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Article ; Online: Naturalistic assessment of everyday multitasking in Parkinson's disease with and without mild cognitive impairment.

Schmitter-Edgecombe, Maureen / Brown, Katelyn / Chilton, Reanne Cunningham / Whiteley, Nicole / Greeley, David

2024 , Page(s) 1–21

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	639080-8
ISSN	1744-4144 ; 0920-1637 ; 1385-4046
ISSN (online)	1744-4144
ISSN	0920-1637 ; 1385-4046
DOI	10.1080/13854046.2024.2325681
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Article: A Retrospective Cost Analysis of Patients Who Switched from OnabotulinumtoxinA to IncobotulinumtoxinA in a Private Neurology Practice.

Karschney, Victoria K / Greeley, David R

American health & drug benefits

2019 Volume 13, Issue 5, Page(s) 205–210

Abstract: Background: Botulinum neurotoxin type A (BoNT-A) is an effective treatment for many chronic conditions, but the economic implications of repeated treatments can be a burden on patients. The 3 commercial preparations of BoNT-A types available today are ... ...

Abstract	Background: Botulinum neurotoxin type A (BoNT-A) is an effective treatment for many chronic conditions, but the economic implications of repeated treatments can be a burden on patients. The 3 commercial preparations of BoNT-A types available today are onabotulinumtoxinA, abobotulinumtoxinA, and incobotulinumtoxinA, but no clear differences have been found in clinical efficacy between these 3 type A toxins in blinded comparative studies. Objective: To conduct a cost-minimization analysis in a cohort of patients with chronic neurologic conditions who switched treatment from onabotulinumtoxinA to incobotulinumtoxinA. Methods: The study was a single-center, retrospective review of data from a large, private, neurological practice in Spokane, WA. A comprehensive patient chart review was conducted of all patients who were switched from established onabotulinumtoxinA therapy to incobotulinumtoxinA therapy between 2012 and 2019. The patients were switched at a 1:1-unit ratio. All patients had commercial insurance or Medicare coverage. Dosage, injection intervals, wastage, treatment costs, switchback data, and patient savings program eligibility were evaluated for the period of 1 year before and 1 year after the switch from onabotulinumtoxinA to incobotulinumtoxinA therapy. Results: The most frequently treated indication was cervical dystonia (N = 61; 54.5%), followed by chronic migraine (N = 36; 32.1%). After switching to incobotulinumtoxinA therapy, botulinum toxin wastage was reduced by 87.3% (from 150.9 units to 19.1 units), and the cost was reduced by 32.2% (from $5108 to $3461) per patient annually. A total of 14,635 units in unavoidable wastage and $182,792 in annual botulinum toxin costs were saved as a result of the switch in therapy. Patients remained at consistent dosing intervals after switching to incobotulinumtoxinA therapy. A total of 8 patients switched back to onabotulinumtoxinA treatment during this review, including 3 patients who switched back because of insurance reasons, and 5 who had self-reported efficacy concerns. The 70 commercially insured patients in the study who were eligible for the patient savings program for each of the 2 therapies saved an average of $2076 (241.5%) in annual costs after switching from onabotulinumtoxinA to incobotulinumtoxinA. Conclusion: Our findings showed that switching from onabotulinumtoxinA to incobotulinumtoxinA at similar intervals and dosages achieved considerable cost-savings, with a low incidence of switching back.
Language	English
Publishing date	2019-12-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2853721-X
ISSN	1942-2970 ; 1942-2962
ISSN (online)	1942-2970
ISSN	1942-2962
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Article ; Online: A Comparison of Functional Abilities in Individuals with Mild Cognitive Impairment and Parkinson's Disease with Mild Cognitive Impairment Using Multiple Assessment Methods.

