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  1. AU="Gregg, R J"
  2. AU="Zou, Peiyuan"
  3. AU="Sasha Stevenson"
  4. AU="Boncompagni, Alessandra"
  5. AU="Lewis, Annisa L"
  6. AU="Daniel Freilich"
  7. AU="Glascock, Abigail L"
  8. AU="Gordon Bernard"
  9. AU="Lv, Mengwen"
  10. AU="Rottman Pietrzak, Kathleen A"
  11. AU=Panczak Radoslaw
  12. AU="Hosseini, Seyed Mohammad Hadi"
  13. AU="Noda, Haruna"
  14. AU="Raoul, Cédric"
  15. AU=Wissing Silke AU=Wissing Silke
  16. AU="Chun-Lin Yang"
  17. AU="Romine, Kyle A"
  18. AU="Cunsolo, Vincenzo"
  19. AU="Ba, Aboubacar"
  20. AU="Prisca, Mirandolina"
  21. AU="Perez, Tate"
  22. AU="Bakkaloglu, Sevan"
  23. AU="Guernieri, Rebecca L"
  24. AU="Xing, Z Y"
  25. AU="Yu-Heng Cheng"
  26. AU=Freeman Richard B Jr
  27. AU="Wang, Qi-En"
  28. AU="Mallamaci, M"
  29. AU="Turk, Yael R"
  30. AU="Tinto, Monica"
  31. AU="Selvendiran, Karuppaiyah" AU="Selvendiran, Karuppaiyah"
  32. AU="Enns, Murray W"
  33. AU="Yaohua Yang" AU="Yaohua Yang"

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  1. Buch: German gas appliance industry

    Gregg, R. J

    (B.I.O.S. final report ; 1591)

    1947  

    Verfasserangabe reported by R. J. Gregg
    Serientitel B.I.O.S. final report ; 1591
    Sprache Englisch
    Umfang 21 S
    Verlag British Intelligence Objectives Sub-Committee
    Erscheinungsort London
    Dokumenttyp Buch
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  2. Artikel: P2X7-related modulation of pathological nociception in rats.

    McGaraughty, S / Chu, K L / Namovic, M T / Donnelly-Roberts, D L / Harris, R R / Zhang, X-F / Shieh, C-C / Wismer, C T / Zhu, C Z / Gauvin, D M / Fabiyi, A C / Honore, P / Gregg, R J / Kort, M E / Nelson, D W / Carroll, W A / Marsh, K / Faltynek, C R / Jarvis, M F

    Neuroscience

    2007  Band 146, Heft 4, Seite(n) 1817–1828

    Abstract: Growing evidence supports a role for the immune system in the induction and maintenance of chronic pain. ATP is a key neurotransmitter in this process. Recent studies demonstrate that the glial ATP receptor, P2X7, contributes to the modulation of ... ...

    Abstract Growing evidence supports a role for the immune system in the induction and maintenance of chronic pain. ATP is a key neurotransmitter in this process. Recent studies demonstrate that the glial ATP receptor, P2X7, contributes to the modulation of pathological pain. To further delineate the endogenous mechanisms that are involved in P2X7-related antinociception, we utilized a selective P2X7 receptor antagonist, A-438079, in a series of in vivo and in vitro experiments. Injection of A-438079 (10-300 micromol/kg, i.p.) was anti-allodynic in three different rat models of neuropathic pain and it attenuated formalin-induced nocifensive behaviors. Using in vivo electrophysiology, A-438079 (80 micromol/kg, i.v.) reduced noxious and innocuous evoked activity of different classes of spinal neurons (low threshold, nociceptive specific, wide dynamic range) in neuropathic rats. The effects of A-438079 on evoked firing were diminished or absent in sham rats. Spontaneous activity of all classes of spinal neurons was also significantly reduced by A-438079 in neuropathic but not sham rats. In vitro, A-438079 (1 microM) blocked agonist-induced (2,3-O-(4-benzoylbenzoyl)-ATP, 30 microM) current in non-neuronal cells taken from the vicinity of the dorsal root ganglia. Furthermore, A-438079 dose-dependently (0.3-3 microM) decreased the quantity of the cytokine, interleukin-1beta, released from peripheral macrophages. Thus, ATP, acting through the P2X7 receptor, exerts a wide-ranging influence on spinal neuronal activity following a chronic injury. Antagonism of the P2X7 receptor can in turn modulate central sensitization and produce antinociception in animal models of pathological pain. These effects are likely mediated through immuno-neural interactions that affect the release of endogenous cytokines.
    Mesh-Begriff(e) Action Potentials/drug effects ; Adenosine Triphosphate/analogs & derivatives ; Adenosine Triphosphate/pharmacology ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Animals ; Astrocytoma ; Behavior, Animal/drug effects ; Cell Line, Tumor ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Ganglia, Spinal ; Humans ; Interleukin-1beta/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Neurons ; Pain Measurement/methods ; Purinergic P2 Receptor Agonists ; Purinergic P2 Receptor Antagonists ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Receptors, Purinergic P2/physiology ; Receptors, Purinergic P2X7 ; Sciatica/drug therapy ; Sciatica/metabolism ; Sciatica/physiopathology ; Tetrazoles/pharmacology ; Tetrazoles/therapeutic use ; Time Factors
    Chemische Substanzen 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine ; Analgesics ; Interleukin-1beta ; P2RX7 protein, human ; P2rx7 protein, mouse ; P2rx7 protein, rat ; Purinergic P2 Receptor Agonists ; Purinergic P2 Receptor Antagonists ; Pyridines ; Receptors, Purinergic P2 ; Receptors, Purinergic P2X7 ; Tetrazoles ; 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate (4P5DXU1F8Q) ; Adenosine Triphosphate (8L70Q75FXE)
    Sprache Englisch
    Erscheinungsdatum 2007-06-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2007.03.035
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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