LIVIVO - Search results -

Search results

Result 1 - 10 of total 109

Search options

Article: Hormonal control of bone architecture throughout the lifespan: Implications for fracture prediction and prevention.

Grigoryan, Seda / Clines, Gregory A

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

2024

Abstract: Skeletal modeling in childhood and adolescence and continuous remodeling throughout the lifespan are designed to adapt to a changing environment and resist external forces and fractures. The flux of sex steroids in men and women, beginning from fetal ... ...

Abstract	Skeletal modeling in childhood and adolescence and continuous remodeling throughout the lifespan are designed to adapt to a changing environment and resist external forces and fractures. The flux of sex steroids in men and women, beginning from fetal development and evolving through infancy, childhood, puberty, young adulthood, peri/menopause transition, and post-menopause, is critical for bone size, peak bone mass, and the risk for fractures. The contributions of estrogen and testosterone on skeletal development have been difficult to study due to the reciprocal and intertwining contributions of one on the other. While orchiectomy in men renders circulating testosterone absent, circulating estrogen also declines due to testosterone being the substrate for estradiol. The discovery of men with absent estradiol or resistance to estrogen and the study of mouse models led to the understanding that estrogen has a larger direct role in skeletal development and maintenance in men and women. The mechanistic reason for larger bone size in men is incompletely understood but related to indirect effects of testosterone on the skeleton, such as higher muscle mass leading to larger skeletal loads. Declines in sex steroids during menopause in women and androgen deprivation therapies in men have profound and negative effects on the skeleton. Therapies to prevent such bone loss are available, but how such therapies can be tailored based on bone size and architecture remains an area of investigation. In this review, the elegant interplay and contribution of sex steroids on bone architecture in men and women throughout the lifespan is described.
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1473503-9
ISSN	1530-891X
ISSN	1530-891X
DOI	10.1016/j.eprac.2024.04.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5034: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 508: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Inflammation and Coagulation are Two Interconnected Pathophysiological Pathways in Atrial Fibrillation Pathogenesis.

Hazarapetyan, Lusine / Zelveian, Parounak H / Grigoryan, Svetlana

Journal of inflammation research

2023 Volume 16, Page(s) 4967–4975

Abstract: Introduction: Atrial fibrillation (AF) is associated with elevated levels of clotting factors such as tissue factor (TF) and factor XII (FXII). Various inflammation markers, such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF- α), and high- ... ...

Abstract	Introduction: Atrial fibrillation (AF) is associated with elevated levels of clotting factors such as tissue factor (TF) and factor XII (FXII). Various inflammation markers, such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF- α), and high-sensitive C-reactive protein (hs-CRP), have also been associated with AF. This study explores the relationship between inflammation markers and coagulation activity, including their impact on heart structural changes in these patients. Methods: We observed 283 patients with nonvalvular AF who underwent a complete examination at admission, but only 183 patients have successful cardioversion. As a control group, similar patients without AF were examined. The markers of the coagulation and inflammation were studied by ELISA on the analyzer "Stat Fax 303 Plus". Studies were conducted using l statistical package SPSS 13.0. Results: It was revealed that patients with AF had significantly higher levels of hs-CRP, IL-6, and TNF-α and had elevated levels of TF and FXII compared with control group. The moderate correlations were observed between IL-6 and left atrial diameter (LAD), IL-6 and LA stiffness, hs-CRP and left atrial volume (LAV), TF and LAV. Conclusion: We have demonstrated that patients with AF have the relationship between elevated levels of inflammatory markers and coagulation activity, which contributes to structural atrial remodeling.
Language	English
Publishing date	2023-10-31
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S429892
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article: [Concept of optimal body composition of professional football players].

Grigoryan, S

Georgian medical news

2011 , Issue 198, Page(s) 23–28

Abstract: Body composition and body weight are two of the many factors that contribute to optimal exercise performance. Body weight can influence an athlete's speed, endurance, and power, whereas body composition can affect an athlete's strength, agility, and ... ...

