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Article ; Online: Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease.

Lee, Jonathan Wei Jie / Plichta, Damian / Hogstrom, Larson / Borren, Nynke Z / Lau, Helena / Gregory, Sara M / Tan, William / Khalili, Hamed / Clish, Clary / Vlamakis, Hera / Xavier, Ramnik J / Ananthakrishnan, Ashwin N

Cell host & microbe

2021 Volume 29, Issue 8, Page(s) 1294–1304.e4

Abstract: The intestinal microbiome is a key determinant of responses to biologic therapy in inflammatory bowel disease (IBD). However, diverse therapeutics and variable responses among IBD patients have posed challenges in predicting clinical therapeutic success. ...

Abstract	The intestinal microbiome is a key determinant of responses to biologic therapy in inflammatory bowel disease (IBD). However, diverse therapeutics and variable responses among IBD patients have posed challenges in predicting clinical therapeutic success. In this prospective study, we profiled baseline stool and blood in patients with moderate-to-severe Crohn's disease or ulcerative colitis initiating anti-cytokine therapy (anti-TNF or -IL12/23) or anti-integrin therapy. Patients were assessed at 14 weeks for clinical remission and 52 weeks for clinical and endoscopic remission. Baseline microbial richness indicated preferential responses to anti-cytokine therapy and correlated with the abundance of microbial species capable of 7α/β-dehydroxylation of primary to secondary bile acids. Serum signatures of immune proteins reflecting microbial diversity identified patients more likely to achieve remission with anti-cytokine therapy. Remission-associated multi-omic profiles were unique to each therapeutic class. These profiles may facilitate a priori determination of optimal therapeutics for patients and serve as targets for newer therapies.
MeSH term(s)	Antibodies, Monoclonal, Humanized ; Biological Therapy ; Biomarkers ; Blood ; Colitis, Ulcerative/therapy ; Crohn Disease/therapy ; Cytokines/blood ; Cytokines/drug effects ; Feces ; Gastrointestinal Microbiome/physiology ; Humans ; Inflammatory Bowel Diseases/microbiology ; Inflammatory Bowel Diseases/therapy ; Infliximab ; Metabolomics ; Metagenome ; Prospective Studies ; Proteomics ; Tumor Necrosis Factor Inhibitors/therapeutic use
Chemical Substances	Antibodies, Monoclonal, Humanized ; Biomarkers ; Cytokines ; Tumor Necrosis Factor Inhibitors ; vedolizumab (9RV78Q2002) ; Infliximab (B72HH48FLU)
Language	English
Publishing date	2021-07-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2278004-X
ISSN	1934-6069 ; 1931-3128
ISSN (online)	1934-6069
ISSN	1931-3128
DOI	10.1016/j.chom.2021.06.019
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Zs.A 6578: Show issues

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Article: Physical activity, cognitive function, and brain health: what is the role of exercise training in the prevention of dementia?

Gregory, Sara M / Parker, Beth / Thompson, Paul D

Brain sciences

2012 Volume 2, Issue 4, Page(s) 684–708

Abstract: Tor preventive measures are necessary to attenuate the increased economic and social burden of dementia. This review will focus on the potential for physical activity and exercise training to promote brain health and improve cognitive function via ... ...

Abstract	Tor preventive measures are necessary to attenuate the increased economic and social burden of dementia. This review will focus on the potential for physical activity and exercise training to promote brain health and improve cognitive function via neurophysiological changes. We will review pertinent animal and human research examining the effects of physical activity on cognitive function and neurophysiology. We will discuss cross-sectional and longitudinal studies addressing the relationship between neurocognitive health and cardiorespiratory fitness or habitual activity level. We will then present and discuss longitudinal investigations examining the effects of exercise training on cognitive function and neurophysiology. We will conclude by summarizing our current understanding of the relationship between physical activity and brain health, and present areas for future research given the current gaps in our understanding of this issue.
Language	English
Publishing date	2012-11-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci2040684
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Article ; Online: Effects of dietary macronutrient distribution on vascular integrity in obesity and metabolic syndrome.

