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Article ; Online: Greater affective network maturity is associated with better clinical outcomes in women with early sexual trauma.

Kleshchova, Olena / Grinband, Jack / Weierich, Mariann R

2023 , Page(s) 1–11

Abstract: Early-life adversity accelerates the maturation of affect-related circuitry, which might be a short-term adaptation with long-term tradeoffs. Sexual trauma is associated with a particularly strong impact on pubertal development and mental health outcomes. ...

Abstract	Early-life adversity accelerates the maturation of affect-related circuitry, which might be a short-term adaptation with long-term tradeoffs. Sexual trauma is associated with a particularly strong impact on pubertal development and mental health outcomes. Our objective was to test the relations between trauma type, affective network maturity, and mental health outcomes in young women with trauma history. Trauma-exposed women aged 18-29 completed a clinical interview (
Language	English
Publishing date	2023-07-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1036173-x
ISSN	1469-2198 ; 0954-5794
ISSN (online)	1469-2198
ISSN	0954-5794
DOI	10.1017/S0954579423000676
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Zs.A 2601: Show issues

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Article ; Online: Tardive Dyskinesia Suppressed With Ginkgo Biloba.

Petridis, Petros D / Jaffe, Ari B / Kantrowitz, Joshua T / Grinband, Jack

Journal of clinical psychopharmacology

2023 Volume 43, Issue 6, Page(s) 549–551

MeSH term(s)	Humans ; Tardive Dyskinesia/chemically induced ; Tardive Dyskinesia/drug therapy ; Ginkgo biloba ; Plant Extracts/adverse effects ; Antipsychotic Agents/adverse effects
Chemical Substances	Plant Extracts ; Antipsychotic Agents
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Letter
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
DOI	10.1097/JCP.0000000000001764
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Zs.A 1664: Show issues

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Article ; Online: Progressive microvascular failure in acute ischemic stroke: A systematic review, meta-analysis, and time-course analysis.

Tudor, Thilan / Spinazzi, Eleonora F / Alexander, Julia E / Mandigo, Grace K / Lavine, Sean D / Grinband, Jack / Connolly, E Sander

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

2023 Volume 44, Issue 2, Page(s) 192–208

Abstract: This systematic review, meta-analysis, and novel time course analysis examines microvascular failure in the treatment of acute ischemic stroke (AIS) patients undergoing endovascular therapy (EVT) and/or thrombolytic administration for stroke management. ... ...

Abstract	This systematic review, meta-analysis, and novel time course analysis examines microvascular failure in the treatment of acute ischemic stroke (AIS) patients undergoing endovascular therapy (EVT) and/or thrombolytic administration for stroke management. A systematic review and meta-analysis following PRIMSA-2020 guidelines was conducted along with a novel curve-of-best fit analysis to elucidate the time-course of microvascular failure. Scopus and PubMed were searched using relevant keywords to identify studies that examine recanalization and reperfusion assessment of AIS patients following large vessel occlusion. Meta-analysis was conducted using a random-effects model. Curve-of-best-fit analysis of microvascular failure rate was performed with a negative exponential model. Twenty-seven studies with 1151 patients were included. Fourteen studies evaluated patients within a standard stroke onset-to-treatment time window (≤6 hours after last known normal) and thirteen studies had an extended time window (>6 hours). Our analysis yields a 22% event rate of microvascular failure following successful recanalization (95% CI: 16-30%). A negative exponential curve modeled a microvascular failure rate asymptote of 28.5% for standard time window studies, with no convergence of the model for extended time window studies. Progressive microvascular failure is a phenomenon that is increasingly identified in clinical studies of AIS patients undergoing revascularization treatment.
MeSH term(s)	Humans ; Brain Ischemia/surgery ; Brain Ischemia/drug therapy ; Ischemic Stroke/drug therapy ; Thrombolytic Therapy ; Treatment Outcome ; Endovascular Procedures/adverse effects ; Stroke/surgery ; Stroke/drug therapy ; Thrombectomy/adverse effects
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	604628-9
ISSN	1559-7016 ; 0271-678X
ISSN (online)	1559-7016
ISSN	0271-678X
DOI	10.1177/0271678X231216766
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Zs.A 1663: Show issues

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Article ; Online: Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure in the dorsal striatum.

