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Article: Svyaz' polimorfizmov gena serotoninovogo transportera SLC6A4 s depressiei.

Gafarov, V V / Gromova, E A / Gubina, M A / Gagulin, I V / Maksimov, V N / Gafarova, A V

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

2024 Volume 124, Issue 2, Page(s) 135–139

Abstract: Objective: To study the relationship of polymorphic variants of the SLC6A4 gene with depression among people aged 25-44 years in Novosibirsk.: Material and methods: Under the WHO program «MONICA-psychosocial (MOPSY)», a random representative sample ... ...

Title translation	The association of polymorphisms of the serotonin transporter gene SLC6A4 with depression.
Abstract	Objective: To study the relationship of polymorphic variants of the SLC6A4 gene with depression among people aged 25-44 years in Novosibirsk. Material and methods: Under the WHO program «MONICA-psychosocial (MOPSY)», a random representative sample of people aged 25-44 years from the population of the Oktyabrsky district of Novosibirsk (men Results: The high level of depression among people aged 25-44 was 12.8% (for men 9.1%, for women - 15.92%); the average level of depression occurred in 24.5% of the population (among men in 21.24%, among women in 26.76%) (χ Conclusion: Associative links between polymorphic variants of the SLC6A4 gene and depression have been established.
MeSH term(s)	Male ; Humans ; Female ; Adult ; Middle Aged ; Depression/epidemiology ; Depression/genetics ; Serotonin Plasma Membrane Transport Proteins/genetics ; Polymorphism, Genetic ; Genotype ; Surveys and Questionnaires
Chemical Substances	Serotonin Plasma Membrane Transport Proteins ; SLC6A4 protein, human
Language	Russian
Publishing date	2024-03-11
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	1201462-x
ISSN	2309-4729 ; 1997-7298 ; 0044-4588
ISSN (online)	2309-4729
ISSN	1997-7298 ; 0044-4588
DOI	10.17116/jnevro2024124021135
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Article: Geny tsirkadnogo ritma i narusheniya sna v otkrytoi populyatsii muzhchin 25—64 let (epidemiologicheskoe issledovanie po programme VOZ MONICA-PSYCHOSOCIAL).

Gafarov, V V / Gromova, E A / Tripelgorn, A N / Gagulin, I V / Maksimov, V N / Gafarova, A V

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

2023 Volume 123, Issue 6, Page(s) 88–93

Abstract: Objective: To study an effect of polymorphisms of genes encoding circadian rhythm proteins (: Material and methods: The general examination was carried out according to standard methods included in the WHO MONICA-psychosocial (MOPSY) program. The ... ...

Title translation	Genes of the circadian rhythm and sleep disorders in an open population of men aged 25-64 years (an epidemiological study under the WHO MONICA-PSYCHOSOCIAL program).
Abstract	Objective: To study an effect of polymorphisms of genes encoding circadian rhythm proteins ( Material and methods: The general examination was carried out according to standard methods included in the WHO MONICA-psychosocial (MOPSY) program. The standard Jenkins questionnaire was used to study sleep disorders. Genotyping of the polymorphisms of Results: Carriers of the Conclusion: An association of certain polymorphisms of t
MeSH term(s)	Male ; Humans ; ARNTL Transcription Factors ; Circadian Rhythm/genetics ; Epidemiologic Studies ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/genetics ; World Health Organization
Chemical Substances	ARNTL Transcription Factors
Language	Russian
Publishing date	2023-06-01
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	1201462-x
ISSN	2309-4729 ; 1997-7298 ; 0044-4588
ISSN (online)	2309-4729
ISSN	1997-7298 ; 0044-4588
DOI	10.17116/jnevro202312306188
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Article: Gendernye osobennosti riska razvitiya serdechno-sosudistykh zabolevanii u naseleniya s narusheniem sna: programma VOZ MONICA-psychosocial.

Gafarov, V V / Gromova, E A / Panov, D O / Gagulin, I V / Gafarova, A V

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

2021 Volume 121, Issue 5, Page(s) 98–104

Abstract: Objective: To determine the gender differences in the effect of sleep disorders (SD) on the risk of myocardial infarction (MI) and stroke in an open population, aged 25-64 years, of Russia/Siberia over 16 years of follow-up.: Material and methods: ... ...