Gregory, Sara M / Headley, Samuel A / Wood, Richard J

Nutrition reviews

2011 Volume 69, Issue 9, Page(s) 509–519

Abstract: Metabolic syndrome is a condition characterized by a clustering of risk factors for cardiovascular disease. Emerging data suggest vascular integrity is disrupted in metabolic syndrome. Vascular integrity may be determined using several measurements, ... ...

Abstract	Metabolic syndrome is a condition characterized by a clustering of risk factors for cardiovascular disease. Emerging data suggest vascular integrity is disrupted in metabolic syndrome. Vascular integrity may be determined using several measurements, including pulse wave velocity, augmentation index, and flow-mediated dilation. Arterial stiffness has become an important clinical indicator of cardiovascular disease risk. Several circulating inflammatory peptides also impact vascular integrity. The present review examines the efficacy of nutritional interventions aimed at improving vascular integrity and reducing levels of associated inflammatory peptides in individuals with metabolic syndrome, with a specific focus on the effect of dietary macronutrient redistribution on these factors.
MeSH term(s)	Animals ; Diet, Reducing/methods ; Humans ; Metabolic Syndrome/diet therapy ; Metabolic Syndrome/physiopathology ; Obesity/diet therapy ; Obesity/physiopathology ; Vascular Diseases/etiology ; Vascular Diseases/prevention & control ; Vascular Stiffness
Language	English
Publishing date	2011-09
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Review
ZDB-ID	82067-2
ISSN	1753-4887 ; 0029-6643
ISSN (online)	1753-4887
ISSN	0029-6643
DOI	10.1111/j.1753-4887.2011.00390.x
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Zs.A 3388: Show issues

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Article: A randomized trial of coenzyme Q10 in patients with statin myopathy: rationale and study design.

Parker, Beth A / Gregory, Sara M / Lorson, Lindsay / Polk, Donna / White, C Michael / Thompson, Paul D

Journal of clinical lipidology

2013 Volume 7, Issue 3, Page(s) 187–193

Abstract: Background: Statins are the most commonly prescribed and effective medications for reducing low-density lipoprotein levels. Some patients experience myopathic symptoms during statin treatment. The etiology is not known, but depletion of mevalonate ... ...

Abstract	Background: Statins are the most commonly prescribed and effective medications for reducing low-density lipoprotein levels. Some patients experience myopathic symptoms during statin treatment. The etiology is not known, but depletion of mevalonate pathway metabolites, including coenzyme Q10 (CoQ10), has been suggested. Despite a lack of conclusive evidence supporting its utility, CoQ10 supplementation has been recommended to patients who experience myalgic symptoms. Objective: The Co-Enzyme Q10 in Statin Myopathy study is designed to examine the effect of CoQ10 supplementation on the extent and intensity of muscle pain during treatment with simvastatin. Methods: We will recruit patients with a documented history of myalgia during statin treatment. The presence of statin-related myalgia will be confirmed in a crossover run-in trial during which the presence and absence of symptoms will be documented during statin and placebo treatment, respectively. Individuals experience myalgic symptoms while taking statins but not placebo will be randomized to receive simvastatin 20 mg daily plus either 600 mg daily of CoQ10 or placebo. Muscle pain intensity will be documented during weekly phone calls via use of the Brief Pain Inventory, Short Form. Treatment will continue for 8 weeks or until muscle symptoms are reported continuously for 1 week or become intolerable, and then subjects will crossover to the alternative treatment (CoQ10 or placebo). Results: This study is an ongoing clinical trial. Conclusions: This study will determine the utility of CoQ10 for reducing pain intensity in myalgic patients and will provide guidance for clinicians treating patients with hypercholesterolemia who are intolerant to statins.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Muscles/drug effects ; Muscles/pathology ; Muscular Diseases/drug therapy ; Simvastatin/therapeutic use ; Ubiquinone/analogs & derivatives ; Ubiquinone/therapeutic use ; Young Adult
Chemical Substances	Ubiquinone (1339-63-5) ; Simvastatin (AGG2FN16EV) ; coenzyme Q10 (EJ27X76M46)
Language	English
Publishing date	2013-02-26
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	2365061-8
ISSN	1876-4789 ; 1933-2874
ISSN (online)	1876-4789
ISSN	1933-2874
DOI	10.1016/j.jacl.2013.02.002
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Article ; Online: Genomics analysis of Drosophila sechellia response to Morinda citrifolia fruit diet.

