LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 63

Search options

  1. Article ; Online: Effects of Physician Experience, Specialty Training, and Self-referral on Inappropriate Diagnostic Imaging.

    Young, Gary J / Flaherty, Stephen / Zepeda, E David / Mortele, Koenraad J / Griffith, John L

    Journal of general internal medicine

    2020  Volume 35, Issue 6, Page(s) 1661–1667

    Abstract: Background: Although previous research has demonstrated high rates of inappropriate diagnostic imaging, the potential influence of several physician-level characteristics is not well established.: Objective: To examine the influence of three types of ...

    Abstract Background: Although previous research has demonstrated high rates of inappropriate diagnostic imaging, the potential influence of several physician-level characteristics is not well established.
    Objective: To examine the influence of three types of physician characteristics on inappropriate imaging: experience, specialty training, and self-referral.
    Design: A retrospective analysis of over 70,000 MRI claims submitted for commercially insured individuals. Physician characteristics were identified through a combination of administrative records and primary data collection. Multi-level modeling was used to assess relationships between physician characteristics and inappropriate MRIs.
    Setting: Massachusetts PARTICIPANTS: Commercially insured individuals who received an MRI between 2010 and 2013 for one of three conditions: low back pain, knee pain, and shoulder pain.
    Measurements: Guidelines from the American College of Radiology were used to classify MRI referrals as appropriate/inappropriate. Experience was measured from the date of medical school graduation. Specialty training comprised three principal groups: general internal medicine, family medicine, and orthopedics. Two forms of self-referral were examined: (a) the same physician who ordered the procedure also performed it, and (b) the physicians who ordered and performed the procedure were members of the same group practice and the procedure was performed outside the hospital setting.
    Results: Approximately 23% of claims were classified as inappropriate. Physicians with 10 or less years of experience had significantly higher odds of ordering inappropriate MRIs. Primary care physicians were almost twice as likely to order an inappropriate MRI as orthopedists. Self-referral was not associated with higher rates of inappropriate MRIs.
    Limitations: Classification of MRIs was conducted with claims data. Not all self-referred MRIs could be detected.
    Conclusions: Inappropriate imaging continues to be a driver of wasteful health care spending. Both physician experience and specialty training were highly associated with inappropriate imaging.
    MeSH term(s) Humans ; Low Back Pain ; Magnetic Resonance Imaging ; Massachusetts ; Practice Patterns, Physicians' ; Referral and Consultation ; Retrospective Studies
    Language English
    Publishing date 2020-01-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-019-05621-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2205: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Correction to: Effects of Physician Experience, Specialty Training, and Self-referral on Inappropriate Diagnostic Imaging.

    Young, Gary J / Flaherty, Stephen / Zepeda, E David / Mortele, Koenraad J / Griffith, John L

    Journal of general internal medicine

    2020  

    Abstract: There were some errors in the variables in this paper. ...

    Abstract There were some errors in the variables in this paper.
    Language English
    Publishing date 2020-05-06
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-020-05761-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2205: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Urbanicity matters in self-reported child maltreatment prevalence: Findings from a nationally representative study.

    Beatriz, Elizabeth D / Salhi, Carmel / Griffith, John L / Molnar, Beth E

    Child abuse & neglect

    2018  Volume 79, Page(s) 371–383

    Abstract: Despite indications that there are differences in rates of child maltreatment (CM) cases in the child protection system between urban and rural areas, there are no published studies examining the differences in self-reported CM prevalence and its ... ...