Title translation	Gender differences of cardiovascular diseases risk in the population with sleep disorders: WHO's program MONICA-psychosocial.
Abstract	Objective: To determine the gender differences in the effect of sleep disorders (SD) on the risk of myocardial infarction (MI) and stroke in an open population, aged 25-64 years, of Russia/Siberia over 16 years of follow-up. Material and methods: Within the framework of the III screening of WHO's MONICA-psychosocial program, a random representative sample of the Novosibirsk population, which comprised both sexes (657 men, 689 women), aged 25-64 years, was examined in 1994. The screening included socio-demographic data, the assessment of SD according to the Jenkins scale. The analysis included people without MI, stroke. In 16 years, new-onset cases of MI and stroke were identified in women (15 and 35 cases, respectively) and in men (30 and 22 cases, respectively). Results: In the open population among the population of 25-64 years, 48.6% of men and 65.9% of women had SD (c Conclusion: SD are a risk factor for stroke in men and women, and a risk factor of MI in men. A negative social gradient increases the risk of cardiovascular diseases in people with SD.
MeSH term(s)	Adult ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Russia/epidemiology ; Siberia/epidemiology ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/epidemiology ; World Health Organization
Language	Russian
Publishing date	2021-06-28
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	1201462-x
ISSN	2309-4729 ; 1997-7298 ; 0044-4588
ISSN (online)	2309-4729
ISSN	1997-7298 ; 0044-4588
DOI	10.17116/jnevro202112105198
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Article: Effect of stress at work on the risk of cardiovascular diseases among the population of 25-64 years in Russia/Siberia (WHO program "MONICA-psychosocial").

Gafarov, V V / Gromova, E A / Panov, D O / Gagulin, I V / Gafarova, A V

Terapevticheskii arkhiv

2019 Volume 91, Issue 1, Page(s) 13–18

Abstract: Aim: The aim of the study was to determine the impact of stress on work on the risk of cardiovascular disease over a 16-year period in an open population of 25-64 years in Russia/Siberia.: Materials and methods: A random representative sample of the ... ...

Abstract	Aim: The aim of the study was to determine the impact of stress on work on the risk of cardiovascular disease over a 16-year period in an open population of 25-64 years in Russia/Siberia. Materials and methods: A random representative sample of the population of both sexes of 25-64 years old in Novosibirsk in 1994 (men: n=657, 44.3±0.4 years, response - 82.1%, women: n=689, 45.4±0.4 years, response - 72.5%). The screening survey program included: registration of socio-demographic data, determination of stress at work (Karazek scale). The period of prospective follow-up of participants was 16 years. The study identified the following "end points": the first cases of myocardial infarction (MI), stroke. Results: A high level of stress at work was in 29.5% of men and 31.6% of women, the average level in 48.9% of men and 50.7% of women (χ2=2.574, υ=2, p=0.276). The risk of developing MI for a 16-year period, among people experiencing stressful situations at work, was: in men, HR=3.592, and women HR=3.218 (95% CI 1.146-9.042); stroke risk - among men, HR=2.603 (95% CI 1.06-4.153) in women HR=1.956 (95% CI 1.008-3.795). In multivariate analysis, in men with stress at work, the risk of MI among men was HR=1.15 (95% CI 0.6-2.2), among women - HR=2.543 (95% CI 1.88-7.351); risk of stroke, was in men, HR=3.8 (95% CI 1.6-8.8), in women - HR=1.95 (95% CI 0.984-3.887). The risk of stroke was higher among single, divorced and widowed men, HR=4.2 (95% CI 1.5-13.2), and in women with secondary or primary education, HR=3 (95% CI 0.852-11.039). Conclusion: It was established that a high level of stress at work is not gender-specific; the risk of developing MI over a 16-year period is higher in women than in men, stroke in men; the risk of myocardial infarction and stroke in both sexes is affected by the social gradient.
MeSH term(s)	Adult ; Aged ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/psychology ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Risk Factors ; Russia/epidemiology ; Siberia ; Stress, Psychological ; Stroke ; Workplace
Language	English
Publishing date	2019-05-14
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	40718-5
ISSN	2309-5342 ; 0040-3660
ISSN (online)	2309-5342
ISSN	0040-3660
DOI	10.26442/00403660.2019.01.000022
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Article: [Psychosocial risk factors for cardiovascular disease: gender differences and 22-year dynamics among the population of Siberia (WHO MONICA-Psychosocial Program, HAPIEE)].

Gafarov, V V / Gagulin, I V / Gafarova, A V / Panov, D O / Krymov, E A / Gromova, E A

Terapevticheskii arkhiv

2020 Volume 92, Issue 1, Page(s) 15–24

Abstract: Aim: To determine the gender differentiation and dynamics for 22 years of psychosocial factors (PSF) of the risk of cardiovascular disease among the population aged 25-64 years in Russia / Siberia (Novosibirsk).: Materials and methods: Representative ...