Schmitter-Edgecombe, Maureen / McAlister, Courtney / Greeley, David

Journal of the International Neuropsychological Society : JINS

2021 Volume 28, Issue 8, Page(s) 798–809

Abstract: Objective: This study used multiple assessment methods to examine instrumental activities of daily living (IADLs) performance in individuals with Parkinson's disease with mild cognitive impairment (PD-MCI) compared to individuals with mild cognitive ... ...

Abstract	Objective: This study used multiple assessment methods to examine instrumental activities of daily living (IADLs) performance in individuals with Parkinson's disease with mild cognitive impairment (PD-MCI) compared to individuals with mild cognitive impairment (MCI) and cognitively healthy older adults (HOA). Associations between functional performance and cognition were also examined. Methods: Eighteen individuals with PD-MCI, 48 individuals with MCI, and 66 HOAs were assessed with multiple IADL measures, including direct observation, a performance-based measure, and self- and informant-report questionnaires. Performance on the direct-observation measure was further characterized by coding for four error types: omissions, substitutions, and inefficient and irrelevant/off-task actions. Results: Both the PD-MCI and MCI groups performed more poorly on the overall score for all IADL measures relative to HOAs. Although the PD-MCI and MCI groups did not differ in overall performance, on the direct-observation measure, the PD-MCI group took longer and made more inefficient and irrelevant/off-task errors relative to the HOA and MCI groups, whereas the MCI group made more omission and substitution errors relative to HOAs. Further, the pattern of cognitive correlates that associated most strongly with the functional measures varied across groups and functional assessment methods. Conclusion: Compared to HOAs, PD-MCI and MCI groups demonstrated increased difficulties performing everyday activities, and cognitive and motor abilities differentially contributed to the everyday task difficulties of these two groups.
MeSH term(s)	Activities of Daily Living/psychology ; Aged ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/psychology ; Humans ; Neuropsychological Tests ; Parkinson Disease/complications ; Parkinson Disease/psychology
Language	English
Publishing date	2021-09-06
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	1230632-0
ISSN	1469-7661 ; 1355-6177
ISSN (online)	1469-7661
ISSN	1355-6177
DOI	10.1017/S1355617721001077
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Book: Parkinson's disease

Greeley, David R

current therapeutic approach

(On call)

2003

Abstract: Producer) Focuses on the current therapeutic approach to the management of Parkinson's disease. Discusses currently available medications and the most important side effects. Covers essential patient counseling points. Explains an algorithm for the ... ...

Institution	HSTN
Author's details	[HSTN]
Series title	On call
Abstract	(Producer) Focuses on the current therapeutic approach to the management of Parkinson's disease. Discusses currently available medications and the most important side effects. Covers essential patient counseling points. Explains an algorithm for the treatment of Parkinson's disease. Addresses the importance of adjunctive therapies such as speech therapy and physical conditioning.
MeSH term(s)	Parkinson Disease/therapy ; Parkinson Disease/diagnosis
Language	English
Size	1 videocassette (60 min.) :, sd., col. ;, 1/2 in.
Publisher	Primedia Workplace Learning
Publishing place	Carrollton, TX
Document type	Book
Note	"Month of February 2003 tape 7"--Label. ; Approved for 1.0 AMA PRA category 1 credit hr. of CME credit; for 1.2 contact hr. of CNE credit; and for 1.0 hr./0.10 CEUs of CPE credit.
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: ALSUntangled #66: antimycobacterial antibiotics.

Pierce, Ellen S / Barkhaus, Paul / Beauchamp, Morgan / Bromberg, Mark / Carter, Gregory T / Goslinga, Jill / Greeley, David / Kihuwa-Mani, Sky / Levitsky, Gleb / Lund, Isaac / McDermott, Christopher / Pattee, Gary / Pierce, Kaitlyn / Polak, Meraida / Ratner, Dylan / Wicks, Paul / Bedlack, Richard

Amyotrophic lateral sclerosis & frontotemporal degeneration

2022 Volume 24, Issue 5-6, Page(s) 539–543

Abstract: Several infections have been associated with motor neuron diseases resembling ALS, including species of viruses, bacteria, and parasites. ...

