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  1. Article ; Online: Non-ischemic rupture of the posteromedial papillary muscle due to

    Tunovic, Sanjin / Boateng, Percy / Song, David / Graziano, Rebecca / Silbiger, Jeffrey J

    Journal of cardiology cases

    2024  Volume 29, Issue 3, Page(s) 101–103

    Abstract: Papillary muscle rupture is usually caused by myocardial infarction although rare cases of non-ischemic etiology have also been described. Among these, infective endocarditis represents an important cause. Herein, we report a case due to : Learning ... ...

    Abstract Papillary muscle rupture is usually caused by myocardial infarction although rare cases of non-ischemic etiology have also been described. Among these, infective endocarditis represents an important cause. Herein, we report a case due to
    Learning objective: Non-ischemic papillary muscle rupture should be suspected when there is no evidence of atherosclerotic coronary artery disease. In the febrile patient, infective endocarditis should be considered in the differential diagnosis.
    Language English
    Publishing date 2024-01-19
    Publishing country Japan
    Document type Case Reports
    ISSN 1878-5409
    ISSN (online) 1878-5409
    DOI 10.1016/j.jccase.2023.09.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Significance of the Percentage of Gleason Pattern 4 at Prostate Biopsy in Predicting Adverse Pathology on Radical Prostatectomy: Application in Active Surveillance.

    Ordner, Jeffrey / Flaifel, Abdallah / Serrano, Antonio / Graziano, Rebecca / Melamed, Jonathan / Deng, Fang-Ming

    American journal of clinical pathology

    2023  Volume 160, Issue 1, Page(s) 35–40

    Abstract: Objectives: To determine the prognostic significance of the maximum allowable percentage of Gleason pattern 4 (GP4) at prostate biopsy compared with adverse pathology observed at radical prostatectomy (RP) to expand active surveillance eligibility among ...

    Abstract Objectives: To determine the prognostic significance of the maximum allowable percentage of Gleason pattern 4 (GP4) at prostate biopsy compared with adverse pathology observed at radical prostatectomy (RP) to expand active surveillance eligibility among a cohort with intermediate risk of prostate cancer.
    Methods: A retrospective study of patients with grade group (GG) 1 or 2 prostate cancer on prostate biopsy with subsequent RP was performed at our institution. A Fisher exact test was used to understand the relationship among GP4 subgroups (0%, ≤5%, 6%-10%, and 11%-49%) assigned at biopsy and adverse pathologic findings at RP. Additional analyses comparing the GP4 ≤5% cohort's prebiopsy prostate-specific antigen (PSA) level and GP4 length with adverse pathology at RP were also performed.
    Results: No statistically significant difference in adverse pathology at RP was observed between the active surveillance-eligible control (GP4 0%) and the GP4 ≤5% subgroup. In total, 68.9% of the GP4 ≤5% cohort showed favorable pathologic outcomes. A separate analysis of the GP4 ≤5% subgroup revealed that neither prebiopsy serum PSA levels nor GP4 length showed statistical correlation with adverse pathology at RP.
    Conclusions: Active surveillance may be a reasonable option for management of patients in the GP4 ≤5% group until long-term follow-up data become available.
    MeSH term(s) Male ; Humans ; Prostate/surgery ; Prostate/pathology ; Prostate-Specific Antigen ; Retrospective Studies ; Watchful Waiting ; Biopsy ; Prostatectomy ; Prostatic Neoplasms/pathology ; Neoplasm Grading
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77) ; GP 4 (81746-15-8)
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqad005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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