Abstract	Aim: To determine the gender differentiation and dynamics for 22 years of psychosocial factors (PSF) of the risk of cardiovascular disease among the population aged 25-64 years in Russia / Siberia (Novosibirsk). Materials and methods: Representative samples of the population of the city of Novosibirsk under the program of the World Health Organization "MONICA-MOPSY" in 1994-1995 were examined. III screening (men - 657, women - 870, 25-64 years old); IV screening project HAPIEE in 2003-2005 (men - 576, women - 1074, 45-64 years old) and V screening in 2013-2016. (men - 427, women - 548, 25-44 years old). We used Spielberger tests, MONICA-MOPSY tests, the Breckman - Sim test, the "Knowledge and attitude to your health" questionnaire. Results: In an open population of 25-64 years old, high levels of anxiety (T), depression (D), life exhaustion (LM), and hostility (B) were higher in women than in men. In the group of 55-64 years over 10 years, women have increased personality T, decreased D and LM. Over 22 years, in the group of 25-34 years, men and women decreased T and MI, but D and B increased, while women decreased T, LM and B and D. grew. Low and high close contact indices were higher among men. A low index of social ties prevailed in men, and a high index in women. High levels of stress in the family were more common in women, and at work - in men. For 10 years, the level of stress in the family and at work in men has decreased. Sleep disorders in the population in all age groups were more often in women. Conclusion: It was found that women have significantly higher PSF than men, with the exception of stress at work. The decrease in PSF in women and men in the dynamics.
MeSH term(s)	Adult ; Cardiovascular Diseases ; Female ; Humans ; Male ; Middle Aged ; Risk Factors ; Russia ; Sex Factors ; Siberia
Language	Russian
Publishing date	2020-01-15
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	40718-5
ISSN	2309-5342 ; 0040-3660
ISSN (online)	2309-5342
ISSN	0040-3660
DOI	10.26442/00403660.2020.01.000249
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Article: [Tendencies in cardiovascular morbidity and mortality in the population of Siberia].

Gafarov, V V / Gromova, E A / Gagulin, I V / Panov, D O / Gafarova, A V

Klinicheskaia meditsina

2018 Volume 94, Issue 8, Page(s) 601–608

Abstract: Aim: To characterize differences in the risk of development (RD) of myocardial infarction (MI) and stroke during 16 years in an open Siberian population aged 25-64 years and suffering vital exhaustion (VE).: Materials and methods: We examined a ... ...

Abstract	Aim: To characterize differences in the risk of development (RD) of myocardial infarction (MI) and stroke during 16 years in an open Siberian population aged 25-64 years and suffering vital exhaustion (VE). Materials and methods: We examined a random representative sample of 657 men and 870 women from the Novosibirsk population in the framework of the WHO «MONICA-psychosocial» screening III program (1954). It included registration of socio-demographic data and cases of VE. A total of 15 episodes of MI and 35 strokes were documented in 30 women and 22 men. Results: The level of VE in men was 66,8% (high in 14,6%), in women75,7% (high in 44,4%). RD of MI estimated from the relative risk (RR) in men with VE(RR=2) was higher than in women. It was higher in divorced women (RR=5,4) than in men (RR=4,7). RD of MI was higher in men with VE (OR=2,2 in subjects having elementary education, OR=3,7 in bachelors, OR = 7 in widowers;at the age from 45 to 54 years OR=3,8, at the age from 55 to 64 years OR=5,9) than in women. The overall RD of stroke in subjects of either sex with VE was not significantly different (OR=3,34 in women and 3,1). However, it was higher than in women in men with VE having partially completed secondary-level and elementary education RR=4.8), in divorced and widowed men (RR=3.8 and 3.6 respectively. Conclusion: The study showed that the prevalence of VE in the population aged 25-64yearsis higher than in other age groups and higher in women than in men. VE is a more reliable predictor of MI in men than in women; it is a predictor of stroke in either sexes.
MeSH term(s)	Adult ; Age Factors ; Aged ; Demography ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/diagnosis ; Myocardial Infarction/mortality ; Prevalence ; Risk Factors ; Sex Factors ; Siberia/epidemiology ; Socioeconomic Factors ; Stroke/diagnosis ; Stroke/mortality
Language	Russian
Publishing date	2018-10-05
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	391034-9
ISSN	0023-2149
ISSN	0023-2149
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Article ; Online: Corrigendum to "Interleukin-1β, interleukin-1 receptor antagonist, interleukin-6, interleukin-10, and tumor necrosis factor-α levels in CSF and serum in relation to the clinical diversity of Parkinson's disease" [Cell. Immunol. 327 (2018) 77-82].

