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  1. Article: Total artificial heart in patients with post-infarction ventricular septal defect.

    Gregoric, Igor D

    Annals of cardiothoracic surgery

    2020  Volume 9, Issue 2, Page(s) 116–117

    Language English
    Publishing date 2020-04-11
    Publishing country China
    Document type Editorial
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs.2020.01.04
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: In search for "healthy" landing zones for coronary stent placement: are the largest intrasegmental lumens adequate?

    Kranjec, Igor / Klemenc, Matjaž / Zavrl Dzananovic, Dinko / Bunc, Matjaz / Gregoric, Igor D / Kar, Biswajit

    Journal of thoracic disease

    2024  Volume 16, Issue 1, Page(s) 457–468

    Abstract: Background: Coronary lesions are supposed to be enclosed between proximal and distal reference segments (RSs), the sites with the largest lumens within the same vessel segment. Finding "healthy" landing zones has been fundamental for efficient stent ... ...

    Abstract Background: Coronary lesions are supposed to be enclosed between proximal and distal reference segments (RSs), the sites with the largest lumens within the same vessel segment. Finding "healthy" landing zones has been fundamental for efficient stent implantation. Consequently, our study aimed to determine, using optical coherence tomography (OCT), to what degree RSs conform to this concept.
    Methods: Sixty-seven patients with a mean age of 63.5 years underwent culprit lesion stenting due to acute myocardial infarction (MI) (Group 1) or stable angina (Group 2). OCT was performed with commercially available equipment; all evaluations were made at RSs and minimal lumens.
    Results: Normal vessel wall was infrequent (~10%) at RSs. Acceptable external elastic 220°) occurred in 55% to 67% and in 28% to 31% of RSs, respectively. Tissue composition at RSs was similar in both study groups except for a greater accumulation of thin-cap fibroatheromas (TCFA) in acute MI (29% in Group 1
    Conclusions: Optimal landing zones for stent placement should frequently be searched for beyond the culprit lesion segments although utilizing the largest intrasegmental lumens does not seem to cause immediate harm. However, TCFA at the landings should definitely be avoided.
    Language English
    Publishing date 2024-01-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-23-924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Role of Extracellular Heat Shock Proteins in Cardiovascular Diseases.

    Patnaik, Soumya / Nathan, Sriram / Kar, Biswajit / Gregoric, Igor D / Li, Yi-Ping

    Biomedicines

    2023  Volume 11, Issue 6

    Abstract: In the early 1960s, heat shock proteins (HSPs) were first identified as vital intracellular proteinaceous components that help in stress physiology and reprogram the cellular responses to enable the organism's survival. By the early 1990s, HSPs were ... ...

    Abstract In the early 1960s, heat shock proteins (HSPs) were first identified as vital intracellular proteinaceous components that help in stress physiology and reprogram the cellular responses to enable the organism's survival. By the early 1990s, HSPs were detected in extracellular spaces and found to activate gamma-delta T-lymphocytes. Subsequent investigations identified their association with varied disease conditions, including autoimmune disorders, diabetes, cancer, hepatic, pancreatic, and renal disorders, and cachexia. In cardiology, extracellular HSPs play a definite, but still unclear, role in atherosclerosis, acute coronary syndromes, and heart failure. The possibility of HSP-targeted novel molecular therapeutics has generated much interest and hope in recent years. In this review, we discuss the role of Extracellular Heat Shock Proteins (Ec-HSPs) in various disease states, with a particular focus on cardiovascular diseases.
    Language English
    Publishing date 2023-05-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11061557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Is Sternal Sparing Left Ventricular Assist Device Implantation "Minimally" Invasive?

    Akay, Mehmet H / De Armas, Ismael A Salas / Kar, Biswajit / Gregoric, Igor D

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2023  Volume 69, Issue 10, Page(s) e441–e442

    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000001987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Inflammation of carotid plaques and risk of cerebrovascular events.

    Poredos, Pavel / Gregoric, Igor D / Jezovnik, Mateja K

    Annals of translational medicine

    2020  Volume 8, Issue 19, Page(s) 1281

    Abstract: Carotid atherosclerotic plaques represent a risk for ischemic stroke. The data indicate that the risk for distal embolization from atherosclerotic lesions in internal carotid arteries is not related only to the degree of stenosis but also to the ... ...

