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  1. Book: Pocket guide to ocular oncology and pathology

    Grossniklaus, Hans E.

    2013  

    Author's details Hans E. Grossniklaus ed
    Keywords Augentumor
    Subject Auge
    Language English
    Size XVI, 433 S. : zahlr. Ill., graph. Darst.
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017411051
    ISBN 978-3-642-28911-8 ; 9783642297823 ; 3-642-28911-8 ; 364229782X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 4025 order for loan Magazin

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  2. Book: Eye pathology

    Heegaard, Steffen / Grossniklaus, Hans E.

    an illustrated guide

    2015  

    Author's details Steffen Heegaard ; Hans Grossniklaus ed
    Keywords Augenkrankheit
    Subject Ophthalmopathia ; Ophthalmopathie ; Augenerkrankung
    Language English
    Size VIII, 739 S. : zahlr. Ill.
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT018511425
    ISBN 978-3-662-43381-2 ; 978-3-662-51182-4 ; 3-662-43381-8 ; 9783662433829 ; 3-662-51182-7 ; 3662433826
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 143 available for loan (reading room) Lesesaal EG

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  3. Book: WHO classification of tumours of the eye

    Eberhart, Charles G. / Kivelä, Tero / Grossniklaus, Hans E.

    (World Health Organization classification of tumours. 4th edition ; 12)

    2018  

    Institution Weltgesundheitsorganisation
    International Agency for Research on Cancer
    Author's details edited by Hans E. Grossniklaus, Charles G. Eberhart, Tero T. Kivelä
    Series title World Health Organization classification of tumours. 4th edition ; 12
    World Health Organization classification of tumours
    World Health Organization classification of tumours. 4th edition
    Collection World Health Organization classification of tumours
    World Health Organization classification of tumours. 4th edition
    Keywords Eye Neoplasms / pathology
    Language English
    Size 223 Seiten, Illustrationen
    Edition 4th edition
    Publisher International Agency for Research on Cancer
    Publishing place Lyon
    Publishing country France
    Document type Book
    Note "The WHO Classification of Tumors of the Eye presented in this book reflects the views of a Working Group that convened for a Consensus and Editorial Meeting at the International Agency for Research on Cancer, Lyon, 11-13 January 2018"
    HBZ-ID HT019920529
    ISBN 978-92-832-4497-4 ; 92-832-4497-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 1025 available for loan (reading room) Lesesaal EG

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  4. Article ; Online: Overrepresentation of human epidermal growth factor receptor 2 positive- and Luminal B breast cancer metastases in the eyes and orbit.

    Stålhammar, Gustav / Grossniklaus, Hans E

    Eye (London, England)

    2022  Volume 37, Issue 12, Page(s) 2499–2504

    Abstract: Background: Breast cancer is the most common cancer to spread to the choroid and orbit. Depending on a set of prognostic and predictive biomarkers, breast cancer can be divided into at least four distinct subtypes with separate treatment and clinical ... ...

    Abstract Background: Breast cancer is the most common cancer to spread to the choroid and orbit. Depending on a set of prognostic and predictive biomarkers, breast cancer can be divided into at least four distinct subtypes with separate treatment and clinical course.
    Subjects: Thirty-two patients with metastases to the eye and periocular area diagnosed between 2005 and 2020, of which 11 also had primary tumour tissue available. Expression levels of oestrogen- (ER) and progesterone receptors (PR), Human epidermal growth factor receptor 2 (HER2) and the proliferation marker Ki67 were analysed.
    Results: Twenty-five of 32 patients (78%) had a history of primary breast cancer, whereas the remaining 7 (22%) presented with metastatic disease. Of available metastases, 83% were positive for ER, 37% for PR, 54% for HER2, and 50% for Ki67. Metastases had significantly lower proportions of PR-positive cells than primary tumours, and the distribution of the Luminal A, Luminal B, HER2 enriched and triple-negative subtypes differed between primary tumours and metastases (P = 0.012): Six of 9 patients with a full set of biomarkers on both primary tumours and metastases switched subtype (67%), and 23 of 32 metastases (77%) were of the Luminal B subtype.
    Conclusions: Nearly 4 in 5 breast cancer metastases in the eyes and orbit are of the Luminal B subtype, and a majority are HER2 positive. The breast cancer subtype frequently switches between primary tumours and metastases. Future studies should evaluate these results in larger cohorts.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/pathology ; Biomarkers, Tumor/analysis ; Ki-67 Antigen/metabolism ; Orbit/pathology ; Orbital Neoplasms
    Chemical Substances ERBB2 protein, human (EC 2.7.10.1) ; Biomarkers, Tumor ; Ki-67 Antigen
    Language English
    Publishing date 2022-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-022-02363-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3010: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 603: Show issues

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  5. Article ; Online: Understanding Uveal Melanoma Metastasis to the Liver: The Zimmerman Effect and the Zimmerman Hypothesis.