Abstract	Body composition and body weight are two of the many factors that contribute to optimal exercise performance. Body weight can influence an athlete's speed, endurance, and power, whereas body composition can affect an athlete's strength, agility, and appearance. Individualized assessment of an athlete's body composition and body weight or body image may be advantageous for the improvement of athletic performance. The purpose of the present research consists in development of physiologically proved modelling characteristic of high performance football players on the basis of the analysis of dynamics (changes) of the major parameters of structure of weight of football players of various ages in process of acquiring game experience and skill. 344 football players from 15 to 35 years old were surveyed. The basic parameters of body composition were determined. It was found that general tendency in dynamics of the basic components of structure of body composition at the end of playing season is expressed in appreciable gain of active cellular weight as analogue of the muscular mass, decrease in the absolute fat contents, increase in endocellular liquid and eritrocyte mass. Comparison of changeable parameters to external criteria of success in competition and tested productivity, adaptive reactions and stability of motivation led to the conclusion that quantitative sports-skill evaluation and forecast of the growth in achievements is possible.
MeSH term(s)	Adult ; Anthropometry/methods ; Athletes ; Athletic Performance/physiology ; Body Weights and Measures ; Exercise/physiology ; Humans ; Male ; Muscle Strength/physiology ; Muscle, Skeletal/physiology ; Physical Endurance/physiology ; Physical Fitness/physiology ; Soccer/physiology ; Young Adult
Language	Russian
Publishing date	2011-09
Publishing country	Georgia (Republic)
Document type	English Abstract ; Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Aggregation and Adhesion Activity of Lactobacilli Isolated from Fermented Products In Vitro and In Vivo: a Potential Probiotic Strain

Grigoryan, S / I. Bazukyan / A. Trchounian

Probiotics and antimicrobial proteins. 2018 June, v. 10, no. 2

2018

Abstract: Approximately 25 strains of lactobacilli isolated from different dairy products and fermented vegetables were screened according to their possibility to show the high auto-aggregation and co-aggregation. The strains Lactobacillus helveticus INRA-2010-H11, ...

Abstract	Approximately 25 strains of lactobacilli isolated from different dairy products and fermented vegetables were screened according to their possibility to show the high auto-aggregation and co-aggregation. The strains Lactobacillus helveticus INRA-2010-H11, Lactobacillus rhamnosus INA-5.1, and Lactobacillus acidophilus JM-2012 were determined to have the high auto-aggregation (approximately 73, 46, and 70.5% correspondingly). A high co-aggregation capacity (75.53%) for strains INRA-2010-H11 and JM-2012 was shown. The adhesion degree of INRA-2010-H11 on the surface of buccal epithelial cells was 88.23%. The study of INRA-2010-H11, JM-2012, and both strains’ mixture (1:1) adhesion capacity on the surface of epithelial HeLa cells revealed the adhesion of 1.1 × 10⁶, 6.3 × 10⁴, and 2.3 × 10⁵ CFU, respectively, from starter amount of CFU 10⁷ and 10⁸ for both strains. In vivo experiments of LAB adhesion in gastrointestinal tract of mouse revealed the presence of 2.5 × 10⁹, 1.2 × 10⁹, and 1.5 × 10⁹ CFU of LAB in control and groups of mouse, fed by INRA-2010-H11 and mixture, respectively. Feeding by investigated lactobacilli was suggested to lead to microbiota biodiversity reduction in small intestine and colon and its augmentation in stomach. Thus, INRA-2010-H11 demonstrated a high aggregation and adhesion activity so it has the potential as a good probiotic strain.
Keywords	Lactobacillus acidophilus ; Lactobacillus helveticus ; Lactobacillus rhamnosus ; adhesion ; biodiversity ; colon ; dairy products ; epithelial cells ; epithelium ; fermented vegetables ; human cell lines ; in vivo studies ; mice ; probiotics ; small intestine ; stomach
Language	English
Dates of publication	2018-06
Size	p. 269-276.
Publishing place	Springer US
Document type	Article
ZDB-ID	2487792-X
ISSN	1867-1314 ; 1867-1306
ISSN (online)	1867-1314
ISSN	1867-1306
DOI	10.1007/s12602-017-9283-9
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Aggregation and Adhesion Activity of Lactobacilli Isolated from Fermented Products In Vitro and In Vivo: a Potential Probiotic Strain.

