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  1. Book ; Online ; E-Book: On call surgery

    Adams, Gregg A. / Forrester, Jared A. / Rosenberg, Graeme

    (Expert consult)

    2020  

    Author's details Gregg A. Adams, Jared A. Forrester, Graeme M. Rosenberg, Stephen D. Bresnick
    Series title Expert consult
    Keywords Surgical emergencies
    Subject code 617.026
    Language English
    Size 1 Online-Ressource (xvi, 624 Seiten), Illustrationen
    Edition Fourth edition
    Publisher Elsevier
    Publishing place St. Louis, Missouri
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020132292
    ISBN 978-0-323-53166-5 ; 9780323528894 ; 0-323-53166-0 ; 0323528899
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Ham's primary care geriatrics

    Ham, Richard J. / Warshaw, Gregg A. / Potter, Jane F. / Flaherty, Ellen / Heflin, Mitchell T. / McNabney, Matthew K.

    a case-based approach

    2022  

    Title variant Primary care geriatrics
    Author's details edited by Gregg A. Warshaw [and five others]
    Keywords Geriatrics
    Subject code 618.97
    Language English
    Size xviii, 570 Seiten, 28 cm
    Edition Seventh edition
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    Note Previous edition: Philadelphia: Elsevier/Saunders, 2014 ; Includes bibliographical references and index ; Zugang zu Online-Ausgabe über Code
    HBZ-ID HT021073370
    ISBN 978-0-323-72168-4 ; 9780323721691 ; 0-323-72168-0 ; 0323721699
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 A 169 available for loan (reading room) Lesesaal EG
    Zugang zu Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  3. Article ; Online: Phytohormones in a universe of regulatory metabolites: lessons from jasmonate.

    Gasperini, Debora / Howe, Gregg A

    Plant physiology

    2024  Volume 195, Issue 1, Page(s) 135–154

    Abstract: Small-molecule phytohormones exert control over plant growth, development, and stress responses by coordinating the patterns of gene expression within and between cells. Increasing evidence indicates that currently recognized plant hormones are part of a ...

    Abstract Small-molecule phytohormones exert control over plant growth, development, and stress responses by coordinating the patterns of gene expression within and between cells. Increasing evidence indicates that currently recognized plant hormones are part of a larger group of regulatory metabolites that have acquired signaling properties during the evolution of land plants. This rich assortment of chemical signals reflects the tremendous diversity of plant secondary metabolism, which offers evolutionary solutions to the daunting challenges of sessility and other unique aspects of plant biology. A major gap in our current understanding of plant regulatory metabolites is the lack of insight into the direct targets of these compounds. Here, we illustrate the blurred distinction between classical phytohormones and other bioactive metabolites by highlighting the major scientific advances that transformed the view of jasmonate from an interesting floral scent to a potent transcriptional regulator. Lessons from jasmonate research generally apply to other phytohormones and thus may help provide a broad understanding of regulatory metabolite-protein interactions. In providing a framework that links small-molecule diversity to transcriptional plasticity, we hope to stimulate future research to explore the evolution, functions, and mechanisms of perception of a broad range of plant regulatory metabolites.
    MeSH term(s) Cyclopentanes/metabolism ; Oxylipins/metabolism ; Plant Growth Regulators/metabolism ; Gene Expression Regulation, Plant ; Signal Transduction ; Plants/metabolism ; Plants/genetics
    Chemical Substances Cyclopentanes ; Oxylipins ; Plant Growth Regulators ; jasmonic acid (6RI5N05OWW)
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1093/plphys/kiae045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 1193: Show issues

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  4. Article ; Online: Evolving Beyond Average: A Commentary on Murai et al. (2024).

    Weisenbach, S L / Gregg, A P

    Cognitive, affective & behavioral neuroscience

    2024  Volume 24, Issue 2, Page(s) 349–350

    MeSH term(s) Humans
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2029088-3
    ISSN 1531-135X ; 1530-7026
    ISSN (online) 1531-135X
    ISSN 1530-7026
    DOI 10.3758/s13415-024-01176-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5947: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: LGBTQ+ Source.

