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  1. Article ; Online: Advanced Cardiac Imaging in the Assessment of Aortic Stenosis.

    Grodecki, Kajetan / Warniello, Mateusz / Spiewak, Mateusz / Kwiecinski, Jacek

    Journal of cardiovascular development and disease

    2023  Volume 10, Issue 5

    Abstract: Aortic stenosis is the most common form of valve disease in the Western world and a major healthcare burden. Although echocardiography remains the central modality for the diagnosis and assessment of aortic stenosis, recently, advanced cardiac imaging ... ...

    Abstract Aortic stenosis is the most common form of valve disease in the Western world and a major healthcare burden. Although echocardiography remains the central modality for the diagnosis and assessment of aortic stenosis, recently, advanced cardiac imaging with cardiovascular magnetic resonance, computed tomography, and positron emission tomography have provided invaluable pathological insights that may guide the personalized management of the disease. In this review, we discuss applications of these novel non-invasive imaging modalities for establishing the diagnosis, monitoring disease progression, and eventually planning the invasive treatment of aortic stenosis.
    Language English
    Publishing date 2023-05-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd10050216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Letter: Refining the prediction of side branch occlusion following percutaneous coronary intervention in bifurcation lesions.

    Grodecki, Kajetan / Opolski, Maksymilian P

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2020  Volume 16, Issue 6, Page(s) e525–e526

    MeSH term(s) Coronary Angiography ; Coronary Occlusion ; Humans ; Percutaneous Coronary Intervention ; Prospective Studies
    Language English
    Publishing date 2020-08-07
    Publishing country France
    Document type Letter ; Comment
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJ-D-19-01107L
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Noninvasive Atherosclerotic Phenotyping: The Next Frontier into Understanding the Pathobiology of Coronary Artery Disease.

    Wolny, Rafal / Geers, Jolien / Grodecki, Kajetan / Kwiecinski, Jacek / Williams, Michelle C / Slomka, Piotr J / Hasific, Selma / Lin, Andrew K / Dey, Damini

    Current atherosclerosis reports

    2024  

    Abstract: Purpose of review: Despite recent advances, coronary artery disease remains one of the leading causes of mortality worldwide. Noninvasive imaging allows atherosclerotic phenotyping by measurement of plaque burden, morphology, activity and inflammation, ... ...

    Abstract Purpose of review: Despite recent advances, coronary artery disease remains one of the leading causes of mortality worldwide. Noninvasive imaging allows atherosclerotic phenotyping by measurement of plaque burden, morphology, activity and inflammation, which has the potential to refine patient risk stratification and guide personalized therapy. This review describes the current and emerging roles of advanced noninvasive cardiovascular imaging methods for the assessment of coronary artery disease.
    Recent findings: Cardiac computed tomography enables comprehensive, noninvasive imaging of the coronary vasculature, and is used to assess luminal stenoses, coronary calcifications, and distinct adverse plaque characteristics, helping to identify patients prone to future events. Novel software tools, implementing artificial intelligence solutions, can automatically quantify and characterize atherosclerotic plaque from standard computed tomography datasets. These quantitative imaging biomarkers have been shown to improve patient risk stratification beyond clinical risk scores and current clinical interpretation of cardiac computed tomography. In addition, noninvasive molecular imaging in higher risk patients can be used to assess plaque activity and plaque thrombosis. Noninvasive imaging allows unique insight into the burden, morphology and activity of atherosclerotic coronary plaques. Such phenotyping of atherosclerosis can potentially improve individual patient risk prediction, and in the near future has the potential for clinical implementation.
    Language English
    Publishing date 2024-05-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057369-8
    ISSN 1534-6242 ; 1523-3804
    ISSN (online) 1534-6242
    ISSN 1523-3804
    DOI 10.1007/s11883-024-01205-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Increased Plasma Concentrations of Extracellular Vesicles Are Associated with Pro-Inflammatory and Pro-Thrombotic Characteristics of Left and Right Ventricle Mechanical Support Devices.