Grigoryan, S / Bazukyan, I / Trchounian, A

Probiotics and antimicrobial proteins

2017 Volume 10, Issue 2, Page(s) 269–276

Abstract	Approximately 25 strains of lactobacilli isolated from different dairy products and fermented vegetables were screened according to their possibility to show the high auto-aggregation and co-aggregation. The strains Lactobacillus helveticus INRA-2010-H11, Lactobacillus rhamnosus INA-5.1, and Lactobacillus acidophilus JM-2012 were determined to have the high auto-aggregation (approximately 73, 46, and 70.5% correspondingly). A high co-aggregation capacity (75.53%) for strains INRA-2010-H11 and JM-2012 was shown. The adhesion degree of INRA-2010-H11 on the surface of buccal epithelial cells was 88.23%. The study of INRA-2010-H11, JM-2012, and both strains' mixture (1:1) adhesion capacity on the surface of epithelial HeLa cells revealed the adhesion of 1.1 × 10
MeSH term(s)	Adolescent ; Adult ; Animals ; Bacterial Adhesion ; Biodiversity ; Cheek/microbiology ; Dairy Products/microbiology ; Epithelial Cells/microbiology ; Feces/microbiology ; Female ; Fermented Foods/microbiology ; Gastrointestinal Microbiome ; Gastrointestinal Tract/microbiology ; HeLa Cells ; Humans ; Lactobacillus/classification ; Lactobacillus/genetics ; Lactobacillus/isolation & purification ; Lactobacillus/physiology ; Mice ; Mice, Inbred BALB C ; Probiotics/chemistry ; Probiotics/classification ; Probiotics/isolation & purification ; Young Adult
Language	English
Publishing date	2017-04-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2487792-X
ISSN	1867-1314 ; 1867-1306
ISSN (online)	1867-1314
ISSN	1867-1306
DOI	10.1007/s12602-017-9283-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Functional imaging in ectopic Cushing syndrome.

Grigoryan, Seda / Avram, Anca M / Turcu, Adina F

Current opinion in endocrinology, diabetes, and obesity

2020 Volume 27, Issue 3, Page(s) 146–154

Abstract: Purpose of review: Ectopic adrenocorticotropic hormone (ACTH)-secreting tumors are commonly small, yet they often lead to fulminant forms of Cushing syndrome. High-resolution functional imaging modalities, such as [Ga]-DOTATATE, have been recently ... ...

