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  1. Article ; Online: Lipoxins A

    Livne-Bar, Izhar / Maurya, Shubham / Gronert, Karsten / Sivak, Jeremy M

    Journal of neuroinflammation

    2024  Volume 21, Issue 1, Page(s) 18

    Abstract: Lipoxins are small lipids that are potent endogenous mediators of systemic inflammation resolution in a variety of diseases. We previously reported that Lipoxins ... ...

    Abstract Lipoxins are small lipids that are potent endogenous mediators of systemic inflammation resolution in a variety of diseases. We previously reported that Lipoxins A
    MeSH term(s) Inflammation/chemically induced ; Lipopolysaccharides/toxicity ; Lipoxins/pharmacology ; Lipoxins/metabolism ; Neuroglia/metabolism ; Neuroinflammatory Diseases ; Receptors, CXCR3 ; Animals
    Chemical Substances Lipopolysaccharides ; Lipoxins ; Receptors, CXCR3
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2156455-3
    ISSN 1742-2094 ; 1742-2094
    ISSN (online) 1742-2094
    ISSN 1742-2094
    DOI 10.1186/s12974-024-03010-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Protective Effects of Lipoxin A

    Liu, Hsin-Hua / Cullen, Paul F / Sivak, Jeremy M / Gronert, Karsten / Flanagan, John G

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Glaucoma is a common neurodegenerative disease characterized by progressive degeneration of retinal ganglion cells (RGCs) and the retinal nerve fiber layer (RNFL), resulting in a gradual decline of vision. A recent study by our groups indicated that the ... ...

    Abstract Glaucoma is a common neurodegenerative disease characterized by progressive degeneration of retinal ganglion cells (RGCs) and the retinal nerve fiber layer (RNFL), resulting in a gradual decline of vision. A recent study by our groups indicated that the levels of lipoxins A
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.17.575414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Regulation of Diseases-Associated Microglia in the Optic Nerve by Lipoxin B

    Maurya, Shubham / Lin, Maggie / Karnam, Shruthi / Singh, Tanirika / Kumar, Matangi / Ward, Emily / Flanagan, John G / Gronert, Karsten

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Background: The resident astrocyte-retinal ganglion cell (RGC) lipoxin circuit is impaired during retinal stress, which includes ocular hypertension-induced neuropathy. Lipoxin B: Methods: Cellular targets and signaling of LXB: Results: Single- ... ...

    Abstract Background: The resident astrocyte-retinal ganglion cell (RGC) lipoxin circuit is impaired during retinal stress, which includes ocular hypertension-induced neuropathy. Lipoxin B
    Methods: Cellular targets and signaling of LXB
    Results: Single-cell transcriptomics identified microglia as a primary target for LXB
    Conclusion: We identified early and dynamic changes in the microglia functional phenotype, reactivity, and induction of a unique CD74 microglia population in the distal optic nerve as key features of ocular hypertension-induced neurodegeneration. Our findings establish microglia regulation as a novel LXB
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.18.585452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension​.

    Karnam, Shruthi / Maurya, Shubham / Ng, Elainna / Choudhary, Amodini / Thobani, Arzin / Flanagan, John G / Gronert, Karsten

    Acta neuropathologica communications

    2024  Volume 12, Issue 1, Page(s) 58

    Abstract: Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. Our recent study found that lipoxin ... ...

    Abstract Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. Our recent study found that lipoxin B
    MeSH term(s) Humans ; Animals ; Mice ; Lipoxins/pharmacology ; Astrocytes ; Cytokines ; Glaucoma ; Ocular Hypertension ; Retina ; Disease Models, Animal ; Primates
    Chemical Substances Lipoxins ; Cytokines
    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2715589-4
    ISSN 2051-5960 ; 2051-5960
    ISSN (online) 2051-5960
    ISSN 2051-5960
    DOI 10.1186/s40478-024-01767-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Eicosanoid and Specialized Proresolving Mediator Regulation of Lymphoid Cells

    Wei, Jessica / Gronert, Karsten

    Trends in biochemical sciences. 2019 Mar., v. 44, no. 3

    2019  

    Abstract: Eicosanoids and specialized proresolving mediators (SPMs) regulate leukocyte function and inflammation. They are ideally positioned at the interface of the innate and adaptive immune responses when lymphocytes interact with leukocytes. Receptors for ... ...

    Abstract Eicosanoids and specialized proresolving mediators (SPMs) regulate leukocyte function and inflammation. They are ideally positioned at the interface of the innate and adaptive immune responses when lymphocytes interact with leukocytes. Receptors for leukotriene B4 (LTB4), prostaglandin E2 (PGE2), and SPMs are expressed on lymphocytes. Evidence points toward an essential role of these lipid mediators (LMs) in direct regulation of lymphocyte functions. SPMs, which include lipoxins, demonstrate comprehensive protective actions with lymphocytes. LTB4 and PGE2 regulation of lymphocytes is diverse and depends on the interaction of lymphocytes with other cells. Importantly, both LTB4 and PGE2 are essential regulators of T cell antitumor activity. These LMs are attractive therapeutic targets to control dysregulated innate and adaptive immune responses, promote lymphocyte antitumor activity, and prevent tumor immune evasion.
    Keywords T-lymphocytes ; adaptive immunity ; antineoplastic activity ; immune evasion ; inflammation ; neoplasms ; prostaglandins ; receptors ; therapeutics
    Language English
    Dates of publication 2019-03
    Size p. 214-225.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 194220-7
    ISSN 0968-0004 ; 0376-5067
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2018.10.007
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 78/716: Show issues

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  6. Article: Eicosanoid and Specialized Proresolving Mediator Regulation of Lymphoid Cells.

