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  1. Book: Sertoli cell biology

    Griswold, Michael D.

    (Elsevier insights)

    2015  

    Author's details ed. by Michael D. Griswold
    Series title Elsevier insights
    Keywords Sertoli cells
    Subject code 571.8451
    Language English
    Size XVII, 469 S. : zahlr. Ill., graph. Darst., 23 cm
    Edition 2. ed.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT018474933
    ISBN 978-0-12-417047-6 ; 0-12-417047-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 278 available for loan (reading room) Lesesaal EG

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  2. Book ; Online ; E-Book: The biology of mammalian spermatogonia

    Oatley, Jon M. / Griswold, Michael D.

    2017  

    Author's details Jon M. Oatley, Michael D. Griswold editor
    Keywords Medicine ; Human physiology ; Molecular biology ; Reproductive medicine ; Cell biology ; Animal physiology
    Subject code 611.01816
    Language English
    Size 1 Online-Ressource (xi, 387 Seiten), Illustrationen
    Publisher Springer
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019558528
    ISBN 978-1-4939-7505-1 ; 9781493975037 ; 1-4939-7505-6 ; 149397503X
    DOI 10.1007/978-1-4939-7505-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Cellular and molecular basis for the action of retinoic acid in spermatogenesis.

    Griswold, Michael D

    Journal of molecular endocrinology

    2022  Volume 69, Issue 4, Page(s) T51–T57

    Abstract: Spermatogenesis is a highly organized and regulated process that requires the constant production of millions of gametes over the reproductive lifetime of the mammalian male. This is possible because of an active stem cell pool and an ordered entry into ... ...

    Abstract Spermatogenesis is a highly organized and regulated process that requires the constant production of millions of gametes over the reproductive lifetime of the mammalian male. This is possible because of an active stem cell pool and an ordered entry into the germ cell developmental sequence. The ordered entry is a result of the synthesis and action of retinoic acid allowing for the onset of spermatogonial differentiation and an irreversible commitment to spermatogenesis. The periodic appearance and actions of retinoic acid along the seminiferous tubules is a result of the interactions between germ cells and Sertoli cells that result in the generation and maintenance of the cycle of the seminiferous epithelium and is the subject of this review.
    MeSH term(s) Animals ; Male ; Mammals/metabolism ; Seminiferous Epithelium/metabolism ; Sertoli Cells/metabolism ; Spermatogenesis ; Spermatogonia/metabolism ; Testis/metabolism ; Tretinoin/metabolism ; Tretinoin/pharmacology
    Chemical Substances Tretinoin (5688UTC01R)
    Language English
    Publishing date 2022-10-11
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 645012-x
    ISSN 1479-6813 ; 0952-5041
    ISSN (online) 1479-6813
    ISSN 0952-5041
    DOI 10.1530/JME-22-0067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2406: Show issues Location:
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  4. Article: Global Deletion of ALDH1A1 and ALDH1A2 Genes Does Not Affect Viability but Blocks Spermatogenesis.

    Topping, Traci / Griswold, Michael D

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 871225

    Abstract: The transition of undifferentiated A spermatogonia to differentiated spermatogonia requires the action of retinoic acid (RA). The synthesis of retinoic acid from retinal in the seminiferous epithelium is a result of the action of aldehyde dehydrogenases ... ...

    Abstract The transition of undifferentiated A spermatogonia to differentiated spermatogonia requires the action of retinoic acid (RA). The synthesis of retinoic acid from retinal in the seminiferous epithelium is a result of the action of aldehyde dehydrogenases termed ALDH1A1, ALDH1A2, and ALDH1A3. We used a mouse with a global deletion of the
    MeSH term(s) Aldehyde Dehydrogenase 1 Family/metabolism ; Animals ; Cell Differentiation ; Male ; Mice ; Retinal Dehydrogenase/genetics ; Retinal Dehydrogenase/metabolism ; Sertoli Cells ; Spermatogenesis/genetics ; Spermatogonia ; Tretinoin
    Chemical Substances Tretinoin (5688UTC01R) ; Aldehyde Dehydrogenase 1 Family (EC 1.2.1) ; ALDH1A1 protein, mouse (EC 1.2.1.36) ; Aldh1a2 protein, mouse (EC 1.2.1.36) ; Retinal Dehydrogenase (EC 1.2.1.36)
    Language English
    Publishing date 2022-04-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.871225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: 50 years of spermatogenesis: Sertoli cells and their interactions with germ cells.

