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  1. Article ; Online: Foundational and Clinical Science Integration in a Team-Based Learning Module Modeling Care of a Patient With Dyslipidemia.

    Megee, Paul C / Uhley, Virginia / Grogan, James / Silverman, Alan

    MedEdPORTAL : the journal of teaching and learning resources

    2024  Volume 20, Page(s) 11397

    Abstract: Introduction: Foundational and clinical science integration, a long-standing goal of undergraduate medical education, benefits learners by promoting retention of critical knowledge and skills as well as their transfer to the clinical setting. We ... ...

    Abstract Introduction: Foundational and clinical science integration, a long-standing goal of undergraduate medical education, benefits learners by promoting retention of critical knowledge and skills as well as their transfer to the clinical setting. We implemented a team-based learning (TBL) module in which foundational knowledge and skills from the disciplines of biochemistry, nutrition, and genetics were leveraged in a simulated patient encounter for diagnosis and management of a patient with dyslipidemia.
    Methods: The TBL was deployed in a first-year medical student cardiovascular system course with 125 students over three academic years. Following individual and team readiness assurance tests (iRAT and tRAT, respectively), teams participated in an initial application exercise requiring consideration of clinical and laboratory data and other risk factors to engage the patient in a shared decision-making process. Using dietary and family history narratives in subsequent application exercises, teams completed recommendations for an individualized diet plan and an assessment of potential disease inheritance patterns to formulate appropriate patient care management strategies.
    Results: Student engagement with prelearning materials and session team activities was high as judged by RAT performance and application exercise outcomes: iRAT question performance ranged from 89% to 99% for individual items, and tRAT performance was routinely 100%. Learners reported that the exercises were impactful and believed the learned foundational knowledge and skills were transferable to future patient care.
    Discussion: The dyslipidemia TBL module provides an illustration for early clinical learners of how foundational knowledge and skills can be operationalized and transferred for optimal patient care.
    MeSH term(s) Humans ; Learning ; Students, Medical ; Curriculum ; Educational Measurement ; Education, Medical, Undergraduate
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ISSN 2374-8265
    ISSN (online) 2374-8265
    DOI 10.15766/mep_2374-8265.11397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Palliative specialists for patients with ALS: Making best use of a limited resource.

    Grogan, James / Simmons, Zachary

    Muscle & nerve

    2021  Volume 63, Issue 6, Page(s) 790–792

    MeSH term(s) Amyotrophic Lateral Sclerosis/therapy ; Humans ; Palliative Care ; Specialization
    Language English
    Publishing date 2021-04-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.27239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Physician-hastened death in California for patients with amyotrophic lateral sclerosis: Part of a bigger picture.

    Grogan, James / Simmons, Zachary

    Muscle & nerve

    2021  Volume 64, Issue 4, Page(s) 381–384

    MeSH term(s) Amyotrophic Lateral Sclerosis/diagnosis ; Amyotrophic Lateral Sclerosis/epidemiology ; Amyotrophic Lateral Sclerosis/therapy ; California/epidemiology ; Humans ; Physician's Role ; Suicide, Assisted/legislation & jurisprudence ; Terminal Care/legislation & jurisprudence ; Terminal Care/methods
    Language English
    Publishing date 2021-08-26
    Publishing country United States
    Document type Editorial
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.27388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reply to the letter to the editor regarding "nutritional neuropathies".

    Gwathmey, Kelly G / Grogan, James

    Muscle & nerve

    2020  Volume 62, Issue 6, Page(s) E89–E90

    MeSH term(s) Humans ; Nervous System Diseases/etiology ; Nutritional Status
    Language English
    Publishing date 2020-09-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.27067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Nutritional neuropathies.

    Gwathmey, Kelly G / Grogan, James

    Muscle & nerve

    2019  Volume 62, Issue 1, Page(s) 13–29

    Abstract: Neuropathies associated with nutritional deficiencies are routinely encountered by the practicing neurologist. Although these neuropathies assume different patterns, most are length-dependent, sensory axonopathies. Cobalamin deficiency neuropathy is the ... ...

    Abstract Neuropathies associated with nutritional deficiencies are routinely encountered by the practicing neurologist. Although these neuropathies assume different patterns, most are length-dependent, sensory axonopathies. Cobalamin deficiency neuropathy is the exception, often presenting with a non-length-dependent sensory neuropathy. Patients with cobalamin and copper deficiency neuropathy characteristically have concomitant myelopathy, whereas vitamin E deficiency is uniquely associated with a spinocerebellar syndrome. In contrast to those nutrients for which deficiencies produce neuropathies, pyridoxine toxicity results in a non-length-dependent sensory neuronopathy. Deficiencies occur in the context of malnutrition, malabsorption, increased nutrient loss (such as with dialysis), autoimmune conditions such as pernicious anemia, and with certain drugs that inhibit nutrient absorption. When promptly identified, therapeutic nutrient supplementation may result in stabilization or improvement of these neuropathies.
    MeSH term(s) Anemia, Pernicious/diagnosis ; Anemia, Pernicious/drug therapy ; Anemia, Pernicious/metabolism ; Avitaminosis/diagnosis ; Avitaminosis/drug therapy ; Avitaminosis/metabolism ; Dietary Supplements ; Humans ; Nutritional Status/drug effects ; Nutritional Status/physiology ; Peripheral Nervous System Diseases/diagnosis ; Peripheral Nervous System Diseases/drug therapy ; Peripheral Nervous System Diseases/metabolism ; Thiamine Deficiency/diagnosis ; Thiamine Deficiency/drug therapy ; Thiamine Deficiency/metabolism ; Vitamin B 12 Deficiency/diagnosis ; Vitamin B 12 Deficiency/drug therapy ; Vitamin B 12 Deficiency/metabolism ; Vitamins/administration & dosage
    Chemical Substances Vitamins
    Language English
    Publishing date 2019-12-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.26783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Using What's at Hand: The Creation of an Online Microbiology Outreach Program.