Abstract	Several infections have been associated with motor neuron diseases resembling ALS, including species of viruses, bacteria, and parasites.
MeSH term(s)	Animals ; Humans ; Anti-Bacterial Agents/therapeutic use ; Amyotrophic Lateral Sclerosis/drug therapy ; Amyotrophic Lateral Sclerosis/complications ; Crohn Disease/etiology ; Crohn Disease/microbiology ; Mycobacterium avium subsp. paratuberculosis ; Motor Neuron Disease/complications
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-08-01
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2705049-X
ISSN	2167-9223 ; 2167-8421
ISSN (online)	2167-9223
ISSN	2167-8421
DOI	10.1080/21678421.2022.2104650
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Article: Characterizing multiple memory deficits and their relation to everyday functioning in individuals with mild cognitive impairment.

Schmitter-Edgecombe, Maureen / Woo, Ellen / Greeley, David R

Neuropsychology

2009 Volume 23, Issue 2, Page(s) 168–177

Abstract: The authors evaluated multiple memory processes and explored their contributions to everyday functional limitations in persons with mild cognitive impairment (MCI). Participants included individuals with amnestic MCI, nonamnestic MCI, and healthy older ... ...

Abstract	The authors evaluated multiple memory processes and explored their contributions to everyday functional limitations in persons with mild cognitive impairment (MCI). Participants included individuals with amnestic MCI, nonamnestic MCI, and healthy older adults. As expected, the amnestic MCI group performed more poorly than the control and nonamnestic MCI groups on a content memory measure. Both MCI groups, however, performed more poorly than controls on the noncontent memory measures of prospective memory, temporal order memory, and source memory. Informants also reported that the MCI groups were experiencing greater difficulty than controls completing instrumental activities of daily living (IADLs). Noncontent memory measures were found to make an independent contribution to IADL performances over and above that of content memory. These findings demonstrate that impairments in memory beyond the traditionally assessed content memory are present in individuals with amnestic MCI and with nonamnestic MCI. The results further show that these noncontent memory processes, which have been linked with executive functioning, play a role in supporting IADLs.
MeSH term(s)	Activities of Daily Living ; Aged ; Aged, 80 and over ; Analysis of Variance ; Cognition Disorders/complications ; Cognition Disorders/psychology ; Female ; Humans ; Male ; Memory Disorders/classification ; Memory Disorders/etiology ; Middle Aged ; Neuropsychological Tests
Language	English
Publishing date	2009-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042412-x
ISSN	1931-1559 ; 0894-4105
ISSN (online)	1931-1559
ISSN	0894-4105
DOI	10.1037/a0014186
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Article: Prospective Study Evaluating IncobotulinumtoxinA for Cervical Dystonia or Blepharospasm: Interim Results from the First 145 Subjects with Cervical Dystonia.

Fernandez, Hubert H / Pagan, Fernando / Danisi, Fabio / Greeley, David / Jankovic, Joseph / Verma, Amit / Sethi, Kapil / Pappert, Eric J

Tremor and other hyperkinetic movements (New York, N.Y.)

2013 Volume 3

Abstract: Background: We report the interim results from XCiDaBLE, a large, prospective, observational "naturalistic" study evaluating Xeomin® (incobotulinumtoxinA) for Cervical Dystonia or BLEpharospasm in the United States.: Methods: Subjects (≥ 18 years old) ...

