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Artikel: Macrophages from disease resistant B2 haplotype chickens activate T lymphocytes more effectively than macrophages from disease susceptible B19 birds

Collisson, Ellen / Griggs, Lisa / Drechsler, Yvonne

Developmental and comparative immunology. 2017 Feb., v. 67

2017

Abstract: Resistance to respiratory pathogens, including coronavirus-induced infection and clinical illness in chickens has been correlated with the B (MHC) complex and differential ex vivo macrophage responses. In the current study, in vitro T lymphocyte ... ...

Abstract	Resistance to respiratory pathogens, including coronavirus-induced infection and clinical illness in chickens has been correlated with the B (MHC) complex and differential ex vivo macrophage responses. In the current study, in vitro T lymphocyte activation measured by IFNγ release was significantly higher in B2 versus B19 haplotypes. AIV infection of macrophages was required to activate T lymphocytes and prior in vivo exposure of chickens to NP AIV plasmid enhanced responses to infected macrophages. This study suggests that the demonstrated T lymphocyte activation is in part due to antigen presentation by the macrophages as well as cytokine release by the infected macrophages, with B2 haplotypes showing stronger activation. These responses were present both in CD4 and CD8 T lymphocytes. In contrast, T lymphocytes stimulated by ConA showed greater IFNγ release of B19 haplotype cells, further indicating the greater responses in B2 haplotypes to infection is due to macrophages, but not T cells. In summary, resistance of B2 haplotype chickens appears to be directly linked to a more vigorous innate immune response and the role macrophages play in activating adaptive immunity.
Schlagwörter	CD8-positive T-lymphocytes ; antigen presentation ; chickens ; concanavalin A ; cytokines ; haplotypes ; innate immunity ; lymphocyte proliferation ; macrophages ; pathogens ; plasmids ; covid19
Sprache	Englisch
Erscheinungsverlauf	2017-02
Umfang	p. 249-256.
Erscheinungsort	Elsevier Ltd
Dokumenttyp	Artikel
ZDB-ID	752411-0
ISSN	1879-0089 ; 0145-305X
ISSN (online)	1879-0089
ISSN	0145-305X
DOI	10.1016/j.dci.2016.09.013
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Host Gene Expression of Macrophages in Response to Feline Coronavirus Infection.

Drechsler, Yvonne / Vasconcelos, Elton J R / Griggs, Lisa M / Diniz, Pedro P P V / Collisson, Ellen

Cells

2020 Band 9, Heft 6

Abstract: Feline coronavirus is a highly contagious virus potentially resulting in feline infectious peritonitis (FIP), while the pathogenesis of FIP remains not well understood, particularly in the events leading to the disease. A predominant theory is that the ... ...

Abstract	Feline coronavirus is a highly contagious virus potentially resulting in feline infectious peritonitis (FIP), while the pathogenesis of FIP remains not well understood, particularly in the events leading to the disease. A predominant theory is that the pathogenic FIPV arises from a mutation, so that it could replicate not only in enterocytes of the intestines but also in monocytes, subsequently systemically transporting the virus. The immune status and genetics of affected cats certainly play an important role in the pathogenesis. Considering the importance of genetics and host immune responses in viral infections, the goal of this study was to elucidate host gene expression in macrophages using RNA sequencing. Macrophages from healthy male cats infected with FIPV 79-1146 ex vivo displayed a differential host gene expression. Despite the virus uptake, aligned viral reads did not increase from 2 to 17 h. The overlap of host gene expression among macrophages from different cats was limited, even though viral transcripts were detected in the cells. Interestingly, some of the downregulated genes in all macrophages were involved in immune signaling, while some upregulated genes common for all cats were found to be inhibiting immune activation. Our results highlight individual host responses playing an important role, consistent with the fact that few cats develop feline infectious peritonitis despite a common presence of enteric FCoV.
Mesh-Begriff(e)	Animals ; Cats ; Cell Line ; Coronavirus, Feline/genetics ; Coronavirus, Feline/immunology ; Feline Infectious Peritonitis/immunology ; Feline Infectious Peritonitis/pathology ; Feline Infectious Peritonitis/virology ; Gene Expression Regulation ; Immunity, Innate/genetics ; Immunity, Innate/immunology ; Macrophages/cytology ; Macrophages/immunology ; Monocytes/cytology ; Monocytes/immunology ; RNA, Viral/isolation & purification ; Sequence Analysis, RNA ; Transcriptome/genetics
Chemische Substanzen	RNA, Viral
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2020-06-09
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells9061431
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: CRFK and Primary Macrophages Transcriptomes in Response to Feline Coronavirus Infection Differ Significantly.

