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  1. Article ; Online: Characterization of sleep in emerging adults with cystic fibrosis on elexacaftor/tezacaftor/ivacaftor.

    Meltzer, Lisa J / Gross, Jane E

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2023  Volume 23, Issue 1, Page(s) 132–136

    MeSH term(s) Adult ; Humans ; Cystic Fibrosis/complications ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis/drug therapy ; Sleep ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Aminophenols/adverse effects ; Benzodioxoles/adverse effects ; Mutation ; Chloride Channel Agonists/adverse effects ; Drug Combinations ; Indoles ; Pyrazoles ; Pyridines ; Pyrrolidines ; Quinolones
    Chemical Substances elexacaftor (RRN67GMB0V) ; ivacaftor (1Y740ILL1Z) ; tezacaftor ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Aminophenols ; Benzodioxoles ; Chloride Channel Agonists ; Drug Combinations ; Indoles ; Pyrazoles ; Pyridines ; Pyrrolidines ; Quinolones
    Language English
    Publishing date 2023-05-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2023.05.005
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  2. Article ; Online: Monoclonal Antibodies: Medical Uses for the Prevention and Treatment of Disease.

    Carlos, W Graham / Gross, Jane E / Cruz, Charles Dela / Jamil, Shazia

    American journal of respiratory and critical care medicine

    2021  Volume 203, Issue 11, Page(s) P26–P27

    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; COVID-19/drug therapy ; Drug Combinations ; Humans
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Drug Combinations ; bamlanivimab and etesevimab drug combination ; casirivimab and imdevimab drug combination
    Language English
    Publishing date 2021-04-16
    Publishing country United States
    Document type Patient Education Handout
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.2021C3
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  3. Article ; Online: Prevention of transmission of Mycobacterium abscessus among patients with cystic fibrosis.

    Gross, Jane E / Martiniano, Stacey L / Nick, Jerry A

    Current opinion in pulmonary medicine

    2019  Volume 25, Issue 6, Page(s) 646–653

    Abstract: Purpose of review: Pulmonary nontuberculous mycobacterial (NTM) infection is recognized as one of the most challenging infections to treat among cystic fibrosis patients. The source of NTM infection, modes of transmission, and exposure risks are poorly ... ...

    Abstract Purpose of review: Pulmonary nontuberculous mycobacterial (NTM) infection is recognized as one of the most challenging infections to treat among cystic fibrosis patients. The source of NTM infection, modes of transmission, and exposure risks are poorly understood. Healthcare-associated transmission of Mycobacterium abscessus among cystic fibrosis patients has been suspected and is a growing concern for cystic fibrosis centers worldwide. This review describes our current understanding of prevention of healthcare-associated transmission of M. abscessus among patients with cystic fibrosis.
    Recent findings: Multiple healthcare-associated outbreaks of M. abscessus among cystic fibrosis patients within cystic fibrosis care centers have been reported. The percentage of patients involved in the reported outbreaks, as well as the perceived impact of patient-to-patient transmission varies dramatically between the reporting centers and population surveys. Several groups have now proposed M. abscessus-specific measures to limit future outbreaks.
    Summary: Improved NTM surveillance combined with a standardized, systematic approach to epidemiologic investigation of potential episodes of healthcare-associated transmission will help to reveal risk factors for NTM acquisition and inform future evidence-based infection prevention and control measures for patients with cystic fibrosis.
    MeSH term(s) Cross Infection/microbiology ; Cross Infection/prevention & control ; Cross Infection/transmission ; Cystic Fibrosis/microbiology ; Cystic Fibrosis/therapy ; Humans ; Infection Control/methods ; Infection Control/organization & administration ; Mycobacterium Infections, Nontuberculous/microbiology ; Mycobacterium Infections, Nontuberculous/prevention & control ; Mycobacterium Infections, Nontuberculous/transmission ; Mycobacterium abscessus/isolation & purification ; Risk Factors
    Language English
    Publishing date 2019-08-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000621
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  4. Article ; Online: ATS core curriculum 2023. Pediatric pulmonary medicine: Respiratory disorders in infants.