Abstract	Background: We report the interim results from XCiDaBLE, a large, prospective, observational "naturalistic" study evaluating Xeomin® (incobotulinumtoxinA) for Cervical Dystonia or BLEpharospasm in the United States. Methods: Subjects (≥ 18 years old) with cervical dystonia (CD) are followed for two treatment cycles and monitored via Interactive Voice/Web Response. The subject's physician must have chosen to treat with incobotulinumtoxinA prior to and independent of enrollment in this study. Subject-reported scales include the Subject Global Impression-Severity and Improvement and Cervical Dystonia Impact Profile (CDIP-58), and Work Productivity and Quality of Life (QoL) are assessed by means of an employment questionnaire and work history and the SF-12v2 Health Survey (SF-12v2). Subjects are seen by the investigator for three visits, which include a baseline visit (including the first injection), a second injection visit, and a final study visit (12 weeks after the second injection). Results: This ongoing study includes 145 subjects with a diagnosis of CD. The majority were female (82.3%) and white (91.0%) and had previously been treated with botulinum toxins (77.2%). There were 106 employed at the time of disease onset, but 12.6 years later only 44% were still employed at the time of enrolment into the study, and 20% were either receiving or seeking disability benefits. The mean total dose/treatment of CD was 225.2 units for the first injection. The CDIP-58 total score was significantly improved 4 weeks after the first injection compared to baseline (p≤0.0001). Most subjects noted improvement in their global impression assessment. No new or unexpected adverse events occurred. Discussion: The results from these interim analyses confirm previous controlled, single-dose studies of incobotulinumtoxinA in terms of efficacy and safety.
Language	English
Publishing date	2013-05-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2674453-3
ISSN	2160-8288
ISSN	2160-8288
DOI	10.7916/D8CF9NVD
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Article ; Online: Gamma knife radiosurgery for movement disorders

Demakas John J / Lamoreaux Wayne T / Arthurs Benjamin J / Elaimy Ameer L / Mackay Alexander R / Fairbanks Robert K / Greeley David R / Cooke Barton S / Lee Christopher M

World Journal of Surgical Oncology, Vol 8, Iss 1, p

a concise review of the literature

2010 Volume 61

Abstract: Abstract Medication is the predominant method for the management of patients with movement disorders. However, there is a fraction of patients who experience limited relief from pharmaceuticals or experience bothersome side-effects of the drugs. Deep ... ...

Abstract	Abstract Medication is the predominant method for the management of patients with movement disorders. However, there is a fraction of patients who experience limited relief from pharmaceuticals or experience bothersome side-effects of the drugs. Deep brain stimulation (DBS) and surgical lesioning of the thalamus and basal ganglia are respected neurosurgical procedures, with valued success rates and a very low incidence of complications. Despite these positive outcomes, DBS and surgical lesioning procedures are contraindicated for some patients. Stereotactic radiosurgery with the Gamma Knife (GK) has been used as a lesioning technique for patients seeking a non-invasive treatment alternative and for medication-intolerable patients, who are unable to undergo DBS or lesioning due to comorbid medical conditions. Tremors of various etiologies are treated using GK thalamotomy, which targets the ventralis intermedius nucleus. GK thalamotomy produces favorable outcomes when treating tremors, with success rates ranging from 80-100%. In contrast, GK pallidotomy targets the internal globus pallidus, and is used in treating bradykinesia, rigidity, and dyskinesia. Although radiosurgery has proven beneficial for tremors, radiosurgical pallidotomy for bradykinesia, rigidity, and dyskinesia remains questionable, with mixed success rates in the literature that ranges from 0-87%. We suggest that GK thalamotomy be offered along with other neurosurgical approaches as a feasible treatment option to patients who prefer the non-invasive nature of radiosurgery and to those who are unqualified candidates for the neurosurgical alternatives. Also, we advise that patients with bradykinesia, rigidity, and dyskinesia be educated about the variability in the literature pertaining to GK pallidotomy before proceeding with treatment.
Keywords	Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	616
Language	English
Publishing date	2010-07-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Gamma knife radiosurgery for essential tremor

Fairbanks Robert K / Cooke Barton S / Arthurs Benjamin J / Demakas John J / Elaimy Ameer L / Lamoreaux Wayne T / Mackay Alexander R / Greeley David R / Lee Christopher M

World Journal of Surgical Oncology, Vol 8, Iss 1, p

A Case report and review of the literature

2010 Volume 20

Abstract: Abstract Approximately 5 million people in America are affected by essential tremors (ET), which are classified as a type of benign movement disorder. This disease manifests as tremors that usually occur in the hands, but they may also be present in the ... ...