    Abstract Carotid atherosclerotic plaques represent a risk for ischemic stroke. The data indicate that the risk for distal embolization from atherosclerotic lesions in internal carotid arteries is not related only to the degree of stenosis but also to the composition of plaques. The stability of atherosclerotic plaque depends on the thickness of the fibrous cap and plaque hemorrhage. Recent research indicated that the inflammatory activity of atherosclerotic lesions is pivotal in the progression of atherosclerotic plaques. It also promotes the development of unstable atherosclerotic lesions and is related to thromboembolic cerebrovascular complications. Inflammation destabilizes atherosclerotic plaques through the degradation of their fibrotic structure. Inflammation of atherosclerotic plaques was confirmed by histopathologic findings and levels of circulating inflammatory markers which were correlated to the intensity of the inflammation in atherosclerotic lesions. Recently, new techniques like fluorodeoxyglucose positron emission tomography (18-FDG PET) were developed for the identification of inflammation of atherosclerotic lesions in the vessel wall
    Language English
    Publishing date 2020-10-02
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-2020-cass-15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mechanical circulatory support in acute heart failure.

    Gregoric, Igor D

    Texas Heart Institute journal

    2013  Volume 39, Issue 6, Page(s) 854–855

    MeSH term(s) Acute Disease ; Heart Failure/therapy ; Heart-Assist Devices ; Humans ; Treatment Outcome
    Language English
    Publishing date 2013-01-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604761-0
    ISSN 1526-6702 ; 0730-2347
    ISSN (online) 1526-6702
    ISSN 0730-2347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Impact of structured physical therapy protocol among heart transplant recipients while on intra-aortic balloon pump in the pretransplant period.

    Patnaik, Soumya / Nathan, Sriram / Bui, Amanda / Kar, Biswajit / Gregoric, Igor D / Gilley, Christa Bauer

    Artificial organs

    2022  

    Abstract: Background: Use of prolonged femoral intra-aortic balloon pump support limits the mobility of patients awaiting heart transplant. We assessed the safety and outcomes of a structured, tilting physical therapy protocol in patients supported by intra- ... ...

    Abstract Background: Use of prolonged femoral intra-aortic balloon pump support limits the mobility of patients awaiting heart transplant. We assessed the safety and outcomes of a structured, tilting physical therapy protocol in patients supported by intra-aortic balloon pumps while awaiting transplant.
    Methods: We retrospectively reviewed five years of transplant patients. Eighteen patients received femoral intra-aortic balloon support, a heart transplant, and met all eligibility criteria. We compared complications and outcomes between patients who received the structured, tilting physical therapy (Protocol Group) and those that received standard of care (Control Group).
    Results: Complications were not significantly different between groups. The majority of the Protocol Group were discharged to home (10/12), while half (3/6) of the Control Group were discharged to a rehabilitation facility. Post-transplant length of stay was significantly less in the Protocol Group (median 16 vs. 28 days, p = 0.03).
    Conclusion: Despite the small number analyzed, the data indicates that the structured, tilting physical therapy protocol led to a significantly reduced length of stay post-transplantation. Importantly, use of the protocol did not result in access site complications, thrombosis, or arrhythmias in the majority of the patients.
    Language English
    Publishing date 2022-08-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 441812-8
    ISSN 1525-1594 ; 0160-564X
    ISSN (online) 1525-1594
    ISSN 0160-564X
    DOI 10.1111/aor.14378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Case Report: WATCHMAN Procedure Complicated By Atrial Perforation and Device Dislodgement.

    Al Rameni, Dina / de Armas, Ismael Salas / Al Rameeni, Aon / Gupta, Sameer / Gregoric, Igor D

    Cardiovascular revascularization medicine : including molecular interventions

    2022  Volume 53S, Page(s) S188–S190

    Abstract: Atrial perforation and device dislodgment are uncommon encounters after percutaneous left atrial appendage exclusion procedures. The literature describes how various endovascular and surgical approaches can be applied to treat these complications. In ... ...