Drum, Zachary / Lanno, Stephen / Gregory, Sara M / Shimshak, Serena / Barr, Will / Gatesman, Austin / Schadt, Mark / Sanford, Jack / Arkin, Aaron / Assignon, Brynn / Colorado, Sofia / Dalgarno, Carol / Devanny, Trevor / Ghandour, Tara / Griffin, Rose / Hogan, Mia / Horowitz, Erica / McGhie, Emily / Multer, Jake /

O'Halloran, Hannah / Ofori-Darko, Kofi / Pokushalov, Dmitry / Richards, Nick / Sagarin, Kathleen / Taylor, Nicholas / Thielking, Acadia / Towle, Phie / Coolon, Joseph

G3 (Bethesda, Md.)

2022 Volume 12, Issue 10

Abstract: Drosophila sechellia is an island endemic host specialist that has evolved to consume the toxic fruit of Morinda citrifolia, also known as noni fruit. Recent studies by our group and others have examined genome-wide gene expression responses of fruit ... ...

Abstract	Drosophila sechellia is an island endemic host specialist that has evolved to consume the toxic fruit of Morinda citrifolia, also known as noni fruit. Recent studies by our group and others have examined genome-wide gene expression responses of fruit flies to individual highly abundant compounds found in noni responsible for the fruit's unique chemistry and toxicity. In order to relate these reductionist experiments to the gene expression responses to feeding on noni fruit itself, we fed rotten noni fruit to adult female D. sechellia and performed RNA-sequencing. Combining the reductionist and more wholistic approaches, we have identified candidate genes that may contribute to each individual compound and those that play a more general role in response to the fruit as a whole. Using the compound specific and general responses, we used transcription factor prediction analyses to identify the regulatory networks and specific regulators involved in the responses to each compound and the fruit itself. The identified genes and regulators represent the possible genetic mechanisms and biochemical pathways that contribute to toxin resistance and noni specialization in D. sechellia.
MeSH term(s)	Animals ; Diet ; Drosophila/genetics ; Female ; Genomics ; Morinda/chemistry ; RNA ; Transcription Factors
Chemical Substances	Transcription Factors ; RNA (63231-63-0)
Language	English
Publishing date	2022-06-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2629978-1
ISSN	2160-1836 ; 2160-1836
ISSN (online)	2160-1836
ISSN	2160-1836
DOI	10.1093/g3journal/jkac153
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Article ; Online: Genomics analysis of hexanoic acid exposure in Drosophila species.

Drum, Zachary A / Lanno, Stephen M / Gregory, Sara M / Shimshak, Serena J / Ahamed, Mukshud / Barr, Will / Bekele, Bethlehem / Biester, Alison / Castro, Colleen / Connolly, Lauren / DelGaudio, Nicole / Humphrey, William / Karimi, Helen / Karolczak, Sophie / Lawrence, Tay-Shaun / McCracken, Andrew / Miller-Medzon, Noah / Murphy, Leah / Park, Cameron /

Park, Sojeong / Qiu, Chloe / Serra, Kevin / Snyder, Gigi / Strauss, Alexa / Tang, Spencer / Vyzas, Christina / Coolon, Joseph D

G3 (Bethesda, Md.)

2021 Volume 12, Issue 1

Abstract: Drosophila sechellia is a dietary specialist endemic to the Seychelles islands that has evolved to consume the fruit of Morinda citrifolia. When ripe, the fruit of M. citrifolia contains octanoic acid and hexanoic acid, two medium-chain fatty acid ... ...