Drechsler, Yvonne / Vasconcelos, Elton J R / Griggs, Lisa M / Diniz, Pedro P P V

Frontiers in genetics

2020 Band 11, Seite(n) 584744

Abstract: Coronaviruses are highly infectious and common in many species, including in humans, and agricultural and domestic animals. Host responses play an important role in viral entry, replication, assembly, and pathogenesis, although much is still to be ... ...

Abstract	Coronaviruses are highly infectious and common in many species, including in humans, and agricultural and domestic animals. Host responses play an important role in viral entry, replication, assembly, and pathogenesis, although much is still to be understood, particularly host-virus interactions. Feline coronavirus is highly contagious, and ubiquitous in virtually all cat populations. Host-pathogen interactions have not been studied extensively due to the complex pathogenesis and development of clinical disease. Few studies have investigated cellular host responses to feline coronavirus infection, particularly at early time points. Transcriptome studies based on next-generation sequencing have the potential to elucidate the early responses of cells after viral infection and, consequently, give further insight into the pathogenesis of viruses. The current study aims to characterize and compare the viral- and immune-related differentially expressed genes in response to the coronavirus FIPV across different time points in a cell line which is permissive for productive replication versus primary cells implicated in pathogenesis. When comparing host responses in Crandell-Rees Feline Kidney (CRFK) cells to primary macrophages, many differences were observed with regards to expressed genes and their enrichments for both KEGG pathways and GO terms. CRFK cells which are permissive for productive replication of feline infectious peritonitis virus, showed induction of a large network of immunological and virally induced pathways. In contrast, Macrophages did not show similar host responses, with stronger pathway enrichment in downregulated transcripts. This study provides insights to better understand gene transcription in immune cells compared to epithelial cells discerning pathways relevant to pathogenesis in the early stages of infection.
Sprache	Englisch
Erscheinungsdatum	2020-12-03
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2020.584744
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Transcriptomes of an Array of Chicken Ovary, Intestinal, and Immune Cells and Tissues.

Overbey, Eliah G / Ng, Theros T / Catini, Pietro / Griggs, Lisa M / Stewart, Paul / Tkalcic, Suzana / Hawkins, R David / Drechsler, Yvonne

Frontiers in genetics

2021 Band 12, Seite(n) 664424

Abstract: While the chicken ( ...

Abstract	While the chicken (
Sprache	Englisch
Erscheinungsdatum	2021-06-30
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2021.664424
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Macrophages from disease resistant B2 haplotype chickens activate T lymphocytes more effectively than macrophages from disease susceptible B19 birds.

Collisson, Ellen / Griggs, Lisa / Drechsler, Yvonne

Developmental and comparative immunology

2016 Band 67, Seite(n) 249–256

Abstract	Resistance to respiratory pathogens, including coronavirus-induced infection and clinical illness in chickens has been correlated with the B (MHC) complex and differential ex vivo macrophage responses. In the current study, in vitro T lymphocyte activation measured by IFNγ release was significantly higher in B2 versus B19 haplotypes. AIV infection of macrophages was required to activate T lymphocytes and prior in vivo exposure of chickens to NP AIV plasmid enhanced responses to infected macrophages. This study suggests that the demonstrated T lymphocyte activation is in part due to antigen presentation by the macrophages as well as cytokine release by the infected macrophages, with B2 haplotypes showing stronger activation. These responses were present both in CD4 and CD8 T lymphocytes. In contrast, T lymphocytes stimulated by ConA showed greater IFNγ release of B19 haplotype cells, further indicating the greater responses in B2 haplotypes to infection is due to macrophages, but not T cells. In summary, resistance of B2 haplotype chickens appears to be directly linked to a more vigorous innate immune response and the role macrophages play in activating adaptive immunity.
Mesh-Begriff(e)	Adaptive Immunity ; Animals ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cells, Cultured ; Chickens/immunology ; Disease Susceptibility ; Haplotypes ; Immunity, Innate ; Influenza in Birds/immunology ; Lymphocyte Activation ; Macrophages/immunology ; Macrophages/virology ; Orthomyxoviridae/immunology ; Paracrine Communication ; Species Specificity
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2016-10-14
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	752411-0
ISSN	1879-0089 ; 0145-305X
ISSN (online)	1879-0089
ISSN	0145-305X
DOI	10.1016/j.dci.2016.09.013
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Host Gene Expression of Macrophages in Response to Feline Coronavirus Infection

Drechsler, Yvonne / Vasconcelos, Elton J R / Griggs, Lisa M / Diniz, Pedro P P V / Collisson, Ellen