    Abstract Despite indications that there are differences in rates of child maltreatment (CM) cases in the child protection system between urban and rural areas, there are no published studies examining the differences in self-reported CM prevalence and its correlates by urbanicity. The present study aimed to: (1) identify the distribution of self-reported childhood experiences of maltreatment by urbanicity, (2) assess whether differences by urbanicity persist after adjusting for known risk factors, and (3) explore whether the associations between these risk factors and CM are modified by urban-rural designation. Using nationally representative data from waves I and III of the National Longitudinal Study of Adolescent to Adult Health, the prevalence of six maltreatment outcomes was estimated for rural, minor urban, and major urban areas (N = 14,322). Multivariable logistic models were estimated identifying if risk associated with urbanicity persisted after adjusting for other risk factors. Interactions between urbanicity and main effects were explored. Prevalence estimates of any CM, poly-victimization, supervision neglect, and physical abuse were significantly higher in major urban areas. Those from major urban areas were more likely to report any maltreatment and supervision neglect even after adjusting for child and family risk factors. The association between race/ethnicity, welfare receipt, low parental educational attainment, and disability status and CM were modified by urbanicity. Significant differences in the prevalence and correlates of CM exist between urban and rural areas. Future research and policy should use self-reported prevalence, in conjunction with official reports, to inform child maltreatment prevention and intervention.
    MeSH term(s) Adolescent ; Adult ; Child ; Child Abuse/diagnosis ; Child Abuse/statistics & numerical data ; Crime Victims/statistics & numerical data ; Female ; Humans ; Logistic Models ; Longitudinal Studies ; Male ; Mandatory Reporting ; New England/epidemiology ; Prevalence ; Risk Factors ; Rural Health/statistics & numerical data ; Self Report ; Urban Health/statistics & numerical data ; Young Adult
    Language English
    Publishing date 2018-03-20
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 799143-5
    ISSN 1873-7757 ; 0145-2134
    ISSN (online) 1873-7757
    ISSN 0145-2134
    DOI 10.1016/j.chiabu.2018.02.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1437: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Urban-rural disparity and urban population growth: A multilevel analysis of under-5 mortality in 30 sub-Saharan African countries.

    Beatriz, Elizabeth D / Molnar, Beth E / Griffith, John L / Salhi, Carmel

    Health & place

    2018  Volume 52, Page(s) 196–204

    Abstract: Objectives: To assess whether country-level urban population growth is associated with the magnitude of the urban-rural disparity in under-five mortality (U5M) using ecologic and multilevel analyses.: Methods: We used data from 2010 to 2015 ... ...

    Abstract Objectives: To assess whether country-level urban population growth is associated with the magnitude of the urban-rural disparity in under-five mortality (U5M) using ecologic and multilevel analyses.
    Methods: We used data from 2010 to 2015 Demographic and Health Surveys and World Bank data from 30 sub-Saharan African countries (n = 411,054 women). Country-level linear regressions determined associations between urban population growth and economic growth between 2005 and 2010 on U5M risk differences. Multilevel logistic regression models were used to determine the impact of urban population growth on the urban advantage in U5M, adjusting for child and maternal factors.
    Results: Countries with greater urban population growth and low economic growth had greater disparities in U5M between urban and rural areas. After adjusting for known U5M risk factors in multilevel analyses, interactions between country-level urban population growth and urbanicity were identified.
    Conclusions: Continued efforts to evaluate and address disparities in child mortality outcomes in sub-Saharan Africa should acknowledge urbanicity in context, as well as socioeconomic and geographic realities of families, mothers and children. Low-resource, demographically shifting environments require novel strategies to decrease child mortality.
    MeSH term(s) Adolescent ; Adult ; Africa South of the Sahara/epidemiology ; Child Mortality ; Child, Preschool ; Demography ; Developing Countries ; Female ; Geography ; Health Status Disparities ; Health Surveys ; Humans ; Infant ; Infant Mortality ; Infant, Newborn ; Linear Models ; Male ; Middle Aged ; Multilevel Analysis ; Population Dynamics ; Risk Factors ; Rural Health ; Rural Population/statistics & numerical data ; Urban Health ; Urban Population/statistics & numerical data ; Young Adult
    Language English
    Publishing date 2018-06-26
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 1262540-1
    ISSN 1873-2054 ; 1353-8292
    ISSN (online) 1873-2054
    ISSN 1353-8292
    DOI 10.1016/j.healthplace.2018.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4333: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Social Determinants of Health and Delirium Occurrence and Duration in Critically Ill Adults.

    Wu, Ting-Ting / Zegers, Marieke / Kooken, Rens / Griffith, John L / Molnar, Beth E / Devlin, John W / van den Boogaard, Mark

    Critical care explorations

    2021  Volume 3, Issue 9, Page(s) e0532

    Abstract: Social determinants of health may affect ICU outcome, but the association between social determinants of health and delirium remains unclear. We evaluated the association between three social determinants of health and delirium occurrence and duration in ...