    Griswold, Michael D

    Biology of reproduction

    2018  Volume 99, Issue 1, Page(s) 87–100

    Abstract: The complex morphology of the Sertoli cells and their interactions with germ cells has been a focus of investigators since they were first described by Enrico Sertoli. In the past 50 years, information on Sertoli cells has transcended morphology alone to ...

    Abstract The complex morphology of the Sertoli cells and their interactions with germ cells has been a focus of investigators since they were first described by Enrico Sertoli. In the past 50 years, information on Sertoli cells has transcended morphology alone to become increasingly more focused on molecular questions. The goal of investigators has been to understand the role of the Sertoli cells in spermatogenesis and to apply that information to problems relating to male fertility. Sertoli cells are unique in that they are a nondividing cell population that is active for the reproductive lifetime of the animal and cyclically change morphology and gene expression. The numerous and distinctive junctional complexes and membrane specializations made by Sertoli cells provide a scaffold and environment for germ cell development. The increased focus of investigators on the molecular components and putative functions of testicular cells has resulted primarily from procedures that isolate specific cell types from the testicular milieu. Products of Sertoli cells that influence germ cell development and vice versa have been characterized from cultured cells and from the application of transgenic technologies. Germ cell transplantation has shown that the Sertoli cells respond to cues from germ cells with regard to developmental timing and has furthered a focus on spermatogenic stem cells and the stem cell niche. Very basic and universal features of spermatogenesis such as the cycle of the seminiferous epithelium and the spermatogenic wave are initiated by Sertoli cells and maintained by Sertoli-germ cell cooperation.
    MeSH term(s) Animals ; Fertility/physiology ; Germ Cells/cytology ; Humans ; Male ; Seminiferous Epithelium/cytology ; Sertoli Cells/cytology ; Spermatogenesis/physiology ; Testis/cytology
    Language English
    Publishing date 2018-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1118-6
    ISSN 1529-7268 ; 0006-3363
    ISSN (online) 1529-7268
    ISSN 0006-3363
    DOI 10.1093/biolre/ioy027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 551: Show issues Location:
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  6. Book: Sertoli cell biology

    Skinner, Michael K. / Griswold, Michael D.

    2005  

    Author's details Michael K. Skinner ; Michael D. Griswold
    Language English
    Size XV, 494 S., [6] Bl. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT014102667
    ISBN 0-12-647751-5 ; 978-0-12-647751-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 5250 order for loan Magazin

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  7. Article ; Online: Function of Retinoic Acid in Development of Male and Female Gametes.

    Schleif, M Christine / Havel, Shelby L / Griswold, Michael D

    Nutrients

    2022  Volume 14, Issue 6

    Abstract: Retinoic acid, an active metabolite of vitamin A, is necessary for many developmental processes in mammals. Much of the field of reproduction has looked toward retinoic acid as a key transcriptional regulator and catalyst of differentiation events. This ... ...

    Abstract Retinoic acid, an active metabolite of vitamin A, is necessary for many developmental processes in mammals. Much of the field of reproduction has looked toward retinoic acid as a key transcriptional regulator and catalyst of differentiation events. This review focuses on the effects of retinoic acid on male and female gamete formation and regulation. Within spermatogenesis, it has been well established that retinoic acid is necessary for the proper formation of the blood-testis barrier, spermatogonial differentiation, spermiation, and assisting in meiotic completion. While many of the roles of retinoic acid in male spermatogenesis are known, investigations into female oogenesis have provided differing results.
    MeSH term(s) Animals ; Female ; Male ; Mammals/metabolism ; Oogenesis ; Spermatogenesis ; Spermatogonia/metabolism ; Tretinoin/pharmacology ; Vitamin A/metabolism
    Chemical Substances Vitamin A (11103-57-4) ; Tretinoin (5688UTC01R)
    Language English
    Publishing date 2022-03-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14061293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: MEIOSIN: A New Watchman of Meiotic Initiation in Mammalian Germ Cells.

    Oatley, Jon M / Griswold, Michael D

    Developmental cell

    2020  Volume 52, Issue 4, Page(s) 397–398

    Abstract: The capacity to undergo meiosis defines vertebrate germ cells, yet mechanisms driving initiation of this specialized process are largely undefined. In this issue of Developmental Cell,Ishiguro et al. (2020) identified the transcription factor MEIOSIN as ... ...

