Article ; Online: Non-AIDS Events in Individuals With Spontaneous Control of HIV-1: A Systematic Review.
Journal of acquired immune deficiency syndromes (1999)
2022 Volume 91, Issue 3, Page(s) 242–250
Abstract: Background: Despite antiretroviral therapy (ART), people living with HIV (PLHIV) are at increased risk for non-AIDS-defining events (nADEs), including cardiovascular events, non-AIDS malignances, hepatic disease, and bacterial pneumonia.: Setting: ... ...
| Abstract | Background: Despite antiretroviral therapy (ART), people living with HIV (PLHIV) are at increased risk for non-AIDS-defining events (nADEs), including cardiovascular events, non-AIDS malignances, hepatic disease, and bacterial pneumonia. Setting: This systematic review seeks to answer the question: are PLHIV who spontaneously control HIV-1 subject to an increased risk of various nADEs relative to noncontrolling PLHIV on ART and people without HIV? Methods: Databases were searched on June 9, 2021 with a search syntax focused on the elements "HIV," "spontaneous control," and "clinical outcomes": Embase.com (includes Embase and Medline), Medline Ovid (includes PubMed), Cochrane library, Web of Science, and Google Scholar. Included were studies reporting non-AIDS events in spontaneous controllers. Excluded were case reports, conference papers, editorials, and reviews. Results: Of 1134 identified records, 34 were assessed for full-text and 12 studies were included in the qualitative synthesis: 5 cohorts, 2 cross-sectional prevalence studies, 4 cross-sectional imaging studies, and one case series. Four of 5 cohort studies showed that spontaneous controllers have a similar risk to develop nADEs compared with PLHIV on suppressive ART, specifically cardiovascular events, non-AIDS malignancies, hepatic disease, and bacterial pneumonia. Cross-sectional imaging studies showed a higher presence of subclinical cardiovascular disease in spontaneous controllers, than in people without HIV. Conclusion: Individuals with spontaneous control of HIV-1 do not seem to be at a greater risk to develop different nADEs compared with PLHIV on suppressive ART. More data are needed, because the present conclusions are based on a limited number of studies that show large heterogeneity among them. |
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| MeSH term(s) | Acquired Immunodeficiency Syndrome/complications ; Acquired Immunodeficiency Syndrome/drug therapy ; Cardiovascular Diseases/epidemiology ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Seropositivity ; HIV-1 ; Humans |
| Language | English |
| Publishing date | 2022-08-11 |
| Publishing country | United States |
| Document type | Journal Article ; Systematic Review |
| ZDB-ID | 645053-2 |
| ISSN | 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135 |
| ISSN (online) | 1944-7884 ; 1077-9450 |
| ISSN | 0897-5965 ; 0894-9255 ; 1525-4135 |
| DOI | 10.1097/QAI.0000000000003066 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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