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  1. Article ; Online: Professor Lionel Fry (1933-2021).

    Griffiths, C E M

    The British journal of dermatology

    2021  Volume 185, Issue 1, Page(s) 237–238

    Language English
    Publishing date 2021-05-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.20075
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  2. Book: The spectrum of photodamage and its treatment

    Griffiths, C. E. M.

    (The journal of dermatological treatment ; 7, Suppl. 2)

    1996  

    Author's details suppl. ed. C. E. M. Griffiths
    Series title The journal of dermatological treatment ; 7, Suppl. 2
    Collection
    Keywords Skin Aging ; Pigmentation Disorders ; Ultraviolet Rays / adverse effects ; Skin Diseases
    Language English
    Size S27 S. : Ill., graph. Darst.
    Publisher Dunitz u.a.
    Publishing place Basingstoke
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT007406799
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2627 -7,Suppl.2- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: Immediate global support is needed for Myanmar.

    Lwin, S M / Griffiths, C E M

    The British journal of dermatology

    2021  Volume 185, Issue 2, Page(s) 466–467

    Language English
    Publishing date 2021-05-17
    Publishing country England
    Document type Letter
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.20385
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  4. Article ; Online: The promise and challenges of cell therapy for psoriasis.

    Lwin, S M / Snowden, J A / Griffiths, C E M

    The British journal of dermatology

    2021  Volume 185, Issue 5, Page(s) 887–898

    Abstract: The management of moderate-to-severe psoriasis has been transformed by the introduction of biological therapies. These medicines, particularly those targeting interleukin (IL)-17 and IL-23p19, can offer clear or nearly clear skin for the majority of ... ...

    Abstract The management of moderate-to-severe psoriasis has been transformed by the introduction of biological therapies. These medicines, particularly those targeting interleukin (IL)-17 and IL-23p19, can offer clear or nearly clear skin for the majority of patients with psoriasis, with good long-term drug survival. However, as currently used, none of these therapies is curative and disconcertingly there is a small but increasing number of patients with severe psoriasis who have failed all currently available therapeutic modalities. A similar scenario has occurred in other immune-mediated inflammatory diseases (IMIDs) where treatment options are limited in severely affected patients. In these cases, cell therapy, including haematopoietic stem cell transplantation (HSCT) and mesenchymal stromal cells (MSC), has been utilized. This review discusses the various forms of cell therapy currently available, their utility in the management of IMIDs and emerging evidence for efficacy in severe psoriasis that is unresponsive to biological therapy. Balancing the risks and benefits of treatment vs. the underlying disease is key; cell therapy carries significant risks, costs, regulation and other complexities, which must be justified by outcomes. Although HSCT has anecdotally been reported to benefit severe psoriasis, sometimes with apparent cure, this has mainly been in the setting of other coincidental 'routine' indications. In psoriasis, cell therapies, such as MSC and regulatory T cells, with a lower risk of complications are likely to be more appropriate. Well-designed controlled trials coupled with mechanistic studies are warranted if advanced cell therapies are to be developed and delivered as a realistic option for severe psoriasis.
    MeSH term(s) Biological Therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Psoriasis/therapy
    Language English
    Publishing date 2021-07-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.20517
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  5. Article ; Online: Tender facial nodules in a man receiving adalimumab for psoriasis.

    Kreeshan, F C / Jamieson, L A / Griffiths, C E M

    Clinical and experimental dermatology

    2021  Volume 47, Issue 1, Page(s) 202–205

    MeSH term(s) Adalimumab/adverse effects ; Adalimumab/therapeutic use ; Drug Eruptions/etiology ; Drug Eruptions/pathology ; Granuloma/chemically induced ; Granuloma/pathology ; Humans ; Male ; Middle Aged ; Psoriasis/drug therapy
    Chemical Substances Adalimumab (FYS6T7F842)
    Language English
    Publishing date 2021-08-26
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1111/ced.14813
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  6. Article ; Online: Systems medicine and psoriasis.