    Wei, Jessica / Gronert, Karsten

    Trends in biochemical sciences

    2018  Volume 44, Issue 3, Page(s) 214–225

    Abstract: Eicosanoids and specialized proresolving mediators (SPMs) regulate leukocyte function and inflammation. They are ideally positioned at the interface of the innate and adaptive immune responses when lymphocytes interact with leukocytes. Receptors for ... ...

    Abstract Eicosanoids and specialized proresolving mediators (SPMs) regulate leukocyte function and inflammation. They are ideally positioned at the interface of the innate and adaptive immune responses when lymphocytes interact with leukocytes. Receptors for leukotriene B
    MeSH term(s) Animals ; Dinoprostone/metabolism ; Eicosanoids/metabolism ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Leukotriene B4/metabolism ; Lymphocytes/metabolism
    Chemical Substances Eicosanoids ; Leukotriene B4 (1HGW4DR56D) ; Dinoprostone (K7Q1JQR04M)
    Language English
    Publishing date 2018-11-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2018.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Resolution, the grail for healthy ocular inflammation.

    Gronert, Karsten

    Experimental eye research

    2010  Volume 91, Issue 4, Page(s) 478–485

    Abstract: Acute inflammation is a frequent, essential and beneficial response to maintain normal tissue function. PMN are the primary effector cells of acute inflammatory responses and their timely resolution by macrophages from an injured, stressed or infected ... ...

    Abstract Acute inflammation is a frequent, essential and beneficial response to maintain normal tissue function. PMN are the primary effector cells of acute inflammatory responses and their timely resolution by macrophages from an injured, stressed or infected tissues are required for the successful execution of this routine tissue response. Dysregulation of this fundamental program is a major factor in the global disease burden and contributes to many ocular diseases. Counter-regulatory signals are critical to the controlled activation of innate and adaptive immune responses in the eye and recent studies have identified two circuits in the cornea, uvea and/or retina, namely 15-lipoxygenase and heme-oxygenase, which control inflammation, promote resolution of PMN and afford neuroprotection. The role of these counter-regulator and pro-resolution circuits may provide insight into ocular inflammatory diseases and opportunities to restore stressed ocular tissue to a pre-inflammatory state, namely homeostasis, rather than limiting therapeutic options to palliative inhibition of pro-inflammatory circuits.
    MeSH term(s) Animals ; Arachidonate 15-Lipoxygenase/physiology ; Endophthalmitis/immunology ; Eye/immunology ; Heme Oxygenase (Decyclizing)/physiology ; Humans ; Inflammation/immunology ; Macrophages/immunology ; Neutrophils/immunology
    Chemical Substances Arachidonate 15-Lipoxygenase (EC 1.13.11.33) ; Heme Oxygenase (Decyclizing) (EC 1.14.14.18)
    Language English
    Publishing date 2010-07-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80122-7
    ISSN 1096-0007 ; 0014-4835
    ISSN (online) 1096-0007
    ISSN 0014-4835
    DOI 10.1016/j.exer.2010.07.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 163: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: The role of pro-resolving lipid mediators in ocular diseases.

    Wei, Jessica / Gronert, Karsten

    Molecular aspects of medicine

    2017  Volume 58, Page(s) 37–43

    MeSH term(s) Animals ; Corneal Diseases/metabolism ; Humans ; Inflammation/metabolism ; Inflammation Mediators/metabolism ; Lipids/chemistry ; Photoreceptor Cells, Vertebrate/metabolism ; Wound Healing/physiology
    Chemical Substances Inflammation Mediators ; Lipids
    Language English
    Publishing date 2017-04-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2017.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1189: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Dysregulation of Neuroprotective Lipoxin Pathway in Astrocytes in Response to Cytokines and Ocular Hypertension.

    Karnam, Shruthi / Maurya, Shubham / Ng, Elainna / Choudhary, Amodini / Thobani, Arzin / Flanagan, John G / Gronert, Karsten

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. Our recent study found that lipoxin ... ...

    Abstract Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. Our recent study found that lipoxin B
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.22.546157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The potential of lipid mediator networks as ocular surface therapeutics and biomarkers.

    Flitter, Becca A / Fang, Xiaohui / Matthay, Michael A / Gronert, Karsten

    The ocular surface

    2020  Volume 19, Page(s) 104–114

    Abstract: In the last twenty years an impressive body of evidence in diverse inflammatory animal disease models and human tissues, has established polyunsaturated fatty acids (PUFA) derived specialized-pro-resolving mediators (SPM), as essential mediators for ... ...

    Abstract In the last twenty years an impressive body of evidence in diverse inflammatory animal disease models and human tissues, has established polyunsaturated fatty acids (PUFA) derived specialized-pro-resolving mediators (SPM), as essential mediators for controlling acute inflammation, immune responses, wound healing and for resolving acute inflammation in many non-ocular tissues. SPM pathways and receptors are highly expressed in the ocular surface where they regulate wound healing, nerve regeneration, innate immunity and sex-specific regulation of auto-immune responses. Recent evidence indicates that in the eye these resident SPM networks are important for maintaining ocular surface health and immune homeostasis. Here, we will review and discuss evidence for SPMs and other PUFA-derived mediators as important endogenous regulators, biomarkers for ocular surface health and disease and their therapeutic potential.
    MeSH term(s) Animals ; Biomarkers ; Female ; Homeostasis ; Humans ; Inflammation ; Inflammation Mediators ; Lipids ; Male
    Chemical Substances Biomarkers ; Inflammation Mediators ; Lipids
    Language English
    Publishing date 2020-04-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2208578-6
    ISSN 1937-5913 ; 1542-0124
    ISSN (online) 1937-5913
    ISSN 1542-0124
    DOI 10.1016/j.jtos.2020.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6458: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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