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  1. AU="Grossouw, Laurens M"
  2. AU=Tse Tony
  3. AU="Desarkar, Satyapriya"
  4. AU="R. Bischof"
  5. AU="Eileen McNeely"
  6. AU="Canales-Manchuria, Fabrizzio"
  7. AU="Schäfer, Martin"
  8. AU=Lodhia Nilesh
  9. AU="Philippe Lefebvre"
  10. AU="McClorey, Graham"
  11. AU="Henein, Sandra"
  12. AU=Ng Michael
  13. AU="Elgammal, S"
  14. AU="Vaghela, Dixa A"
  15. AU="Lebigot, E O"
  16. AU="Abnave, Prasad"
  17. AU="Honkanen, Robert"
  18. AU="Talior-Volodarsky, Ilana"
  19. AU="Ellison, J"
  20. AU=Yang Ruinan
  21. AU=Lund Harald
  22. AU="Puskar, Werner"
  23. AU=Klotz S.
  24. AU="Andrea Puebla-Huerta"
  25. AU="Hartley, Tim"
  26. AU="Beucher, G"
  27. AU="Phan, Phuc Huu"
  28. AU="Arwanto, Viviana"
  29. AU="Miguel E. Rentería"
  30. AU="Zhou Bingfeng, Fujian Agriculture and Forestry University, Fuzhou(China), College of Bee Science"
  31. AU="Anant Desai, (UK)"
  32. AU="Mauget-Faÿsse, Martine"
  33. AU="Pang, Yuyang"
  34. AU="Akinwunmi, Adenike O"
  35. AU="Gopalakrishnan, Shyam"
  36. AU="Muralidharan, K K"
  37. AU="Andersson, Borje S"
  38. AU="Bajaj, Sumali"
  39. AU="Iwanaga, Terunao"
  40. AU="Alanazi, Bader S"
  41. AU="Tsuda, Kazutoshi"
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  43. AU="Yang, Shaofan"
  44. AU="Cucui, Andrea"
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  46. AU="Schrader, Thomas"
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  49. AU=Singh B N
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  51. AU="A.E.Pace, "
  52. AU="Scharbert, J"
  53. AU=Alganabi Mashriq
  54. AU=Balthazar Emil J
  55. AU="Pallos, Debora"
  56. AU="Tatsuya Igarashi"
  57. AU="Martinez, Randy"
  58. AU="Fu, Yayan"
  59. AU=Hertel Laura
  60. AU="Sasivimolrattana, Thanayod"
  61. AU="McAuley, Arnold" AU="McAuley, Arnold"
  62. AU="Reithmeier, Reinhart A F"
  63. AU="Ma, Dongmei"
  64. AU="Suh, M. H"
  65. AU="Xiao-Cheng Sun"
  66. AU="Belizario Quispe, Germán"

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  1. Artikel ; Online: Development, wiring and function of dopamine neuron subtypes.

    Garritsen, Oxana / van Battum, Eljo Y / Grossouw, Laurens M / Pasterkamp, R Jeroen

    Nature reviews. Neuroscience

    2023  Band 24, Heft 3, Seite(n) 134–152

    Abstract: The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviours and are linked to various brain diseases. Considerable progress has been made in identifying mDA neuron subtypes, and ...

    Abstract The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviours and are linked to various brain diseases. Considerable progress has been made in identifying mDA neuron subtypes, and recent work has begun to unveil how these neuronal subtypes develop and organize into functional brain structures. This progress is important for further understanding the disparate physiological functions of mDA neurons and their selective vulnerability in disease, and will ultimately accelerate therapy development. This Review discusses recent advances in our understanding of molecularly defined mDA neuron subtypes and their circuits, ranging from early developmental events, such as neuron migration and axon guidance, to their wiring and function, and future implications for therapeutic strategies.
    Mesh-Begriff(e) Humans ; Dopaminergic Neurons/physiology ; Mesencephalon ; Brain ; Dopamine ; Brain Diseases
    Chemische Substanzen Dopamine (VTD58H1Z2X)
    Sprache Englisch
    Erscheinungsdatum 2023-01-18
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2034150-7
    ISSN 1471-0048 ; 1471-0048 ; 1471-003X
    ISSN (online) 1471-0048
    ISSN 1471-0048 ; 1471-003X
    DOI 10.1038/s41583-022-00669-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development.

    Brignani, Sara / Raj, Divya D A / Schmidt, Ewoud R E / Düdükcü, Özge / Adolfs, Youri / De Ruiter, Anna A / Rybiczka-Tesulov, Mateja / Verhagen, Marieke G / van der Meer, Christiaan / Broekhoven, Mark H / Moreno-Bravo, Juan A / Grossouw, Laurens M / Dumontier, Emilie / Cloutier, Jean-François / Chédotal, Alain / Pasterkamp, R Jeroen

    Neuron

    2020  Band 107, Heft 4, Seite(n) 684–702.e9

    Abstract: The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviors and show select disease vulnerability, including in Parkinson's disease. Despite progress in identifying mDA neuron ... ...

    Abstract The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviors and show select disease vulnerability, including in Parkinson's disease. Despite progress in identifying mDA neuron subtypes, how these neuronal subsets develop and organize into functional brain structures remains poorly understood. Here we generate and use an intersectional genetic platform, Pitx3-ITC, to dissect the mechanisms of substantia nigra (SN) development and implicate the guidance molecule Netrin-1 in the migration and positioning of mDA neuron subtypes in the SN. Unexpectedly, we show that Netrin-1, produced in the forebrain and provided to the midbrain through axon projections, instructs the migration of GABAergic neurons into the ventral SN. This migration is required to confine mDA neurons to the dorsal SN. These data demonstrate that neuron migration can be controlled by remotely produced and axon-derived secreted guidance cues, a principle that is likely to apply more generally.
    Mesh-Begriff(e) Animals ; Axons/metabolism ; Cell Movement/physiology ; Dopaminergic Neurons/cytology ; Dopaminergic Neurons/metabolism ; GABAergic Neurons/cytology ; GABAergic Neurons/metabolism ; Mice ; Mice, Transgenic ; Netrin-1/metabolism ; Prosencephalon/metabolism ; Substantia Nigra/cytology ; Substantia Nigra/metabolism
    Chemische Substanzen Netrin-1 (158651-98-0)
    Sprache Englisch
    Erscheinungsdatum 2020-06-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2020.05.037
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2496: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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