Abstract	Abstract Approximately 5 million people in America are affected by essential tremors (ET), which are classified as a type of benign movement disorder. This disease manifests as tremors that usually occur in the hands, but they may also be present in the head, face, tongue, and lower limbs. Radiofrequency thalamotomy (RF) and deep brain stimulation (DBS) are common invasive procedures with proven track records that are used to treat ET. Although these procedures have high success rates, they still put patients at risk of potential side effects and are invasive by nature. Thalamotomy using the gamma knife (GK) also produces favorable outcomes in treating tremors, without the complications associated with invasive neurosurgery procedures. This report describes the presenting symptoms and extended treatment outcome for a patient with an advanced case of ET, who received GK thalamotomy treatment six years ago. Because of this non-invasive treatment, she regained the ability to paint and live with an improved quality of life. We also discuss and review the relevant literature regarding the risks and benefits of this treatment modality. GK thalamotomy is one effective option for the treatment of ET, and due to its noninvasive nature, it has a different risk profile than neurosurgery. We suggest that GK thalamotomy should be presented as one viable treatment option to all ET patients, and should be recommended to those who would be best served by less invasive treatment techniques.
Keywords	Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2010-03-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Gamma knife radiosurgery for movement disorders: a concise review of the literature.

Elaimy, Ameer L / Arthurs, Benjamin J / Lamoreaux, Wayne T / Demakas, John J / Mackay, Alexander R / Fairbanks, Robert K / Greeley, David R / Cooke, Barton S / Lee, Christopher M

World journal of surgical oncology

2010 Volume 8, Page(s) 61

Abstract: Medication is the predominant method for the management of patients with movement disorders. However, there is a fraction of patients who experience limited relief from pharmaceuticals or experience bothersome side-effects of the drugs. Deep brain ... ...

Abstract	Medication is the predominant method for the management of patients with movement disorders. However, there is a fraction of patients who experience limited relief from pharmaceuticals or experience bothersome side-effects of the drugs. Deep brain stimulation (DBS) and surgical lesioning of the thalamus and basal ganglia are respected neurosurgical procedures, with valued success rates and a very low incidence of complications. Despite these positive outcomes, DBS and surgical lesioning procedures are contraindicated for some patients. Stereotactic radiosurgery with the Gamma Knife (GK) has been used as a lesioning technique for patients seeking a non-invasive treatment alternative and for medication-intolerable patients, who are unable to undergo DBS or lesioning due to comorbid medical conditions. Tremors of various etiologies are treated using GK thalamotomy, which targets the ventralis intermedius nucleus. GK thalamotomy produces favorable outcomes when treating tremors, with success rates ranging from 80-100%. In contrast, GK pallidotomy targets the internal globus pallidus, and is used in treating bradykinesia, rigidity, and dyskinesia. Although radiosurgery has proven beneficial for tremors, radiosurgical pallidotomy for bradykinesia, rigidity, and dyskinesia remains questionable, with mixed success rates in the literature that ranges from 0-87%. We suggest that GK thalamotomy be offered along with other neurosurgical approaches as a feasible treatment option to patients who prefer the non-invasive nature of radiosurgery and to those who are unqualified candidates for the neurosurgical alternatives. Also, we advise that patients with bradykinesia, rigidity, and dyskinesia be educated about the variability in the literature pertaining to GK pallidotomy before proceeding with treatment.
MeSH term(s)	Humans ; Movement Disorders/surgery ; Radiosurgery
Language	English
Publishing date	2010-07-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2118383-1
ISSN	1477-7819 ; 1477-7819
ISSN (online)	1477-7819
ISSN	1477-7819
DOI	10.1186/1477-7819-8-61
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