    Urbanowicz, Tomasz / Olasińska-Wiśniewska, Anna / Grodecki, Kajetan / Gąsecka, Aleksandra / Filipiak, Krzysztof J / Gawlikowski, Maciej / Mucha, Łukasz / Jemielity, Marek

    Journal of cardiovascular development and disease

    2023  Volume 10, Issue 1

    Abstract: Mechanical circulatory support (MCS) allows for functional left and right heart ventricle replacement. MCS induces a systemic inflammatory reaction and prothrombotic state leading to an increased risk of thrombus formation. The extracellular vesicles ( ... ...

    Abstract Mechanical circulatory support (MCS) allows for functional left and right heart ventricle replacement. MCS induces a systemic inflammatory reaction and prothrombotic state leading to an increased risk of thrombus formation. The extracellular vesicles (EVs) are nanoparticles released from active/injured cells characterized by prothrombotic properties. Simple inflammatory parameters from whole blood count analysis have established a clinical role in everyday practice to describe immune-inflammatory activation. We hypothesized that increased plasma concentrations of EVs might be associated with the proinflammatory and pro-thrombotic characteristics of left ventricle assist device (LVAD) and right ventricle assist device (RVAD) devices. We presented a pilot study showing the concentration of peripheral blood serum, right and left ventricle mechanical assist device extracellular concentration in relation to thrombotic complication in patients treated with a biventricular pulsatile assist device (BIVAD). The observation was based on 12 replacements of pulsatile pumps during 175 days of observation. The proinflammatory characteristics of LVAD were noted. The proinflammatory and procoagulant activation by RVAD was observed. The results may provide possible explanations for the worse results of right-sided mechanical supports observed in clinical practice.
    Language English
    Publishing date 2023-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd10010021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Impact of previous coronary artery revascularization on outcomes in patients undergoing transcatheter aortic valve implantation.

    Wilimski, Radosław / Huczek, Zenon / Krauz, Kamil / Rymuza, Bartosz / Mazurek, Maciej / Scisło, Piotr / Zbroński, Karol / Grodecki, Kajetan / Kochman, Janusz / Kuśmierczyk, Mariusz

    Postepy w kardiologii interwencyjnej = Advances in interventional cardiology

    2023  Volume 19, Issue 3, Page(s) 243–250

    Abstract: Introduction: Coexistence of coronary artery disease (CAD) in patients with severe aortic stenosis (AS) referred for transcatheter aortic valve implantation (TAVI) raises questions regarding the safety and efficacy of TAVI in this subset of patients.: ...

    Abstract Introduction: Coexistence of coronary artery disease (CAD) in patients with severe aortic stenosis (AS) referred for transcatheter aortic valve implantation (TAVI) raises questions regarding the safety and efficacy of TAVI in this subset of patients.
    Aim: To evaluate the impact of previous coronary revascularization in terms of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) on clinical outcomes after TAVI.
    Material and methods: A total of 507 consecutive patients who underwent TAVI were divided into: non-revascularization (NR), post-PCI and post-CABG groups. The endpoints were established according to VARC-2 definitions.
    Results: Patients with previous coronary revascularization (36.7% of the population) were younger, more often male and their EuroSCORE II risk evaluation was significantly higher (NR 7.9% vs. post-PCI 8.0% vs. post-CABG 20.5%,
    Conclusions: TAVI seems to be a safe and effective procedure for the treatment of severe AS in patients with previous coronary revascularization.
    Language English
    Publishing date 2023-09-27
    Publishing country Poland
    Document type Journal Article
    ISSN 1734-9338
    ISSN 1734-9338
    DOI 10.5114/aic.2023.131477
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Commentary: Extended Reality in Percutaneous Interventions: Toward a Revolution, but in Baby Steps.

    Grodecki, Kajetan / Huczek, Zenon / Filipiak, Krzysztof J

    Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

    2019  Volume 26, Issue 4, Page(s) 548–549

    MeSH term(s) Aortic Aneurysm, Abdominal/surgery ; Aortography ; Blood Vessel Prosthesis Implantation ; Endovascular Procedures ; Humans ; Treatment Outcome
    Language English
    Publishing date 2019-06-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2006618-1
    ISSN 1545-1550 ; 1526-6028
    ISSN (online) 1545-1550
    ISSN 1526-6028
    DOI 10.1177/1526602819855482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Bioprosthetic Aortic Scallop Intentional Laceration to prevent Iatrogenic Coronary Artery obstruction (BASILICA) in valve-in-valve Transcatheter Aortic Valve Implantation (ViV-TAVI): First experience in Poland.