Abstract	Purpose of review: Ectopic adrenocorticotropic hormone (ACTH)-secreting tumors are commonly small, yet they often lead to fulminant forms of Cushing syndrome. High-resolution functional imaging modalities, such as [Ga]-DOTATATE, have been recently introduced in clinical practice for the identification of neuroendocrine tumors. In this review, we focus on the performance of [Ga]-DOTATATE as a tool for localizing primary and metastatic sources of ectopic Cushing syndrome (ECS). Recent findings: Prompt surgical removal of ectopic ACTH-secreting tumors is the mainstay of therapy in patients with ECS. Detecting such tumors with conventional cross-sectional imaging is often unsuccessful, owing to their small size. [Ga]-DOTATATE has been approved in 2016 by the Federal Drug Administration for imaging well differentiated neuroendocrine tumors. Data regarding the performance of [Ga]-DOTATATE for detecting ectopic ACTH-secreting tumors remain limited, in part owing to the recent introduction of this imaging modality in clinical practice, and in part because of the low prevalence of ECS. Nevertheless, [Ga]-DOTATATE has been reported to be useful in identifying primary and metastatic ectopic ACTH-secreting lesions that were not apparent on other imaging studies, impacting the clinical care of many patients with ECS. Summary: [Ga]-DOTATATE-based imaging, which targets the somatostatin receptors abundantly expressed in neuroendocrine tumors, has generally high, although variable resolution in detecting the source(s) of ECS.
MeSH term(s)	Cushing Syndrome/diagnostic imaging ; Cushing Syndrome/metabolism ; Gallium Radioisotopes/pharmacology ; Humans ; Multimodal Imaging/methods ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/metabolism ; Organometallic Compounds/pharmacology ; Radionuclide Imaging/methods ; Receptors, Somatostatin/metabolism
Chemical Substances	Gallium Radioisotopes ; Organometallic Compounds ; Receptors, Somatostatin ; gallium Ga 68 dotatate (9L17Y0H71P)
Language	English
Publishing date	2020-03-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2272017-0
ISSN	1752-2978 ; 1752-296X
ISSN (online)	1752-2978
ISSN	1752-296X
DOI	10.1097/MED.0000000000000541
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Se 1363: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Rates of Pheochromocytoma/Paraganglioma Screening in At-Risk Populations.

Grigoryan, Seda / Nhan, Winnie / Zhang, Lei / Urban, Caitlin / Zhao, Lili / Turcu, Adina F

The Journal of clinical endocrinology and metabolism

2022 Volume 108, Issue 6, Page(s) e343–e349

Abstract: Context: Pheochromocytomas and paragangliomas (PPGL) are rare causes of secondary hypertension, but when unrecognized, they can lead to serious complications. Data regarding PPGL screening are lacking.: Objective: This study aimed to assess the rates ...

Abstract	Context: Pheochromocytomas and paragangliomas (PPGL) are rare causes of secondary hypertension, but when unrecognized, they can lead to serious complications. Data regarding PPGL screening are lacking. Objective: This study aimed to assess the rates and patterns of PPGL screening among eligible patients. Methods: We conducted a retrospective review of adults with hypertension seen in outpatient clinics of a large academic center between January 1, 2017, and June 30, 2020. We included patients with treatment-resistant hypertension, hypertension at age < 35 years, and/or adrenal mass(es). Results: Of 203 535 patients with hypertension identified, 71 088 (35%) met ≥ 1 inclusion criteria, and 2013 (2.83%) were screened for PPGL. Patients screened were younger (56.2 ± 17.4 vs 64.0 ± 17.1 years), more often women (54.1% vs 44.2%), and never-smokers (54.6% vs 47.5%, P < 0.001 for all). The rate of screening was highest in patients with hypertension and adrenal mass(es) (51.7%, vs 3.9% in patients with early-onset hypertension, and 2.4% in those with treatment-resistant hypertension). Multivariable logistic regression showed higher odds ratio (OR) of PPGL screening in women (OR [95% CI]: 1.48 [1.34-1.63]); Black vs White patients (1.35 [1.19-1.53]); patients with adrenal mass(es) (55.1 [44.53-68.15]), stroke (1.34 [1.16-1.54]), dyslipidemia (1.41 [1.26-1.58]), chronic kidney disease (1.40 [1.26-1.56]), and obstructive sleep apnea (1.96 [1.76-2.19]). Conclusion: PPGL screening is pursued in roughly half of patients with adrenal nodules and hypertension, but rarely in patients with treatment-resistant or early-onset hypertension. Similar to screening for other forms of secondary hypertension, PPGL screening occurs more often after serious complications develop.
MeSH term(s)	Adult ; Humans ; Female ; Pheochromocytoma/complications ; Pheochromocytoma/diagnosis ; Pheochromocytoma/epidemiology ; Paraganglioma/diagnosis ; Paraganglioma/epidemiology ; Paraganglioma/complications ; Risk Factors ; Adrenal Gland Neoplasms/complications ; Adrenal Gland Neoplasms/diagnosis ; Adrenal Gland Neoplasms/epidemiology ; Hypertension/complications ; Hypertension/diagnosis ; Hypertension/epidemiology
Language	English
Publishing date	2022-12-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgac701
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.134: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Hidden population size estimation and diagnostics using two respondent-driven samples with applications in Armenia.