Liu, Dong / Munoz, Fabian / Sanatkhani, Soroosh / Pouliopoulos, Antonios N / Konofagou, Elisa E / Grinband, Jack / Ferrera, Vincent P

Brain stimulation

2023 Volume 16, Issue 4, Page(s) 1196–1204

Abstract: Background: Focused ultrasound (FUS) is a non-invasive neuromodulation technology that is being investigated for potential treatment of neurological and psychiatric disorders. FUS combined with microbubbles can temporarily open the intact blood-brain ... ...

Abstract	Background: Focused ultrasound (FUS) is a non-invasive neuromodulation technology that is being investigated for potential treatment of neurological and psychiatric disorders. FUS combined with microbubbles can temporarily open the intact blood-brain barrier (BBB) of animals and humans, and facilitate drug delivery. FUS exposure, either with or without microbubbles, has been demonstrated to alter the behavior of non-human primates (NHP), and previous studies have demonstrated the transient and long-term effects of FUS neuromodulation on functional connectivity using resting state functional MRI. The behavioral effects of FUS vary depending on whether or not it is applied in conjunction with microbubbles to open the BBB, but it is unknown whether opening the BBB affects functional connectivity differently than FUS alone. Objective: To compare the effects of applying FUS alone (FUS neuromodulation) and FUS with microbubbles (FUS-BBB opening) on changes of resting state functional connectivity in NHP. Methods: We applied 2 min FUS exposure without (neuromodulation) and with microbubbles (BBB opening) in the dorsal striatum of lightly anesthetized non-human primates, and acquired resting state functional MRI 40 min respectively after FUS exposure. The functional connectivity (FC) in the cortex and major brain networks between the two approaches were measured and compared. Results: When applying FUS exposure to the caudate nucleus of NHP, we found that both FUS neuromodulation can activate FC between caudate and insular cortex, while inhibiting the FC between caudate and motor cortex. FUS-BBB opening can activate FC between the caudate and medial prefrontal cortex, and within the frontotemporal network (FTN). We also found both FUS and FUS-BBB opening can significantly activate FC within the default mode network (DMN). Conclusion: The results suggest applying FUS to a deep brain structure can alter functional connectivity in the DMN and FTN, and that FUS neuromodulation and FUS-mediated BBB opening can have different effects on patterns of functional connectivity.
MeSH term(s)	Animals ; Humans ; Brain/diagnostic imaging ; Brain/physiology ; Blood-Brain Barrier ; Primates ; Cerebral Cortex/diagnostic imaging ; Microbubbles ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-08-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2394410-9
ISSN	1876-4754 ; 1935-861X
ISSN (online)	1876-4754
ISSN	1935-861X
DOI	10.1016/j.brs.2023.08.003
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Zs.A 6740: Show issues

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Article ; Online: Rejection Distress Suppresses Medial Prefrontal Cortex in Borderline Personality Disorder.

Fertuck, Eric A / Stanley, Barbara / Kleshchova, Olena / Mann, J John / Hirsch, Joy / Ochsner, Kevin / Pilkonis, Paul / Erbe, Jeff / Grinband, Jack

Biological psychiatry. Cognitive neuroscience and neuroimaging

2022 Volume 8, Issue 6, Page(s) 651–659

Abstract: Background: Borderline personality disorder (BPD) is characterized by an elevated distress response to social exclusion (i.e., rejection distress), the neural mechanisms of which remain unclear. Functional magnetic resonance imaging studies of social ... ...

Abstract	Background: Borderline personality disorder (BPD) is characterized by an elevated distress response to social exclusion (i.e., rejection distress), the neural mechanisms of which remain unclear. Functional magnetic resonance imaging studies of social exclusion have relied on the classic version of the Cyberball task, which is not optimized for functional magnetic resonance imaging. Our goal was to clarify the neural substrates of rejection distress in BPD using a modified version of Cyberball, which allowed us to dissociate the neural response to exclusion events from its modulation by exclusionary context. Methods: Twenty-three women with BPD and 22 healthy control participants completed a novel functional magnetic resonance imaging modification of Cyberball with 5 runs of varying exclusion probability and rated their rejection distress after each run. We tested group differences in the whole-brain response to exclusion events and in the parametric modulation of that response by rejection distress using mass univariate analysis. Results: Although rejection distress was higher in participants with BPD (F Conclusions: Heightened rejection distress in BPD might stem from a failure to maintain or upregulate the activity of the rostromedial prefrontal cortex, a key node of the mentalization network. Inverse coupling between rejection distress and mentalization-related brain activity might contribute to heightened rejection expectation in BPD.
MeSH term(s)	Humans ; Female ; Borderline Personality Disorder/pathology ; Prefrontal Cortex ; Brain ; Brain Mapping ; Magnetic Resonance Imaging
Language	English
Publishing date	2022-12-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2879089-3
ISSN	2451-9030 ; 2451-9022
ISSN (online)	2451-9030
ISSN	2451-9022
DOI	10.1016/j.bpsc.2022.11.006
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Article: Biologically-informed deep neural networks provide quantitative assessment of intratumoral heterogeneity in post-treatment glioblastoma.

