =0.73, 95%CI =0.03-1.39). Conclusions: This preliminary report suggests that there may be distinct temporal trajectories of neurocognitive improvement following remission in MDD. Aspects of neurocognitive functioning should be examined further as a means of providing a useful objective marker of treatment response.
MeSH term(s)	Adolescent ; Adult ; Brain/physiopathology ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology ; Cognition Disorders/physiopathology ; Depressive Disorder, Major/psychology ; Diagnostic and Statistical Manual of Mental Disorders ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Paired-Associate Learning ; Psychometrics ; Remission Induction ; Severity of Illness Index
Language	English
Publishing date	2007-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	221140-3
ISSN	1440-1614 ; 0004-8674
ISSN (online)	1440-1614
ISSN	0004-8674
DOI	10.1080/00048670601057734
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Article ; Online: Differential deficit in executive control in euthymic bipolar disorder.

Thompson, Jill Maria / Gray, John M / Crawford, John R / Hughes, John H / Young, Allan H / Ferrier, I Nicol

Journal of abnormal psychology

2009 Volume 118, Issue 1, Page(s) 146–160

Abstract: Patients with remitted bipolar disorder (BD) have persistent cognitive deficits, but the nature and specificity of this deficit remain unclear. The authors evaluated the executive hypothesis of BD by determining whether (a) patients' executive deficits ... ...

Abstract	Patients with remitted bipolar disorder (BD) have persistent cognitive deficits, but the nature and specificity of this deficit remain unclear. The authors evaluated the executive hypothesis of BD by determining whether (a) patients' executive deficits qualify as differential deficits, that is, that these significantly exceed deficits in other cognitive domains; (b) deficits in particular executive functions are evident, and (c) executive difficulties mediate declarative memory deficits in BD. The cognitive performance of 63 prospectively verified euthymic bipolar patients was compared with controls, using J. Baron and R. Trieman's (1980) method of testing for differences in nonindependent correlations. There were no differential deficits within the executive domain. Patients' generic executive performance was differentially impaired relative to primary verbal memory and retention in declarative memory, but not relative to their declarative recall, recognition, or their psychomotor performance. However, patients' executive deficit was not an artifact of their poor psychomotor performance. Executive performance accounted for all but a trivial portion of the between-group variance in declarative memory. Persistent cognitive difficulties in euthymic bipolar disorder (EBD) are thus usefully characterized as a generic dysexecutive syndrome.
MeSH term(s)	Bipolar Disorder/epidemiology ; Cognition Disorders/diagnosis ; Cognition Disorders/epidemiology ; Diagnostic and Statistical Manual of Mental Disorders ; Female ; Humans ; Male ; Memory Disorders/diagnosis ; Memory Disorders/epidemiology ; Middle Aged ; Neuropsychological Tests ; Prospective Studies ; Psychomotor Disorders/diagnosis ; Psychomotor Disorders/epidemiology ; Recovery of Function ; Retention (Psychology) ; Severity of Illness Index
Language	English
Publishing date	2009-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3127-6
ISSN	1939-1846 ; 0021-843X ; 0096-851X ; 0145-2339 ; 0145-2347
ISSN (online)	1939-1846
ISSN	0021-843X ; 0096-851X ; 0145-2339 ; 0145-2347
DOI	10.1037/a0014740
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Book ; Online: Schools on the Edge

MacBeath, John / Cullen, Jane / Frost, David / Gray, John M / Steward, Susan / Swaffield, Sue

Responding to Challenging Circumstances

2006

Abstract: An ideal text for challenging the thinking of those studying for NPQH… The conclusion by the authors suggests nine major points to consider if improvement for schools in extremely challenging circumstances is to happen and be sustained. These 'nine ... ...

Abstract	'An ideal text for challenging the thinking of those studying for NPQH… The conclusion by the authors suggests nine major points to consider if improvement for schools in extremely challenging circumstances is to happen and be sustained. These 'nine lesson for policy makers' are very frank and pertinent points, let's hope at least some of our policy makers read them!' - ESCalate 'Rarely does a book on education reform capture both the big and the small picture with such brilliant clarity. MacBeath and his colleagues furnish a 'no holds barred' account of the ins and outs of understanding an
Language	English
Size	Online-Ressource (167 p)
Publisher	SAGE Publications
Publishing place	London
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9781412929707 ; 1412929709
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Impaired working memory monitoring in euthymic bipolar patients.

