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  1. Article ; Online: Biomimetic In Vitro Lung Models: Current Challenges and Future Perspective.

    Doryab, Ali / Groll, Jürgen

    Advanced materials (Deerfield Beach, Fla.)

    2023  Volume 35, Issue 13, Page(s) e2210519

    Abstract: As post-COVID complications, chronic respiratory diseases are one of the foremost causes of mortality. The quest for a cure for this recent global challenge underlines that the lack of predictive in vitro lung models is one of the main bottlenecks in ... ...

    Abstract As post-COVID complications, chronic respiratory diseases are one of the foremost causes of mortality. The quest for a cure for this recent global challenge underlines that the lack of predictive in vitro lung models is one of the main bottlenecks in pulmonary preclinical drug development. Despite rigorous efforts to develop biomimetic in vitro lung models, the current cutting-edge models represent a compromise in numerous technological and biological aspects. Most advanced in vitro models are still in the "proof-of-concept" phase with a low clinical translation of the findings. On the other hand, advances in cellular and molecular studies are mainly based on relatively simple and unrealistic in vitro models. Herein, the current challenges and potential strategies toward not only bioinspired but truly biomimetic lung models are discussed.
    MeSH term(s) Humans ; Biomimetics ; COVID-19 ; Lung
    Language English
    Publishing date 2023-02-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202210519
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  2. Article ; Online: Machine Learning Reveals a General Understanding of Printability in Formulations Based on Rheology Additives.

    Nadernezhad, Ali / Groll, Jürgen

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2022  Volume 9, Issue 29, Page(s) e2202638

    Abstract: Hydrogel ink formulations based on rheology additives are becoming increasingly popular as they enable 3-dimensional (3D) printing of non-printable but biologically relevant materials. Despite the widespread use, a generalized understanding of how these ... ...

    Abstract Hydrogel ink formulations based on rheology additives are becoming increasingly popular as they enable 3-dimensional (3D) printing of non-printable but biologically relevant materials. Despite the widespread use, a generalized understanding of how these hydrogel formulations become printable is still missing, mainly due to their variety and diversity. Employing an interpretable machine learning approach allows the authors to explain the process of rendering printability through bulk rheological indices, with no bias toward the composition of formulations and the type of rheology additives. Based on an extensive library of rheological data and printability scores for 180 different formulations, 13 critical rheological measures that describe the printability of hydrogel formulations, are identified. Using advanced statistical methods, it is demonstrated that even though unique criteria to predict printability on a global scale are highly unlikely, the accretive and collaborative nature of rheological measures provides a qualitative and physically interpretable guideline for designing new printable materials.
    MeSH term(s) Hydrogels ; Ink ; Machine Learning ; Printing, Three-Dimensional ; Rheology
    Chemical Substances Hydrogels
    Language English
    Publishing date 2022-08-25
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202202638
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  3. Article ; Online: Freeform printing of thermoresponsive poly(2-cyclopropyl-oxazoline) as cytocompatible and on-demand dissolving template of hollow channel networks in cell-laden hydrogels.

    Mair, Vincent / Paulus, Ilona / Groll, Jürgen / Ryma, Matthias

    Biofabrication

    2022  Volume 14, Issue 2

    Abstract: Conventional additive-manufacturing technologies rely on the vertical stacking of layers, whereas each layer provides the structural integrity for the upcoming one. This inherently gives rise to limitations in freedom of design especially when structures ...

    Abstract Conventional additive-manufacturing technologies rely on the vertical stacking of layers, whereas each layer provides the structural integrity for the upcoming one. This inherently gives rise to limitations in freedom of design especially when structures containing large voids or truly 3D pathways for printed filaments are aspired. An especially interesting technique, which overcomes these layer limitations, is freeform printing, where thermoplastic materials are printed in 3D through controlling the temperature profile such that the polymer melt solidifies right when it exits the nozzle. In this study, we introduce freeform printing for thermoresponsive polymers at the example of poly(2-cyclopropyl-oxazoline) (P
    MeSH term(s) Hydrogels ; Printing, Three-Dimensional
    Chemical Substances Hydrogels
    Language English
    Publishing date 2022-03-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2500944-8
    ISSN 1758-5090 ; 1758-5082
    ISSN (online) 1758-5090
    ISSN 1758-5082
    DOI 10.1088/1758-5090/ac57a7
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  4. Article ; Online: Layer-by-layer assembly methods and their biomedical applications.

    Zhang, Zhuying / Zeng, Jinfeng / Groll, Jürgen / Matsusaki, Michiya

    Biomaterials science

    2022  Volume 10, Issue 15, Page(s) 4077–4094

    Abstract: Layer-by-layer (LbL) assembly has attracted much interest because of its ability to provide nanoscale control over film characteristics and because of a wide choice of available materials. The methods of LbL not only determine the process properties, but ...