Kim, Brian J / Johnston, Lisa G / Grigoryan, Trdat / Papoyan, Arshak / Grigoryan, Samvel / McLaughlin, Katherine R

Biometrical journal. Biometrische Zeitschrift

2023 Volume 65, Issue 5, Page(s) e2200136

Abstract: Estimating the size of hidden populations is essential to understand the magnitude of social and healthcare needs, risk behaviors, and disease burden. However, due to the hidden nature of these populations, they are difficult to survey, and there are no ... ...

Abstract	Estimating the size of hidden populations is essential to understand the magnitude of social and healthcare needs, risk behaviors, and disease burden. However, due to the hidden nature of these populations, they are difficult to survey, and there are no gold standard size estimation methods. Many different methods and variations exist, and diagnostic tools are needed to help researchers assess method-specific assumptions as well as compare between methods. Further, because many necessary mathematical assumptions are unrealistic for real survey implementation, assessment of how robust methods are to deviations from the stated assumptions is essential. We describe diagnostics and assess the performance of a new population size estimation method, capture-recapture with successive sampling population size estimation (CR-SS-PSE), which we apply to data from 3 years of studies from three cities and three hidden populations in Armenia. CR-SS-PSE relies on data from two sequential respondent-driven sampling surveys and extends the successive sampling population size estimation (SS-PSE) framework by using the number of individuals in the overlap between the two surveys and a model for the successive sampling process to estimate population size. We demonstrate that CR-SS-PSE is more robust to violations of successive sampling assumptions than SS-PSE. Further, we compare the CR-SS-PSE estimates to population size estimations using other common methods, including unique object and service multipliers, wisdom of the crowd, and two-source capture-recapture to illustrate volatility across estimation methods.
MeSH term(s)	Humans ; Population Density ; Armenia/epidemiology ; Surveys and Questionnaires ; Cities ; Sampling Studies
Language	English
Publishing date	2023-03-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	131640-0
ISSN	1521-4036 ; 0323-3847 ; 0006-3452
ISSN (online)	1521-4036
ISSN	0323-3847 ; 0006-3452
DOI	10.1002/bimj.202200136
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 1267: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: [An Experience of Meldonium Use in Patients with Ventricular Arrhythmias of Ischemic Genesis].

Grigoryan, S V / Hazarapetyan, L G / Stepanyan, A A

Kardiologiia

2019 Volume 59, Issue 7, Page(s) 26–30

Abstract: Ischemic heart disease (IHD) is often accompanied by cardiac rhythm disturbances particularly ventricular arrhythmias (VA) and their appearance in both chronic and acute forms of IHD is usually regarded as dangerous signal requiring the use of ... ...