Abstract	Feline coronavirus is a highly contagious virus potentially resulting in feline infectious peritonitis (FIP), while the pathogenesis of FIP remains not well understood, particularly in the events leading to the disease. A predominant theory is that the pathogenic FIPV arises from a mutation, so that it could replicate not only in enterocytes of the intestines but also in monocytes, subsequently systemically transporting the virus. The immune status and genetics of affected cats certainly play an important role in the pathogenesis. Considering the importance of genetics and host immune responses in viral infections, the goal of this study was to elucidate host gene expression in macrophages using RNA sequencing. Macrophages from healthy male cats infected with FIPV 79-1146 ex vivo displayed a differential host gene expression. Despite the virus uptake, aligned viral reads did not increase from 2 to 17 h. The overlap of host gene expression among macrophages from different cats was limited, even though viral transcripts were detected in the cells. Interestingly, some of the downregulated genes in all macrophages were involved in immune signaling, while some upregulated genes common for all cats were found to be inhibiting immune activation. Our results highlight individual host responses playing an important role, consistent with the fact that few cats develop feline infectious peritonitis despite a common presence of enteric FCoV.
Schlagwörter	covid19
Verlag	WHO
Dokumenttyp	Artikel
Anmerkung	WHO #Covidence: #619132
Datenquelle	COVID19

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Artikel: Dramatic differences in the response of macrophages from B2 and B19 MHC-defined haplotypes to interferon gamma and polyinosinic:polycytidylic acid stimulation.

Dawes, Maisie E / Griggs, Lisa M / Collisson, Ellen W / Briles, Worthie E / Drechsler, Yvonne

Poultry science

2014 Band 93, Heft 4, Seite(n) 830–838

Abstract: The chicken MHC has been associated with disease resistance, though the mechanisms are not understood. The functions of macrophages, critical to both innate and acquired immunity, were compared between the more infectious bronchitis virus-resistant B2 ... ...

Abstract	The chicken MHC has been associated with disease resistance, though the mechanisms are not understood. The functions of macrophages, critical to both innate and acquired immunity, were compared between the more infectious bronchitis virus-resistant B2 and the more infectious bronchitis virus-susceptible B19 lines. In vivo peripheral blood concentrations of monocytes were similar in B2 or B19 homozygous haplotypes. Peripheral blood-derived macrophages were stimulated with poly I:C, simulating an RNA virus, or IFNγ, a cytokine at the interface of innate and adaptive immunity. Not only did B2-derived peripheral monocytes differentiate into macrophages more readily than the B19 monocytes, but as determined by NO production, macrophages from B2 and B2 on B19 genetic background chicks were also significantly more responsive to either stimulant. In conclusion, the correlation with resistance to illness following viral infection may be directly linked to a more vigorous innate immune response.
Mesh-Begriff(e)	Adaptive Immunity ; Animals ; Cell Differentiation ; Cells, Cultured ; Chickens/genetics ; Chickens/immunology ; Coronavirus Infections/veterinary ; Coronavirus Infections/virology ; Disease Resistance ; Haplotypes ; Immunity, Innate ; Infectious bronchitis virus/physiology ; Interferon-gamma/administration & dosage ; Macrophages/immunology ; Macrophages/metabolism ; Major Histocompatibility Complex ; Monocytes/cytology ; Monocytes/metabolism ; Poly I-C/administration & dosage ; Poultry Diseases/virology
Chemische Substanzen	Interferon-gamma (82115-62-6) ; Poly I-C (O84C90HH2L)
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2014-04-04
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.3382/ps.2013-03511
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Delta 9-tetrahydrocannabinol suppresses vomiting behavior and Fos expression in both acute and delayed phases of cisplatin-induced emesis in the least shrew.

Ray, Andrew P / Griggs, Lisa / Darmani, Nissar A

Behavioural brain research

2008 Band 196, Heft 1, Seite(n) 30–36

Abstract: Cisplatin chemotherapy frequently causes severe vomiting in two temporally separated clusters of bouts dubbed the acute and delayed phases. Cannabinoids can inhibit the acute phase, albeit through a poorly understood mechanism. We examined the substrates ...