Karpenko, M N / Vasilishina, A A / Gromova, E A / Muruzheva, Z M / Bernadotte, A

Cellular immunology

2018 Volume 334, Page(s) 99

Language	English
Publishing date	2018-09-10
Publishing country	Netherlands
Document type	Journal Article ; Published Erratum
ZDB-ID	80094-6
ISSN	1090-2163 ; 0008-8749
ISSN (online)	1090-2163
ISSN	0008-8749
DOI	10.1016/j.cellimm.2018.08.007
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Article: 23-year dynamics (1994-2016) relationships to its health, behavioral characteristics and prevention of cardiovascular diseases among women 25-44 years in Russia /Siberia.

Gafarov, V V / Panov, D O / Gromova, E A / Gagulin, I V / Gafarova, A V / Krymov, E A

Terapevticheskii arkhiv

2019 Volume 90, Issue 1, Page(s) 36–44

Abstract: Aim: To determine the 23-year dynamics (1994-2016) of attitudes toward one's health, behavioral characteristics and the prevention of cardiovascular diseases in an open population among women 25-44 years old in Russia / Siberia (Novosibirsk).: ... ...

Abstract	Aim: To determine the 23-year dynamics (1994-2016) of attitudes toward one's health, behavioral characteristics and the prevention of cardiovascular diseases in an open population among women 25-44 years old in Russia / Siberia (Novosibirsk). Materials and methods: In the framework of the third screening of the MONICA program for the study of trends and control of cardiovascular diseases and the MONICA-psychosocial (MOPSY) subprogram, in 1994 a random representative sample of women aged 25-64 years of age from one from the districts of Novosibirsk (n = 870, the average age is 45.4±0.4 years); in the age group 25-44 years - 284 persons. In 2016 years. in the framework of screening studies on the budgetary issue of NIITPM No. gos. reg. 01201282292, a random representative sample of women aged 25-44 years old in the same district of Novosibirsk (n = 540) was examined. Attitude to their health, behavioral characteristics and the prevention of cardiovascular diseases were studied using the "Knowledge and attitude to their health" scale, validated for the Russian population under the WHO "MONICA" program. The chi-square test (x2) was used to calculate the indices. The criterion of statistical significance was the reliability of the result at p<0.05. Results: The analysis showed that in the open population among women aged 25-44 years, there is a positive dynamics in assessing their health (21% and 50.7%, respectively). But, despite this, 50% of women negatively assess their health and 96% note the probability of getting a serious illness for 5-10 years. Most women believe in the ability of medicine to successfully prevent and treat heart disease, but the proportion of people using health resources for preventive purposes remains extremely low and does not exceed 10%. In the open population among women aged 25-44 years for 23 years there is an increase in stress in the workplace and the trend of growth in changes in marital status. Recorded in the period 1994-2016 gg. changes in the behavior of women associated with health: increased the proportion of people who gave up smoking and regularly doing physical exercises, and improved eating behavior. Conclusion: It was found that among women aged 25-44 years there is a positive dynamics in relation to the prevention of behavioral risk factors for CVD. But despite this, half of women negatively assess their health and use health resources only slightly.
MeSH term(s)	Adult ; Aged ; Attitude to Health ; Cardiovascular Diseases ; Female ; Health Behavior ; Humans ; Middle Aged ; Reproducibility of Results ; Risk Factors ; Russia ; Siberia ; Surveys and Questionnaires
Language	English
Publishing date	2019-01-30
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	40718-5
ISSN	2309-5342 ; 0040-3660
ISSN (online)	2309-5342
ISSN	0040-3660
DOI	10.26442/terarkh201890136-44
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Article: Gendernye osobennosti riska razvitiia serdechno-sosudistykh zabolevaniĭ u naseleniia s simptomami depressii v Sibiri (programma VOZ 'MONICA-psikhosotsial'naia').

Gafarov, V V / Gromova, E A / Gagulin, I V / Panov, D O / Gafarova, A V

Terapevticheskii arkhiv

2017 Volume 89, Issue 9, Page(s) 60–67

Abstract: Aim: To identify gender differences in the prevalence of depression in an open population of individuals aged 25-64 years and to evaluate its impact on the risk of cardiovascular diseases (CVD) in the population of Siberia.: Subjects and methods: A ... ...