    Abstract Layer-by-layer (LbL) assembly has attracted much interest because of its ability to provide nanoscale control over film characteristics and because of a wide choice of available materials. The methods of LbL not only determine the process properties, but also directly affect film properties. In this review, we will discuss LbL methodologies that have been used in biomedical fields. Special attention is devoted to different properties arising from methods that allow for diverse biomedical applications, ranging from surface modification to tissue engineering. We conclude with a discussion of the current challenges and future perspectives.
    MeSH term(s) Tissue Engineering
    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d2bm00497f
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  5. Article ; Online: Evaluation of the Influence of Biosurface Design on the Interaction between the Regulatory Peptide RS1-reg and ODC1 Reveals a Membrane-Dependent Affinity Increase.

    Keller, Thorsten / Koepsell, Hermann / Groll, Jürgen

    Advanced biology

    2022  Volume 6, Issue 10, Page(s) e2101108

    Abstract: The regulatory solute carrier protein, family 1, member 1 (RS1) modulates via its N-terminal domain RS1-reg the activity of ... ...

    Abstract The regulatory solute carrier protein, family 1, member 1 (RS1) modulates via its N-terminal domain RS1-reg the activity of Na
    MeSH term(s) Humans ; Glucose/metabolism ; Hypoglycemic Agents ; Monosaccharide Transport Proteins/metabolism ; Ornithine ; Peptides/metabolism ; Putrescine ; Mitochondrial Membrane Transport Proteins/metabolism
    Chemical Substances Glucose (IY9XDZ35W2) ; Hypoglycemic Agents ; Monosaccharide Transport Proteins ; Ornithine (E524N2IXA3) ; Peptides ; Putrescine (V10TVZ52E4) ; SLC25A21 protein, human ; Mitochondrial Membrane Transport Proteins
    Language English
    Publishing date 2022-06-23
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2701-0198
    ISSN (online) 2701-0198
    DOI 10.1002/adbi.202101108
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  6. Article ; Online: Dual setting brushite-gelatin cement with increased ductility and sustained drug release.

    Rödel, Michaela / Teßmar, Jörg / Groll, Jürgen / Gbureck, Uwe

    Journal of biomaterials applications

    2022  Volume 36, Issue 10, Page(s) 1882–1898

    Abstract: A novel dual setting brushite-gelatin cement was achieved by genip ininitiated cross-linking of gelatin during cement setting. Although the combination of an inorganic and organic phase resulted in a decrease of the compressive strength from about 10 MPa ...

    Abstract A novel dual setting brushite-gelatin cement was achieved by genip ininitiated cross-linking of gelatin during cement setting. Although the combination of an inorganic and organic phase resulted in a decrease of the compressive strength from about 10 MPa without polymeric phase to 3-6-MPa for gelatin modified composites, an increase in elastic properties due to the gelatin hydrogel with a concentration of 10.0 w/v% was achieved. For a powder-to-liquid ratio of 2.5 g*mL
    MeSH term(s) Bone Cements ; Calcium Phosphates ; Compressive Strength ; Drug Liberation ; Gelatin ; Materials Testing
    Chemical Substances Bone Cements ; Calcium Phosphates ; Gelatin (9000-70-8) ; calcium phosphate, dibasic, dihydrate (O7TSZ97GEP)
    Language English
    Publishing date 2022-03-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639283-0
    ISSN 1530-8022 ; 0885-3282
    ISSN (online) 1530-8022
    ISSN 0885-3282
    DOI 10.1177/08853282221075877
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3175: Show issues Location:
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  7. Book ; Online ; Thesis: Tailoring Hyaluronic Acid and Gelatin for Bioprinting

    Shan, Junwen [Verfasser] / Groll, Jürgen [Gutachter]

    2022  

    Author's details Junwen Shan ; Gutachter: Jürgen Groll
    Keywords Technische Chemie ; Technical Chemistry
    Subject code sg660
    Language English
    Publisher Universität Würzburg
    Publishing place Würzburg
    Document type Book ; Online ; Thesis
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  8. Book ; Online ; Thesis: Einfluss des extrusionsbasierten 3D-Drucks von Einzelzellen und Sphäroiden in Alginat-Gelatine-Hydrogelen auf die chondrogene Differenzierung humaner mesenchymaler Stromazellen

    Nadolinski, Annemarie [Verfasser] / Groll, Jürgen [Gutachter]

    2022  

    Author's details Annemarie Nadolinski ; Gutachter: Jürgen Groll
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universität Würzburg
    Publishing place Würzburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Book ; Online ; Thesis: Correlation of FluidFM® Technology and Fluorescence Microscopy for the Visualization of Cellular Detachment Steps

    Weigl, Franziska [Verfasser] / Groll, Jürgen [Gutachter] / Sauer, Markus [Gutachter]

    2023  

    Author's details Franziska Weigl ; Gutachter: Jürgen Groll, Markus Sauer
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universität Würzburg
    Publishing place Würzburg
    Document type Book ; Online ; Thesis
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  10. Article ; Online: Building Blocks for Biofabricated Models.

    Malda, Jos / Groll, Jürgen

    Advanced healthcare materials

    2019  Volume 8, Issue 7, Page(s) e1900326

    MeSH term(s) Bioprinting/methods ; Bioreactors ; Extracellular Matrix/chemistry ; Ink ; Models, Biological ; Printing, Three-Dimensional
    Language English
    Publishing date 2019-04-10
    Publishing country Germany
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.201900326
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6966: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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