Article: The impact of
Pharmacogenomics and personalized medicine
2018 Volume 11, Page(s) 127–137
Abstract: Background: Non-vitamin K oral anticoagulants (NOACs) are commonly used for prophylaxis of venous thromboembolism (VTE) in orthopedic patients. Despite known safety and high potency of NOACs, potential interactions of NOACs with genetic polymorphisms ... ...
| Abstract | Background: Non-vitamin K oral anticoagulants (NOACs) are commonly used for prophylaxis of venous thromboembolism (VTE) in orthopedic patients. Despite known safety and high potency of NOACs, potential interactions of NOACs with genetic polymorphisms are poorly understood. Dabigatran etexilate is one of the most commonly prescribed direct thrombin inhibitors for the prevention of VTE. The objectives of this study were to assess the effect of Patients and methods: A total of 60 patients, aged 37-81 years, who underwent surgery for knee replacement have been included in the study. VTE prophylaxis was conducted via administration of dabigatran etexilate 220 mg once daily. Genotyping for carrier state of polymorphic variants such as rs1045642 and rs4148738 of the Results: Our study revealed that TT genotype of rs1045642 polymorphism of the Conclusion: Our findings indicate that the polymorphisms of |
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| Language | English |
| Publishing date | 2018-07-25 |
| Publishing country | New Zealand |
| Document type | Journal Article |
| ZDB-ID | 2508173-1 |
| ISSN | 1178-7066 |
| ISSN | 1178-7066 |
| DOI | 10.2147/PGPM.S169277 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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