Abstract	Drosophila sechellia is a dietary specialist endemic to the Seychelles islands that has evolved to consume the fruit of Morinda citrifolia. When ripe, the fruit of M. citrifolia contains octanoic acid and hexanoic acid, two medium-chain fatty acid volatiles that deter and are toxic to generalist insects. Drosophila sechellia has evolved resistance to these volatiles allowing it to feed almost exclusively on this host plant. The genetic basis of octanoic acid resistance has been the focus of multiple recent studies, but the mechanisms that govern hexanoic acid resistance in D. sechellia remain unknown. To understand how D. sechellia has evolved to specialize on M. citrifolia fruit and avoid the toxic effects of hexanoic acid, we exposed adult D. sechellia, D. melanogaster and D. simulans to hexanoic acid and performed RNA sequencing comparing their transcriptional responses to identify D. sechellia specific responses. Our analysis identified many more genes responding transcriptionally to hexanoic acid in the susceptible generalist species than in the specialist D. sechellia. Interrogation of the sets of differentially expressed genes showed that generalists regulated the expression of many genes involved in metabolism and detoxification whereas the specialist primarily downregulated genes involved in the innate immunity. Using these data, we have identified interesting candidate genes that may be critically important in aspects of adaptation to their food source that contains high concentrations of HA. Understanding how gene expression evolves during dietary specialization is crucial for our understanding of how ecological communities are built and how evolution shapes trophic interactions.
MeSH term(s)	Animals ; Caproates/metabolism ; Caproates/toxicity ; Drosophila/physiology ; Drosophila melanogaster/genetics ; Genomics ; Species Specificity
Chemical Substances	Caproates ; hexanoic acid (1F8SN134MX)
Language	English
Publishing date	2021-10-30
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2629978-1
ISSN	2160-1836 ; 2160-1836
ISSN (online)	2160-1836
ISSN	2160-1836
DOI	10.1093/g3journal/jkab354
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Article ; Online: Effects of a short-term carbohydrate-restricted diet on strength and power performance.

Sawyer, Jason C / Wood, Richard J / Davidson, Patrick W / Collins, Sean M / Matthews, Tracey D / Gregory, Sara M / Paolone, Vincent J

Journal of strength and conditioning research

2013 Volume 27, Issue 8, Page(s) 2255–2262

Abstract: The purpose of the study was to examine the effects of switching from a habitual diet to a carbohydrate-restricted diet (CRD) on strength and power performance in trained men (n = 16) and women (n = 15). Subjects performed handgrip dynamometry, vertical ... ...

Abstract	The purpose of the study was to examine the effects of switching from a habitual diet to a carbohydrate-restricted diet (CRD) on strength and power performance in trained men (n = 16) and women (n = 15). Subjects performed handgrip dynamometry, vertical jump, 1RM bench press and back squat, maximum-repetition bench press, and a 30-second Wingate anaerobic cycling test after consuming a habitual diet (40.7% carbohydrate, 22.2% protein, and 34.4% fat) for 7 days and again after following a CRD (5.4% carbohydrate, 35.1% protein, and 53.6% fat) for 7 days. Before both testing sessions, body weight and composition were examined using bioelectrical impedance analysis. Three 2 × 2 multiple analyses of variance were used to compare performance variables between the habitual diet and CRD. Subjects consumed significantly fewer (p < 0.05) total kilocalories during the CRD (2,156.55 ± 126.7) compared with the habitual diet (2,537.43 ± 99.5). Body mass decreased significantly (p < 0.05). Despite a reduction in body mass, strength and power outputs were maintained for men and women during the CRD. These findings may have implications for sports that use weight classes, and in which strength and power are determinants of success. A CRD may be an alternative method for short-term weight loss without compromising strength and power outputs. The use of a 7-day CRD could replace weight loss methods employing severe dehydration before competition.
MeSH term(s)	Adult ; Athletic Performance/physiology ; Body Composition ; Body Weight ; Diet, Carbohydrate-Restricted ; Exercise Test ; Female ; Hand Strength/physiology ; Humans ; Male ; Muscle Strength ; Time Factors ; Weight Lifting/physiology ; Young Adult
Language	English
Publishing date	2013-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1156349-7
ISSN	1533-4287 ; 1064-8011
ISSN (online)	1533-4287
ISSN	1064-8011
DOI	10.1519/JSC.0b013e31827da314
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Article ; Online: Preservation of fat-free mass after two distinct weight loss diets with and without progressive resistance exercise.