    Hurse, Deidre / Kemp, Kyeorda / Grogan, James / Taylor, Tracey A H

    Journal of microbiology & biology education

    2021  Volume 22, Issue 3

    Abstract: Outreach programs lead to increased student interest to pursue careers in science fields. However, hosting existing programs during a pandemic has proven difficult. We used "The Seven Principles of Good Practice," which emphasizes interactions between ... ...

    Abstract Outreach programs lead to increased student interest to pursue careers in science fields. However, hosting existing programs during a pandemic has proven difficult. We used "The Seven Principles of Good Practice," which emphasizes interactions between the instructor and students, feedback, and peer interactions, to design an online microbiology program for high school students. Moreover, we incorporated diverse learning techniques to reach learners at disparate levels. While our program was primarily asynchronous, to accommodate for the schedules of our student population, synchronous sessions were held each morning to answer questions, ensure clarity of instructions, and encourage students to benefit from the content expertise of the multidisciplinary faculty. Student and faculty assessment indicated that the program was a success. Our online microbiology precollege outreach program demonstrated an effective way to expose students to infectious disease concepts and information literacy. In this paper, we describe some tips and tools from lessons learned in our outreach program for high school students that was offered online on the topic of microbiology and antimicrobial resistance.
    Language English
    Publishing date 2021-12-15
    Publishing country United States
    Document type Journal Article
    ISSN 1935-7877
    ISSN 1935-7877
    DOI 10.1128/jmbe.00201-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Rapid Conversion to a Completely Virtual Multidisciplinary ALS Clinic in Response to the COVID-19 Pandemic: Implications for Future Care Delivery.

    Grogan, James / Walsh, Susan / Haulman, Anne / Yazgi, Habib / Geronimo, Andrew / Mamarabadi, Mansoureh / Simmons, Zachary

    Journal of clinical neuromuscular disease

    2022  Volume 24, Issue 4, Page(s) 207–213

    Abstract: Objectives: The goals of this study were to assess the feasibility of maintaining multidisciplinary remote care, patient preferences, and outcomes of this transition because of COVID-19.: Methods: From March 18, 2020 to June 3, 2020, 127 patients ... ...

    Abstract Objectives: The goals of this study were to assess the feasibility of maintaining multidisciplinary remote care, patient preferences, and outcomes of this transition because of COVID-19.
    Methods: From March 18, 2020 to June 3, 2020, 127 patients with amyotrophic lateral sclerosis (ALS) who were scheduled to be seen in our ALS clinic were contacted and scheduled according their preference for a telemedicine visit, telephone visit, or postponement until the next available in-person visit. Age, time from disease onset, ALS Functional Rating Scale-Revised, patient choices, and outcomes were recorded.
    Results: Patient visit preferences were 69% telemedicine, 21% telephone, and 10% postpone for a later in-clinic visit. Patients with higher ALS Functional Rating Scale-Revised were more likely to choose the next in-person opening (P = 0.04). Age and time from disease onset were not related to visit type preference. There were 118 virtual encounters, of which 91 (77%) began as telemedicine and 27 (23%) as telephone visits. Most telemedicine visits were conducted successfully, but 10 were converted to a telephone visit. The clinic maintained 88.6% of patient volume compared with the prior year, during which most visits were in-person.
    Conclusions: Telemedicine care using synchronous videoconferencing is preferable and feasible for most patients on short notice, with telephone as back-up. Clinic volumes can be maintained. These findings support the conversion of a multidisciplinary ALS clinic to 1 with exclusively virtual visits when future events again disrupt in-person care.
    MeSH term(s) Humans ; Amyotrophic Lateral Sclerosis ; COVID-19 ; Pandemics
    Language English
    Publishing date 2022-12-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1454947-5
    ISSN 1537-1611 ; 1522-0443
    ISSN (online) 1537-1611
    ISSN 1522-0443
    DOI 10.1097/CND.0000000000000430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Serogroup B Meningococcus Outbreaks, Prevalence, and the Case for Standard Vaccination.