    Jędrzejczyk, Szymon / Rymuza, Bartosz / Ścisło, Piotr / Grodecki, Kajetan / Pędzich-Placha, Ewa / Grabowski, Marcin / Kochman, Janusz / Huczek, Zenon

    Kardiologia polska

    2022  Volume 80, Issue 12, Page(s) 1266–1267

    MeSH term(s) Humans ; Transcatheter Aortic Valve Replacement/adverse effects ; Coronary Vessels ; Lacerations ; Poland ; Coronary Occlusion ; Aortic Valve/surgery ; Iatrogenic Disease/prevention & control ; Heart Valve Prosthesis/adverse effects ; Bioprosthesis/adverse effects ; Treatment Outcome ; Prosthesis Design ; Aortic Valve Stenosis/surgery
    Language English
    Publishing date 2022-09-26
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/KP.a2022.0227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Influence of cusp morphology and sex on quantitative valve composition in severe aortic stenosis.

    Patel, Kush P / Lin, Andrew / Kumar, Niraj / Esposito, Giulia / Grodecki, Kajetan / Lloyd, Guy / Mathur, Anthony / Baumbach, Andreas / Mullen, Michael J / Williams, Michelle C / Newby, David E / Treibel, Thomas A / Dweck, Marc R / Dey, Damini

    European heart journal. Cardiovascular Imaging

    2023  Volume 24, Issue 12, Page(s) 1653–1660

    Abstract: Aims: Aortic stenosis is characterized by fibrosis and calcification of the valve, with a higher proportion of fibrosis observed in women. Stenotic bicuspid aortic valves progress more rapidly than tricuspid valves, which may also influence the relative ...

    Abstract Aims: Aortic stenosis is characterized by fibrosis and calcification of the valve, with a higher proportion of fibrosis observed in women. Stenotic bicuspid aortic valves progress more rapidly than tricuspid valves, which may also influence the relative composition of the valve. We aimed to investigate the influence of cusp morphology on quantitative aortic valve composition quantified from contrast-enhanced computed tomography angiography in severe aortic stenosis.
    Methods and results: Patients undergoing transcatheter aortic valve implantation with bicuspid and tricuspid valves were propensity matched 1:1 by age, sex, and comorbidities. Computed tomography angiograms were analysed using semi-automated software to quantify the fibrotic and calcific scores (volume/valve annular area) and the fibro-calcific ratio (fibrotic score/calcific score). The study population (n = 140) was elderly (76 ± 10 years, 62% male) and had a peak aortic jet velocity of 4.1 ± 0.7 m/s. Compared with those with tricuspid valves (n = 70), patients with bicuspid valves (n = 70) had higher fibrotic scores [204 (interquartile range 118-267) vs. 144 (99-208) mm3/cm2, P = 0.006] with similar calcific scores (P = 0.614). Women had greater fibrotic scores than men in bicuspid [224 (181-307) vs. 169 (109-247) mm3/cm2, P = 0.042] but not tricuspid valves (P = 0.232). Men had greater calcific scores than women in both bicuspid [203 (124-355) vs. 130 (70-182) mm3/cm2, P = 0.008] and tricuspid [177 (136-249) vs. 100 (62-150) mm3/cm2, P = 0.004] valves. Among both valve types, women had a greater fibro-calcific ratio compared with men [tricuspid 1.86 (0.94-2.56) vs. 0.86 (0.54-1.24), P = 0.001 and bicuspid 1.78 (1.21-2.90) vs. 0.74 (0.44-1.53), P = 0.001].
    Conclusions: In severe aortic stenosis, bicuspid valves have proportionately more fibrosis than tricuspid valves, especially in women.
    MeSH term(s) Humans ; Male ; Female ; Aged ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve/pathology ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Aortic Valve Stenosis/pathology ; Bicuspid Aortic Valve Disease/pathology ; Transcatheter Aortic Valve Replacement ; Fibrosis
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jead142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Red blood cell distribution width as a prognostic marker of prolonged mechanical ventilation after paediatric cardiac surgery.