    Leon-Astudillo, Carmen / Dy, Fei J / McCown, Michael Y / Perez, Iris A / Chhabra, Divya / Bansal, Manvi / Maloney, Melissa A / Bedoya, Mariana / Ezmigna, Dima / Bush, Douglas / Okorie, Caroline U A / Gross, Jane E

    Pediatric pulmonology

    2024  

    Abstract: The American Thoracic Society Core Curriculum updates clinicians annually in pediatric pulmonary disease. This is a summary of the Pediatric Pulmonary Medicine Core Curriculum presented at the 2023 American Thoracic Society International Conference. The ... ...

    Abstract The American Thoracic Society Core Curriculum updates clinicians annually in pediatric pulmonary disease. This is a summary of the Pediatric Pulmonary Medicine Core Curriculum presented at the 2023 American Thoracic Society International Conference. The respiratory disorders of infancy discussed in this year's review include: the care of the patient with bronchopulmonary dysplasia in the neonatal intensive care unit, clinical phenotypes and comorbidities; diffuse lung disease; pulmonary hypertension; central and obstructive sleep apnea. The care of infants with respiratory disorders often poses significant challenges to the general pediatric pulmonologist, sleep clinician, and neonatologist. This review aims to highlight the most clinically relevant aspects of the evaluation, management, and outcomes of infants with these key respiratory disorders, while emphasizing the importance of multidisciplinary care. Furthermore, this document summarizes essential aspects of genetic testing, novel imaging and treatment modalities, and includes multiple resources for clinical practice.
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26961
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  5. Article ; Online: ATS Core Curriculum 2022. Pediatric Pulmonary Medicine: Updates in pediatric neuromuscular disease.

    Leon-Astudillo, Carmen / Okorie, Caroline U A / McCown, Michael Y / Dy, Fei J / Puranik, Sandeep / Prero, Moshe / ElMallah, Mai K / Treat, Lauren / Gross, Jane E

    Pediatric pulmonology

    2023  Volume 58, Issue 7, Page(s) 1866–1874

    Abstract: The American Thoracic Society Core Curriculum updates clinicians annually in pediatric pulmonary disease. This is a concise review of the Pediatric Pulmonary Medicine Core Curriculum presented at the 2022 American Thoracic Society International ... ...

    Abstract The American Thoracic Society Core Curriculum updates clinicians annually in pediatric pulmonary disease. This is a concise review of the Pediatric Pulmonary Medicine Core Curriculum presented at the 2022 American Thoracic Society International Conference. Neuromuscular diseases (NMD) comprise a variety of conditions that commonly affect the respiratory system and cause significant morbidity including dysphagia, chronic respiratory failure, and sleep disordered breathing. Respiratory failure is the most common cause of mortality in this population. Substantial progress has been made in diagnosis, monitoring and treatment for NMD over the last decade. Pulmonary function testing (PFT) is utilized to objectively measure respiratory pump function and PFT milestones are utilized in NMD-specific pulmonary care guidelines. New disease modifying therapies are approved for the treatment of patients with Duchenne muscular dystrophy and spinal muscular atrophy (SMA), including the first ever approved systemic gene therapy, in the case of SMA. Despite extraordinary progress in the medical management of NMD, little is known regarding the respiratory implications and long-term outcomes for patients in the era of advanced therapeutics and precision medicine. The combination of technological and biomedical advancements has increased the complexity of the medical decision-making process for patients and families, thus emphasizing the importance of balancing respect for autonomy with the other foundational principles of medical ethics. This review features an overview of PFT, noninvasive ventilation strategies, novel and developing therapies, as well as the ethical considerations specific to the management of patients with pediatric NMD.
    MeSH term(s) Humans ; Child ; Pulmonary Medicine ; Neuromuscular Diseases/diagnosis ; Neuromuscular Diseases/therapy ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy ; Respiration ; Muscular Atrophy, Spinal ; Curriculum
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26448
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  6. Article ; Online: COVID-19: How Do We Stay Safe?

    Carlos, W Graham / Cruz, Charles S Dela / Cao, Bin / Gross, Jane E / Pasnick, Susan / Jamil, Shazia

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 5, Page(s) P15–P16

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Disease Transmission, Infectious/prevention & control ; Humans ; Pandemics ; Personal Protective Equipment/supply & distribution ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; SARS-CoV-2
    Language English
    Publishing date 2020-09-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.2025P15
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  7. Article ; Online: Diagnosis and Management of COVID-19 Disease.