Wood, Richard J / Gregory, Sara M / Sawyer, Jason / Milch, Charles M / Matthews, Tracey D / Headley, Samuel A E

Metabolic syndrome and related disorders

2012 Volume 10, Issue 3, Page(s) 167–174

Abstract: Background: Preserving fat-free mass (FFM) during weight loss is important in older adults. The purpose was to examine a low-fat diet (LFD) versus a carbohydrate-restricted diet (CRD) with and without progressive resistance exercise (PRE) on ... ...

Abstract	Background: Preserving fat-free mass (FFM) during weight loss is important in older adults. The purpose was to examine a low-fat diet (LFD) versus a carbohydrate-restricted diet (CRD) with and without progressive resistance exercise (PRE) on preservation of FFM in older men with metabolic syndrome. Methods: A total of 42 men (59±7 years) were matched [body mass index (BMI)] and randomized to LFD, LFD&PRE, CRD, and CRD&PRE. PRE groups performed supervised strength training three times per week. Body weight, composition, metabolic syndrome criteria, and strength were measured at baseline and week 12. A 3-day diet record was kept at baseline and at weeks 1, 6, and 12. Results: Attrition (24%) was similar between groups. Depicted as % carbohydrate:fat:protein, the intervention diet was: LFD=55:24:18, LFD&PRE=57:20:20, CRD=16:54:28, and CRD&PRE=12:56:31. Weight (lb) decreased similarly in all groups (LFD, -18.0±7.4; LFD&PRE, -19.8±12.8; CRD, -20.2±8.0; CRD&PRE, -22.7±6.0; P<0.001), and number of participants with metabolic syndrome decreased in all groups (-3, -6, -3, -4, respectively). Percent of weight loss from appendicular FFM was 27.5%, 15.9%, 15.7%, and 17.3% respectively. A trend was found when comparing LFD and LFD&PRE (P=0.068), and when comparing LFD&CRD (P=0.072). Triglycerides improved more for the LFD&PRE, CRD, and CRD&PRE groups compared to the LFD group (P<0.05). Improvements in high-density lipoprotein-cholesterol were better in the CRD&PRE group (4.1±5.1 mg/dL) versus the LFD group (-5.0±5.9 mg/dL; P<0.01). Conclusions: LFD&PRE, CRD, and CRD&PRE preserve FFM similarly. PRE is an important component of a LFD during weight loss in this population.
MeSH term(s)	Adiposity ; Aged ; Biomarkers/blood ; Blood Pressure ; Body Composition ; Body Mass Index ; Combined Modality Therapy ; Diet, Carbohydrate-Restricted ; Diet, Fat-Restricted ; Factor Analysis, Statistical ; Humans ; Male ; Massachusetts ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/diet therapy ; Metabolic Syndrome/physiopathology ; Metabolic Syndrome/therapy ; Middle Aged ; Muscle Strength ; Overweight/diagnosis ; Overweight/diet therapy ; Overweight/physiopathology ; Overweight/therapy ; Resistance Training ; Time Factors ; Treatment Outcome ; Waist Circumference ; Weight Loss
Chemical Substances	Biomarkers
Language	English
Publishing date	2012-06
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2151220-6
ISSN	1557-8518 ; 1540-4196
ISSN (online)	1557-8518
ISSN	1540-4196
DOI	10.1089/met.2011.0104
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Zs.A 5950: Show issues

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Article ; Online: Genomics Analysis of L-DOPA Exposure in

Lanno, Stephen M / Lam, Ivy / Drum, Zachary / Linde, Samuel C / Gregory, Sara M / Shimshak, Serena J / Becker, Mariel V / Brew, Kerry E / Budhiraja, Aashli / Carter, Eliza A / Chigweshe, Lorencia / Collins, Keagan P / Earley, Timothy / Einstein, Hannah L / Fan, Angela A / Goss, Sarah S / Hagen, Eric R / Hutcheon, Sarah B / Kim, Timothy T /

Mitchell, Mackenzie A / Neri, Nola R / Patterson, Sean E / Ransom, Gregory / Sanchez, Guadalupe J / Wiener, Bella M / Zhao, Dacheng / Coolon, Joseph D

G3 (Bethesda, Md.)

2019 Volume 9, Issue 12, Page(s) 3973–3980

Abstract: Drosophila ... ...