    Abstract Social determinants of health may affect ICU outcome, but the association between social determinants of health and delirium remains unclear. We evaluated the association between three social determinants of health and delirium occurrence and duration in critically ill adults.
    Design: Secondary, subgroup analysis of a cohort study.
    Setting: Single, 36-bed mixed medical-surgical ICU in the Netherlands.
    Patients: Nine hundred fifty-six adults consecutively admitted from July 2016 to February 2020. Patients admitted after elective surgery, residing in a nursing home, or not expected to survive greater than or equal to 48 hours were excluded.
    Intervention: None.
    Measurements and main results: Four factors related to three Center for Disease Control social determinants of health domains (social/community context [ethnicity], education access/quality [educational level], and economic stability [employment status and monthly income]) were collected at ICU admission from patients (or families). Well-trained ICU nurses evaluated patients without coma (Richmond Agitation Sedation Scale, -4, -5) and with the Confusion Assessment Method-ICU and/or a delirium day was defined by greater than or equal to 1 + Confusion Assessment Method-ICU and/or scheduled antipsychotic use. Multivariable logistic regression models controlling for ICU days and 10 delirium risk variables (before-ICU: age, Charlson, cognitive impairment, any antidepressant, antipsychotic, or benzodiazepine use; ICU baseline: Acute Physiology and Chronic Health Evaluation IV and admission type; daily ICU: Sequential Organ Failure Assessment, restraint use, coma, benzodiazepine, or opioid use) evaluated associations between each social determinant of health factor and both ICU delirium occurrence and duration. Delirium occurred in 393/956 patients (45.4%) for 2 days (1-5 d). Patients with low (vs high) income had more ICU delirium (
    Conclusions: Social determinants of health did not affect ICU delirium in one Dutch region. Additional research across different countries/regions and where additional social determinants of health are considered is needed to define the association between social determinants of health and ICU delirium.
    Language English
    Publishing date 2021-09-07
    Publishing country United States
    Document type Journal Article
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000532
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Association Between Perioperative Medication Use and Postoperative Delirium and Cognition in Older Adults Undergoing Elective Noncardiac Surgery.

    Duprey, Matthew S / Devlin, John W / Griffith, John L / Travison, Thomas G / Briesacher, Becky A / Jones, Richard / Saczynski, Jane S / Schmitt, Eva M / Gou, Yun / Marcantonio, Edward R / Inouye, Sharon K

    Anesthesia and analgesia

    2022  Volume 134, Issue 6, Page(s) 1154–1163

    Abstract: Background: Postoperative delirium is frequent in older adults and is associated with postoperative neurocognitive disorder (PND). Studies evaluating perioperative medication use and delirium have generally evaluated medications in aggregate and been ... ...