    Grossniklaus, Hans E

    Ophthalmology

    2019  Volume 126, Issue 4, Page(s) 483–487

    MeSH term(s) DNA Mutational Analysis ; DNA, Neoplasm/genetics ; Disease Progression ; Eye Enucleation ; Humans ; Liver Neoplasms/secondary ; Melanoma/genetics ; Melanoma/secondary ; Neoplasm Metastasis ; Uveal Neoplasms/genetics ; Uveal Neoplasms/pathology
    Chemical Substances DNA, Neoplasm
    Language English
    Publishing date 2019-03-26
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2018.09.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.83: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 533: Show issues

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  6. Article: Intratumor Heterogeneity in Uveal Melanoma BAP-1 Expression.

    Stålhammar, Gustav / Grossniklaus, Hans E

    Cancers

    2021  Volume 13, Issue 5

    Abstract: Malignant tumors are rarely homogenous on the morphological, genome, transcriptome or proteome level. In this study, we investigate the intratumor heterogeneity of BAP-1 expression in uveal melanoma with digital image analysis of 40 tumors. The ... ...

    Abstract Malignant tumors are rarely homogenous on the morphological, genome, transcriptome or proteome level. In this study, we investigate the intratumor heterogeneity of BAP-1 expression in uveal melanoma with digital image analysis of 40 tumors. The proportion of BAP-1 positive cells was measured in full tumor sections, hot spots, cold spots and in scleral margins. The mean difference between hot spots and cold spots was 41 percentage points (pp, SD 29). Tumors with gene expression class 1 (associated with low metastatic risk) and 2 (high metastatic risk) had similar intratumor heterogeneity. Similarly, the level of intratumor heterogeneity was comparable in tumors from patients that later developed metastases as in patients that did not. BAP-1 measured in any tumor region added significant prognostic information to both American Joint Committee on Cancer (AJCC) tumor size category (
    Language English
    Publishing date 2021-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13051143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: What's in a Name? Large Choroidal Nevus, Small Choroidal Melanoma, or Indeterminate Melanocytic Tumor.

    Singh, Arun D / Grossniklaus, Hans E

    Ocular oncology and pathology

    2021  Volume 7, Issue 4, Page(s) 235–238

    Language English
    Publishing date 2021-06-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2806965-1
    ISSN 2296-4657 ; 2296-4681
    ISSN (online) 2296-4657
    ISSN 2296-4681
    DOI 10.1159/000516536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Orbital disease

    Grossniklaus, Hans E.

    (Ophthalmology clinics of North America ; 9,4)

    1996  

    Author's details Hans E. Grossniklaus ..., guest ed
    Series title Ophthalmology clinics of North America ; 9,4
    Collection
    Keywords Orbital Diseases
    Language English
    Size X S., S. 527 - 751 : zahlr. Ill.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT007422380
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1185 -9,4- verfügbar in Königswinter Königswinter

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  9. Article ; Online: Foreign body giant cell reaction to silicone oil presenting as a salmon-patch conjunctival lesion.

    Azarcon, Corrina P / Grossniklaus, Hans E / Wells, Jill R

    American journal of ophthalmology case reports

    2022  Volume 27, Page(s) 101676

    Abstract: Purpose: To describe a case of foreign body giant cell reaction to silicone oil that presented as a salmon-patch conjunctival lesion.: Observations: An elderly female with prior retinal surgery and oil tamponade was referred for a salmon-patch lesion ...

    Abstract Purpose: To describe a case of foreign body giant cell reaction to silicone oil that presented as a salmon-patch conjunctival lesion.
    Observations: An elderly female with prior retinal surgery and oil tamponade was referred for a salmon-patch lesion in the conjunctiva. Biopsy revealed multiple vacuolations and foreign body giant cells in the substantia propria, consistent with a foreign body reaction to silicone oil.
    Conclusion and importance: Silicone oil can elicit an inflammatory reaction in the conjunctiva that could mimic a neoplasm. Excessive leakage of oil into the subconjunctival space should be avoided to prevent this complication.
    Language English
    Publishing date 2022-08-05
    Publishing country United States
    Document type Case Reports
    ISSN 2451-9936
    ISSN (online) 2451-9936
    DOI 10.1016/j.ajoc.2022.101676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Multimodal Imaging and Histopathology Features of a Corneal Keloid.

    Azarcon, Corrina P / Wells, Jill R / Grossniklaus, Hans E

    Ophthalmology

    2022  Volume 129, Issue 4, Page(s) 378

    MeSH term(s) Connective Tissue Diseases ; Corneal Diseases/surgery ; Humans ; Keloid/diagnosis ; Keloid/pathology ; Keloid/surgery ; Keratoplasty, Penetrating/methods ; Multimodal Imaging ; Vision Disorders
    Language English
    Publishing date 2022-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2021.09.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.83: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 533: Show issues

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