    Grogan, James / Roos, Karen

    Current infectious disease reports

    2017  Volume 19, Issue 9, Page(s) 30

    Abstract: Purpose of review: This review explores the history of serogroup B meningitis outbreaks in American universities and the rise of the monovalent serogroup B meningococcus vaccines (MenB).: Recent findings: Serogroup B meningitis represents 30% of ... ...

    Abstract Purpose of review: This review explores the history of serogroup B meningitis outbreaks in American universities and the rise of the monovalent serogroup B meningococcus vaccines (MenB).
    Recent findings: Serogroup B meningitis represents 30% of American meningococcal infections and had no commercially available vaccine in the USA until 2013 when the FDA made an expanded allowance for importation of the MenB-4C vaccine for outbreaks at two American universities. Infections of Neisseria meningitidis, notably meningococcal meningitis represent a continued, lethal threat to the pediatric and adolescent populations and those with primary or acquired complement component deficiencies, largely mitigated by the quadrivalent meningococcal conjugated vaccine against serogroups A, C, W, and Y (MenACWY).
    Language English
    Publishing date 2017-07-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2019948-X
    ISSN 1534-3146 ; 1523-3847
    ISSN (online) 1534-3146
    ISSN 1523-3847
    DOI 10.1007/s11908-017-0587-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Teaching in Uncertain Times: Expanding the Scope of Extraneous Cognitive Load in the Cognitive Load Theory.

    Taylor, Tracey A H / Kamel-ElSayed, Suzan / Grogan, James F / Hajj Hussein, Inaya / Lerchenfeldt, Sarah / Mohiyeddini, Changiz

    Frontiers in psychology

    2022  Volume 13, Page(s) 665835

    Abstract: The COVID-19 pandemic caused an unprecedented and highly threatening, constrained, and confusing social and educational environment, we decided to expand the traditional focus of the extraneous load in Cognitive Load Theory (CLT) acknowledging the ... ...

    Abstract The COVID-19 pandemic caused an unprecedented and highly threatening, constrained, and confusing social and educational environment, we decided to expand the traditional focus of the extraneous load in Cognitive Load Theory (CLT) acknowledging the psychological environment in which learning occurs. We therefore adapted and implemented principles of the CLT to reduce extraneous load for our students by facilitating their educational activities. Given previous empirical support for the principles of CLT, it was expected that the adoption of these principles might enable our students to cultivate attitudes and skills across multiple domains such as online learning and presentation technologies, implementing and maintaining a "classroom atmosphere" in a virtual environment, participating in discussions among large online groups of students, facilitating group work, providing virtual office hours for students, and proactively planning for upcoming semesters.
    Language English
    Publishing date 2022-06-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.665835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Ibogaine Consumption With Seizure-Like Episodes, QTc-Prolongation, and Captured Cardiac Dysrhythmias.

    Grogan, James / Gerona, Roy / Snow, Jerry W / Kao, Louise

    The Journal of emergency medicine

    2019  Volume 57, Issue 4, Page(s) e99–e104

    Abstract: Background: Ibogaine is a psychoactive indole alkaloid that has been investigated for use as a treatment for opioid addiction. While not commercially available in the United States, it is available via Internet suppliers. Ibogaine use has been ... ...

    Abstract Background: Ibogaine is a psychoactive indole alkaloid that has been investigated for use as a treatment for opioid addiction. While not commercially available in the United States, it is available via Internet suppliers. Ibogaine use has been associated with significant cardiac and neurologic effects, such as QT-segment prolongation, cardiac dysrhythmias, hallucinations, seizures, and central nervous system depression. We present a case of verified ibogaine exposure with associated QTc prolongation and torsade de pointes with qualitative analysis of the ingested substance, and examine the history, social context, availability, and perceptions of ibogaine's effects and safety.
    Case report: A 34-year-old white woman with medical history significant for heroin and cocaine use disorder presented with reported seizures 1 day after ingestion of 2 g ibogaine powder purchased from an Internet supplier. Shortly after ingestion, she experienced hallucinations and was reported by family to have four to five seizure-like episodes, at one point becoming apneic. In the emergency department, she was noted to have QTc prolongation and several episodes of torsade de pointes. Qualitative analysis confirmed the presence of ibogaine in the empty foil packages containing the ingested substance. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: As increasing numbers of opioid-dependent patients attempt to curtail their substance use disorders, we anticipate a rise in ibogaine exposures, necessitating awareness by front-line clinicians in recognizing and treating a drug exposure that can rapidly become life-threatening.
    MeSH term(s) Adult ; Arrhythmias, Cardiac/etiology ; Excitatory Amino Acid Antagonists/adverse effects ; Excitatory Amino Acid Antagonists/therapeutic use ; Female ; Heroin Dependence/complications ; Heroin Dependence/psychology ; Humans ; Ibogaine/adverse effects ; Ibogaine/therapeutic use ; Long QT Syndrome/etiology ; Seizures/etiology ; Tabernaemontana/adverse effects
    Chemical Substances Excitatory Amino Acid Antagonists ; Ibogaine (3S814I130U)
    Language English
    Publishing date 2019-10-17
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2019.06.052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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