Thompson, Jill M / Gray, John M / Hughes, John H / Watson, Stuart / Young, Allan H / Ferrier, I Nicol

Bipolar disorders

2007 Volume 9, Issue 5, Page(s) 478–489

Abstract: Objectives: Converging evidence suggests that patients with remitted bipolar disorder (BD) have a persistent cognitive deficit in the executive control of working memory (WM). However, the component operations that contribute to this deficit remain ... ...

Abstract	Objectives: Converging evidence suggests that patients with remitted bipolar disorder (BD) have a persistent cognitive deficit in the executive control of working memory (WM). However, the component operations that contribute to this deficit remain unclear. The aim of the present study was to further profile the nature and specificity of WM impairment in euthymic BD. Methods: Fifty DSM-IV-confirmed patients with euthymic BD and demographically matched controls completed a modified version of the Self-Ordered Pointing Task (SOPT) and the Cambridge Neuropsychological Test Automated Battery Pattern Recognition Test along with traditional executive and WM tasks [Stroop, initial letter Verbal Fluency (FAS), Trail-Making, Digits Forwards and Backwards]. Prospective clinical ratings over one month prior to testing confirmed that patients were euthymic at test. Absence of basal hypercortisolaemia was confirmed by serial saliva sampling. Results: Error analysis revealed that whilst patients made more errors on the SOPT overall, they were no more likely to perseverate than controls. Patients' erroneous responses did not proliferate across trials, suggesting that proactive interference did not contribute to their poor performance, but serial position effects were evident where patients' errors clustered towards the end of a trial. No differences were found on the recognition memory test, in WM capacity, or on two of the three traditional executive procedures (FAS and Trail-Making). However, patients' Digits Backwards was impaired. Conclusions: These data suggest that patients with BD have a deficit in their ability to monitor the contents of WM. This deficit is not an epiphenomenon of mood, but may be due to enduring brain dysfunction, integral to bipolar illness.
MeSH term(s)	Adult ; Affect ; Bipolar Disorder/drug therapy ; Bipolar Disorder/epidemiology ; Demography ; Depression/diagnosis ; Depression/epidemiology ; Diagnostic and Statistical Manual of Mental Disorders ; Female ; Humans ; Hydrocortisone/analysis ; Male ; Memory Disorders/diagnosis ; Memory Disorders/epidemiology ; Memory, Short-Term ; Neuropsychological Tests ; Prospective Studies ; Psychotropic Drugs/therapeutic use ; Recognition (Psychology) ; Saliva/chemistry ; Surveys and Questionnaires
Chemical Substances	Psychotropic Drugs ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2007-08
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1472242-2
ISSN	1399-5618 ; 1398-5647
ISSN (online)	1399-5618
ISSN	1398-5647
DOI	10.1111/j.1399-5618.2007.00470.x
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Article: Executive and visuospatial sketchpad resources in euthymic bipolar disorder: Implications for visuospatial working memory architecture.

Thompson, Jill M / Hamilton, C J / Gray, John M / Quinn, J G / Mackin, Paul / Young, Allan H / Ferrier, I Nicol

Memory (Hove, England)

2006 Volume 14, Issue 4, Page(s) 437–451

Abstract: Visuospatial working memory theory is used to interpret the cognitive impairment in euthymic bipolar disorder. Such patients show deficits in the Corsi Blocks Test (CBT) and executive control. To understand these deficits, 20 euthymic bipolar patients ... ...

Abstract	Visuospatial working memory theory is used to interpret the cognitive impairment in euthymic bipolar disorder. Such patients show deficits in the Corsi Blocks Test (CBT) and executive control. To understand these deficits, 20 euthymic bipolar patients and controls were administered the CBT, Visual Patterns Test (VPT), and a new visual memory task designed to make minimal demands on executive resources. Initial analyses validated the visual memory task and implicated executive involvement in the CBT and VPT. Subsequent analyses on a number of tests confirmed CBT and executive deficits while performance was normal on the VPT and visual memory test. ANCOVA indicated that impaired executive function underpinned patients' CBT performance. Implications for the interface between executive and slave systems of working memory are discussed.
MeSH term(s)	Adolescent ; Adult ; Analysis of Variance ; Bipolar Disorder/psychology ; Cognition ; Cognition Disorders/psychology ; Female ; Humans ; Judgment ; Male ; Memory, Short-Term ; Models, Psychological ; Psychological Tests ; Space Perception ; Visual Perception
Language	English
Publishing date	2006-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1147478-6
ISSN	1464-0686 ; 0965-8211
ISSN (online)	1464-0686
ISSN	0965-8211
DOI	10.1080/09658210500464293
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