Title translation	Gender peculiarities of the risk of cardiovascular diseases in a population with symptoms of depression in Siberia (the WHO MONICA-psychosocial program).
Abstract	Aim: To identify gender differences in the prevalence of depression in an open population of individuals aged 25-64 years and to evaluate its impact on the risk of cardiovascular diseases (CVD) in the population of Siberia. Subjects and methods: A random representative sample of a 25-64-year-old Novosibirsk population (657 men and 689 women) was surveyed within the framework of the third screening of the WHO MONICA-psychosocial program in 1994. The screening program included sociodemographic data registration and depression detection. Over a 16-year study period, women had myocardial infarction (MI) in 15 cases and stroke in 35 cases and men had these conditions in 30 and 22 cases, respectively. Results: In the open 25-64-year-old population, depression was detected in 54.5% of the women and in 29% of the men; major depression was present in 11.8% of the women and 3.1% of the men (χ2=66.724; υ=2; p=0.0001). The risk of MI in the depressed patients was higher in the women (hazard ratio (HR)=2.5) than in the men (HR=2); when social parameters and age are included in the model, only a trend towards the impact of depression on the risk of MI persisted in the women (HR=3.4; p>0.05) and the men were observed to have a 1.6-fold higher risk for MI. The greatest risk of MI was seen in the men (HR=6.8) and women (HR=6.3) at the age of 55-64 years, as well as in the men who had incomplete secondary or primary education (HR=3.2); in blue-collar workers (HR=6.7), in the men who were single (HR=3.6), divorced (HR=4.5), or widowed (HR=6). The risk of stroke in the depressed patients during a 16-year study period was greater in the men (HR=5.8) than in the women (HR=4.6); after adjusting for age and social gradient, the risk of stroke in the women was higher in both the population and those who were aged 55-64 years (HR=8.5 and 6.9, respectively) than that in the men (HR=4.2 and 3.1, respectively). Among the men, the risk of stroke was higher in those who had primary education (HR=8.8), were widowed (HR=8.4) or divorced (HR=2.7). Conclusion: The women are much more susceptible to depression than are the men. The risk of MI with depression is higher in the women than in the men; at the same time, the risk of stroke is higher in the men than in the women. The picture is opposite in the older age group. The risk of CVD in the depressed men is exacerbated by a social gradient; these relationships have not been revealed in the women.
Language	Russian
Publishing date	2017
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	40718-5
ISSN	2309-5342 ; 0040-3660
ISSN (online)	2309-5342
ISSN	0040-3660
DOI	10.17116/terarkh201789960-67
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Article ; Online: Psychic State and Cognitive Function in HIV-infected Patients and Functional State of the Brain Structures (According to Positron Emission Tomography and Magnetic Resonance Spectroscopy)

Gromova E.A. / Kataeva G.V. / Khomenko I.G. / Kotomin I.A. / Bogdan A.A. / Kosych A.V. / Rassokhin V.V. / Belyakov N.A. / Trofimova T.N.

Клиническая и специальная психология, Vol 9, Iss 1, Pp 78-

2020 Volume 103

Abstract: The article presents the results of the study of cognitive functions and the psychic state of HIV-infected patients. 38 patients aged 25-45 years were examined. In HIV-infected patients, dysfunctions of the central nervous system observed, which could be ...

Abstract	The article presents the results of the study of cognitive functions and the psychic state of HIV-infected patients. 38 patients aged 25-45 years were examined. In HIV-infected patients, dysfunctions of the central nervous system observed, which could be detected in the early stages after infection. Indicators of cognitive functions and psychic state correlated with the metabolism of the cerebral cortex, mainly with the metabolism of structures associated with executive functions. Obviously, patients of presented category have a decline in executive functions. Therefore, it is important to include psychocorrective treatment aimed at training of emotional-volitional functions, in the rehabilitation program which should also contribute to the improvement of cognitive functions and better social adaptation. The revealed changes in glucose metabolism and the content of N-acetyl aspartate were nonspecific and could be caused by a combination of the direct effect of the virus on the brain tissue, psychogenic and premorbid factors. Most likely, the existing premorbid features enhanced by the toxic effects of HIV and severe psycho-emotional stress associated with obtaining information about infection.
Keywords	hiv infection ; positron emission tomography ; magnetic resonance spectroscopy ; cognitive impairment ; Medicine ; R
Subject code	616
Language	Russian
Publishing date	2020-03-01T00:00:00Z
Publisher	Moscow State University of Psychology and Education
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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