Wang, Hairong / Argenziano, Michael G / Yoon, Hyunsoo / Boyett, Deborah / Save, Akshay / Petridis, Petros / Savage, William / Jackson, Pamela / Hawkins-Daarud, Andrea / Tran, Nhan / Hu, Leland / Al Dalahmah, Osama / Bruce, Jeffrey N / Grinband, Jack / Swanson, Kristin R / Canoll, Peter / Li, Jing

Research square

2024

Abstract: Intratumoral heterogeneity poses a significant challenge to the diagnosis and treatment of glioblastoma (GBM). This heterogeneity is further exacerbated during GBM recurrence, as treatment-induced reactive changes produce additional intratumoral ... ...

Abstract	Intratumoral heterogeneity poses a significant challenge to the diagnosis and treatment of glioblastoma (GBM). This heterogeneity is further exacerbated during GBM recurrence, as treatment-induced reactive changes produce additional intratumoral heterogeneity that is ambiguous to differentiate on clinical imaging. There is an urgent need to develop non-invasive approaches to map the heterogeneous landscape of histopathological alterations throughout the entire lesion for each patient. We propose to predictively fuse Magnetic Resonance Imaging (MRI) with the underlying intratumoral heterogeneity in recurrent GBM using machine learning (ML) by leveraging image-localized biopsies with their associated locoregional MRI features. To this end, we develop BioNet, a biologically-informed neural network model, to predict regional distributions of three tissue-specific gene modules: proliferating tumor, reactive/inflammatory cells, and infiltrated brain tissue. BioNet offers valuable insights into the integration of multiple implicit and qualitative biological domain knowledge, which are challenging to describe in mathematical formulations. BioNet performs significantly better than a range of existing methods on cross-validation and blind test datasets. Voxel-level prediction maps of the gene modules by BioNet help reveal intratumoral heterogeneity, which can improve surgical targeting of confirmatory biopsies and evaluation of neuro-oncological treatment effectiveness. The non-invasive nature of the approach can potentially facilitate regular monitoring of the gene modules over time, and making timely therapeutic adjustment. These results also highlight the emerging role of ML in precision medicine.
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3891425/v1
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Article ; Online: MR elastography identifies regions of extracellular matrix reorganization associated with shorter survival in glioblastoma patients.

Svensson, Siri Fløgstad / Halldórsson, Skarphéðinn / Latysheva, Anna / Fuster-Garcia, Elies / Hjørnevik, Trine / Fraser-Green, Jorunn / Birkeland Bugge, Robin Anthony / Grinband, Jack / Holm, Sverre / Sinkus, Ralph / Vik-Mo, Einar Osland / Emblem, Kyrre Eeg

Neuro-oncology advances

2023 Volume 5, Issue 1, Page(s) vdad021

Abstract: Background: Biomechanical tissue properties of glioblastoma tumors are heterogeneous, but the molecular mechanisms involved and the biological implications are poorly understood. Here, we combine magnetic resonance elastography (MRE) measurement of ... ...