    Abstract Atrial perforation and device dislodgment are uncommon encounters after percutaneous left atrial appendage exclusion procedures. The literature describes how various endovascular and surgical approaches can be applied to treat these complications. In this case report, we describe an atrial perforation that occurred after a WATCHMAN™ FLX device (Boston Scientific) deployment. Heart manipulation with lifting was required for the atrial repair. During this maneuver, the device dislodged and was managed by surgical device extraction and left atrial appendage resection and suture closure. Minimal to no manipulation of the left atrium during surgical exploration was found to be invaluable in order to avoid device dislodgement and additional surgical corrective interventions. Additionally, intraoperative transesophageal echocardiography at the beginning and conclusion of the case is key in monitoring the device position and identifying device dislodgement.
    MeSH term(s) Humans ; Treatment Outcome ; Atrial Fibrillation ; Atrial Appendage/diagnostic imaging ; Atrial Appendage/surgery ; Cardiac Catheterization ; Heart Atria/diagnostic imaging ; Heart Atria/surgery ; Echocardiography, Transesophageal
    Language English
    Publishing date 2022-05-14
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2212113-4
    ISSN 1878-0938 ; 1553-8389
    ISSN (online) 1878-0938
    ISSN 1553-8389
    DOI 10.1016/j.carrev.2022.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Open Surgical Insertion of TandemHeart Device for Left Ventricular Unloading.

    Al Rameni, Dina / Patel, Manish K / Salas De Armas, Ismael A / Akay, Mehmet H / Marwan, Jumean F / Kar, Biswajit / Gregoric, Igor D

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2023  Volume 69, Issue 10, Page(s) e437–e440

    Abstract: TandemHeart (Cardiac Assist Inc., Pittsburgh, PA) is a valuable mechanical circulatory support (MCS) device that provides left atrial to femoral artery bypass and directly unloads the left ventricle. The device is inserted under fluoroscopic guidance in ... ...

    Abstract TandemHeart (Cardiac Assist Inc., Pittsburgh, PA) is a valuable mechanical circulatory support (MCS) device that provides left atrial to femoral artery bypass and directly unloads the left ventricle. The device is inserted under fluoroscopic guidance in the cardiac catheterization laboratory without requiring invasive surgical exposure. However, this device is unique because it directly unloads the oxygenated blood from the left atrium and may be needed for postoperative support in patients undergoing various open cardiac surgeries. In this article, we provide a detailed description of the open surgical insertion of a TandemHeart device.
    MeSH term(s) Humans ; Heart Ventricles/surgery ; Cardiac Surgical Procedures ; Heart Atria ; Heart-Assist Devices
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000001981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Use of Subclavian Extracorporeal Carbon Dioxide Removal for COVID-19 Acute Respiratory Distress Syndrome as a Bridge to Lung Transplantation.

    Dinh, Kha / Akkanti, Bindu / Patel, Manish / Hussain, Rahat / Basra, Sukhdeep / Gregoric, Igor D / Kar, Biswajit

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2023  Volume 70, Issue 1, Page(s) e9–e12

    Abstract: Severe acute hypercapnia is independently associated with increased adverse effects and intensive care unit mortality in mechanically ventilated patients. During the severe acute respiratory syndrome coronavirus 2 (COVID-19) pandemic, some patients were ... ...

    Abstract Severe acute hypercapnia is independently associated with increased adverse effects and intensive care unit mortality in mechanically ventilated patients. During the severe acute respiratory syndrome coronavirus 2 (COVID-19) pandemic, some patients were placed on extracorporeal carbon dioxide removal support when extracorporeal membrane oxygenation (ECMO) support was at capacity or not offered. We present a patient with severe acute respiratory distress syndrome caused by COVID-19 pneumonia, who was supported with Hemolung Respiratory Assist System (ALung Technologies, Inc., LivaNova, Pittsburgh, PA) via the right subclavian vein as a bridge to lung transplantation after venovenous ECMO support. The patient survived and was discharged home.
    MeSH term(s) Humans ; COVID-19/complications ; Carbon Dioxide ; Extracorporeal Circulation ; Respiratory Distress Syndrome/therapy ; Lung Transplantation
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2023-08-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000002018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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