Abstract	Ischemic heart disease (IHD) is often accompanied by cardiac rhythm disturbances particularly ventricular arrhythmias (VA) and their appearance in both chronic and acute forms of IHD is usually regarded as dangerous signal requiring the use of antiarrhythmic drugs. An important addition to hemodynamic therapy can be considered the use of cytoprotective drugs that improve the energy potential of cardiomyocytes. The purpose of this work is to study the comparative evaluation of the Mildronate effectiveness in patients with IHD and VA. Methods: Under dynamic observation were 147 patients with IHD and VA (Lown II-IV functional class). The diagnosis of angina pectoris was confirmed by clinical, exercise bicycle ergometry, Holter ECG monitoring, and echocardiography data. Holter ECG monitoring was used for recording VA, heart rate, episodes of ST-segment depression. The levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDLC), high-density lipoprotein cholesterol were determined. All patients were randomly divided into 2 groups. The first group (81 patients) received standard antianginal and antiarrhythmic therapy plus meldonium for 2 months. The second (control) group (66 patients) received standard antianginal and antiarrhythmic therapy only. Statistical analysis of the data was carried out using the statistical package SPSS 13.0. Results: A comparative analysis of the results showed that the use of meldonium in combination with basic therapy significantly improved clinical condition and quality of life indicators, increased exercise tolerance and improved systolic and diastolic dysfunction in patients with IHD and VA. The positive effect of meldonium on LDLC levels was observed. Moreover, the combination of basic antianginal and antiarrhythmic therapy and meldonium in patients with ischemic genesis VA promoted significant reduction of ischemic episodes and decrease of VA, in particular allorhythmia. Conclusion: Results of this study suggest that the use of meldonium in patients with IHD and VA helps to optimize myocardial energy metabolism in conditions of ischemia and reperfusion.
MeSH term(s)	Arrhythmias, Cardiac ; Electrocardiography, Ambulatory ; Humans ; Methylhydrazines ; Quality of Life
Chemical Substances	Methylhydrazines ; 3-(2,2,2-trimethylhydrazine)propionate (73H7UDN6EC)
Language	Russian
Publishing date	2019-07-19
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	131029-x
ISSN	0022-9040
ISSN	0022-9040
DOI	10.18087/cardio.2019.7.n552
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 972: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Primary Aldosteronism Screening Rates Differ with Sex, Race, and Comorbidities.

Turcu, Adina F / Nhan, Winnie / Grigoryan, Seda / Zhang, Lei / Urban, Caitlin / Liu, Haiping / Holevinski, Lynn / Zhao, Lili

Journal of the American Heart Association

2022 Volume 11, Issue 14, Page(s) e025952

Abstract: Background Primary aldosteronism (PA) is a common but under-recognized cause of secondary hypertension. Data directly comparing screening rates across single and overlapping indications are lacking. Methods and Results We conducted a retrospective review ...

Abstract	Background Primary aldosteronism (PA) is a common but under-recognized cause of secondary hypertension. Data directly comparing screening rates across single and overlapping indications are lacking. Methods and Results We conducted a retrospective review of adults with hypertension seen in outpatient clinics at a tertiary referral academic center between January 1, 2017, and June 30, 2020. We included patients with hypertension plus at least one of the following: resistant hypertension; age<35 years; obstructive sleep apnea; hypokalemia; or an adrenal mass. We excluded patients with adrenal insufficiency, severe renal disease, or heart failure, and renovascular hypertension. Of 203 535 patients with hypertension, 86044 (42.3%) met at least 1 PA screening criterion, and of these, 2898 (3.4%) were screened for PA. Screening occurred in 2.7% of patients with resistant hypertension; 4.2% of those with obstructive sleep apnea; 5.1% of those <35 years; 10.0% of those with hypokalemia; and 47.3% of patients with an adrenal mass. Screening rates were higher in patients with multiple risk factors: 16.8% for ≥3, 5.7% for 2, and 2.5% for 1 criterion. Multiple logistic regression showed that the odds of PA screening were higher in patients with hypokalemia: odds ratio (95% CI): 3.0 (2.7-3.3); women: 1.3 (1.2-1.4); Black versus White: 1.5 (1.4-1.7); those with obstructive sleep apnea, chronic renal disease, stroke, and dyslipidemia. Conclusions Consideration for PA is given in a small subset of at-risk patients, and typically after comorbidities have developed.
MeSH term(s)	Adult ; Aldosterone ; Female ; Humans ; Hyperaldosteronism/complications ; Hyperaldosteronism/diagnosis ; Hyperaldosteronism/epidemiology ; Hypertension/complications ; Hypertension/diagnosis ; Hypertension/epidemiology ; Hypokalemia/diagnosis ; Male ; Mass Screening ; Renin ; Sleep Apnea, Obstructive/complications
Chemical Substances	Aldosterone (4964P6T9RB) ; Renin (EC 3.4.23.15)
Language	English
Publishing date	2022-07-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.122.025952
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito