LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 114

Search options

  1. Article ; Online: Editorial. Navigation in spine surgery: an innovation here to stay.

    Driver, Joseph / Groff, Michael W

    Journal of neurosurgery. Spine

    2021  Volume 36, Issue 3, Page(s) 347–349

    Language English
    Publishing date 2021-10-08
    Publishing country United States
    Document type Editorial ; Journal Article
    ZDB-ID 2158643-3
    ISSN 1547-5646 ; 1547-5654
    ISSN (online) 1547-5646
    ISSN 1547-5654
    DOI 10.3171/2021.4.SPINE21207
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Introduction: guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine.

    Groff, Michael W

    Journal of neurosurgery. Spine

    2014  Volume 21, Issue 1, Page(s) 1

    MeSH term(s) Humans ; Lumbar Vertebrae/pathology ; Lumbar Vertebrae/surgery ; Practice Guidelines as Topic ; Spinal Diseases/pathology ; Spinal Diseases/surgery ; Spinal Fusion/standards
    Language English
    Publishing date 2014-07
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 2158643-3
    ISSN 1547-5646 ; 1547-5654
    ISSN (online) 1547-5646
    ISSN 1547-5654
    DOI 10.3171/2014.4.SPINE14190
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Evaluation of interdisciplinary care pathway implementation in older elective surgery patients.

    Hu, Frances Y / Rowe, Katherine A / O'Mara, Lynne M / Bulger, Amy / Bleday, Ronald / Groff, Michael W / Cooper, Zara / Bernacki, Rachelle E

    Journal of the American Geriatrics Society

    2023  Volume 71, Issue 4, Page(s) 1310–1322

    Abstract: Background: The American College of Surgeons Geriatric Surgery Verification Program outlines best practices for surgical care in older adults. These recommendations have guided institutions to create workflows to better support needs specific to older ... ...

    Abstract Background: The American College of Surgeons Geriatric Surgery Verification Program outlines best practices for surgical care in older adults. These recommendations have guided institutions to create workflows to better support needs specific to older surgical patients. This qualitative study explored clinician experiences to understand influences on implementation of frailty screening and an interdisciplinary care pathway in older elective colorectal surgery and neurosurgery patients.
    Study design: Semi-structured in-person and video-based interviews were conducted from July 2021 to March 2022 with clinicians caring for patients ≥70 years on the colorectal surgery and neurosurgery services. Interviews addressed familiarity with and beliefs about the intervention, intervention alignment with routine workflow and workflow adaptations, and barriers and facilitators to performing the intervention. Interviews were analyzed using the consolidated framework for implementation research (CFIR) to find themes related to ongoing implementation.
    Results: Thirty-two clinicians participated (56.3% female, 58.8% White). Fifteen relevant CFIR constructs were identified. Key themes to implementation success included strong participant belief in effectiveness of the intervention and its advantage over standard care; the importance of training, reference materials, and champions; and the need for institution-level investment in resources to amplify the impact of the intervention on patients and expand the capacity to address their needs.
    Conclusion: Systematic evaluation found implementation of frailty screening and an interdisciplinary care pathway in elective colorectal surgery and neurosurgery patients to be supported by participating clinicians, yet sustainability of the intervention and further adoption across surgical services to better meet the needs of older patients would necessitate organizational resource allocation.
    MeSH term(s) Humans ; Female ; Aged ; Male ; Primary Health Care ; Frailty ; Critical Pathways ; Qualitative Research ; Patients
    Language English
    Publishing date 2023-01-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18244
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: The effect of interbody fusion cage design on the stability of the instrumented spine in response to cyclic loading: an experimental study.

    Alkalay, Ron N / Adamson, Robert / Groff, Michael W

    The spine journal : official journal of the North American Spine Society

    2018  Volume 18, Issue 10, Page(s) 1867–1876

    Abstract: Background context: In the lumbar spine, end plate preparation for the interbody fusion cages may critically affect the cage's long-term performance. This study investigated the effect of the interbody cage design on the compliance and cage subsidence ... ...

    Abstract Background context: In the lumbar spine, end plate preparation for the interbody fusion cages may critically affect the cage's long-term performance. This study investigated the effect of the interbody cage design on the compliance and cage subsidence of instrumented spines under cyclic compression.
    Purpose: We aimed to quantify the role of cage geometry and bone density on the stability of the spinal construct in response to cyclic compressive loads.
    Study design: Changes in the cage-bone interface and the effect of bone density on these changes were evaluated in a human cadaveric model for three intervertebral cage designs.
    Methods: The intervertebral space of 27 functional cadaveric spinal units was instrumented with bilateral linear cages, single anterior conformal cages, or single unilateral oblique cages. Once augmented with a pedicle screw fixation system, the instrumented spine unit was tested under cyclic compression loads (400-1,200 N) to 20,000 cycles at a rate of 2 Hz. Compliance of the cage-bone interface and cage subsidence was computed. Two-way repeated multivariate analysis of variance was used to test the effects of cage design and bone density on the compliance and subsidence of the cages.
    Results: The anterior conformal shaped cage showed reduced interface stiffness (p<.01) and higher hysteresis (p<.01) and subsidence rate (10%-30%) than the bilateral linear and unilateral oblique-shaped cages. Bone density was not associated with the initial compliance of the cage-bone interface or the rate of cage subsidence. Higher bone density did decrease the rate of reduction in cage-bone interface stiffness under higher cyclic loads for the anterior conformal shaped and unilateral oblique cages.
    Conclusions: Cage design and position significantly affected the degradation of the cage-bone interface under cyclic loading. Comparisons of subsidence rate between the different cage designs suggest the peripheral location of the cages, using the stronger peripheral subchondral bone of the apophyseal ring, to be advantageous in preventing the subsidence and failure of the cage-bone interface.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biomechanical Phenomena ; Bone Density ; Bone Plates ; Cadaver ; Female ; Humans ; Internal Fixators/adverse effects ; Male ; Middle Aged ; Pedicle Screws ; Prosthesis Design/methods ; Spinal Fusion/instrumentation ; Spinal Fusion/methods ; Spine/physiopathology ; Spine/surgery ; Weight-Bearing
    Language English
    Publishing date 2018-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2037072-6
    ISSN 1878-1632 ; 1529-9430
    ISSN (online) 1878-1632
    ISSN 1529-9430
    DOI 10.1016/j.spinee.2018.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Evaluation of Load-To-Strength Ratios in Metastatic Vertebrae and Comparison With Age- and Sex-Matched Healthy Individuals.

    Anderson, Dennis E / Groff, Michael W / Flood, Thomas F / Allaire, Brett T / Davis, Roger B / Stadelmann, Marc A / Zysset, Philippe K / Alkalay, Ron N

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 866970

    Abstract: Vertebrae containing osteolytic and osteosclerotic bone metastases undergo pathologic vertebral fracture (PVF) when the lesioned vertebrae fail to carry daily loads. We hypothesize that task-specific spinal loading patterns amplify the risk of PVF, with ... ...

    Abstract Vertebrae containing osteolytic and osteosclerotic bone metastases undergo pathologic vertebral fracture (PVF) when the lesioned vertebrae fail to carry daily loads. We hypothesize that task-specific spinal loading patterns amplify the risk of PVF, with a higher degree of risk in osteolytic than in osteosclerotic vertebrae. To test this hypothesis, we obtained clinical CT images of 11 cadaveric spines with bone metastases, estimated the individual vertebral strength from the CT data, and created spine-specific musculoskeletal models from the CT data. We established a musculoskeletal model for each spine to compute vertebral loading for natural standing, natural standing + weights, forward flexion + weights, and lateral bending + weights and derived the individual vertebral load-to-strength ratio (LSR). For each activity, we compared the metastatic spines' predicted LSRs with the normative LSRs generated from a population-based sample of 250 men and women of comparable ages. Bone metastases classification significantly affected the CT-estimated vertebral strength (Kruskal-Wallis,
    Language English
    Publishing date 2022-08-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.866970
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Impact of Neurosurgery Research and Education Foundation awards on subsequent grant funding and career outcomes of neurosurgeon-scientists.

    Javeed, Saad / Pugazenthi, Sangami / Huguenard, Anna L / Haid, Regis W / Groff, Michael W / Limbrick, David D / Zipfel, Gregory J

    Journal of neurosurgery

    2022  Volume 139, Issue 1, Page(s) 255–265

    Abstract: Objective: The Neurosurgery Research and Education Foundation (NREF) provides diverse funding opportunities for in-training and early-career neurosurgeon-scientists. The authors analyzed the impact of NREF funding on the subsequent career success of ... ...

    Abstract Objective: The Neurosurgery Research and Education Foundation (NREF) provides diverse funding opportunities for in-training and early-career neurosurgeon-scientists. The authors analyzed the impact of NREF funding on the subsequent career success of neurosurgeons in obtaining research funding and academic achievements.
    Methods: The NREF database was queried to identify NREF winners from 2000 to 2015. The award recipients were surveyed to obtain information about their demographic characteristics, academic career, and research funding. Only subsequent research support with an annual funding amount of $50,000 or greater was included. The primary outcome was the NREF impact ratio, defined as the ratio between NREF award research dollars and subsequent grant funding dollars. The secondary outcomes were time to subsequent grant funding as principal investigator (PI), clinical practice settings, and final academic position achieved.
    Results: From 2000 to 2015, 158 neurosurgeons received 164 NREF awards totaling $8.3 million (M), with $1.7 M awarded to 46 Young Clinician Investigators (YCIs), $1.5 M to 18 Van Wagenen Fellows (VWFs), and $5.1 M to 100 resident Research Fellowship Grant (RFG) awardees. Of all awardees, 73% have current academic appointments, and the mean ± SD number of publications and H-index were 71 ± 82 and 20 ± 15, respectively. The overall response rate to our survey was 70%, and these respondents became the cohort for our analysis. In total, respondents cumulatively obtained $776 M in post-NREF award grant funding, with the most common sources of funding including the National Institutes of Health ($327 M) and foundational awards ($306 M). The NREF impact ratios for awardees were $1:$381 for YCI, $1:$113 for VWF, and $1:$41 for resident RFG. Awardees with NREF projects in functional neurosurgery, pediatric neurosurgery, and neuro-oncology had the highest NREF impact ratios of $1:$194, $1:$185, and $1:$162, respectively. Of respondents, 9% became department chairs, 26% became full professors, 82% received at least 1 subsequent research grant, and 66% served as PI on a subsequent research grant after receiving their NREF awards.
    Conclusions: In-training and early-career neurosurgeons who were awarded NREF funding had significant success in acquiring subsequent grant support, research productivity, and achievements of academic rank. NREF grants provide a tremendous return on investment across various career stages and subspecialities. They also appeared to have a broader impact on trajectory of research and innovation within the field of neurosurgery.
    MeSH term(s) United States ; Humans ; Child ; Neurosurgeons ; Neurosurgery ; Biomedical Research ; Financing, Organized ; National Institutes of Health (U.S.) ; Awards and Prizes
    Language English
    Publishing date 2022-12-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2022.11.JNS221391
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Superiority Claims for Spinal Devices: A Systematic Review of Randomized Controlled Trials.

    Golish, S Raymond / Groff, Michael W / Araghi, Ali / Inzana, Jason A

    Global spine journal

    2019  Volume 10, Issue 3, Page(s) 332–345

    Abstract: Study design: Systematic review.: Objectives: Superiority claims for medical devices are commonly derived from noninferiority trials, but interpretation of such claims can be challenging. This study aimed to (: Methods: Study bias was assessed ... ...

    Abstract Study design: Systematic review.
    Objectives: Superiority claims for medical devices are commonly derived from noninferiority trials, but interpretation of such claims can be challenging. This study aimed to (
    Methods: Study bias was assessed using the Cochrane Risk of Bias Tool. The risk of bias for the superiority claim was established based on post hoc hypothesis specification, analysis of the intention-to-treat population, post hoc modification of a priori primary outcomes, and sensitivity analyses.
    Results: Forty-one studies were identified from 1895 records. Nineteen (46%) were noninferiority trials. Fifteen more (37%) were noninferiority trials with a secondary superiority hypothesis specified a priori. Seven (17%) were superiority trials. Of the 34 noninferiority trials, 14 (41%) made superiority claims. A medium or high risk of bias was related to the superiority claim in 9 of those trials (64%), which was due to the analyzed population, lacking sensitivity analyses, claims not being robust during sensitivity analyses, post hoc hypotheses, or modified endpoints. Only 4 of the 14 (29%) noninferiority studies provided low bias in the superiority claim, compared with 3 of the 5 (60%) superiority trials.
    Conclusions: Health care decision makers should carefully evaluate the risk of bias in each superiority claim and weigh their conclusions appropriately.
    Language English
    Publishing date 2019-06-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2648287-3
    ISSN 2192-5690 ; 2192-5682
    ISSN (online) 2192-5690
    ISSN 2192-5682
    DOI 10.1177/2192568219841046
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: How to incorporate clinical experience into evidence-based medicine.

    Groff, Michael W

    Clinical neurosurgery

    2009  Volume 56, Page(s) 54–56

    MeSH term(s) Clinical Trials as Topic ; Delivery of Health Care/organization & administration ; Epidemiologic Studies ; Evidence-Based Medicine/organization & administration ; Humans ; Neurosurgery/organization & administration ; Reproducibility of Results
    Language English
    Publishing date 2009
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 127548-3
    ISSN 0069-4827
    ISSN 0069-4827
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Author Correction: Bridging the literacy gap for surgical consents: an AI-human expert collaborative approach.

    Ali, Rohaid / Connolly, Ian D / Tang, Oliver Y / Mirza, Fatima N / Johnston, Benjamin / Abdulrazeq, Hael F / Lim, Rachel K / Galamaga, Paul F / Libby, Tiffany J / Sodha, Neel R / Groff, Michael W / Gokaslan, Ziya L / Telfeian, Albert E / Shin, John H / Asaad, Wael F / Zou, James / Doberstein, Curtis E

    NPJ digital medicine

    2024  Volume 7, Issue 1, Page(s) 93

    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Published Erratum
    ISSN 2398-6352
    ISSN (online) 2398-6352
    DOI 10.1038/s41746-024-01099-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Bridging the literacy gap for surgical consents: an AI-human expert collaborative approach.

    Ali, Rohaid / Connolly, Ian D / Tang, Oliver Y / Mirza, Fatima N / Johnston, Benjamin / Abdulrazeq, Hael F / Lim, Rachel K / Galamaga, Paul F / Libby, Tiffany J / Sodha, Neel R / Groff, Michael W / Gokaslan, Ziya L / Telfeian, Albert E / Shin, John H / Asaad, Wael F / Zou, James / Doberstein, Curtis E

    NPJ digital medicine

    2024  Volume 7, Issue 1, Page(s) 63

    Abstract: Despite the importance of informed consent in healthcare, the readability and specificity of consent forms often impede patients' comprehension. This study investigates the use of GPT-4 to simplify surgical consent forms and introduces an AI-human expert ...

    Abstract Despite the importance of informed consent in healthcare, the readability and specificity of consent forms often impede patients' comprehension. This study investigates the use of GPT-4 to simplify surgical consent forms and introduces an AI-human expert collaborative approach to validate content appropriateness. Consent forms from multiple institutions were assessed for readability and simplified using GPT-4, with pre- and post-simplification readability metrics compared using nonparametric tests. Independent reviews by medical authors and a malpractice defense attorney were conducted. Finally, GPT-4's potential for generating de novo procedure-specific consent forms was assessed, with forms evaluated using a validated 8-item rubric and expert subspecialty surgeon review. Analysis of 15 academic medical centers' consent forms revealed significant reductions in average reading time, word rarity, and passive sentence frequency (all P < 0.05) following GPT-4-faciliated simplification. Readability improved from an average college freshman to an 8th-grade level (P = 0.004), matching the average American's reading level. Medical and legal sufficiency consistency was confirmed. GPT-4 generated procedure-specific consent forms for five varied surgical procedures at an average 6th-grade reading level. These forms received perfect scores on a standardized consent form rubric and withstood scrutiny upon expert subspeciality surgeon review. This study demonstrates the first AI-human expert collaboration to enhance surgical consent forms, significantly improving readability without sacrificing clinical detail. Our framework could be extended to other patient communication materials, emphasizing clear communication and mitigating disparities related to health literacy barriers.
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article
    ISSN 2398-6352
    ISSN (online) 2398-6352
    DOI 10.1038/s41746-024-01039-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top