Abstract	Background: Biomechanical tissue properties of glioblastoma tumors are heterogeneous, but the molecular mechanisms involved and the biological implications are poorly understood. Here, we combine magnetic resonance elastography (MRE) measurement of tissue stiffness with RNA sequencing of tissue biopsies to explore the molecular characteristics of the stiffness signal. Methods: MRE was performed preoperatively in 13 patients with glioblastoma. Navigated biopsies were harvested during surgery and classified as "stiff" or "soft" according to MRE stiffness measurements (\|G\| Results:* The mean whole-tumor stiffness was lower than normal-appearing white matter. The surgeon's stiffness evaluation did not correlate with the MRE measurements, which suggests that these measures assess different physiological properties. Pathway analysis of the differentially expressed genes between "stiff" and "soft" biopsies showed that genes involved in extracellular matrix reorganization and cellular adhesion were overexpressed in "stiff" biopsies. Supervised dimensionality reduction identified a gene expression signal separating "stiff" and "soft" biopsies. Using the NIH Genomic Data Portal, 265 glioblastoma patients were divided into those with ( Conclusion: MRE imaging of glioblastoma can provide noninvasive information on intratumoral heterogeneity. Regions of increased stiffness were associated with extracellular matrix reorganization. An expression signal associated with "stiff" biopsies correlated with shorter survival of glioblastoma patients.
Language	English
Publishing date	2023-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	3009682-0
ISSN	2632-2498 ; 2632-2498
ISSN (online)	2632-2498
ISSN	2632-2498
DOI	10.1093/noajnl/vdad021
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Article ; Online: Resting amygdala connectivity and basal sympathetic tone as markers of chronic hypervigilance.

Kleshchova, Olena / Rieder, Jenna K / Grinband, Jack / Weierich, Mariann R

Psychoneuroendocrinology

2018 Volume 102, Page(s) 68–78

Abstract: Background: Chronic hypervigilance, a state of sustained alertness and hyperarousal in the absence of threat, has been shown to predict poorer clinical outcomes post-trauma. An exaggerated and persistent amygdala alerting response to affective ... ...

Abstract	Background: Chronic hypervigilance, a state of sustained alertness and hyperarousal in the absence of threat, has been shown to predict poorer clinical outcomes post-trauma. An exaggerated and persistent amygdala alerting response to affective information has been proposed as a reactivity-based, and thus indirect, marker of hypervigilance. However, because chronic hypervigilance is a persistent rather than reactive state, it should be directly observable under resting-state conditions without the need for exposure to affectively charged stimuli. Objective: We tested resting amygdala connectivity and basal sympathetic and hypothalamic-pituitary-adrenal axis activity as direct neural and neuroendocrine markers of chronic hypervigilance. Participants: 24 trauma-exposed women (age M = 22.9, SD = 5.5) and 20 no-trauma controls (age M = 21.1, SD = 3.2). Measures: Amygdala connectivity was measured using functional magnetic resonance imaging at rest and during viewing of novel and familiar affective scenes. Elevated amygdala connectivity during the viewing of novel scenes (exaggerated alerting response) and familiar scenes (persistent alerting response) was used as a reactivity-based index of hypervigilance. Resting amygdala connectivity and basal salivary alpha-amylase (sAA) and cortisol were tested as neural and neuroendocrine markers of hypervigilance, respectively. Results: Compared to no-trauma controls, trauma-exposed women showed greater connectivity between the left amygdala and the ventral anterior cingulate cortex (vACC) both during affective processing and at rest. Exaggerated neural novelty response was associated with greater resting left amygdala-vACC connectivity and higher basal sAA, but not cortisol. Conclusions: Greater synchronization of threat-detection circuitry in the absence of threat and basal sympathetic tone might serve as complementary resting-state markers of the cognitive and physiological components of chronic hypervigilance, respectively.
MeSH term(s)	Adult ; Amygdala/diagnostic imaging ; Amygdala/physiology ; Anxiety/diagnostic imaging ; Anxiety/metabolism ; Anxiety/physiopathology ; Biomarkers ; Female ; Gyrus Cinguli/physiology ; Humans ; Hydrocortisone/analysis ; Hypothalamo-Hypophyseal System/physiology ; Magnetic Resonance Imaging/methods ; Neural Pathways/physiopathology ; Pituitary-Adrenal System/physiology ; Rest ; Wounds and Injuries/diagnostic imaging ; Wounds and Injuries/physiopathology ; Young Adult
Chemical Substances	Biomarkers ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2018-11-26
Publishing country	England
Document type	Journal Article ; Research Support, American Recovery and Reinvestment Act ; Research Support, N.I.H., Extramural
ZDB-ID	197636-9
ISSN	1873-3360 ; 0306-4530
ISSN (online)	1873-3360
ISSN	0306-4530
DOI	10.1016/j.psyneuen.2018.11.036
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Article ; Online: Optic nerve tortuosity and displacements during horizontal eye movements in healthy and highly myopic subjects.