    Abstract Background: Postoperative delirium is frequent in older adults and is associated with postoperative neurocognitive disorder (PND). Studies evaluating perioperative medication use and delirium have generally evaluated medications in aggregate and been poorly controlled; the association between perioperative medication use and PND remains unclear. We sought to evaluate the association between medication use and postoperative delirium and PND in older adults undergoing major elective surgery.
    Methods: This is a secondary analysis of a prospective cohort study of adults ≥70 years without dementia undergoing major elective surgery. Patients were interviewed preoperatively to determine home medication use. Postoperatively, daily hospital use of 7 different medication classes listed in guidelines as risk factors for delirium was collected; administration before delirium was verified. While hospitalized, patients were assessed daily for delirium using the Confusion Assessment Method and a validated chart review method. Cognition was evaluated preoperatively and 1 month after surgery using a neurocognitive battery. The association between prehospital medication use and postoperative delirium was assessed using a generalized linear model with a log link function, controlling for age, sex, type of surgery, Charlson comorbidity index, and baseline cognition. The association between daily postoperative medication use (when class exposure ≥5%) and time to delirium was assessed using time-varying Cox models adjusted for age, sex, surgery type, Charlson comorbidity index, Acute Physiology and Chronic Health Evaluation (APACHE)-II score, and baseline cognition. Mediation analysis was utilized to evaluate the association between medication use, delirium, and cognitive change from baseline to 1 month.
    Results: Among 560 patients enrolled, 134 (24%) developed delirium during hospitalization. The multivariable analyses revealed no significant association between prehospital benzodiazepine (relative risk [RR], 1.44; 95% confidence interval [CI], 0.85-2.44), beta-blocker (RR, 1.38; 95% CI, 0.94-2.05), NSAID (RR, 1.12; 95% CI, 0.77-1.62), opioid (RR, 1.22; 95% CI, 0.82-1.82), or statin (RR, 1.34; 95% CI, 0.92-1.95) exposure and delirium. Postoperative hospital benzodiazepine use (adjusted hazard ratio [aHR], 3.23; 95% CI, 2.10-4.99) was associated with greater delirium. Neither postoperative hospital antipsychotic (aHR, 1.48; 95% CI, 0.74-2.94) nor opioid (aHR, 0.82; 95% CI, 0.62-1.11) use before delirium was associated with delirium. Antipsychotic use (either presurgery or postsurgery) was associated with a 0.34 point (standard error, 0.16) decrease in general cognitive performance at 1 month through its effect on delirium (P = .03), despite no total effect being observed.
    Conclusions: Administration of benzodiazepines to older adults hospitalized after major surgery is associated with increased postoperative delirium. Association between inhospital, postoperative medication use and cognition at 1 month, independent of delirium, was not detected.
    MeSH term(s) Aged ; Analgesics, Opioid ; Antipsychotic Agents ; Benzodiazepines ; Cognition ; Delirium/chemically induced ; Delirium/diagnosis ; Delirium/epidemiology ; Humans ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Prospective Studies ; Risk Factors
    Chemical Substances Analgesics, Opioid ; Antipsychotic Agents ; Benzodiazepines (12794-10-4)
    Language English
    Publishing date 2022-02-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000005959
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.78: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 149: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Approaches to Optimize Medication Data Analysis in Clinical Cohort Studies.

    Duprey, Matthew S / Devlin, John W / Briesacher, Becky A / Travison, Thomas G / Griffith, John L / Inouye, Sharon K

    Journal of the American Geriatrics Society

    2020  Volume 68, Issue 12, Page(s) 2921–2926

    Abstract: Objectives: Methods for pharmacoepidemiologic studies of large-scale data repositories are established. Although clinical cohorts of older adults often contain critical information to advance our understanding of medication risk and benefit, the methods ...

    Abstract Objectives: Methods for pharmacoepidemiologic studies of large-scale data repositories are established. Although clinical cohorts of older adults often contain critical information to advance our understanding of medication risk and benefit, the methods best suited to manage medication data in these samples are sometimes unclear and their degree of validation unknown. We sought to provide researchers, in the context of a clinical cohort study of delirium in older adults, with guidance on the methodological tools to use data from clinical cohorts to better understand medication risk factors and outcomes.
    Design: Prospective cohort study.
    Setting: The Successful Aging After Elective Surgery (SAGES) prospective cohort.
    Participants: A total of 560 older adults (aged ≥70 years) without dementia undergoing elective major surgery.
    Measurements: Using the SAGES clinical cohort, methods used to characterize medications were identified, reviewed, analyzed, and distinguished by appropriateness and degree of validation for characterizing pharmacoepidemiologic data in smaller clinical data sets.
    Results: Medication coding is essential; the American Hospital Formulary System, most often used in the United States, is not preferred over others. Use of equivalent dosing scales (e.g., morphine equivalents) for a single medication class (e.g., opioids) is preferred over multiclass analgesic equivalency scales. Medication aggregation from the same class (e.g., benzodiazepines) is well established; the optimal prevalence breakout for aggregation remains unclear. Validated scale(s) to combine structurally dissimilar medications (e.g., anticholinergics) should be used with caution; a lack of consensus exists regarding the optimal scale. Directed acyclic graph(s) are an accepted method to conceptualize causative frameworks when identifying potential confounders. Modeling-based strategies should be used with evidence-based, a priori variable-selection strategies.
    Conclusion: As highlighted in the SAGES cohort, the methods used to classify and analyze medication data in clinically rich cohort studies vary in the rigor by which they have been developed and validated.
    MeSH term(s) Aged ; Analgesics/therapeutic use ; Analgesics, Opioid/standards ; Analgesics, Opioid/therapeutic use ; Data Analysis ; Elective Surgical Procedures ; Female ; Humans ; Male ; Medication Reconciliation/classification ; Medication Reconciliation/standards ; Pharmacoepidemiology ; Prospective Studies ; Research Design ; United States/epidemiology
    Chemical Substances Analgesics ; Analgesics, Opioid
    Language English
    Publishing date 2020-10-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.16844
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.168: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Dietary Approaches to Stop Hypertension, Mediterranean, and Alternative Healthy Eating indices are associated with bone health among Puerto Rican adults from the Boston Puerto Rican Osteoporosis Study.

