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  1. Article: The potential for reducing the impact of aviation on climate

    Green, John E

    Technology analysis & strategic management Vol. 21, No. 1 , p. 39-59

    2009  Volume 21, Issue 1, Page(s) 39–59

    Author's details J. E. Green
    Keywords Immissionsschutz ; Luftverkehr ; Klimawandel ; Flugzeugantrieb
    Language English
    Size Ill., graph. Darst.
    Publisher Routledge, Taylor & Francis
    Publishing place Abingdon, Oxfordshire
    Document type Article
    ZDB-ID 32138-2
    Database ECONomics Information System

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  2. Article ; Online: Dynamin function is important for chemokine receptor-induced cell migration.

    Jacques, Richard O / Mills, Shirley C / Cazzonatto Zerwes, Paula / Fagade, Feyisope O / Green, John E / Downham, Scott / Sexton, Darren W / Mueller, Anja

    Cell biochemistry and function

    2015  Volume 33, Issue 6, Page(s) 407–414

    Abstract: The HIV viral entry co-receptors CCR5 and CXCR4 function physiologically as typical chemokine receptors. Activation leads to cytosolic signal transduction that results in a variety of cellular responses such as cytoskeletal rearrangement and chemotaxis ( ... ...

    Abstract The HIV viral entry co-receptors CCR5 and CXCR4 function physiologically as typical chemokine receptors. Activation leads to cytosolic signal transduction that results in a variety of cellular responses such as cytoskeletal rearrangement and chemotaxis (CTX). Our aim was to investigate the signalling pathways involved in CC and CXC receptor-mediated cell migration. Inhibition of dynamin I and II GTPase with dynasore completely inhibited CCL3-stimulated CTX in THP-1 cells, whereas the dynasore analogue Dyngo-4a, which is a more potent inhibitor, showed reduced ability to inhibit CC chemokine-induced CTX. In contrast, dynasore was not able to block cell migration via CXCR4. The same activation/inhibition pattern was verified in activated T lymphocytes for different CC and CXC chemokines. Cell migration induced by CC and CXC receptors does not rely on active internalization processes driven by dynamin because the blockade of internalization does not affect migration, but it might rely on dynamin interaction with the cytoskeleton. We identify here a functional difference in how CC and CXC receptor migration is controlled, suggesting that specific signalling networks are being employed for different receptor classes and potentially specific therapeutic targets to prevent receptor migration can be identified.
    MeSH term(s) Calcium/metabolism ; Cell Line, Tumor ; Cell Movement/drug effects ; Chemokine CCL3/metabolism ; Chemotaxis/drug effects ; Dynamins/antagonists & inhibitors ; Dynamins/chemistry ; Dynamins/metabolism ; Humans ; Hydrazones/pharmacology ; Monocytes/cytology ; Monocytes/metabolism ; Naphthols/pharmacology ; Receptors, CCR5/metabolism ; Receptors, CXCR4/antagonists & inhibitors ; Receptors, CXCR4/metabolism ; Signal Transduction/drug effects ; T-Lymphocytes/metabolism
    Chemical Substances CCR5 protein, human ; Chemokine CCL3 ; Hydrazones ; N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide ; Naphthols ; Receptors, CCR5 ; Receptors, CXCR4 ; dyngo-4a ; Dynamins (EC 3.6.5.5) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2015-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 283643-9
    ISSN 1099-0844 ; 0263-6484
    ISSN (online) 1099-0844
    ISSN 0263-6484
    DOI 10.1002/cbf.3131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Book ; Conference proceedings: Composites for the real world

    Beckwith, Scott W / Green, John E / Strong, A. Brent

    29th International SAMPE Technical Conference, Disney's Coronado Springs Resort, Orlando, Florida, October 28 - November 1, 1997

    (International SAMPE Technical Conference ; v. 29)

    1997  

    Institution Society for the Advancement of Material and Process Engineering
    Event/congress International SAMPE Technical Conference (29, 1997.10.28-11.01, OrlandoFla.)
    Author's details ed. by John E. Green
    Series title International SAMPE Technical Conference ; v. 29
    Language English
    Size XVII, 823 S, Ill, 24 cm
    Publisher Society for the Advancement of Material and Process Engineering
    Publishing place Covina, Calif
    Document type Book ; Conference proceedings
    Note Includes bibliographical references and indexes
    ISBN 0938994786 ; 9780938994787
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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