    Stevens, Gregg A

    Medical reference services quarterly

    2021  Volume 39, Issue 3, Page(s) 280–285

    Abstract: LGBTQ+ Source is a multidisciplinary database from EBSCO. This column will describe the coverage, search features, and potential use for health sciences libraries. Search examples with keywords and controlled vocabulary are provided to show how health ... ...

    Abstract LGBTQ+ Source is a multidisciplinary database from EBSCO. This column will describe the coverage, search features, and potential use for health sciences libraries. Search examples with keywords and controlled vocabulary are provided to show how health topics related to the LGBTQ + community can be explored through this database.
    MeSH term(s) Humans ; Libraries, Medical ; Sexual and Gender Minorities
    Language English
    Publishing date 2021-05-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605941-7
    ISSN 1540-9597 ; 0276-3869
    ISSN (online) 1540-9597
    ISSN 0276-3869
    DOI 10.1080/02763869.2020.1769426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2751: Show issues Location:
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  6. Article ; Online: Perioperative Stroke: Comment.

    Korbon, Gregg A

    Anesthesiology

    2021  Volume 135, Issue 4, Page(s) 760–761

    MeSH term(s) Humans ; Risk Factors ; Stroke/epidemiology
    Language English
    Publishing date 2021-06-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000003856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.133: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 199: Show issues

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  7. Article ; Online: Integrative approaches to enhance adeno-associated viral gene delivery.

    Duncan, Gregg A

    Journal of controlled release : official journal of the Controlled Release Society

    2021  Volume 341, Page(s) 44–50

    Abstract: To meet the present and future challenges in achieving therapeutic in vivo gene delivery using adeno-associated virus (AAV), new innovations are required that integrate knowledge from disciplines ranging from biomaterials science, drug delivery, ... ...

    Abstract To meet the present and future challenges in achieving therapeutic in vivo gene delivery using adeno-associated virus (AAV), new innovations are required that integrate knowledge from disciplines ranging from biomaterials science, drug delivery, immunobiology, to tissue engineering. One of the foremost challenges remaining is in addressing pre-existing and therapy induced immune responses to AAV which significantly limit its therapeutic effect. In addition, functional correction of diseased tissues will depend on the ability of AAVs to retain activity after local or systemic administration and broadly distribute in target tissues. In this contribution to the Orations - New Horizons of the Journal of Controlled Release, I will introduce new concepts and potential strategies pursued by our lab and others to better understand and overcome these hurdles to effective AAV gene therapy. These multi-disciplinary approaches may open the door to the creation of precision gene therapies to treat heavily burdensome and often deadly diseases.
    MeSH term(s) Dependovirus/genetics ; Gene Transfer Techniques ; Genes, Viral ; Genetic Therapy ; Genetic Vectors/genetics
    Language English
    Publishing date 2021-11-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2021.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2055: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Synthetic mucus biomaterials for antimicrobial peptide delivery.

    Yang, Sydney / Duncan, Gregg A

    Journal of biomedical materials research. Part A

    2023  Volume 111, Issue 10, Page(s) 1616–1626

    Abstract: Despite the promise of antimicrobial peptides (AMPs) as treatments for antibiotic-resistant infections, their therapeutic efficacy is limited due to the rapid degradation and low bioavailability of AMPs. To address this, we have developed and ... ...