    Noel, Sabrina E / Mangano, Kelsey M / Mattei, Josiemer / Griffith, John L / Dawson-Hughes, Bess / Bigornia, Sherman / Tucker, Katherine L

    The American journal of clinical nutrition

    2020  Volume 111, Issue 6, Page(s) 1267–1277

    Abstract: Background: Conflicting results on associations between dietary quality and bone have been noted across populations, and this has been understudied in Puerto Ricans, a population at higher risk of osteoporosis than previously appreciated.: Objective: ...

    Abstract Background: Conflicting results on associations between dietary quality and bone have been noted across populations, and this has been understudied in Puerto Ricans, a population at higher risk of osteoporosis than previously appreciated.
    Objective: To compare cross-sectional associations between 3 dietary quality indices [Dietary Approaches to Stop Hypertension (DASH), Alternative Health Eating Index (AHEI-2010), and Mediterranean Diet Score (MeDS)] with bone outcomes.
    Method: Participants (n = 865-896) from the Boston Puerto Rican Osteoporosis Study (BPROS) with complete bone and dietary data were included. Indices were calculated from validated food frequency data. Bone mineral density (BMD) was measured using DXA. Associations between dietary indices (z-scores) and their individual components with BMD and osteoporosis were tested with ANCOVA and logistic regression, respectively, at the lumbar spine and femoral neck, stratified by male, premenopausal women, and postmenopausal women.
    Results: Participants were 59.9 y ± 7.6 y and mostly female (71%). Among postmenopausal women not taking estrogen, DASH (score: 11-38) was associated with higher trochanter (0.026 ± 0.006 g/cm2, P <0.001), femoral neck (0.022 ± 0.006 g/cm2, P <0.001), total hip (0.029 ± 0.006 g/cm2, P <0.001), and lumbar spine BMD (0.025 ± 0.007 g/cm2, P = 0.001). AHEI (score: 25-86) was also associated with spine and all hip sites (P <0.02), whereas MeDS (0-9) was associated only with total hip (P = 0.01) and trochanter BMD (P = 0.007) in postmenopausal women. All indices were associated with a lower likelihood of osteoporosis (OR from 0.54 to 0.75). None of the results were significant for men or premenopausal women.
    Conclusions: Although all appeared protective, DASH was more positively associated with BMD than AHEI or MeDS in postmenopausal women not taking estrogen. Methodological differences across scores suggest that a bone-specific index that builds on existing indices and that can be used to address dietary differences across cultural and ethnic minority populations should be considered.
    MeSH term(s) Aged ; Bone Density ; Boston/ethnology ; Cross-Sectional Studies ; Diet, Healthy ; Diet, Mediterranean ; Dietary Approaches To Stop Hypertension ; Female ; Hispanic or Latino/statistics & numerical data ; Humans ; Male ; Middle Aged ; Osteoporosis, Postmenopausal/diet therapy ; Osteoporosis, Postmenopausal/ethnology ; Osteoporosis, Postmenopausal/metabolism ; Osteoporosis, Postmenopausal/physiopathology ; Postmenopause/metabolism
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 280048-2
    ISSN 1938-3207 ; 0002-9165
    ISSN (online) 1938-3207
    ISSN 0002-9165
    DOI 10.1093/ajcn/nqaa090
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Opioid Use Increases the Risk of Delirium in Critically Ill Adults Independently of Pain.

    Duprey, Matthew S / Dijkstra-Kersten, Sandra M A / Zaal, Irene J / Briesacher, Becky A / Saczynski, Jane S / Griffith, John L / Devlin, John W / Slooter, Arjen J C

    American journal of respiratory and critical care medicine

    2021  Volume 204, Issue 5, Page(s) 566–572

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Aged ; Analgesics, Opioid/adverse effects ; Analgesics, Opioid/therapeutic use ; Critical Illness/therapy ; Delirium/chemically induced ; Female ; Humans ; Male ; Middle Aged ; Netherlands ; Odds Ratio ; Pain/drug therapy ; Prospective Studies ; Risk Factors
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2021-04-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202010-3794OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.80: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Association Between Incident Delirium Treatment With Haloperidol and Mortality in Critically Ill Adults.

    Duprey, Matthew S / Devlin, John W / van der Hoeven, Johannes G / Pickkers, Peter / Briesacher, Becky A / Saczynski, Jane S / Griffith, John L / van den Boogaard, Mark

    Critical care medicine

    2021  Volume 49, Issue 8, Page(s) 1303–1311

    Abstract: Objectives: Haloperidol is commonly administered in the ICU to reduce the burden of delirium and its related symptoms despite no clear evidence showing haloperidol helps to resolve delirium or improve survival. We evaluated the association between ... ...

    Abstract Objectives: Haloperidol is commonly administered in the ICU to reduce the burden of delirium and its related symptoms despite no clear evidence showing haloperidol helps to resolve delirium or improve survival. We evaluated the association between haloperidol, when used to treat incident ICU delirium and its symptoms, and mortality.
    Design: Post hoc cohort analysis of a randomized, double-blind, placebo-controlled, delirium prevention trial.
    Setting: Fourteen Dutch ICUs between July 2013 and December 2016.
    Patients: One-thousand four-hundred ninety-five critically ill adults free from delirium at ICU admission having an expected ICU stay greater than or equal to 2 days.
    Interventions: Patients received preventive haloperidol or placebo for up to 28 days until delirium occurrence, death, or ICU discharge. If delirium occurred, treatment with open-label IV haloperidol 2 mg tid (up to 5 mg tid per delirium symptoms) was administered at clinician discretion.
    Measurements and main results: Patients were evaluated tid for delirium and coma for 28 days. Time-varying Cox hazards models were constructed for 28-day and 90-day mortality, controlling for study-arm, delirium and coma days, age, Acute Physiology and Chronic Health Evaluation-II score, sepsis, mechanical ventilation, and ICU length of stay. Among the 1,495 patients, 542 (36%) developed delirium within 28 days (median [interquartile range] with delirium 4 d [2-7 d]). A total of 477 of 542 (88%) received treatment haloperidol (2.1 mg [1.0-3.8 mg] daily) for 6 days (3-11 d). Each milligram of treatment haloperidol administered daily was associated with decreased mortality at 28 days (hazard ratio, 0.93; 95% CI, 0.91-0.95) and 90 days (hazard ratio, 0.97; 95% CI, 0.96-0.98). Treatment haloperidol administered later in the ICU course was less protective of death. Results were stable by prevention study-arm, predelirium haloperidol exposure, and haloperidol treatment protocol adherence.
    Conclusions: Treatment of incident delirium and its symptoms with haloperidol may be associated with a dose-dependent improvement in survival. Future randomized trials need to confirm these results.
    MeSH term(s) Adult ; Aged ; Antipsychotic Agents/therapeutic use ; Critical Care/methods ; Critical Illness/mortality ; Critical Illness/therapy ; Delirium/drug therapy ; Delirium/mortality ; Female ; Haloperidol/therapeutic use ; Humans ; Intensive Care Units ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Netherlands ; Survival Analysis
    Chemical Substances Antipsychotic Agents ; Haloperidol (J6292F8L3D)
    Language English
    Publishing date 2021-04-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000004976
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top