    Abstract The capacity to undergo meiosis defines vertebrate germ cells, yet mechanisms driving initiation of this specialized process are largely undefined. In this issue of Developmental Cell,Ishiguro et al. (2020) identified the transcription factor MEIOSIN as a gatekeeper of meiotic initiation in both male and female germ cells.
    MeSH term(s) Animals ; Female ; Gene Expression Regulation ; Germ Cells ; Male ; Meiosis ; Mitosis ; Transcription Factors
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2020-03-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2020.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5742: Show issues Location:
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  9. Article ; Online: Spermatogenesis: The Commitment to Meiosis.

    Griswold, Michael D

    Physiological reviews

    2016  Volume 96, Issue 1, Page(s) 1–17

    Abstract: Mammalian spermatogenesis requires a stem cell pool, a period of amplification of cell numbers, the completion of reduction division to haploid cells (meiosis), and the morphological transformation of the haploid cells into spermatozoa (spermiogenesis). ... ...

    Abstract Mammalian spermatogenesis requires a stem cell pool, a period of amplification of cell numbers, the completion of reduction division to haploid cells (meiosis), and the morphological transformation of the haploid cells into spermatozoa (spermiogenesis). The net result of these processes is the production of massive numbers of spermatozoa over the reproductive lifetime of the animal. One study that utilized homogenization-resistant spermatids as the standard determined that human daily sperm production (dsp) was at 45 million per day per testis (60). For each human that means ∼1,000 sperm are produced per second. A key to this level of gamete production is the organization and architecture of the mammalian testes that results in continuous sperm production. The seemingly complex repetitious relationship of cells termed the "cycle of the seminiferous epithelium" is driven by the continuous commitment of undifferentiated spermatogonia to meiosis and the period of time required to form spermatozoa. This commitment termed the A to A1 transition requires the action of retinoic acid (RA) on the undifferentiated spermatogonia or prospermatogonia. In stages VII to IX of the cycle of the seminiferous epithelium, Sertoli cells and germ cells are influenced by pulses of RA. These pulses of RA move along the seminiferous tubules coincident with the spermatogenic wave, presumably undergoing constant synthesis and degradation. The RA pulse then serves as a trigger to commit undifferentiated progenitor cells to the rigidly timed pathway into meiosis and spermatid differentiation.
    MeSH term(s) Animals ; Cell Lineage ; Cell Proliferation ; Humans ; Male ; Meiosis ; Morphogenesis ; Signal Transduction ; Spermatogenesis ; Spermatozoa/physiology ; Stem Cells/physiology ; Testis/cytology ; Testis/embryology ; Testis/physiology ; Tretinoin/metabolism
    Chemical Substances Tretinoin (5688UTC01R)
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 209902-0
    ISSN 1522-1210 ; 0031-9333
    ISSN (online) 1522-1210
    ISSN 0031-9333
    DOI 10.1152/physrev.00013.2015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The role of retinoic acid in the commitment to meiosis.

    Gewiss, Rachel L / Schleif, M Christine / Griswold, Michael D

    Asian journal of andrology

    2021  Volume 23, Issue 6, Page(s) 549–554

    Abstract: Male meiosis is a complex process whereby spermatocytes undergo cell division to form haploid cells. This review focuses on the role of retinoic acid (RA) in meiosis, as well as several processes regulated by RA before cell entry into meiosis that are ... ...

    Abstract Male meiosis is a complex process whereby spermatocytes undergo cell division to form haploid cells. This review focuses on the role of retinoic acid (RA) in meiosis, as well as several processes regulated by RA before cell entry into meiosis that are critical for proper meiotic entry and completion. Here, we discuss RA metabolism in the testis as well as the roles of stimulated by retinoic acid gene 8 (STRA8) and MEIOSIN, which are responsive to RA and are critical for meiosis. We assert that transcriptional regulation in the spermatogonia is critical for successful meiosis.
    MeSH term(s) Animals ; Cell Differentiation/genetics ; Humans ; Meiosis/drug effects ; Spermatogenesis/drug effects ; Spermatogenesis/physiology ; Tretinoin/metabolism
    Chemical Substances Tretinoin (5688UTC01R)
    Language English
    Publishing date 2021-09-01
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2075824-8
    ISSN 1745-7262 ; 1008-682X
    ISSN (online) 1745-7262
    ISSN 1008-682X
    DOI 10.4103/aja202156
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