    Jamil, Shazia / Mark, Nick / Carlos, Graham / Cruz, Charles S Dela / Gross, Jane E / Pasnick, Susan

    American journal of respiratory and critical care medicine

    2020  Volume 201, Issue 10, Page(s) P19–P20

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.2020C1
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  8. Article: Eradication of

    Anisowicz, Sarah K / Welsh, Sebastian K / Gross, Jane E

    Global pediatric health

    2016  Volume 3, Page(s) 2333794X16670985

    Language English
    Publishing date 2016-11-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785531-4
    ISSN 2333-794X ; 2333-794X
    ISSN (online) 2333-794X
    ISSN 2333-794X
    DOI 10.1177/2333794X16670985
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  9. Article ; Online: Prospective healthcare-associated links in transmission of nontuberculous mycobacteria among people with cystic fibrosis (pHALT NTM) study: Rationale and study design.

    Gross, Jane E / Caceres, Silvia / Poch, Katie / Epperson, L Elaine / Hasan, Nabeeh A / Jia, Fan / Calado Nogueira de Moura, Vinicius / Strand, Matthew / Lipner, Ettie M / Honda, Jennifer R / Strong, Michael / Davidson, Rebecca M / Daley, Charles L / Nick, Jerry A

    PloS one

    2023  Volume 18, Issue 12, Page(s) e0291910

    Abstract: Background: Healthcare-associated acquisition and transmission of nontuberculous mycobacteria (NTM) among people with cystic fibrosis (pwCF) has been described, and remains a concern for both patients and providers. This report describes the design of a ...

    Abstract Background: Healthcare-associated acquisition and transmission of nontuberculous mycobacteria (NTM) among people with cystic fibrosis (pwCF) has been described, and remains a concern for both patients and providers. This report describes the design of a prospective observational study utilizing the standardized epidemiologic investigation toolkit for healthcare-associated links in transmission of NTM among pwCF.
    Methods: This is a parallel multi-site study of pwCF who have infections with respiratory NTM isolates and receive healthcare within a common CF Care Center. Participants have a history of one or more NTM positive airway cultures and have been identified as having NTM infections suggestive of a possible outbreak within a single Center, based on NTM isolate genomic analysis. Participants are enrolled in the study over a 3-year period. Primary endpoints are identification of shared healthcare-associated source(s) among pwCF in a Center, identification of healthcare environmental dust and water biofilm NTM isolates that are genetically highly-related to respiratory isolates, and identification of common home of residence watersheds among pwCF infected with clustered isolates. Secondary endpoints include characterization of healthcare-associated transmission and/or acquisition modes and settings as well as description of incidence and prevalence of healthcare-associated environmental NTM species/subspecies by geographical region.
    Discussion: We hypothesize that genetically highly-related isolates of NTM among pwCF cared for at the same Center may arise from healthcare sources including patient-to-patient transmission and/or acquisition from health-care environmental dust and/or water biofilms. This study design utilizes a published, standardized, evidence-based epidemiologic toolkit to facilitate confidential, independent healthcare-associated NTM outbreak investigations within CF Care Centers. This study will facilitate real-time, rapid detection and mitigation of healthcare-associated NTM outbreaks to reduce NTM risk, inform infection prevention and control guidelines, and characterize the prevalence and origin of NTM outbreaks from healthcare-associated patient-to-patient transmission and/or environmental acquisition. This study will systematically characterize human disease causing NTM isolates from serial collection of healthcare environmental dust and water biofilms and define the most common healthcare environmental sources harboring NTM biofilms.
    Trial registration: ClinicalTrials.gov NCT05686837.
    MeSH term(s) Humans ; Cystic Fibrosis/microbiology ; Delivery of Health Care ; Dust ; Mycobacterium Infections, Nontuberculous/microbiology ; Nontuberculous Mycobacteria/genetics ; Prospective Studies ; Water
    Chemical Substances Dust ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0291910
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  10. Article ; Online: SARS-CoV-2 Transmission and the Risk of Aerosol-Generating Procedures.

    Pasnick, Susan / Carlos, W Graham / Dela Cruz, Charles S / Gross, Jane E / Garrison, Garth / Jamil, Shazia

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 4, Page(s) P13–P14

    MeSH term(s) Aerosols/adverse effects ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Disease Transmission, Infectious/statistics & numerical data ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; SARS-CoV-2
    Chemical Substances Aerosols
    Language English
    Publishing date 2020-08-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.2024P13
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