Abstract	Drosophila sechellia
MeSH term(s)	Animals ; Caprylates/pharmacology ; Diet ; Drosophila/drug effects ; Drosophila/genetics ; Gene Expression Regulation/drug effects ; Gene Ontology ; Genome, Insect ; Genomics ; Levodopa/pharmacology ; Species Specificity
Chemical Substances	Caprylates ; Levodopa (46627O600J) ; octanoic acid (OBL58JN025)
Language	English
Publishing date	2019-12-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2629978-1
ISSN	2160-1836 ; 2160-1836
ISSN (online)	2160-1836
ISSN	2160-1836
DOI	10.1534/g3.119.400552
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Article ; Online: Exercise-induced insulin-like growth factor I system concentrations after training in women.

Gregory, Sara M / Spiering, Barry A / Alemany, Joseph A / Tuckow, Alexander P / Rarick, Kevin R / Staab, Jeffery S / Hatfield, Disa L / Kraemer, William J / Maresh, Carl M / Nindl, Bradley C

Medicine and science in sports and exercise

2013 Volume 45, Issue 3, Page(s) 420–428

Abstract: Introduction: This study examined the effects of short-term physical training on the acute hormonal response (i.e., growth hormone, total and free insulin-like growth factor I [IGF-I], and IGF binding proteins [IGFBP]-1, IGFBP-2, and IGFBP-3) to ... ...

Abstract	Introduction: This study examined the effects of short-term physical training on the acute hormonal response (i.e., growth hormone, total and free insulin-like growth factor I [IGF-I], and IGF binding proteins [IGFBP]-1, IGFBP-2, and IGFBP-3) to resistance exercise (RE) in women. Methods: Forty-six women (20.3 ± 0.3 yr, mass = 64.1 ± 7.3 kg, height = 165.7 ± 1.0 cm) were randomly assigned to an endurance training (E), resistance training (R), combined training (R + E), or control (C) group for 8wk. Subjects completed a standardized bout of RE (six sets of back squats at 10 repetition maximum) before and after training. Blood samples were obtained at rest (PRE), after the third set, immediately postexercise (POST), and at 15 min and 30 min after exercise. Results: Acute RE significantly increased (P < 0.05) serum growth hormone (mean ± SD; change from PRE to POST = +10.9 ± 7.5 μg·L-1), total IGF-I (+66.1 ± 25.4 μg·L-1), IGFBP-1 (+2.5 ± 3.1 μg·L-1), IGFBP-2 (+86.0 ± 86.8 μg·L-1), and IGFBP-3 (+0.69 ± 0.25 mg·L-1) concentrations and decreased free IGF-I concentrations (-0.14 ± 0.21 μg·L-1). After 8 wk of training, total IGF-I concentrations were significantly increased (change in POST concentrations from week 0 to week 8 = +82.5 ± 120.8 μg·L-1), and IGFBP-1 concentrations were significantly decreased (-6.7 ± 13.6 μg·L-1) during exercise in groups that participated in resistance training (R and R + E); no significant changes were seen after E or C. Conclusions: Participation in resistance training increased total IGF-I and reduced IGFBP-1 concentrations during acute RE, indicating exercise mode-specific adaptations in the circulating IGF-I system.
MeSH term(s)	Adult ; Analysis of Variance ; Female ; Growth Hormone/blood ; Humans ; Insulin-Like Growth Factor Binding Protein 1/blood ; Insulin-Like Growth Factor Binding Protein 2/blood ; Insulin-Like Growth Factor Binding Protein 3/blood ; Insulin-Like Growth Factor I/metabolism ; Muscle Strength ; Muscle, Skeletal/physiology ; Resistance Training ; Running/physiology ; Time Factors ; Young Adult
Chemical Substances	Insulin-Like Growth Factor Binding Protein 1 ; Insulin-Like Growth Factor Binding Protein 2 ; Insulin-Like Growth Factor Binding Protein 3 ; Insulin-Like Growth Factor I (67763-96-6) ; Growth Hormone (9002-72-6)
Language	English
Publishing date	2013-03
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	603994-7
ISSN	1530-0315 ; 0195-9131 ; 0025-7990
ISSN (online)	1530-0315
ISSN	0195-9131 ; 0025-7990
DOI	10.1249/MSS.0b013e3182750bd4
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