Abstract	Cisplatin chemotherapy frequently causes severe vomiting in two temporally separated clusters of bouts dubbed the acute and delayed phases. Cannabinoids can inhibit the acute phase, albeit through a poorly understood mechanism. We examined the substrates of cannabinoid-mediated inhibition of both the emetic phases via immunolabeling for serotonin, Substance P, cannabinoid receptors 1 and 2 (CB(1), CB(2)), and the neuronal activation marker Fos in the least shrew (Cryptotis parva). Shrews were injected with cisplatin (10mg/kg i.p.), and one of vehicle, Delta(9)-THC, or both Delta(9)-THC and the CB(1) receptor antagonist SR141716A (2mg/kg i.p.), and monitored for vomiting. Delta(9)-THC-pretreatment caused concurrent decreases in the number of shrews expressing vomiting and Fos-immunoreactivity (Fos-IR), effects which were blocked by SR141716A-pretreatment. Acute phase vomiting induced Fos-IR in the solitary tract nucleus (NTS), dorsal motor nucleus of the vagus (DMNX), and area postrema (AP), whereas in the delayed phase Fos-IR was not induced in the AP at all, and was induced at lower levels in the other nuclei when compared to the acute phase. CB(1) receptor-IR in the NTS was dense, punctate labeling indicative of presynaptic elements, which surrounded Fos-expressing NTS neurons. CB(2) receptor-IR was not found in neuronal elements, but in vascular-appearing structures. All areas correlated with serotonin- and Substance P-IR. These results support published acute phase data in other species, and are the first describing Fos-IR following delayed phase emesis. The data suggest overlapping but separate mechanisms are invoked for each phase, which are sensitive to antiemetic effects of Delta(9)-THC mediated by CB(1) receptors.
Mesh-Begriff(e)	Analgesics, Non-Narcotic/administration & dosage ; Analgesics, Non-Narcotic/therapeutic use ; Animals ; Area Postrema/cytology ; Area Postrema/drug effects ; Area Postrema/metabolism ; Brain Stem/drug effects ; Brain Stem/metabolism ; Cisplatin ; Dronabinol/administration & dosage ; Dronabinol/therapeutic use ; Drug Therapy, Combination ; Female ; Immunohistochemistry ; Injections, Intraperitoneal ; Microscopy, Confocal ; Neurons/drug effects ; Neurons/metabolism ; Oncogene Proteins v-fos/metabolism ; Piperidines/administration & dosage ; Piperidines/therapeutic use ; Presynaptic Terminals/drug effects ; Presynaptic Terminals/metabolism ; Pyrazoles/administration & dosage ; Pyrazoles/therapeutic use ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/metabolism ; Rimonabant ; Serotonin/metabolism ; Shrews ; Solitary Nucleus/drug effects ; Solitary Nucleus/metabolism ; Substance P/metabolism ; Time Factors ; Vomiting/chemically induced ; Vomiting/metabolism ; Vomiting/prevention & control
Chemische Substanzen	Analgesics, Non-Narcotic ; Oncogene Proteins v-fos ; Piperidines ; Pyrazoles ; Receptor, Cannabinoid, CB1 ; Receptor, Cannabinoid, CB2 ; Serotonin (333DO1RDJY) ; Substance P (33507-63-0) ; Dronabinol (7J8897W37S) ; Cisplatin (Q20Q21Q62J) ; Rimonabant (RML78EN3XE)
Sprache	Englisch
Erscheinungsdatum	2008-07-31
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2008.07.028
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: RNA sequencing demonstrates large-scale temporal dysregulation of gene expression in stimulated macrophages derived from MHC-defined chicken haplotypes.

Irizarry, Kristopher J L / Downs, Eileen / Bryden, Randall / Clark, Jory / Griggs, Lisa / Kopulos, Renee / Boettger, Cynthia M / Carr, Thomas J / Keeler, Calvin L / Collisson, Ellen / Drechsler, Yvonne

PloS one

2017 Band 12, Heft 8, Seite(n) e0179391

Abstract: Discovering genetic biomarkers associated with disease resistance and enhanced immunity is critical to developing advanced strategies for controlling viral and bacterial infections in different species. Macrophages, important cells of innate immunity, ... ...

Abstract	Discovering genetic biomarkers associated with disease resistance and enhanced immunity is critical to developing advanced strategies for controlling viral and bacterial infections in different species. Macrophages, important cells of innate immunity, are directly involved in cellular interactions with pathogens, the release of cytokines activating other immune cells and antigen presentation to cells of the adaptive immune response. IFNγ is a potent activator of macrophages and increased production has been associated with disease resistance in several species. This study characterizes the molecular basis for dramatically different nitric oxide production and immune function between the B2 and the B19 haplotype chicken macrophages.A large-scale RNA sequencing approach was employed to sequence the RNA of purified macrophages from each haplotype group (B2 vs. B19) during differentiation and after stimulation. Our results demonstrate that a large number of genes exhibit divergent expression between B2 and B19 haplotype cells both prior and after stimulation. These differences in gene expression appear to be regulated by complex epigenetic mechanisms that need further investigation.
Mesh-Begriff(e)	Adaptive Immunity/physiology ; Animals ; Cell Differentiation/physiology ; Chickens ; Gene Expression Regulation ; Haplotypes ; Interferon-gamma/pharmacology ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/metabolism ; Nitric Oxide/biosynthesis ; Sequence Analysis, RNA
Chemische Substanzen	Nitric Oxide (31C4KY9ESH) ; Interferon-gamma (82115-62-6)
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2017
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0179391
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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