    Olasińska-Wiśniewska, Anna / Urbanowicz, Tomasz / Gładki, Marcin / Grodecki, Kajetan / Michalak, Michał / Węclewska, Anita / Sochacki, Mateusz / Bobkowski, Waldemar / Zalas, Dominika / Jemielity, Marek

    Archives of medical science : AMS

    2023  Volume 19, Issue 3, Page(s) 825–828

    Language English
    Publishing date 2023-05-24
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2203781-0
    ISSN 1734-1922
    ISSN 1734-1922
    DOI 10.5114/aoms/161247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Nationwide experience with transcarotid transcatheter aortic valve implantation: Insights from the POL-CAROTID registry.

    Wilimski, Radosław / Huczek, Zenon / Grodecki, Kajetan / Kochman, Janusz / Rymuza, Bartosz / Wojakowski, Wojciech / Hudziak, Damian / Jagielak, Dariusz / Sacha, Jerzy / Grygier, Marek / Walczak, Andrzej / Hendzel, Piotr / Cichoń, Romuald / Grabowski, Marcin / Kuśmierczyk, Mariusz

    Kardiologia polska

    2023  Volume 81, Issue 4, Page(s) 373–380

    Abstract: Background: The carotid artery is an alternative access route for transcatheter aortic valve implantation (TAVI), especially useful in patients unsuitable for traditional access routes including transfemoral (TF), subclavian, transapical, and aortic.: ...

    Abstract Background: The carotid artery is an alternative access route for transcatheter aortic valve implantation (TAVI), especially useful in patients unsuitable for traditional access routes including transfemoral (TF), subclavian, transapical, and aortic.
    Aims: To investigate the feasibility and safety of transcarotid (TC) access for TAVI in comparison to the TF approach in a multicenter setting.
    Methods: A total of 41 patients, treated between December 2014 and December 2018, were retrospectively reported to the Polish Registry of Common Carotid Artery Access for TAVI (POL-CAROTID). The median follow-up time was 619 (365-944) days, and Valve Academic Research Consortium-2 (VARC-2) definitions were applied. Clinical outcomes were compared with 41 propensity-matched TF-TAVI patients.
    Results: The mean (standard deviation [SD]) patients' age was 78.0 (7.2) years, and 29 patients (70.7%) were men. Prohibitive iliofemoral anatomy and/or obesity (46.3%) and/or the presence of a stent graft in the abdominal aorta (31.7%) were the most common indications for TC-TAVI. Device success for TC-TAVI was comparable with the matched TF-TAVI group (90.2% vs. 95.3%, respectively, P = 0.396), and no periprocedural mortality was observed. Moreover, early safety was similar between the two groups (92.7% vs. 95.3%, respectively, log-rank P = 0.658) with only 1 case of non-disabling stroke during the first month after TC-TAVI. Consequently, no cerebrovascular events were observed in the mid-term, and the clinical efficacy of TC-TAVI corresponded well with TF-TAVI (90.2% vs. 92.7%, respectively, log-rank P = 0.716). A total of 4 (9.8%) deaths were noted in the TC-TAVI cohort in comparison to 3 (7.3%) in the TF-TAVI group.
    Conclusions: The results of the study indicated that the first cohort of Polish patients with implantations of second-generation transcarotid transcatheter heart valves had a similar prognosis to TF-TAVI with regard to safety and feasibility. TC access may be considered an optimal alternative for patients in whom the TF approach is precluded.
    MeSH term(s) Male ; Humans ; Aged ; Female ; Transcatheter Aortic Valve Replacement/adverse effects ; Aortic Valve Stenosis/surgery ; Retrospective Studies ; Carotid Arteries ; Aortic Valve/surgery ; Treatment Outcome ; Registries
    Language English
    Publishing date 2023-01-03
    Publishing country Poland
    Document type Multicenter Study ; Journal Article
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/KP.a2022.0288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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