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  1. Article ; Online: Marijuana Use and Potential Implications of Marijuana Legalization.

    Grigsby, Tamara M / Hoffmann, Laurel M / Moss, Michael J

    Pediatrics in review

    2020  Volume 41, Issue 2, Page(s) 61–72

    Abstract: Most states in the United States have legalized medical and/or recreational cannabis in response to public demand. Trends in states adopting such legislation demonstrate an increasing prevalence of cannabis use coincident to decreasing perceptions of ... ...

    Abstract Most states in the United States have legalized medical and/or recreational cannabis in response to public demand. Trends in states adopting such legislation demonstrate an increasing prevalence of cannabis use coincident to decreasing perceptions of risk of harm from cannabis products. When providing anticipatory guidance, pediatricians should be prepared to address childhood unintentional ingestion management and prevention, adolescent problem use, and cannabis as an alternative therapy for seizure disorders and other conditions.
    MeSH term(s) Adolescent ; Adolescent Behavior ; Cannabinoids/adverse effects ; Cannabinoids/pharmacology ; Child ; Health Behavior ; Humans ; Marijuana Abuse/diagnosis ; Marijuana Abuse/prevention & control ; Marijuana Use/adverse effects ; Marijuana Use/epidemiology ; Marijuana Use/legislation & jurisprudence ; Marijuana Use/psychology ; Medical Marijuana/therapeutic use ; Pediatricians ; Physician's Role ; Risk Factors ; Seizures/drug therapy ; United States/epidemiology
    Chemical Substances Cannabinoids ; Medical Marijuana
    Language English
    Publishing date 2020-01-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 774515-1
    ISSN 1526-3347 ; 0191-9601
    ISSN (online) 1526-3347
    ISSN 0191-9601
    DOI 10.1542/pir.2018-0347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2595: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 53: Show issues

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  2. Article ; Online: Cannabis use and measurement of cannabinoids in plasma and breast milk of breastfeeding mothers.

    Moss, Michael J / Bushlin, Ittai / Kazmierczak, Steven / Koop, Dennis / Hendrickson, Robert G / Zuckerman, Katharine E / Grigsby, Tamara M

    Pediatric research

    2021  Volume 90, Issue 4, Page(s) 861–868

    Abstract: Background: Information on cannabinoids in breast milk and maternal cannabis use is limited. We quantified cannabinoids in plasma and breast milk of breastfeeding mothers and assessed cannabis use patterns.: Methods: This is a prospective study at a ... ...

    Abstract Background: Information on cannabinoids in breast milk and maternal cannabis use is limited. We quantified cannabinoids in plasma and breast milk of breastfeeding mothers and assessed cannabis use patterns.
    Methods: This is a prospective study at a university hospital in a state with legal medical and recreational cannabis. Breast milk and plasma samples along with survey data were collected from volunteers using cannabis in the last 48 h at 2 weeks and 2 months postpartum.
    Results: Twenty subjects were enrolled. Median age (IQR) was 27 (24-34) years. Median (IQR) instances of cannabis use in the last 7 days were visit 1: 17 (6-29) and visit 2: 23 (15-45). Median (IQR) tetrahydrocannabinol (THC) concentrations were: plasma 3.7 ng/ml (0.8-56.8) and breast milk 27.5 ng/ml (0.8-190.5). Median (IQR) cannabidiol (CBD) concentrations were: plasma 0.6 ng/ml (0.5-6.4) and breast milk 1.2 ng/ml (0.5-17.0). Median (IQR) THC M/P: 7.0 (1.8-34.6) and CBD M/P: 2.6. Median breast milk THC concentration increased from visit 1 to visit 2 by 30.2 ng/ml (95% CI 3.05-69.3 ng/ml).
    Conclusions: THC and CBD accumulate in breast milk. Breastfeeding mothers used cannabis frequently and increased use in the early postpartum period. Research on the effects of infant exposure to cannabinoids in breast milk is urgently needed.
    Impact: Cannabis use is increasing in the general population and many nursing mothers use cannabis. THC has been previously detected in breast milk but little is known on how it concentrates relative to plasma. Data on cannabinoids other than THC, reasons for cannabis use, and patterns of use in breastfeeding women are also limited. We detected THC and CBD in breast milk. Both concentrate in breast milk relative to plasma. We showed that breastfeeding mothers increased cannabis use in the weeks after childbirth. Further research is needed to evaluate infant exposure to cannabinoids via breast milk and effects on infant health.
    MeSH term(s) Adult ; Breast Feeding ; Cannabinoids/analysis ; Cannabinoids/blood ; Cannabis ; Female ; Humans ; Infant, Newborn ; Milk, Human/chemistry ; Mothers ; Prospective Studies
    Chemical Substances Cannabinoids
    Language English
    Publishing date 2021-01-19
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-020-01332-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 373: Show issues

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