    Griffiths, C E M

    The British journal of dermatology

    2017  Volume 176, Issue 3, Page(s) 560–562

    Language English
    Publishing date 2017
    Publishing country England
    Document type Editorial
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.15334
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  7. Article ; Online: Physical activity is important for cardiovascular health and cardiorespiratory fitness in patients with psoriasis.

    Auker, L / Cordingley, L / Griffiths, C E M / Young, H S

    Clinical and experimental dermatology

    2021  Volume 47, Issue 2, Page(s) 289–296

    Abstract: Background: Patients with psoriasis have a level of physical activity below that recommended for cardiovascular health, which is significantly limited by disease severity and other psoriasis-specific barriers. We hypothesized that physical activity is ... ...

    Abstract Background: Patients with psoriasis have a level of physical activity below that recommended for cardiovascular health, which is significantly limited by disease severity and other psoriasis-specific barriers. We hypothesized that physical activity is important for cardiovascular health in patients with psoriasis and that its objective measurement could have clinical utility.
    Aim: To explore whether physical activity influences the risk of cardiovascular disease (CVD) in patients with psoriasis.
    Methods: In total, 242 patients with chronic plaque psoriasis were recruited. History, examination and physical activity were assessed and arteriography, the noninvasive measurement of arterial function, was performed for each participant.
    Results: We observed a significant relationship between volume of physical activity and the likelihood of future CVD as measured by pulse wave velocity (PWV; P < 0.02). We identified a significant relationship between the diastolic reflection area (DRA) and health-promoting levels of physical activity (P < 0.001), in addition to a significant correlation between DRA and the likelihood of future CVD (P < 0.001). The DRA is a complex, dimensionless variable that describes the intensity of diastolic wave reflection and the duration of diastole, which are key determinants of the blood supply to the left ventricle. Our data suggest that DRA may represent a surrogate marker for cardiorespiratory fitness.
    Conclusion: Our study describes a significant relationship between exercise, cardiorespiratory fitness and PWV, a preclinical indicator of future CVD risk, in patients with psoriasis. The DRA offers a noninvasive, objective measurement of exercise adherence, which could have clinical utility in the future.
    MeSH term(s) Adult ; Age of Onset ; Cardiorespiratory Fitness ; Exercise/physiology ; Female ; Heart Disease Risk Factors ; Humans ; Male ; Middle Aged ; Psoriasis/physiopathology ; Pulse Wave Analysis ; Severity of Illness Index
    Language English
    Publishing date 2021-09-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1111/ced.14872
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  8. Article ; Online: Tofacitinib efficacy, patient-reported outcomes and safety in patients with psoriasis and a medical history of psoriatic arthritis: Pooled analysis of two Phase III studies.

    Bachelez, H / Griffiths, C E M / Papp, K A / Hall, S / Merola, J F / Feldman, S R / Khraishi, M / Tan, H / Fallon, L / Cappelleri, J C / Bushmakin, A G / Young, P

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2024  

    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19701
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    Zs.A 3492: Show issues Location:
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    Zs.MO 413: Show issues

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  9. Article ; Online: A quasquicentennial reflection on psoriasis.

    Griffiths, C E M

    The British journal of dermatology

    2014  Volume 170, Issue 2, Page(s) 231–233

    MeSH term(s) Dermatologic Agents/therapeutic use ; Dermatology/trends ; Forecasting ; Humans ; Psoriasis/drug therapy ; Psoriasis/genetics
    Chemical Substances Dermatologic Agents
    Language English
    Publishing date 2014-02
    Publishing country England
    Document type Editorial
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.12834
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  10. Article ; Online: Development of clinical diagnostic criteria for chronic plaque psoriasis: an international e-Delphi study.

    Abo-Tabik, M / Parisi, R / Willis, S C / Griffiths, C E M / Ashcroft, D M

    The British journal of dermatology

    2021  Volume 185, Issue 2, Page(s) 455–456

    Language English
    Publishing date 2021-05-31
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.20096
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