Wang, Xiaofei / Chang, Stanley / Grinband, Jack / Yannuzzi, Lawrence A / Freund, K Bailey / Hoang, Quan V / Girard, Michael Ja

The British journal of ophthalmology

2021 Volume 106, Issue 11, Page(s) 1596–1602

Abstract: Aims: (1) To assess the morphology and 3-dimensional (3D) displacements of the eye globe and optic nerve (ON) in adduction/abduction using MRI. (2) To assess differences between healthy emmetropic and highly myopic (HM) subjects.: Methods: MRI ... ...

Abstract	Aims: (1) To assess the morphology and 3-dimensional (3D) displacements of the eye globe and optic nerve (ON) in adduction/abduction using MRI. (2) To assess differences between healthy emmetropic and highly myopic (HM) subjects. Methods: MRI volumes of both eyes from 18 controls and 20 HM subjects in primary gaze, abduction and adduction (15°) were postprocessed. All ONs were manually segmented and fitted to a 3D curve to assess ON tortuosity. ON displacements were evaluated in four quasicoronal planes which were perpendicular to the ON in primary gaze and were 3 mm apart. Results: Axial length was higher in the HM group (28.62±2.60 vs 22.84±0.89 mm; p<0.0001). Adjusted ON tortuosities (ie, ON tortuosities estimated before myopia onset) were lower in HM eyes (0.9063±0.0591) versus controls (1.0152±0.02981) in primary gaze, adduction (0.9023±0.05538 vs 1.0137±0.0299) and abduction (0.9100±0.0594 vs 1.0182±0.0316); p<0.0001 for all cases. In all eyes, ON displacements in adduction were significantly different from those in abduction in the naso-temporal direction (p<0.0001 in all planes) but not in the supero-inferior direction. ON displacements in the posterior segments of the ON were smaller in the HM group in both gaze directions and were larger in the anterior-most ON segment in adduction only. Conclusion: The adjusted tortuosity of the ON was significantly lower in HM eyes, suggesting that eyes destined towards HM exhibited higher ON traction forces during eye movements before the onset of myopia. Our ON metrics may be valuable to explore a potential link between eye movements and axial elongation.
MeSH term(s)	Humans ; Eye Movements ; Optic Nerve ; Optic Nerve Diseases ; Myopia/diagnosis ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2021-05-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80078-8
ISSN	1468-2079 ; 0007-1161
ISSN (online)	1468-2079
ISSN	0007-1161
DOI	10.1136/bjophthalmol-2021-318968
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Article ; Online: The importance of decision onset.

Teichert, Tobias / Grinband, Jack / Ferrera, Vincent

Journal of neurophysiology

2016 Volume 115, Issue 2, Page(s) 643–661

Abstract: The neural mechanisms of decision making are thought to require the integration of evidence over time until a response threshold is reached. Much work suggests that response threshold can be adjusted via top-down control as a function of speed or ... ...

Abstract	The neural mechanisms of decision making are thought to require the integration of evidence over time until a response threshold is reached. Much work suggests that response threshold can be adjusted via top-down control as a function of speed or accuracy requirements. In contrast, the time of integration onset has received less attention and is believed to be determined mostly by afferent or preprocessing delays. However, a number of influential studies over the past decade challenge this assumption and begin to paint a multifaceted view of the phenomenology of decision onset. This review highlights the challenges involved in initiating the integration of evidence at the optimal time and the potential benefits of adjusting integration onset to task demands. The review outlines behavioral and electrophysiolgical studies suggesting that the onset of the integration process may depend on properties of the stimulus, the task, attention, and response strategy. Most importantly, the aggregate findings in the literature suggest that integration onset may be amenable to top-down regulation, and may be adjusted much like response threshold to exert cognitive control and strategically optimize the decision process to fit immediate behavioral requirements.
MeSH term(s)	Adaptation, Physiological ; Animals ; Brain/physiology ; Decision Making ; Humans ; Models, Neurological ; Reaction Time ; Sensation
Language	English
Publishing date	2016-02-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80161-6
ISSN	1522-1598 ; 0022-3077
ISSN (online)	1522-1598
ISSN	0022-3077
DOI	10.1152/jn.00274.2015
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