    Abstract Despite the promise of antimicrobial peptides (AMPs) as treatments for antibiotic-resistant infections, their therapeutic efficacy is limited due to the rapid degradation and low bioavailability of AMPs. To address this, we have developed and characterized a synthetic mucus (SM) biomaterial capable of delivering LL37 AMPs and enhancing their therapeutic effect. LL37 is an AMP that exhibits a wide range of antimicrobial activity against bacteria, including Pseudomonas aeruginosa. LL37 loaded SM hydrogels demonstrated controlled release with 70%-95% of loaded LL37 over 8 h due to charge-mediated interactions between mucins and LL37 AMPs. Compared to treatment with LL37 alone where antimicrobial activity was reduced after 3 h, LL37-SM hydrogels inhibited P. aeruginosa (PAO1) growth over 12 h. LL37-SM hydrogel treatment reduced PAO1 viability over 6 h whereas a rebound in bacterial growth was observed when treated with LL37 only. These data demonstrate LL37-SM hydrogels enhance antimicrobial activity by preserving LL37 AMP activity and bioavailability. Overall, this work establishes SM biomaterials as a platform for enhanced AMP delivery for antimicrobial applications.
    MeSH term(s) Antimicrobial Peptides/chemistry ; Antimicrobial Peptides/pharmacology ; Hydrogels/chemistry ; Mucus/chemistry ; Drug Delivery Systems ; Pseudomonas aeruginosa/drug effects
    Chemical Substances Antimicrobial Peptides ; Hydrogels
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2099989-6
    ISSN 1552-4965 ; 1549-3296 ; 0021-9304
    ISSN (online) 1552-4965
    ISSN 1549-3296 ; 0021-9304
    DOI 10.1002/jbm.a.37559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Prebiotics and Probiotics for Gastrointestinal Disorders.

    Rau, Sameeha / Gregg, Andrew / Yaceczko, Shelby / Limketkai, Berkeley

    Nutrients

    2024  Volume 16, Issue 6

    Abstract: The complex role of the gut microbiome in the pathogenesis of gastrointestinal (GI) disorders is an emerging area of research, and there is considerable interest in understanding how diet can alter the composition and function of the microbiome. ... ...

    Abstract The complex role of the gut microbiome in the pathogenesis of gastrointestinal (GI) disorders is an emerging area of research, and there is considerable interest in understanding how diet can alter the composition and function of the microbiome. Prebiotics and probiotics have been shown to beneficially modulate the gut microbiome, which underlies their potential for benefit in GI conditions. Formulating specific recommendations for the public regarding these dietary supplements has been difficult due to the significant heterogeneity between strains, doses, and duration of treatment investigated across studies, as well as safety concerns with administering live organisms. This review aims to summarize the existing evidence for the use of prebiotics and probiotics in various GI disorders, paying special attention to strain-specific effects that emerged and any adverse effects noted.
    MeSH term(s) Humans ; Prebiotics ; Irritable Bowel Syndrome/therapy ; Probiotics/therapeutic use ; Dietary Supplements ; Gastrointestinal Diseases/therapy
    Chemical Substances Prebiotics
    Language English
    Publishing date 2024-03-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16060778
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Integrative approaches to enhance adeno-associated viral gene delivery

    Duncan, Gregg A.

    Journal of controlled release. 2022 Jan., v. 341

    2022  

    Abstract: To meet the present and future challenges in achieving therapeutic in vivo gene delivery using adeno-associated virus (AAV), new innovations are required that integrate knowledge from disciplines ranging from biomaterials science, drug delivery, ... ...

    Abstract To meet the present and future challenges in achieving therapeutic in vivo gene delivery using adeno-associated virus (AAV), new innovations are required that integrate knowledge from disciplines ranging from biomaterials science, drug delivery, immunobiology, to tissue engineering. One of the foremost challenges remaining is in addressing pre-existing and therapy induced immune responses to AAV which significantly limit its therapeutic effect. In addition, functional correction of diseased tissues will depend on the ability of AAVs to retain activity after local or systemic administration and broadly distribute in target tissues. In this contribution to the Orations – New Horizons of the Journal of Controlled Release, I will introduce new concepts and potential strategies pursued by our lab and others to better understand and overcome these hurdles to effective AAV gene therapy. These multi-disciplinary approaches may open the door to the creation of precision gene therapies to treat heavily burdensome and often deadly diseases.
    Keywords Dependoparvovirus ; biocompatible materials ; drugs ; gene therapy ; gene transfer ; genes
    Language English
    Dates of publication 2022-01
    Size p. 44-50.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2021.11.013
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2055: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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