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  1. Article: La chambre des erreurs, ludique et pédagogique.

    Oriol, Pascale / Fortier, Élise / Grenier, Dominique

    Revue de l'infirmiere

    2016  Volume 221, Page(s) 33–34

    Abstract: Simulation in health care opens the way for innovative pedagogical developments particularly well suited to the training of nursing teams. It is ideal for acquiring or reinforcing knowledge, without any risk to patients, in a climate which facilitates ... ...

    Title translation The room of errors, fun and pedagogical.
    Abstract Simulation in health care opens the way for innovative pedagogical developments particularly well suited to the training of nursing teams. It is ideal for acquiring or reinforcing knowledge, without any risk to patients, in a climate which facilitates exchanges. In this article, users share their experiences.
    MeSH term(s) Audiovisual Aids ; Clinical Competence/standards ; Education, Nursing, Continuing/methods ; Humans ; Motivation ; Simulation Training/methods
    Language French
    Publishing date 2016-05
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 632538-5
    ISSN 1293-8505 ; 0397-7900
    ISSN 1293-8505 ; 0397-7900
    DOI 10.1016/j.revinf.2016.02.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2782: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A mutated factor X activatable by thrombin corrects bleedings in vivo in a rabbit model of antibody-induced hemophilia A.

    Abache, Toufik / Fontayne, Alexandre / Grenier, Dominique / Jacque, Emilie / Longue, Alain / Dezetter, Anne-Sophie / Souilliart, Béatrice / Chevreux, Guillaume / Bataille, Damien / Chtourou, Sami / Plantier, Jean-Luc

    Haematologica

    2020  Volume 105, Issue 9, Page(s) 2335–2340

    Abstract: Rendering coagulation factor X sensitive to thrombin was proposed as a strategy that can bypass the need for factor VIII. In this paper, this non-replacement strategy was evaluated in vitro and in vivo in its ability to correct factor VIII but also ... ...

    Abstract Rendering coagulation factor X sensitive to thrombin was proposed as a strategy that can bypass the need for factor VIII. In this paper, this non-replacement strategy was evaluated in vitro and in vivo in its ability to correct factor VIII but also factor IX, X and XI deficiencies. A novel modified factor X, named Actiten, was generated and produced in the HEK293F cell line. The molecule possesses the required post-translational modifications, partially keeps its ability to be activated by RVV-X, factor VIIa/tissue factor, factor VIIIa/factor IXa and acquires the ability to be activated by thrombin. The potency of the molecule was evaluated in respective deficient plasmas or hemophilia A plasmas, for some with inhibitors. Actiten corrects dose dependently all the assayed deficient plasmas. It is able to normalize the thrombin generation at 20 μg/mL showing however an increased lagtime. It was then assayed in a rabbit antibody-induced model of hemophilia A where, in contrast to recombinant factor X wild-type, it normalized the bleeding time and the loss of hemoglobin. No sign of thrombogenicity was observed and the generation of activated factor X was controlled by the anticoagulation pathway in all performed coagulation assays. This data indicates that Actiten may be considered as a possible non replacement factor to treat hemophilia's with the advantage of being a zymogen correcting bleedings only when needed.
    MeSH term(s) Animals ; Factor IX ; Factor VIII/genetics ; Factor VIIa ; Factor X/genetics ; Hemophilia A/drug therapy ; Hemophilia A/genetics ; Rabbits ; Thrombin
    Chemical Substances Factor VIII (9001-27-8) ; Factor IX (9001-28-9) ; Factor X (9001-29-0) ; Factor VIIa (EC 3.4.21.21) ; Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2020-09-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2019.219865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.76: Show issues Location:
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